Dvl1 (dishevelled segment polarity protein 1)

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Gene: Dvl1 (dishevelled segment polarity protein 1) Rattus norvegicus

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Symbol:

Dvl1

Name:

dishevelled segment polarity protein 1

RGD ID:

620632

Description:

Enables protein kinase binding activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron projection arborization. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dishevelled 1; dishevelled, dsh homolog 1; dishevelled, dsh homolog 1 (Drosophila); dishevelled-1; DSH homolog 1; dvl-1; segment polarity protein dishevelled homolog DVL-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DVL1 (dishevelled segment polarity protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dvl1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dvl1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DVL1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DVL1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dvl1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DVL1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DVL1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dvl1 (dishevelled segment polarity protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DVL1 (dishevelled segment polarity protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dvl1 (dishevelled segment polarity protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DVL1P1 (dishevelled segment polarity protein 1 pseudogene 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	dvl1b (dishevelled segment polarity protein 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dvl1a (dishevelled segment polarity protein 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	dsh-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	dsh	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dsh-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dvl1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	171,738,911 - 171,750,967 (+)	NCBI		GRCr8
mRatBN7.2	5	166,456,989 - 166,468,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	166,456,686 - 166,468,664 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	169,161,665 - 169,173,332 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,983,086 - 170,994,753 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,945,617 - 170,957,284 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	173,295,948 - 173,308,014 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	173,296,270 - 173,307,945 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	176,771,577 - 176,783,630 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	172,705,951 - 172,717,626 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	172,716,445 - 172,728,121 (+)	NCBI
Celera	5	164,657,716 - 164,669,383 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant Robinow syndrome 1 (ISO)

autosomal dominant Robinow syndrome 2 (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital myasthenic syndrome 8 (ISO)

DiGeorge syndrome (ISO)

dilated cardiomyopathy 1LL (ISO)

disease of mental health (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

Goldberg-Shprintzen syndrome (ISO)

idiopathic generalized epilepsy (ISO)

immunodeficiency 16 (ISO)

immunodeficiency 38 (ISO)

Joubert syndrome 25 (ISO)

myocardial infarction (IEP)

Neurodevelopmental Disorders (ISO)

Peroxisome Biogenesis Disorder, Complementation Group 7 (ISO)

Robinow syndrome (ISO)

Shprintzen-Goldberg Craniosynostosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

5-aza-2'-deoxycytidine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

carmustine (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

clofibric acid (EXP)

cocaine (EXP)

curcumin (EXP,ISO)

diazinon (EXP)

dibutyl phthalate (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

lead diacetate (ISO)

malathion (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (EXP)

niclosamide (ISO)

Nor-9-carboxy-delta9-THC (ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

proanthocyanidin (ISO)

resveratrol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tetrachloroethene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triadimefon (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

zearalenone (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon extension (ISO)

axon guidance (ISO)

axonogenesis (ISO)

canonical Wnt signaling pathway (IBA,ISO)

cochlea morphogenesis (ISO)

collateral sprouting (ISO)

convergent extension involved in neural plate elongation (ISO)

convergent extension involved in organogenesis (ISO)

cytoplasmic microtubule organization (ISO)

dendrite morphogenesis (ISO)

dendritic spine morphogenesis (IGI)

heart looping (ISO)

intracellular signal transduction (IEA)

negative regulation of protein phosphorylation (ISO)

neural tube development (ISO)

neuromuscular junction development (ISO)

neurotransmitter secretion (ISO)

outflow tract morphogenesis (ISO)

positive regulation of excitatory postsynaptic potential (IGI)

positive regulation of neuron projection arborization (IGI)

positive regulation of neuron projection development (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

postsynapse organization (ISO)

prepulse inhibition (ISO)

presynapse assembly (ISO)

protein localization to microtubule (ISO)

protein localization to nucleus (ISO)

protein stabilization (ISO)

receptor clustering (ISO)

regulation of DNA-templated transcription (ISO)

regulation of postsynapse organization (ISO)

regulation of protein localization (ISO)

regulation of protein phosphorylation (ISO)

regulation of synaptic vesicle exocytosis (ISO)

skeletal muscle acetylcholine-gated channel clustering (ISO)

social behavior (ISO)

synapse organization (ISO)

synaptic vesicle exocytosis (ISO)

