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Gene: Cyp4a1 (cytochrome P450, family 4, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Description: Exhibits alkane 1-monooxygenase activity and arachidonic acid monooxygenase activity. Involved in animal organ development; fatty acid metabolic process; and icosanoid biosynthetic process. Localizes to the intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A22 (cytochrome P450 family 4 subfamily A member 22); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; linoleic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (2-trans,6-trans)-farnesol; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp4a10; Cyp4a22; CYPIVA10; cytochrome P450 4A10; Cytochrome P450 IVA1; cytochrome P450, 4A1; cytochrome P450, 4a10; cytochrome P450, family 4, subfamily a, polypeptide 10; cytochrome P450, family 4, subfamily A, polypeptide 22; Cytochrome P450, IVA1; cytochrome P450-LA-omega 1; cytochrome P452; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase; MGC108515; P450-LA-omega 1; P452
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05134,492,734 - 134,507,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05138,283,577 - 138,297,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,901,653 - 135,915,754 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15135,906,849 - 135,920,979 (+)NCBI
Celera5127,661,027 - 127,675,153 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp4a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68945
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.