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Gene: Heyl (hes-related family bHLH transcription factor with YRPW motif-like) Rattus norvegicus

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Symbol:

Heyl

Name:

hes-related family bHLH transcription factor with YRPW motif-like

RGD ID:

1305022

Description:

Predicted to enable several functions, including AF-1 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in several processes, including heart development; nephron development; and regulation of DNA-templated transcription. Predicted to act upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation; negative regulation of gene expression; and skeletal muscle cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human HEYL (hes related family bHLH transcription factor with YRPW motif like); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hairy/enhancer-of-split related with YRPW motif-like; LOC313575

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	140,793,271 - 140,810,262 (+)	NCBI		GRCr8
GRCr8 Ensembl	5	140,793,271 - 140,810,262 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	5	135,508,160 - 135,525,152 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	135,508,160 - 135,525,152 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	138,214,573 - 138,231,698 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	139,984,540 - 140,001,666 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	139,991,677 - 140,008,802 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	140,923,914 - 140,940,905 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	140,923,914 - 140,940,905 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	144,713,817 - 144,730,808 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	142,544,185 - 142,561,176 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	134,047,073 - 134,064,064 (+)	NCBI		Celera
RGSC_v3.1	5	142,549,721 - 142,563,036 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Carotid Artery Injuries (IEP)

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (EXP)

amitrole (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

diazinon (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethylparaben (ISO)

folic acid (ISO)

GW 4064 (ISO)

hydrogen peroxide (ISO)

L-methionine (ISO)

lead diacetate (ISO)

maneb (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

Monobutylphthalate (ISO)

monoethyl phthalate (ISO)

monosodium L-glutamate (ISO)

nitrofen (EXP)

Nutlin-3 (ISO)

paraquat (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

sevoflurane (ISO)

sotorasib (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

testosterone (EXP)

titanium dioxide (ISO)

toluene (EXP)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

tungsten (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure formation involved in morphogenesis (IEA)

anterior/posterior pattern specification (IBA)

atrioventricular valve morphogenesis (IEA,ISO)

cardiac epithelial to mesenchymal transition (IEA,ISO)

cardiac ventricle morphogenesis (IEA,ISO)

cellular response to BMP stimulus (IEA,ISO)

endocardial cushion morphogenesis (IEA,ISO)

epithelial to mesenchymal transition involved in endocardial cushion formation (IEA,ISO)

glomerulus development (IEA,ISO)

mesenchymal cell development (IEA,ISO)

muscle organ development (IEA)

negative regulation of androgen receptor signaling pathway (IEA,ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of gene expression (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

Notch signaling pathway (IEA,ISO)

outflow tract morphogenesis (IEA,ISO)

positive regulation of neuron differentiation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

proximal tubule development (IEA,ISO)

pulmonary valve morphogenesis (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of neurogenesis (IBA)

regulation of neuron differentiation (IEA)

regulation of transcription by RNA polymerase II (IBA)

skeletal muscle cell differentiation (IEA,ISO)

striated muscle tissue development (IEA)

tissue morphogenesis (IEA)

ventricular septum morphogenesis (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

AF-1 domain binding (IEA,ISO)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO)

identical protein binding (IEA)

protein binding (ISO)

protein dimerization activity (IEA)

protein homodimerization activity (IEA,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

sequence-specific DNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Notch signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors.	Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK.	Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.

Additional References at PubMed

PMID:10964718	PMID:15485867	PMID:15821257	PMID:16199874	PMID:17303760	PMID:19631204	PMID:21259317	PMID:21290414	PMID:21454491	PMID:22147266	PMID:22615585

Genomics

Comparative Map Data

Heyl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	140,793,271 - 140,810,262 (+)	NCBI		GRCr8
GRCr8 Ensembl	5	140,793,271 - 140,810,262 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	5	135,508,160 - 135,525,152 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	135,508,160 - 135,525,152 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	138,214,573 - 138,231,698 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	139,984,540 - 140,001,666 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	139,991,677 - 140,008,802 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	140,923,914 - 140,940,905 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	140,923,914 - 140,940,905 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	144,713,817 - 144,730,808 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	142,544,185 - 142,561,176 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	134,047,073 - 134,064,064 (+)	NCBI		Celera
RGSC_v3.1	5	142,549,721 - 142,563,036 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

