Gene: Akr1a1 (aldo-keto reductase family 1 member A1) Rattus norvegicus
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Symbol: Akr1a1
Name: aldo-keto reductase family 1 member A1
Description: ENCODES a protein that exhibits glucuronolactone reductase activity; L-glucuronate reductase activity; alditol:NADP+ 1-oxidoreductase activity (ortholog); INVOLVED IN cellular detoxification of aldehyde; D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; PARTICIPATES IN doxorubicin pharmacokinetics pathway; prostaglandin biosynthetic pathway; gluconeogenesis pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); perinatal necrotizing enterocolitis (ortholog); FOUND IN apical plasma membrane (ortholog); cytosol (ortholog); synapse (ortholog); INTERACTS WITH 2,2,2-tetramine; 2,4,6-trinitrotoluene; 2,4-dibromophenyl 2,4,5-tribromophenyl ether
AGR Description: Exhibits L-glucuronate reductase activity and glucuronolactone reductase activity; involved in D-glucuronate catabolic process, L-ascorbic acid biosynthetic process, and cellular detoxification of aldehyde; predicted to localize to the apical plasma membrane, cytosol, and synapse; orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).
Merged Description: Exhibits L-glucuronate reductase activity and glucuronolactone reductase activity; involved in D-glucuronate catabolic process, L-ascorbic acid biosynthetic process, and cellular detoxification of aldehyde; predicted to localize to the apical plasma membrane, cytosol, and synapse; orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1); PARTICIPATES IN doxorubicin pharmacokinetics pathway; prostaglandin biosynthetic pathway; gluconeogenesis pathway; INTERACTS WITH 2,2,2-tetramine; 2,4,6-trinitrotoluene; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-DG-reducing enzyme; Akr1a4; alcohol dehydrogenase; alcohol dehydrogenase [NADP(+)]; alcohol dehydrogenase [NADP+]; aldehyde reductase; aldo-keto reductase family 1 member A1 (aldehyde reductase); aldo-keto reductase family 1, member A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); glucuronate reductase; glucuronolactone reductase
Orthologs:
Homo sapiens (human) : AKR1A1 (aldo-keto reductase family 1 member A1)  HGNC  Alliance
Mus musculus (house mouse) : Akr1a1 (aldo-keto reductase family 1, member A1 (aldehyde reductase))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akr1a1 (aldo-keto reductase family 1 member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : AKR1A1 (aldo-keto reductase family 1 member A1)
Canis lupus familiaris (dog) : AKR1A1 (aldo-keto reductase family 1 member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akr1a1 (aldo-keto reductase family 1 member A1)
Sus scrofa (pig) : AKR1A1 (aldo-keto reductase family 1 member A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05135,482,068 - 135,498,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05139,278,242 - 139,294,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,920,561 - 136,937,422 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15136,925,785 - 136,942,923 (-)NCBI
Celera5128,620,481 - 128,637,092 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Akr1a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68346
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.