Wnt signaling pathway (IEA,IGI,TAS)

Wnt signaling pathway, planar cell polarity pathway (ISO)

Cellular Component

axon (IDA,ISO)

clathrin-coated vesicle (ISO)

cytoplasm (ISO,ISS)

cytoplasmic vesicle (ISO)

cytosol (IBA,ISO)

dendrite (IDA)

dendritic spine (IDA)

glutamatergic synapse (ISO)

growth cone (IDA,ISO)

lateral plasma membrane (ISO)

microtubule (IDA)

microtubule cytoskeleton (IDA,ISO)

neuron projection (ISO)

neuronal cell body (IDA)

neuronal dense core vesicle (ISO)

plasma membrane (ISO,ISS)

postsynaptic density (IDA,ISO)

presynapse (ISO)

Schaffer collateral - CA1 synapse (ISO)

synapse (ISO)

Wnt signalosome (ISO)

Molecular Function

beta-catenin binding (ISO)

enzyme binding (ISO)

frizzled binding (IBA,ISO)

identical protein binding (ISO)

protein binding (ISO)

protein kinase binding (IPI,ISO)

small GTPase binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Notch signaling pathway (IEA)

Wnt signaling pathway (IEA,ISO)

Wnt signaling, canonical pathway (IDA,ISO)

Wnt signaling, non-canonical pathway (ISO)

Wnt signaling, the planar cell polarity pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway.	Aschenbach WG, etal., Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E152-8. Epub 2006 Feb 14.
2.	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
3.	Expression of Dishevelled-1 in wound healing after acute myocardial infarction: possible involvement in myofibroblast proliferation and migration.	Chen L, etal., J Cell Mol Med. 2004 Apr-Jun;8(2):257-64.
4.	Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II.	Ciani L, etal., Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10732-7. doi: 10.1073/pnas.1018132108. Epub 2011 Jun 13.
5.	Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke.	De Lange RP, etal., Neurogenetics 2001 Mar;3(2):99-106.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1.	Lijam N, etal., Cell 1997 Sep 5;90(5):895-905.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12.	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	Pizzuti A, etal., Am J Hum Genet. 1996 Apr;58(4):722-9.
13.	GOA pipeline	RGD automated data pipeline
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
16.	Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development.	Rosso SB, etal., Nat Neurosci. 2005 Jan;8(1):34-42. Epub 2004 Dec 19.
17.	Wnt-mediated relocalization of dishevelled proteins.	Steitz SA, etal., In Vitro Cell Dev Biol Anim. 1996 Jul-Aug;32(7):441-5.
18.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8817329	PMID:9271238	PMID:10330181	PMID:10409711	PMID:11113207	PMID:11742004	PMID:11742073	PMID:12138115	PMID:12165471	PMID:12556519	PMID:12805222	PMID:14648878
PMID:14734535	PMID:14747478	PMID:14960015	PMID:14966280	PMID:15454084	PMID:15548427	PMID:16116426	PMID:16571627	PMID:16818724	PMID:17005174	PMID:17027228	PMID:17212654
PMID:17239604	PMID:17558396	PMID:17593335	PMID:18093802	PMID:18716223	PMID:19008950	PMID:19020093	PMID:19388021	PMID:19625296	PMID:19643732	PMID:20177058	PMID:21189423
PMID:21718540	PMID:21880741	PMID:22899650	PMID:23074275	PMID:23160799	PMID:24305805	PMID:25674206	PMID:26359454	PMID:26400647	PMID:29510185	PMID:32105766	PMID:36726071

