Akr1a1 (aldo-keto reductase family 1 member A1) - Rat Genome Database

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Gene: Akr1a1 (aldo-keto reductase family 1 member A1) Rattus norvegicus
Analyze
Symbol: Akr1a1
Name: aldo-keto reductase family 1 member A1
RGD ID: 68346
Description: Enables L-glucuronate reductase activity and glucuronolactone reductase activity. Involved in carboxylic acid metabolic process; cellular detoxification of aldehyde; and negative regulation of apoptotic process. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1); PARTICIPATES IN doxorubicin pharmacokinetics pathway; prostaglandin biosynthetic pathway; gluconeogenesis pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-DG-reducing enzyme; Akr1a4; alcohol dehydrogenase; alcohol dehydrogenase [NADP(+)]; alcohol dehydrogenase [NADP+]; aldehyde reductase; aldo-keto reductase family 1 member A1 (aldehyde reductase); aldo-keto reductase family 1, member A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); glucuronate reductase; glucuronolactone reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25130,092,945 - 130,130,277 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,092,732 - 130,113,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,717,057 - 132,734,057 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,471,650 - 134,488,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,494,047 - 134,511,049 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,482,068 - 135,498,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,482,068 - 135,498,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,278,242 - 139,294,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,920,561 - 136,937,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,925,785 - 136,942,923 (-)NCBI
Celera5128,620,481 - 128,637,092 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
13-dihydrodaunorubicin  (ISO)
16-Ketoestrone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-formylbenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrobenzaldehyde  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9,10-phenanthroquinone  (ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diethyl maleate  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
Fidarestat  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glucuronic acid  (EXP,ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexane-2,3-dione  (ISO)
hydralazine  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
methidathion  (ISO)
methylglyoxal  (EXP,ISO)
monosodium L-glutamate  (ISO)
Muconic dialdehyde  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
omeprazole  (EXP)
ozone  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
Phenylglyoxal  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP)
pyrogallol  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP,ISO)
streptozocin  (EXP)
succinic semialdehyde  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO,ISS)
synapse  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Hlaváč V, etal., Medicine (Baltimore). 2014 Dec;93(28):e255. doi: 10.1097/MD.0000000000000255.
3. Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury. Homma T, etal., Toxicol Lett. 2018 Sep 15;294:37-43. doi: 10.1016/j.toxlet.2018.05.015. Epub 2018 May 12.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals. Kurahashi T, etal., Biochem Biophys Res Commun. 2014 Sep 12;452(1):136-41. doi: 10.1016/j.bbrc.2014.08.072. Epub 2014 Aug 21.
6. Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases. Lacroix Pepin N, etal., Prostaglandins Other Lipid Mediat. 2013 Oct;106:124-32. doi: 10.1016/j.prostaglandins.2013.05.005. Epub 2013 Jun 6.
7. Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma. Liu C, etal., Cell Cycle. 2019 Mar;18(5):568-579. doi: 10.1080/15384101.2019.1578146. Epub 2019 Feb 17.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone. Suzuki K, etal., J Biochem. 1998 Feb;123(2):353-7.
18. In vivo role of aldehyde reductase. Takahashi M, etal., Biochim Biophys Acta. 2012 Nov;1820(11):1787-96. doi: 10.1016/j.bbagen.2012.07.003. Epub 2012 Jul 20.
19. Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression. Takahashi M, etal., Gene 1993 May 30;127(2):249-53.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
22. Author Correction: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Zhou HL, etal., Nature. 2019 Jun;570(7759):E23. doi: 10.1038/s41586-019-1225-0.
Additional References at PubMed
PMID:7669785   PMID:10510318   PMID:12732097   PMID:14667815   PMID:15489334   PMID:15769935   PMID:16635246   PMID:18276838   PMID:19056867   PMID:19199708   PMID:20410296   PMID:20458337  
PMID:23376485   PMID:23533145   PMID:23580065  


