KCNQ4 (potassium voltage-gated channel subfamily Q member 4) - Rat Genome Database

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Gene: KCNQ4 (potassium voltage-gated channel subfamily Q member 4) Pan paniscus
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Symbol: KCNQ4
Name: potassium voltage-gated channel subfamily Q member 4
RGD ID: 11882345
Description: ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN inner ear morphogenesis (ortholog); negative regulation of synaptic transmission, dopaminergic (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 2A (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); voltage-gated potassium channel complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel, KQT-like subfamily, member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21185,977,915 - 186,035,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,119,207 - 185,176,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0140,076,552 - 40,133,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1141,396,117 - 41,452,780 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl141,396,111 - 41,452,780 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNQ4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21185,977,915 - 186,035,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,119,207 - 185,176,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0140,076,552 - 40,133,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1141,396,117 - 41,452,780 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl141,396,111 - 41,452,780 (+)Ensemblpanpan1.1panPan2
KCNQ4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,783,787 - 40,840,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,783,787 - 40,840,452 (+)EnsemblGRCh38hg38GRCh38
GRCh37141,249,459 - 41,306,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36141,022,271 - 41,076,947 (+)NCBINCBI36Build 36hg18NCBI36
Build 34140,918,776 - 40,973,453NCBI
Celera139,531,891 - 39,588,392 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef139,389,941 - 39,423,633 (+)NCBIHuRef
CHM1_1141,365,539 - 41,422,020 (+)NCBICHM1_1
T2T-CHM13v2.0140,653,010 - 40,709,692 (+)NCBIT2T-CHM13v2.0
Kcnq4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,553,331 - 120,605,809 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,553,335 - 120,605,809 (-)EnsemblGRCm39 Ensembl
GRCm384120,696,134 - 120,747,491 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4120,696,138 - 120,748,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv374120,370,078 - 120,419,781 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364120,193,773 - 120,246,247 (-)NCBIMGSCv36mm8
Celera4119,415,703 - 119,465,580 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map456.52NCBI
Kcnq4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,560,366 - 139,612,212 (-)NCBIGRCr8
mRatBN7.25134,275,145 - 134,326,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,275,934 - 134,326,932 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05139,625,783 - 139,677,300 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,627,576 - 139,677,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,423,596 - 143,443,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,289,211 - 141,339,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5132,831,886 - 132,880,820 (-)NCBICelera
Cytogenetic Map5q36NCBI
Kcnq4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955537624,217 - 674,330 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955537624,217 - 671,407 (+)NCBIChiLan1.0ChiLan1.0
KCNQ4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,203,938 - 2,257,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,205,276 - 2,242,093 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,462,807 - 2,515,471 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,293,829 - 2,346,530 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,293,829 - 2,345,510 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,199,391 - 2,252,017 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,259,444 - 2,320,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,275,224 - 2,327,921 (-)NCBIUU_Cfam_GSD_1.0
Kcnq4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,619,577 - 56,671,314 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647422,444,358 - 22,496,105 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647422,444,359 - 22,496,097 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6170,346,141 - 170,401,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16170,346,135 - 170,401,534 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26157,393,601 - 157,448,978 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNQ4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,083,015 - 92,139,810 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,083,013 - 92,139,728 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,741,206 - 24,797,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624892226,324 - 275,195 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624892226,324 - 275,198 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059660   ⟹   ENSPPAP00000036766
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl141,396,111 - 41,452,780 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059669   ⟹   ENSPPAP00000036775
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl141,396,111 - 41,450,851 (+)Ensembl
RefSeq Acc Id: XM_008968418   ⟹   XP_008966666
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21185,977,915 - 186,035,313 (-)NCBI
NHGRI_mPanPan11185,119,207 - 185,176,590 (-)NCBI
Mhudiblu_PPA_v0140,076,553 - 40,133,913 (+)NCBI
PanPan1.1141,396,117 - 41,452,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034962486   ⟹   XP_034818377
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21185,977,915 - 186,035,314 (-)NCBI
NHGRI_mPanPan11185,119,207 - 185,176,591 (-)NCBI
Mhudiblu_PPA_v0140,076,552 - 40,133,913 (+)NCBI
RefSeq Acc Id: XM_063601406   ⟹   XP_063457476
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21185,977,915 - 186,034,874 (-)NCBI
RefSeq Acc Id: XM_063601409   ⟹   XP_063457479
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21185,977,915 - 186,034,874 (-)NCBI
RefSeq Acc Id: XM_063601410   ⟹   XP_063457480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21185,977,915 - 186,034,874 (-)NCBI
RefSeq Acc Id: XM_063601416   ⟹   XP_063457486
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21185,977,915 - 186,034,874 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008966666   ⟸   XM_008968418
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C497 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034818377   ⟸   XM_034962486
- Peptide Label: isoform X6
- UniProtKB: A0A2R9C4C0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000036775   ⟸   ENSPPAT00000059669
RefSeq Acc Id: ENSPPAP00000036766   ⟸   ENSPPAT00000059660
RefSeq Acc Id: XP_063457479   ⟸   XM_063601409
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063457480   ⟸   XM_063601410
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063457486   ⟸   XM_063601416
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063457476   ⟸   XM_063601406
- Peptide Label: isoform X1
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041138 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059660.1 UniProtKB/TrEMBL
  ENSPPAT00000059669.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/TrEMBL
NCBI Gene KCNQ4 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9C497 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C4C0 ENTREZGENE, UniProtKB/TrEMBL