Genomics

Comparative Map Data

Dvl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	171,738,911 - 171,750,967 (+)	NCBI		GRCr8
mRatBN7.2	5	166,456,989 - 166,468,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	166,456,686 - 166,468,664 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	169,161,665 - 169,173,332 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,983,086 - 170,994,753 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,945,617 - 170,957,284 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	173,295,948 - 173,308,014 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	173,296,270 - 173,307,945 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	176,771,577 - 176,783,630 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	172,705,951 - 172,717,626 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	172,716,445 - 172,728,121 (+)	NCBI
Celera	5	164,657,716 - 164,669,383 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

DVL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	1,335,278 - 1,349,418 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	1,335,276 - 1,349,418 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	1,270,658 - 1,284,798 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	1,260,521 - 1,274,358 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	1,310,581 - 1,324,438	NCBI
Celera	1	1,305,944 - 1,310,484 (+)	NCBI		Celera
Cytogenetic Map	1	p36.33	NCBI
HuRef	1	541,861 - 555,565 (-)	NCBI		HuRef
CHM1_1	1	1,257,686 - 1,271,561 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	766,863 - 781,044 (-)	NCBI		T2T-CHM13v2.0

Dvl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	155,931,829 - 155,943,760 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	155,931,859 - 155,943,760 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	155,847,402 - 155,859,303 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	155,847,402 - 155,859,303 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	155,221,521 - 155,233,412 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	154,691,212 - 154,703,103 (+)	NCBI		MGSCv36	mm8
Celera	4	158,118,352 - 158,130,254 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	87.61	NCBI

Dvl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	9,464,313 - 9,469,984 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	9,464,390 - 9,469,984 (+)	NCBI	ChiLan1.0	ChiLan1.0

DVL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	226,875,118 - 226,889,403 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	225,573,663 - 225,587,944 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	92,469 - 106,748 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	1,292,052 - 1,300,006 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	1,292,052 - 1,301,008 (-)	Ensembl	panpan1.1		panPan2

DVL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	56,507,803 - 56,519,382 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	56,507,739 - 56,519,491 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	56,584,127 - 56,595,703 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	56,710,022 - 56,721,601 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	56,710,027 - 56,721,542 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	56,700,763 - 56,712,335 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	56,593,044 - 56,604,611 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	56,983,289 - 56,994,870 (-)	NCBI		UU_Cfam_GSD_1.0

Dvl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	27,654,912 - 27,668,618 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	1,797,326 - 1,810,286 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936737	1,797,348 - 1,811,043 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DVL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	63,617,789 - 63,628,913 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	63,617,787 - 63,628,965 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	58,115,863 - 58,126,973 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DVL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	130,105,032 - 130,118,978 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	130,104,639 - 130,117,139 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	34,662,915 - 34,682,331 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dvl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	8,267,128 - 8,278,725 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	8,267,111 - 8,283,755 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dvl1
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	121
Count of miRNA genes:	85
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000026439
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat

Markers in Region

RH141334

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	166,468,498 - 166,468,686 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	173,307,780 - 173,307,967	NCBI	Rnor6.0
Rnor_5.0	5	176,783,396 - 176,783,583	UniSTS	Rnor5.0
RGSC_v3.4	5	172,717,461 - 172,717,648	UniSTS	RGSC3.4
Celera	5	164,669,218 - 164,669,405	UniSTS
RH 3.4 Map	5	1174.5	UniSTS
Cytogenetic Map	5	q36	UniSTS

AI406524

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	166,463,925 - 166,464,075 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	173,303,207 - 173,303,356	NCBI	Rnor6.0
Rnor_5.0	5	176,778,823 - 176,778,972	UniSTS	Rnor5.0
RGSC_v3.4	5	172,712,888 - 172,713,037	UniSTS	RGSC3.4
Celera	5	164,664,645 - 164,664,794	UniSTS
RH 3.4 Map	5	1175.1	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC126156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF143545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF143546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH007910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC090034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC160920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026439 ⟹ ENSRNOP00000026439

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	166,456,989 - 166,468,664 (+)	Ensembl
Rnor_6.0 Ensembl	5	173,296,270 - 173,307,945 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107156 ⟹ ENSRNOP00000085309

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	166,456,686 - 166,468,575 (+)	Ensembl

RefSeq Acc Id:

NM_031820 ⟹ NP_114008

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,739,223 - 171,750,898 (+)	NCBI
mRatBN7.2	5	166,456,989 - 166,468,664 (+)	NCBI
Rnor_6.0	5	173,296,270 - 173,307,945 (+)	NCBI
Rnor_5.0	5	176,771,577 - 176,783,630 (+)	NCBI
RGSC_v3.4	5	172,705,951 - 172,717,626 (+)	RGD
Celera	5	164,657,716 - 164,669,383 (+)	RGD

Sequence:

show sequence

CATGGCGGAGACCAAAATCATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAGCTG
CCCGTAGCTCCCGAGCGCGTCACGCTGGCAGACTTCAAGAACGTGCTCAGCAACCGGCCGGTGC
ACGCCTACAAATTCTTCTTCAAGTCTATGGACCAGGACTTCGGGGTGGTGAAGGAGGAGATCTT
CGACGACAATGCCAAGTTGCCCTGCTTCAATGGCCGTGTGGTTTCCTGGCTGGTCCTGGCTGAG
GGCGCTCACTCGGATGCAGGGTCCCAGGGCACTGACAGCCACACGGACCTGCCCCCACCCCTTG
AGAGGACAGGCGGCATTGGGGACTCCAGGCCCCCCTCCTTCCATCCAAATGTTGCCAGTAGCCG
AGATGGAATGGACAATGAGACAGGCACAGAGTCAATGGTCAGTCACCGGCGGGAGCGAGCCCGA
CGTCGAAACCGTGATGAGGCTGCCCGGACCAATGGGCACCCAAGAGGGGACCGGCGGCGGGAGC
TGGGACTACCTCCAGACAGTGCGTCCACTGTACTGAGCAGTGAGCTTGAATCTAGCAGCTTTAT
TGACTCAGATGAGGAGGACAACACGAGCCGGCTGAGCAGCTCTACAGAGCAGAGTACCTCCTCT
CGGCTAATTCGTAAGCACAAATGCCGTCGTCGGAAGCAGCGCTTGAGGCAGACAGACCGGGCAT
CCTCCTTCAGCAGCATCACCGACTCTACCATGTCCCTGAACATCATCACTGTCACGCTCAACAT
GGAGAGGCACCACTTCCTGGGCATCAGCATCGTGGGCCAGAGCAACGACCGGGGTGATGGCGGC
ATCTACATTGGATCCATCATGAAGGGCGGGGCTGTGGCTGCTGATGGCCGCATTGAGCCAGGCG
ACATGTTGCTGCAGGTGAATGATGTCAACTTTGAGAACATGAGCAACGATGATGCCGTGCGGGT
GCTTCGGGAGATCGTATCCCAGACGGGGCCCATCAGTCTCACAGTGGCCAAGTGCTGGGACCCA
ACCCCTCGGAGCTACTTCACCATCCCAAGGGCTGACCCAGTGCGACCCATCGACCCGGCTGCCT
GGCTGTCCCACACAGCAGCACTGACCGGTGCTCTGCCCCGCTATGGTACGAGTCCCTGCTCCAG
CGCCATCACACGCACCAGCTCTTCCTCACTAACCAGCTCAGTGCCTGGCGCCCCACAGCTTGAG
GAGGCACCACTGACTGTGAAGAGTGACATGAGTGCCATTGTCCGCGTCATGCAGTTGCCAGACT