HEYL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	39,623,435 - 39,639,643 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	39,623,435 - 39,639,643 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	40,089,107 - 40,105,315 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	39,861,690 - 39,877,935 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	39,758,917 - 39,774,411	NCBI
Celera	1	38,370,855 - 38,387,100 (-)	NCBI		Celera
Cytogenetic Map	1	p34.2	NCBI
HuRef	1	38,207,488 - 38,223,733 (-)	NCBI		HuRef
CHM1_1	1	40,204,476 - 40,220,725 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	39,487,908 - 39,508,063 (-)	NCBI		T2T-CHM13v2.0

Heyl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	123,127,349 - 123,143,663 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	123,127,349 - 123,143,668 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	123,233,556 - 123,249,870 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	123,233,556 - 123,249,875 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	122,910,799 - 122,927,113 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	122,736,156 - 122,752,173 (+)	NCBI		MGSCv36	mm8
Celera	4	121,565,928 - 121,582,239 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	57.41	NCBI

Heyl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	17,134,770 - 17,152,924 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	17,137,066 - 17,152,714 (-)	NCBI	ChiLan1.0	ChiLan1.0

HEYL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	187,182,481 - 187,198,009 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	186,320,121 - 186,335,647 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	38,913,549 - 38,929,798 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	40,240,114 - 40,256,300 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	40,240,118 - 40,256,933 (-)	Ensembl	panpan1.1		panPan2

Heyl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	55,678,981 - 55,688,610 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	21,505,149 - 21,510,624 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	21,503,763 - 21,513,392 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HEYL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	95,442,661 - 95,459,575 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	95,442,655 - 95,459,597 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	88,532,056 - 88,547,809 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HEYL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	93,230,189 - 93,246,549 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	23,571,967 - 23,587,587 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Heyl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	22,122,079 - 22,135,252 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	22,118,995 - 22,135,280 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Heyl
68 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	746
Count of miRNA genes:	284
Interacting mature miRNAs:	378
Transcripts:	ENSRNOT00000020929
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
7411722	Strs6	Sensitivity to stroke QTL 6	3.9		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	5	140258140	143398122	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

D4Mit11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	92,690,519 - 92,690,793 (+)	Marker Load Pipeline
mRatBN7.2	4	91,360,527 - 91,360,801 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	92,484,039 - 92,484,312	NCBI	Rnor6.0
Rnor_5.0	4	157,291,086 - 157,291,359	UniSTS	Rnor5.0
RGSC_v3.4	4	91,330,582 - 91,330,856	RGD	RGSC3.4
RGSC_v3.4	4	91,330,583 - 91,330,856	UniSTS	RGSC3.4
Celera	4	86,134,746 - 86,135,019	UniSTS
RGSC_v3.1	4	91,575,008 - 91,575,281	RGD
RH 3.4 Map	4	577.9	RGD
RH 3.4 Map	4	577.9	UniSTS
RH 2.0 Map	4	591.5	RGD
Cytogenetic Map	5	q36	UniSTS

RH137535

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	140,802,653 - 140,802,806 (+)	Marker Load Pipeline
mRatBN7.2	5	135,517,542 - 135,517,695 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,933,297 - 140,933,449	NCBI	Rnor6.0
Rnor_5.0	5	144,723,200 - 144,723,352	UniSTS	Rnor5.0
RGSC_v3.4	5	142,553,568 - 142,553,720	UniSTS	RGSC3.4
Celera	5	134,056,456 - 134,056,608	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH143142

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,516,105 - 135,516,206 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,931,860 - 140,931,960	NCBI	Rnor6.0
Rnor_5.0	5	144,721,763 - 144,721,863	UniSTS	Rnor5.0
RGSC_v3.4	5	142,552,131 - 142,552,231	UniSTS	RGSC3.4
Celera	5	134,055,019 - 134,055,119	UniSTS
RH 3.4 Map	5	889.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH143336

