Gene: Dvl1 (dishevelled segment polarity protein 1) Rattus norvegicus
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Symbol: Dvl1
Name: dishevelled segment polarity protein 1
Description: ENCODES a protein that exhibits protein kinase binding; Rac GTPase binding; beta-catenin binding (ortholog); INVOLVED IN dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; positive regulation of neuron projection arborization; PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH myocardial infarction; autosomal dominant Robinow syndrome 1 (ortholog); autosomal dominant Robinow syndrome 2 (ortholog); FOUND IN axon; dendrite; dendritic spine; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride
AGR Description: Exhibits Rac GTPase binding activity and protein kinase binding activity; involved in Wnt signaling pathway, generation of neurons, and positive regulation of excitatory postsynaptic potential; localizes to several cellular components, including the microtubule cytoskeleton, neuron projection, and neuronal cell body; colocalizes with the microtubule; biomarker of myocardial infarction; orthologous to human DVL1 (dishevelled segment polarity protein 1).
Merged Description: Exhibits Rac GTPase binding activity and protein kinase binding activity; involved in Wnt signaling pathway, generation of neurons, and positive regulation of excitatory postsynaptic potential; localizes to several cellular components, including the microtubule cytoskeleton, neuron projection, and neuronal cell body; colocalizes with the microtubule; biomarker of myocardial infarction; orthologous to human DVL1 (dishevelled segment polarity protein 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dishevelled 1; dishevelled, dsh homolog 1; dishevelled, dsh homolog 1 (Drosophila); dishevelled-1; DSH homolog 1; dvl-1; segment polarity protein dishevelled homolog DVL-1
Orthologs:
Homo sapiens (human) : DVL1 (dishevelled segment polarity protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Dvl1 (dishevelled segment polarity protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dvl1 (dishevelled segment polarity protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DVL1 (dishevelled segment polarity protein 1)
Canis lupus familiaris (dog) : DVL1 (dishevelled segment polarity protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dvl1 (dishevelled segment polarity protein 1)
Sus scrofa (pig) : DVL1 (dishevelled segment polarity protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05173,295,948 - 173,308,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05176,771,577 - 176,783,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,705,951 - 172,717,626 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15172,716,445 - 172,728,121 (+)NCBI
Celera5164,657,716 - 164,669,383 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dvl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620632
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.