CGGGACTGGAGATCCGGGACCGCATGTGGCTTAAGATCACCATTGCCAATGCTGTCATTGGGGC
GGATGTGGTGGACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGAAGGGAGGCGAGGAAG
TATGCCAGCAGCATGCTGAAGCATGGTTTCCTGCGGCACACGGTGAACAAGATCACTTTCTCTG
AGCAGTGCTACTATGTCTTTGGTGACCTGTGCAGCAACCTCGCATCCCTGAACCTCAACAGTGG
CTCCAGTGGAGCCTCAGATCAGGACACACTGGCCCCACTGCCCCACCCATCTGTACCCTGGCCC
TTGGGTCAAGGCTATCCCTACCAGTACCCAGGACCCCCGCCCTGCTTCCCACCTGCTTACCAGG
ACCCTGGCTTCAGCTATGGCAGTGGCAGTGCTGGGAGTCAGCAGAGTGAAGGGAGCAAGAGCAG
TGGGTCCACACGGAGCAGCCATCGCACCCCAGGCCGAGAGGAGCGCCGGGCAACTGGAGCTGGG
GGTAGTGGCAGTGAATCAGACCACACAGTACCAAGTGGGTCTGGTAGCACTGGCTGGTGGGAGC
GGCCTGTCAGCCAGCTTAGCCGTGGCAGTAGCCCTCGAAGTCAGGCTTCAGCTGTTGCCCCAGG
GCTCCCTCCACTGCACCCCCTTACCAAGGCCTATGCAGTAGTGGGTGGGCCACCTGGAGGGCCA
CCTGTCCGGGAGCTGGCTGCTGTTCCTCCAGAACTTACAGGTAGCCGCCAGTCCTTCCAAAAGG
CCATGGGAAACCCCTGTGAGTTCTTTGTGGACATCATGTGATGATCAACCAGTGTCTTCAGTGC
TGCCTGTGGCGAGAGTCTGTGTTCCTGCTGTGCCAGGAGCTCTATGGGCTTGCCTTAGTGGTGG
CCGGCCAGGATAGGTCAGTCGTAGGGTCTGGGCCAGGGCAGAGGGAGCAGGCAACAGAAGAAGG
GCTGAGGGCAGCCATACGACCAAGATATCAGCTTGATATTTTGTCTGCTCTTGGGGCTGCTGGT
GGTGGTGCAGCTCAAGTATCTGTAGTCTTGTAAGGAGACATCTCTGTCTTTAAGTCCTCAGCAC
AGATCTCAGGGACCACCTCCTGGTTCCTTTTTTGGAAGTGACCTCCATTTAGGACAAGAAAGGC
TCTCTTGGGCTCTGTCACCCCTTTCCCCAAAGTCTCCCAGAACTGCACAGGGGCACAGGCTGAC
TGTCACTAAGTTTATGGGCCTCACCTGTCAGGCCAAGGTGGGGTTCTTGAGGGGTTAGACAGAG
CCCTCAAACCTCTCTGGCTGCCCAGGTGGGGTCTAACTTACTTATTTATTGCTAGCTTGCCTGC
TCCAAGGGCGGCAGCTGGTCACCCAGTGGGGCAGTTTGCACGCTCCTTTCCTCACCTGCAACTC
GGCACATGACAGCACAGTTTGTGTTGAAGGTATGTGGAGGATGGCTAGTAGGGAAGACAGGAGA
GAGGCCTGGCACTTATCTACTGTCTTAGTCTCAATGGCGGGTGAGAGTGAACACAAGAGCTGAA
GATGTGGGGTCCTGTCCTGTCACTGTTCTCCTGGTGGCTGCCCATCAGCATGTGCCACTGCCAT
CTCGGCACAGCAGCCCCACACATCTACACGAGACACTGTGTCAAGAAGTCTGAGCGACTGGGTA
GTTCACATAGA

hide sequence

RefSeq Acc Id:

XM_006239598 ⟹ XP_006239660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,738,912 - 171,750,967 (+)	NCBI
mRatBN7.2	5	166,456,990 - 166,468,733 (+)	NCBI
Rnor_6.0	5	173,295,949 - 173,308,014 (+)	NCBI
Rnor_5.0	5	176,771,577 - 176,783,630 (+)	NCBI

Sequence:

show sequence

CCGGCCCTGAAGCGCCCTCCGGCGGCCGAGCGCTCAACCCCACCAGGCGGTTCTTGAACAGCCC
GAGGGGGCGGCGGGCCGCAGTAGCCCTCTGAACTGCTTTCCCTCGCGCCCGCTCCGGGGCCGCA
GCGGATGGGCGGCCGCGGGCCGCGGGGCAACAGGCGGGGAACGGGTGCGAGCCGGGACCGGGAG
GGGCGGACGCGCAAAGGGGCCGCGGGGCGGCCGGGCGGGGCGCGGGCCGGCGGTTTGGGAGGGC
GCCCCGCGTCCGAGAGGTGAGCCGGGCCCTGACGCTGCGCGGGTTCCGCGTCGCCCCCGCCGCG
CCATGGCGGAGACCAAAATCATTTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAGCT
GCCCGTAGCTCCCGAGCGCGTCACGCTGGCAGACTTCAAGAACGTGCTCAGCAACCGGCCGGTG
CACGCCTACAAATTCTTCTTCAAGTCTATGGACCAGGACTTCGGGGTGGTGAAGGAGGAGATCT
TCGACGACAATGCCAAGTTGCCCTGCTTCAATGGCCGTGTGGTTTCCTGGCTGGTCCTGGCTGA
GGGCGCTCACTCGGATGCAGGGTCCCAGGGCACTGACAGCCACACGGACCTGCCCCCACCCCTT
GAGAGGACAGGCGGCATTGGGGACTCCAGGCCCCCCTCCTTCCATCCAAATGTTGCCAGTAGCC
GAGATGGAATGGACAATGAGACAGGCACAGAGTCAATGGTCAGTCACCGGCGGGAGCGAGCCCG
ACGTCGAAACCGTGATGAGGCTGCCCGGACCAATGGGCACCCAAGAGGGGACCGGCGGCGGGAG
CTGGGACTACCTCCAGACAGTGCGTCCACTGTACTGAGCAGTGAGCTTGAATCTAGCAGCTTTA
TTGACTCAGATGAGGAGGACAACACGAGCCGGCTGAGCAGCTCTACAGAGCAGAGTACCTCCTC
TCGGCTAATTCGTAAGCACAAATGCCGTCGTCGGAAGCAGCGCTTGAGGCAGACAGACCGGGCA
TCCTCCTTCAGCAGCATCACCGACTCTACCATGTCCCTGAACATCATCACCGTCACTCTCAACA
TGGAGAGGCACCACTTCCTGGGCATCAGCATCGTGGGCCAGAGCAACGACCGGGGTGATGGCGG
CATCTACATTGGATCCATCATGAAGGGCGGGGCTGTGGCTGCTGATGGCCGCATTGAGCCAGGC
GACATGTTGCTGCAGGTGAATGATGTCAACTTTGAGAACATGAGCAACGATGATGCCGTGCGGG
TGCTTCGGGAGATCGTATCCCAGACGGGGCCCATCAGTCTCACAGTGGCCAAGTGCTGGGACCC
AACCCCTCGGAGCTACTTCACCATCCCAAGGGCTGACCCAGTGCGACCCATCGACCCGGCTGCC
TGGCTGTCCCACACAGCAGCACTGACCGGTGCTCTGCCCCGCTATGAGCTTGAGGAGGCACCAC