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,523,274 - 135,523,417 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,939,029 - 140,939,171	NCBI	Rnor6.0
Rnor_5.0	5	144,728,932 - 144,729,074	UniSTS	Rnor5.0
RGSC_v3.4	5	142,559,300 - 142,559,442	UniSTS	RGSC3.4
Celera	5	134,062,188 - 134,062,330	UniSTS
RH 3.4 Map	5	889.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

BG378118

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,524,668 - 135,524,848 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,940,422 - 140,940,601	NCBI	Rnor6.0
Rnor_5.0	5	144,730,325 - 144,730,504	UniSTS	Rnor5.0
RGSC_v3.4	5	142,560,693 - 142,560,872	UniSTS	RGSC3.4
Celera	5	134,063,581 - 134,063,760	UniSTS
RH 3.4 Map	5	875.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

BE100438

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,521,935 - 135,522,102 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,937,690 - 140,937,856	NCBI	Rnor6.0
Rnor_5.0	5	144,727,593 - 144,727,759	UniSTS	Rnor5.0
RGSC_v3.4	5	142,557,961 - 142,558,127	UniSTS	RGSC3.4
Celera	5	134,060,849 - 134,061,015	UniSTS
RH 3.4 Map	5	889.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

D4Mit11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,507,899 - 135,508,022 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,923,654 - 140,923,776	NCBI	Rnor6.0
Rnor_5.0	5	144,713,557 - 144,713,679	UniSTS	Rnor5.0
RGSC_v3.4	5	142,543,925 - 142,544,047	UniSTS	RGSC3.4
Celera	5	134,046,813 - 134,046,935	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	49	113	91	90	59	25	59	6	218	97	11	93	45	60	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020929 ⟹ ENSRNOP00000020928

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	140,793,271 - 140,810,262 (+)	Ensembl
mRatBN7.2 Ensembl	5	135,508,160 - 135,525,152 (+)	Ensembl
Rnor_6.0 Ensembl	5	140,923,914 - 140,940,905 (+)	Ensembl

RefSeq Acc Id:

NM_001107977 ⟹ NP_001101447

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	140,793,271 - 140,810,262 (+)	NCBI
mRatBN7.2	5	135,508,160 - 135,525,152 (+)	NCBI
Rnor_6.0	5	140,923,914 - 140,940,905 (+)	NCBI
Rnor_5.0	5	144,713,817 - 144,730,808 (+)	NCBI
RGSC_v3.4	5	142,544,185 - 142,561,176 (+)	RGD
Celera	5	134,047,073 - 134,064,064 (+)	RGD

Sequence:

