Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dvl1 (dishevelled segment polarity protein 1) Rattus norvegicus
Symbol: Dvl1
Name: dishevelled segment polarity protein 1
RGD ID: 620632
Description: Exhibits Rac GTPase binding activity and protein kinase binding activity. Involved in Wnt signaling pathway; generation of neurons; and positive regulation of excitatory postsynaptic potential. Localizes to several cellular components, including dendritic spine; growth cone; and postsynaptic density. Colocalizes with microtubule. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to human DVL1 (dishevelled segment polarity protein 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
Also known as: dishevelled 1; dishevelled, dsh homolog 1; dishevelled, dsh homolog 1 (Drosophila); dishevelled-1; DSH homolog 1; dvl-1; segment polarity protein dishevelled homolog DVL-1
Homo sapiens (human) : DVL1 (dishevelled segment polarity protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Dvl1 (dishevelled segment polarity protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dvl1 (dishevelled segment polarity protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DVL1 (dishevelled segment polarity protein 1)
Canis lupus familiaris (dog) : DVL1 (dishevelled segment polarity protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dvl1 (dishevelled segment polarity protein 1)
Sus scrofa (pig) : DVL1 (dishevelled segment polarity protein 1)
Chlorocebus sabaeus (African green monkey) : DVL1 (dishevelled segment polarity protein 1)
Heterocephalus glaber (naked mole-rat) : Dvl1 (dishevelled segment polarity protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05173,295,948 - 173,308,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,296,270 - 173,307,945 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,771,577 - 176,783,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,705,951 - 172,717,626 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15172,716,445 - 172,728,121 (+)NCBI
Celera5164,657,716 - 164,669,383 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dvl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620632
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.