TGACTGTGAAGAGTGACATGAGTGCCATTGTCCGCGTCATGCAGTTGCCAGACTCGGGACTGGA
GATCCGGGACCGCATGTGGCTTAAGATCACCATTGCCAATGCTGTCATTGGGGCGGATGTGGTG
GACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGAAGGGAGGCGAGGAAGTATGCCAGCA
GCATGCTGAAGCATGGTTTCCTGCGGCACACGGTGAACAAGATCACTTTCTCTGAGCAGTGCTA
CTATGTCTTTGGTGACCTGTGCAGCAACCTCGCATCCCTGAACCTCAACAGTGGCTCCAGTGGA
GCCTCAGATCAGGACACACTGGCCCCACTGCCCCACCCATCTGTACCCTGGCCCTTGGGTCAAG
GCTATCCCTACCAGTACCCAGGACCCCCGCCCTGCTTCCCACCTGCTTACCAGGACCCTGGCTT
CAGCTATGGCAGTGGCAGTGCTGGGAGTCAGCAGAGTGAAGGGAGCAAGAGCAGTGGGTCCACA
AGGAGCAGCCATCGGACCCCAGGCCGAGAGGAGCGCCGGGCAACTGGAGCTGGGGGTAGTGGCA
GTGAATCAGACCACACAGTACCAAGTGGGTCTGGTAGCACTGGCTGGTGGGAGCGGCCTGTCAG
CCAGCTTAGCCGTGGCAGTAGCCCTCGAAGTCAGGCTTCAGCTGTTGCCCCAGGGCTCCCTCCA
CTGCACCCCCTTACCAAGGCCTATGCAGTAGTGGGTGGGCCACCTGGAGGGCCACCTGTCCGGG
AGCTGGCTGCTGTTCCTCCAGAACTTACAGGTAGCCGCCAGTCCTTCCAAAAGGCCATGGGAAA
CCCCTGTGAGTTCTTTGTGGACATCATGTGATGATCAACCAGTGTCTTCAGTGCTGCCTGTGGC
GAGAGTCTGTGTTCCTGCTGTGCCAGGAGCTCTATGGGCTTGCCTTAGTGGTGGCCGGCCAGGA
TAGGTCAGTCGTAGGGTCTGGGCCAGGGCAGAGGGAGCAGGCAACAGAAGAAGGGCTGAGGGCA
GCCATACGACCAAGATATCAGCTTGATATTTTGTCTGCTCTTGGGGCTGCTGGTGGTGGTGCAG
CTCAAGTATCTGTAGTCTTGTAAGGAGACATCTCTGTCTTTAAGTCCTCAGCACAGATCTCAGG
GACCACCTCCTGGTTCCTTTTTTGGAAGTGACCTCCATTTAGGACAAGAAAGGCTCTCTTGGGC
TCTGTCACCCCTTTCCCCAAAGTCTCCCAGAACTGCACAGGGGCACAGGCTGACTGTCACTAAG
TTTATGGGCCTCACCTGTCAGGCCAAGGTGGGGTTCTTGAGGGGTTAGACAGAGCCCTCAAACC
TCTCTGGCTGCCCAGGTGGGGTCTAACTTACTTATTTATTGCTAGCTTGCCTGCTCCAAGGGCG
GCAGCTGGTCACCCAGTGGGGCAGTTTGCACGCTCCTTTCCTCACCTGCAACTCGGCACATGAC
AGCACAGTTTGTGTTGAAGGTATGTGGAGGATGGCTAGTAGGGAAGACAGGAGAGAGGCCTGGC
ACTTATCTACTGTCTTAGTCTCAATGGCGGGTGAGAGTGAACACAAGAGCTGAAGATGTGGGGT
CCTGTCCTGTCACTGTTCTCCTGGTGGCTGCCCATCAGCATGTGCCACTGCCATCTCGGCACAG
CAGCCCCACACATCTACACGAGACACTGTGTCAAGAAGTCTGAGCGACTGGGTAGTTCACATAG
AGCTGCTTCTGTGTAAATGCTGCTTCTGTGTAAATGCTATTTTAAACACTAAAAAAAGCGTTTA
ATTTTA

hide sequence

RefSeq Acc Id:

XM_039110851 ⟹ XP_038966779

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,739,273 - 171,750,967 (+)	NCBI
mRatBN7.2	5	166,457,025 - 166,468,733 (+)	NCBI

RefSeq Acc Id:

XM_063288482 ⟹ XP_063144552

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,738,911 - 171,749,218 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_114008	(Get FASTA)	NCBI Sequence Viewer
	XP_006239660	(Get FASTA)	NCBI Sequence Viewer
	XP_038966779	(Get FASTA)	NCBI Sequence Viewer
	XP_063144552	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD33896	(Get FASTA)	NCBI Sequence Viewer
	AAD33897	(Get FASTA)	NCBI Sequence Viewer
	AAD41492	(Get FASTA)	NCBI Sequence Viewer
	AAI60920	(Get FASTA)	NCBI Sequence Viewer
	EDL81336	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026439.5
	ENSRNOP00000085309.1
	ENSRNOP00055019229
	ENSRNOP00060005705
	ENSRNOP00065012521
GenBank Protein	Q9WVB9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_114008 ⟸ NM_031820

- UniProtKB:

Q9QUG5 (UniProtKB/Swiss-Prot), Q9WVB8 (UniProtKB/Swiss-Prot), Q9WVB9 (UniProtKB/Swiss-Prot), A6IUT5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIF
DDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSR
DGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRELGLPPDSASTVLSSELESSSFI
DSDEEDNTSRLSSSTEQSTSSRLIRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNM
ERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV
LREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSS
AITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGA
DVVDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSG
SSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSAGSQQSEGSKSS
GSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPG
LPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM

hide sequence

RefSeq Acc Id:

XP_006239660 ⟸ XM_006239598

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIF
DDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSR
DGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRELGLPPDSASTVLSSELESSSFI
DSDEEDNTSRLSSSTEQSTSSRLIRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNM
ERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV
LREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYELEEAPL
TVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASS
MLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQG
YPYQYPGPPPCFPPAYQDPGFSYGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGS
ESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRE
LAAVPPELTGSRQSFQKAMGNPCEFFVDIM

hide sequence

Ensembl Acc Id:

ENSRNOP00000026439 ⟸ ENSRNOT00000026439

RefSeq Acc Id:	XP_038966779 ⟸ XM_039110851
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000085309 ⟸ ENSRNOT00000107156

RefSeq Acc Id:	XP_063144552 ⟸ XM_063288482
- Peptide Label:	isoform X2

Protein Domains

DEP DIX PDZ

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WVB9-F1-model_v2	AlphaFold	Q9WVB9	1-695	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620632	AgrOrtholog
BioCyc Gene	G2FUF-38893	BioCyc
Ensembl Genes	ENSRNOG00000019423	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055013741	UniProtKB/Swiss-Prot
	ENSRNOG00060004547	UniProtKB/Swiss-Prot
	ENSRNOG00065010223	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026439.6	UniProtKB/Swiss-Prot
	ENSRNOT00000107156.1	UniProtKB/TrEMBL
	ENSRNOT00055023623	UniProtKB/Swiss-Prot
	ENSRNOT00060007603	UniProtKB/Swiss-Prot
	ENSRNOT00065016476	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.240.130	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599217	IMAGE-MGC_LOAD
	IMAGE:7461890	IMAGE-MGC_LOAD
InterPro	DEP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dishevelled_C-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dishevelled_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dishevelled_protein_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DIX_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dsh/Dvl-rel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83721	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:188669	IMAGE-MGC_LOAD
	MGC:72382	IMAGE-MGC_LOAD
NCBI Gene	83721	ENTREZGENE
PANTHER	PTHR10878	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10878:SF5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DEP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dishevelled	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dsh_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dvl1	PhenoGen
PRINTS	DISHEVELLED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DISHEVELLED1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	DEP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019423	RatGTEx
	ENSRNOG00055013741	RatGTEx
	ENSRNOG00060004547	RatGTEx
	ENSRNOG00065010223	RatGTEx
SMART	DAX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DEP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50156	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54236	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6IUT5	ENTREZGENE, UniProtKB/TrEMBL
	B1H2A0_RAT	UniProtKB/TrEMBL
	DVL1_RAT	UniProtKB/Swiss-Prot
	Q9QUG5	ENTREZGENE
	Q9WVB8	ENTREZGENE
	Q9WVB9	ENTREZGENE
UniProt Secondary	Q9QUG5	UniProtKB/Swiss-Prot
	Q9WVB8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-06-05	Dvl1	dishevelled segment polarity protein 1	Dvl1	dishevelled, dsh homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Dvl1	dishevelled, dsh homolog 1 (Drosophila)		dishevelled 1	Name updated	1299863	APPROVED
2002-08-07	Dvl1	dishevelled 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_other	excluded as a candidate gene for brain ischemia in the stroke-prone spontaneously hypertensive rat (SHRSP) because sequences in stroke-prone and control rats are identical	634738

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)