show sequence

CTCTGGGCTTCCCCGTGGGGCCTCCCAGGGCACCTGCCCAAGGCCACCCAGCGCGCCAGCCCAG
GCAGCGCCGGTGGAGCGGAGCCGGACCTCCCAGCGGCCGATGGGGGCGGTGACCGCCCGGGGCC
TTCCCACGGTTCGGTGGCGCGTCACCGCGGGGGCGAGGGGGCGCCGGGGCGCCCTGGGCTGCGG
TGCAGGAAAGGGCCCTGGGAAAGGGCGGCGTTGGCTCCTGGGCCGGGGCGGGGCTGAGGCGGGG
CCCAGAGACCAACTCCAGGGATCGCAGGGCTGGGACCCCGCAGCCAGCTTTCGCCATGAAGCGG
CCCAGGGCGCCCAGTGGCTCCGACGGCGAGTCTGATGGACCCATCGACGTGGGTCAGGAGAACG
ATCTTAGCCAGATGGCCAGACCGCTGACCACCCCCAGCCCTTCGCAGATGCAAGCCCGGAAGAA
GCGCAGAGGGATCATAGAGAAACGGCGCCGAGACCGCATCAACAGCAGCCTGTCTGAACTGCGA
CGATTGGTCCCCACTGCCTTTGAGAAACAGGGCTCCTCTAAGCTGGAGAAAGCTGAGGTTTTGC
AGATGACCGTGGATCACTTGAAGATGCTCCATGCCTCTGGTGGCGCAGGGTTCTTTGATGCCCG
AGCCCTGGCTGTTGACTTCCGGAGCATTGGTTTTCGGGAATGCCTTACTGAGGTCGTAAGATAC
CTGGGGGTCCTGGAAGGACCCAGCAGCCATGCAGACCCCGTCCGGATTCGCCTCCTCTCCCACC
TCAACAGCTATGCAGCAGAGATGGAACCCTCGCCCACAACCACCGGTGCCCTGGCCTTTCCCGT
GTGGCCCTGGTCCTTCCTCCATAGCTGTCCAGGCTTGCCTTCCCTGAGCAGTCAGCTAGCCATC
CTGGGAAGAGTGCCCGGCCCCGTCCTTCCCAATGTCTCTTCTCCCCCTTACCCGATCTCAGCCC
TGCGGTCCGCACCAGTGCACAGAGTTCCTGGTACCATTCCCCCAGCCCAGCGGAATTTGCTGCC
CAGCCGAGGGGTGACTTCCTCCCAGAGAGCCCACCCTCCTGAGAGGCCAGCTGCCCCTCCACCC
ACAGCCCTAGGTGTCAGGGCCGCCAGGAGCATAGTCCCCATCCTGCCGTGTTCCTCCCCAGCAG
CCCCTGGAGCTGGGAAATCTGATGACAGTGCGTCTGGTTCTATCTCTAGTCCGTCTCCTTTGGG
ACCAACGGGGAGGCCTGCGGGAGCAGTGTTCTACCACTCCTGGGTATCAGAAATCACTGAAATT
GGGGCTTTCTGAGCTGACTCCCACAACCATCCCCTAGGAATGAGGAAGGTTCTTTATTTTCTCT
CCCTGAAGCCCTAAAAGTGGTTGTCATGTTTTCTGTTTTGTTTTCTCAAATGGCTTCTCTGCAG
AGGCACCTCTCCTCACCCGTCAGAGCCCCACTCCCTCACCCTCCTCACCACTGACCCCGATACT
TACCTGGCTCCCTGCAGCCTTTTGAGAGCTCAGAGCCTCAGTCTCATTTCCCACTGACACAGAG
GAGTTGTGTGGCGTCTTGTGAGCCCTTAGGCACTGTGGGTCCAAAGCCAGGTTGCTCCAATGAA
GAGGTGAGACACACAGCCCACCTCAGTCGGGACGACCGGTGGGATTCAGCCATCCCAAGCCAGC
AGGATAGAATGTACTCCCTGCTTCCCTTCCTGAAGACAGAAACGGAGCAGGGGCTGCGGAGAAG
TCTCTGTGGCTCACCCCACAACAGTGAAACACAGAACTGTTCTCTGGTACTTCTAAGGCCTGCA
GCTACCATCATCCCAACTTCAGTTGTCCAGATGATCGCCTACTGGCTTGACACACCAGGCCAGG
AGGATTCTCCACAGAATCGAAGCTCTGTGGCAGGGCATCCTCACTATCAGGCTTCTAAGTTGCT
TCAGATAGGAGCCAGGGTTGGGAAGGTAACAGAAGAACCCAGCTCCCTGTCTCTCAGGCACCAC
CATCCTCCAGAACTACAGCCCTTCCCACAGGGTTCCCAGTGTGGAGGACCAGTGACCCTGATGG
TGGAACCCCCCAAGAGGCTTTCTCTTGGGATTCAGCCCCAGACATCTGAGCTGCCTGGTTTGCA
TCCGGCTCCCAGAGCCCAGACCGCTGCCACAGCCAAGGGCTGTCAGGCTGGATAAAAATAACTC
AGAGGAGGGGGAGAACCACCAGAGGTGGCTCTTCAAGGTCATGGAGTGGGTTGAGGGCCTGAGA
GCCTGCTCACCCAGATTTCGCACAGCTGGCTCTGCTCAGAAGCCGGCTCACGCCTCAGCTCCGC
CTCAGGCCCCAGGCTTCTAGTGGGAATAAATGGCTGGTGGAACAACAGAGCCTGAACCAACATT
TAGGGTTGTCCCATAATCAAAGTGTGGAAACATTTCTGTCCTCTATGGTGAACACCTGCTCCCC