Genomics

Comparative Map Data
Akr1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25130,092,945 - 130,130,277 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,092,732 - 130,113,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,717,057 - 132,734,057 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,471,650 - 134,488,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,494,047 - 134,511,049 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,482,068 - 135,498,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,482,068 - 135,498,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,278,242 - 139,294,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,920,561 - 136,937,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,925,785 - 136,942,923 (-)NCBI
Celera5128,620,481 - 128,637,092 (-)NCBICelera
Cytogenetic Map5q35NCBI
AKR1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,550,826 - 45,570,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,550,543 - 45,570,049 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,016,498 - 46,035,721 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,789,085 - 45,808,308 (+)NCBINCBI36Build 36hg18NCBI36
Build 34145,685,590 - 45,704,813NCBI
Celera144,300,464 - 44,319,706 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,127,818 - 44,147,063 (+)NCBIHuRef
CHM1_1146,133,579 - 46,152,870 (+)NCBICHM1_1
T2T-CHM13v2.0145,423,192 - 45,442,415 (+)NCBIT2T-CHM13v2.0
Akr1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,493,707 - 116,508,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,493,707 - 116,508,877 (-)EnsemblGRCm39 Ensembl
GRCm384116,636,510 - 116,651,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,636,510 - 116,651,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,309,115 - 116,324,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,134,442 - 116,149,583 (-)NCBIMGSCv36mm8
Celera4115,370,207 - 115,385,626 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.26NCBI
Akr1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,714,717 - 12,729,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,715,238 - 12,729,034 (-)NCBIChiLan1.0ChiLan1.0
AKR1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11180,381,197 - 180,399,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,853,867 - 44,871,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,211,859 - 46,230,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,211,859 - 46,230,072 (+)Ensemblpanpan1.1panPan2
AKR1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,792,398 - 14,808,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,742,012 - 14,808,592 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,913,465 - 14,929,729 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,947,192 - 14,963,694 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,896,489 - 14,963,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,744,329 - 14,760,787 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,814,053 - 14,828,473 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,884,045 - 14,900,543 (-)NCBIUU_Cfam_GSD_1.0
Akr1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,855,920 - 60,872,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,680,676 - 26,697,214 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647426,680,736 - 26,696,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,811,247 - 165,824,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,811,245 - 165,825,168 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AKR1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,228,348 - 87,245,511 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,228,189 - 87,245,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,719,096 - 29,738,521 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akr1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,463,201 - 1,474,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akr1a1
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:69
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000023072
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 10
Medium 3 43 57 41 19 41 8 11 74 25 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023072   ⟹   ENSRNOP00000023072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,092,963 - 130,113,674 (-)Ensembl
Rnor_6.0 Ensembl5135,482,068 - 135,498,822 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101228   ⟹   ENSRNOP00000092196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,092,732 - 130,097,916 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114894   ⟹   ENSRNOP00000081527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,094,166 - 130,113,674 (-)Ensembl
RefSeq Acc Id: NM_031000   ⟹   NP_112262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25130,092,946 - 130,109,575 (-)NCBI
Rnor_6.05135,482,068 - 135,498,693 (-)NCBI
Rnor_5.05139,278,242 - 139,294,867 (-)NCBI
RGSC_v3.45136,920,561 - 136,937,422 (-)RGD
Celera5128,620,481 - 128,637,092 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110816   ⟹   XP_038966744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25130,092,945 - 130,130,277 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112262   ⟸   NM_031000
- UniProtKB: P51635 (UniProtKB/Swiss-Prot),   A6JZ88 (UniProtKB/TrEMBL),   A0A8I6AVC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023072   ⟸   ENSRNOT00000023072
RefSeq Acc Id: XP_038966744   ⟸   XM_039110816
- Peptide Label: isoform X1
- UniProtKB: P51635 (UniProtKB/Swiss-Prot),   A6JZ88 (UniProtKB/TrEMBL),   A0A8I6AVC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081527   ⟸   ENSRNOT00000114894
RefSeq Acc Id: ENSRNOP00000092196   ⟸   ENSRNOT00000101228
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51635-F1-model_v2 AlphaFold P51635 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693937
Promoter ID:EPDNEW_R4462
Type:initiation region
Name:Akr1a1_1
Description:aldo-keto reductase family 1 member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,498,706 - 135,498,766EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68346 AgrOrtholog
BioCyc Gene G2FUF-40245 BioCyc
BioCyc Pathway PWY-6307 [L-tryptophan degradation X (mammalian, via tryptamine)] BioCyc
Ensembl Genes ENSRNOG00000016727 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023072 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000101228 ENTREZGENE
  ENSRNOT00000101228.1 UniProtKB/TrEMBL
  ENSRNOT00000114894.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918695 IMAGE-MGC_LOAD
InterPro AKR UniProtKB/TrEMBL
  AKR1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78959 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72802 IMAGE-MGC_LOAD
NCBI Gene 78959 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKR1A1 RGD
PhenoGen Akr1a1 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016727 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204008
UniProt A0A8I5ZT45_RAT UniProtKB/TrEMBL
  A0A8I6AVC9 ENTREZGENE, UniProtKB/TrEMBL
  A6JZ87_RAT UniProtKB/TrEMBL
  A6JZ88 ENTREZGENE, UniProtKB/TrEMBL
  AK1A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Akr1a1  aldo-keto reductase family 1 member A1  Akr1a1  aldo-keto reductase family 1, member A1 (aldehyde reductase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Akr1a1  aldo-keto reductase family 1, member A1 (aldehyde reductase)  Akr1a1  aldo-keto reductase family 1, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Akr1a1  aldo-keto reductase family 1, member A1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the NADPH-dependent reduction of 3-deoxyglucosone (3-DG) 724707