ACGGCGCCCTCCAGGACCACCCAGCATGCCCTCCGGAAGCACCCGGTGAGAACCTAGAACTCAC
TACCCTGCTGATCATGAAAGACGTTCAAGATCACCCTGGAAAGCCCCCTCCCCCCAACAAACCC
CATTCCCAGACTTTGATGGAACTGTGGTCCCCAGAGCTGTTGTAAGGAGCCTGTGACCGCAAGA
TTAGAGTTTGAAAAAGCCATGGAGCAAAACGGTCACTTCAGAAAAGTGGGACAGAGGGCAGAGG
TCACCTGAGTGACCCAGAAAGTGCTTGCGAATAGGTCAAGAAGACATAAAGGCTCCCTTTTCTC
CCTAATGAAAGCAAGCTCTTTTTAATATTGCTGCCATAGTGGACCTCTCTGAGGGCGTGCATCG
CTGTGGTGTGCATCACCAGCCTGCCGATGGAGACAGATACAGGGACAGCAGGACAGTCTTGCAG
GCCCCTGCGAGTGGGGAGAGGAGGCGGTAAAGGTCCCGGATATTCAGGTCTCTCTGCAAGCCTG
TGGTTTGGCAGCCTCCTAGCCAGAGGTTGAGTGTGGGAAACATTTCTAGGCTGCAGGTACTCAA
ACTGCAGAACCGTCTCTTGACACCGAGATGGCAGAGGCCGCTGCACCCTTTCAGCATCCATCCT
GATTGGTCTTGGGCTCATTCTCCCAGGAGACTGGGCAGGCTACCCCACCCACACCCACACCCAC
ACCCACACCCACACCCACACCCACACCCACACCCAGCTGAGAACTCAAGTCCCCTGTTTCCAGT
CCCAGGCGGAACTCTCTGGTGTCCCCAACACTCATCCCACTGCGGGGTGTTGCAGACAAGTAAT
AAAGATGTTTGTTTCCTTCCACCAGACTCTACGTGCTAAGTATTTCTGGAGTCTTTGAACCTAC
AGCCCCTGGTCTGGCAATGTCCCTTCTCCCCTAGATTCTCCCCAGCTCCCTTGCTTCTCTCTGG
CTGTGCCATCAGTTCTGAACAGCCGCTGGAGAGAACATAGCATGGGCAGGGCACATTGCATCAA
CCCAGCCTCAAACCTAGACACCCCCCCCCCCCGCACCCTGCTATTCTCGTGATGACAACCAGAG
CCCTTTTTACAATCCAAACACGATTCCTAGTCTTATTTCTTGCTGGCCCCAATCTTGCTCAGTG
CTTATGCAACACTGGCCTATTCTCTTCCACCTTAGAGCTGCTCATATGAGGGTCCCAGAATGCC
CCCCTTTATGAGGCGTACTTGAGCCCCTCAGACACCTCCTCCTGGAGGCCTTCCGGGACTAATG
TGCTTGAACAGCTCGTTCATCTGAGAAGCCCATTGTCTCCTGTCCTGGAGAGTTAGCTGATGTC
TAGCTACTTATGTGTCTACTTGATTGGGTATGTTCCCCACTGGAACGTAAGCTCAGTGAAGCCA
GGGGCCAGAGCTGGCCCGTGCTCCCATCTGCACTTGGCACGGAGCACAGTGCCTATCTATCAAT
TTCTGTTGCATAAATCGATCGAGGAGGTGAGACAGCTTCTGGTTTCCTGCTCTGGCTGGCCGAC
TCTGCTGGAGTGGGTTCTACCTCCATTCCTGCTGGCTGACTTTGAGAGGAGGCAGGAGAGCCAA
GGCCAAAGGACTGGGGGTTCTGGAAGAATGGTCAGAAGGCCCTGGCCAGAGGAGACGCAAGCGT
GTTGGCCCTGGAGTGAATGCTGACAGCTGAGCCTGCCAGCGGGTTTGTTCTTTGCTCTTGGCCT
GGCTCCTTGATACATCTAGCTCCTAACAAGCCCAGCATTCACGGAGATCTACTCTGCGCCAGCC
AGGCCTAGCAGAGCCAACAGTAACAAACACATGGTCACTCAGAGGACAATATATCCTCTACCTA
GATAAGAGGGCCATGAGACAGTCCATGGAAAAGGCAGAGGGCTGCAGAGCCGGGTAGGTATTTC
TGGCTAGGTAGGAAGTGGGAGAGGGCCTGGAAGGAAGCCCTCCCAGAGGAGGGCCAGGGGACTC
CCTTTTACAGATCTAGAGGCTGACCCAGGTTCTGAACACATGTGGAAGAAGGGCTAGCCTGAGC
TCTGAAACTAATCTTCTTTATTACACGCTTGCTAATGAGGAATCATTTTCTTCAAGTTCTTTGT
CCTTCTTGAACTTAATGTTTCCATCTGTAAAATGGTTATGTTGTAGCAATGGCTCCCTACATGT
GTGCATGTATGTACACACAACTAAATAAAACTGTCACATTTTTTTTAAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101447	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80374	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020928
	ENSRNOP00000020928.2

RefSeq Acc Id:

NP_001101447 ⟸ NM_001107977

- UniProtKB:

D3ZIH3 (UniProtKB/TrEMBL), A6IS23 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRINSSLS
ELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGAGFFDARALAVDFRSIGFRECLTEV
VRYLGVLEGPSSHADPVRIRLLSHLNSYAAEMEPSPTTTGALAFPVWPWSFLHSCPGLPSLSSQ
LAILGRVPGPVLPNVSSPPYPISALRSAPVHRVPGTIPPAQRNLLPSRGVTSSQRAHPPERPAA
PPPTALGVRAARSIVPILPCSSPAAPGAGKSDDSASGSISSPSPLGPTGRPAGAVFYHSWVSEI
TEIGAF

hide sequence

Ensembl Acc Id:

ENSRNOP00000020928 ⟸ ENSRNOT00000020929

Protein Domains

bHLH Orange

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZIH3-F1-model_v2	AlphaFold	D3ZIH3	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305022	AgrOrtholog
BioCyc Gene	G2FUF-40014	BioCyc
Ensembl Genes	ENSRNOG00000015318	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020929	ENTREZGENE
	ENSRNOT00000020929.4	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
	6.10.250.980	UniProtKB/TrEMBL
InterPro	HES_HEY	UniProtKB/TrEMBL
	HLH_DNA-bd	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	Orange	UniProtKB/TrEMBL
KEGG Report	rno:313575	UniProtKB/TrEMBL
NCBI Gene	313575	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED	UniProtKB/TrEMBL
Pfam	Hairy_orange	UniProtKB/TrEMBL
	HLH	UniProtKB/TrEMBL
PhenoGen	Heyl	PhenoGen
PROSITE	HLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015318	RatGTEx
SMART	HLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
Superfamily-SCOP	HLH_basic	UniProtKB/TrEMBL
	Orange domain-like	UniProtKB/TrEMBL
UniProt	A6IS23	ENTREZGENE, UniProtKB/TrEMBL
	D3ZIH3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-11-11	Heyl	hes-related family bHLH transcription factor with YRPW motif-like	Heyl	hairy/enhancer-of-split related with YRPW motif-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Heyl	hairy/enhancer-of-split related with YRPW motif-like	Heyl_predicted	hairy/enhancer-of-split related with YRPW motif-like (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Heyl_predicted	hairy/enhancer-of-split related with YRPW motif-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations