DVL1 (dishevelled segment polarity protein 1) - Rat Genome Database

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Gene: DVL1 (dishevelled segment polarity protein 1) Canis lupus familiaris
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Symbol: DVL1
Name: dishevelled segment polarity protein 1
RGD ID: 12416019
Description: ENCODES a protein that exhibits enzyme binding (ortholog); protein kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal dominant Robinow syndrome 2 (ortholog); congenital myasthenic syndrome 8 (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dishevelled, dsh homolog 1; segment polarity protein dishevelled homolog DVL-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,507,803 - 56,519,382 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,507,739 - 56,519,491 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,584,127 - 56,595,703 (-)NCBI
ROS_Cfam_1.0556,710,022 - 56,721,601 (-)NCBI
UMICH_Zoey_3.1556,700,763 - 56,712,335 (-)NCBI
UNSW_CanFamBas_1.0556,593,044 - 56,604,611 (-)NCBI
UU_Cfam_GSD_1.0556,983,289 - 56,994,870 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (IEA,ISO)
axon guidance  (IEA,ISO)
axonogenesis  (ISO)
canonical Wnt signaling pathway  (IBA)
cochlea morphogenesis  (IEA,ISO)
collateral sprouting  (IEA,ISO)
convergent extension involved in neural plate elongation  (IEA,ISO)
convergent extension involved in organogenesis  (ISO)
cytoplasmic microtubule organization  (IEA,ISO)
dendrite morphogenesis  (IEA,ISO)
dendritic spine morphogenesis  (ISO)
intracellular signal transduction  (IEA)
negative regulation of protein binding  (IEA)
negative regulation of protein kinase activity  (IEA)
negative regulation of protein phosphorylation  (ISO)
neural tube development  (ISO)
neuromuscular junction development  (ISO)
neurotransmitter secretion  (IEA,ISO)
planar cell polarity pathway involved in neural tube closure  (IBA,ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of neuron projection arborization  (ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
postsynapse organization  (ISO)
prepulse inhibition  (IEA,ISO)
presynapse assembly  (IEA)
protein localization to microtubule  (IEA,ISO)
protein localization to nucleus  (IEA)
protein stabilization  (IEA)
receptor clustering  (ISO)
regulation of cellular protein localization  (IEA)
regulation of neurotransmitter levels  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of synaptic vesicle exocytosis  (IEA)
regulation of transcription, DNA-templated  (ISO)
skeletal muscle acetylcholine-gated channel clustering  (IEA,ISO)
social behavior  (IEA,ISO)
synapse organization  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16707567  


Genomics

Comparative Map Data
DVL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,507,803 - 56,519,382 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,507,739 - 56,519,491 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,584,127 - 56,595,703 (-)NCBI
ROS_Cfam_1.0556,710,022 - 56,721,601 (-)NCBI
UMICH_Zoey_3.1556,700,763 - 56,712,335 (-)NCBI
UNSW_CanFamBas_1.0556,593,044 - 56,604,611 (-)NCBI
UU_Cfam_GSD_1.0556,983,289 - 56,994,870 (-)NCBI
DVL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11,335,276 - 1,349,418 (-)EnsemblGRCh38hg38GRCh38
GRCh3811,335,278 - 1,349,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711,270,658 - 1,284,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,260,521 - 1,274,358 (-)NCBINCBI36hg18NCBI36
Build 3411,310,581 - 1,324,438NCBI
Celera11,305,944 - 1,310,484 (+)NCBI
Cytogenetic Map1p36.33NCBI
HuRef1541,861 - 555,565 (-)NCBIHuRef
CHM1_111,257,686 - 1,271,561 (-)NCBICHM1_1
Dvl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,931,829 - 155,943,760 (+)NCBIGRCm39mm39
GRCm39 Ensembl4155,931,859 - 155,943,760 (+)Ensembl
GRCm384155,847,402 - 155,859,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,847,402 - 155,859,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv374155,221,521 - 155,233,412 (+)NCBIGRCm37mm9NCBIm37
MGSCv364154,691,212 - 154,703,103 (+)NCBImm8
Celera4158,118,352 - 158,130,254 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.61NCBI
Dvl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25166,456,989 - 166,468,733 (+)NCBI
Rnor_6.0 Ensembl5173,296,270 - 173,307,945 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05173,295,948 - 173,308,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05176,771,577 - 176,783,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,705,951 - 172,717,626 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15172,716,445 - 172,728,121 (+)NCBI
Celera5164,657,716 - 164,669,383 (+)NCBICelera
Cytogenetic Map5q36NCBI
Dvl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,464,313 - 9,469,984 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,464,390 - 9,469,984 (+)NCBIChiLan1.0ChiLan1.0
DVL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111,292,052 - 1,300,006 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,292,052 - 1,301,008 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,469 - 106,748 (-)NCBIMhudiblu_PPA_v0panPan3
Dvl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,654,912 - 27,668,618 (-)NCBI
SpeTri2.0NW_0049367371,797,348 - 1,811,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DVL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,617,789 - 63,629,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,617,787 - 63,628,965 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,115,863 - 58,126,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DVL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,105,032 - 130,118,978 (+)NCBI
ChlSab1.1 Ensembl20130,104,639 - 130,117,139 (+)Ensembl
Vero_WHO_p1.0NW_02366605434,662,915 - 34,682,331 (+)NCBI
Dvl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248188,267,111 - 8,283,755 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 22 6 5 6 6 6 12 10 6
Low 1 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003639056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005620382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014113809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022418897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022418898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038476457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038476458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038476459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038537602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038537604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038537605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038601762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038601763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038601764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038666334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038666335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038666336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000030605   ⟹   ENSCAFP00000028442
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl556,507,739 - 56,519,491 (-)Ensembl
RefSeq Acc Id: XM_003639056   ⟹   XP_003639104
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1556,507,803 - 56,519,382 (-)NCBI
Dog10K_Boxer_Tasha556,584,127 - 56,595,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005620382   ⟹   XP_005620439
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1556,507,803 - 56,519,382 (-)NCBI
Dog10K_Boxer_Tasha556,584,127 - 56,595,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014113809   ⟹   XP_013969284
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1556,508,992 - 56,519,382 (-)NCBI
Dog10K_Boxer_Tasha556,585,325 - 56,595,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022418897   ⟹   XP_022274605
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1556,507,803 - 56,519,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022418898   ⟹   XP_022274606
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1556,507,803 - 56,519,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038476457   ⟹   XP_038332385
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1556,700,763 - 56,712,335 (-)NCBI
RefSeq Acc Id: XM_038476458   ⟹   XP_038332386
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1556,700,763 - 56,712,335 (-)NCBI
RefSeq Acc Id: XM_038476459   ⟹   XP_038332387
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1556,701,958 - 56,712,335 (-)NCBI
RefSeq Acc Id: XM_038537602   ⟹   XP_038393530
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0556,983,289 - 56,994,870 (-)NCBI
RefSeq Acc Id: XM_038537604   ⟹   XP_038393532
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0556,983,289 - 56,994,870 (-)NCBI
RefSeq Acc Id: XM_038537605   ⟹   XP_038393533
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0556,984,487 - 56,994,870 (-)NCBI
RefSeq Acc Id: XM_038601762   ⟹   XP_038457690
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0556,593,044 - 56,604,611 (-)NCBI
RefSeq Acc Id: XM_038601763   ⟹   XP_038457691
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0556,593,044 - 56,604,611 (-)NCBI
RefSeq Acc Id: XM_038601764   ⟹   XP_038457692
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0556,594,239 - 56,604,611 (-)NCBI
RefSeq Acc Id: XM_038666334   ⟹   XP_038522262
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0556,710,022 - 56,721,601 (-)NCBI
RefSeq Acc Id: XM_038666335   ⟹   XP_038522263
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0556,710,022 - 56,721,601 (-)NCBI
RefSeq Acc Id: XM_038666336   ⟹   XP_038522264
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0556,711,220 - 56,721,601 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_003639104   ⟸   XM_003639056
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005620439   ⟸   XM_005620382
- Peptide Label: isoform X1
- UniProtKB: E2QY91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013969284   ⟸   XM_014113809
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022274606   ⟸   XM_022418898
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022274605   ⟸   XM_022418897
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000028442   ⟸   ENSCAFT00000030605
RefSeq Acc Id: XP_038332386   ⟸   XM_038476458
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038332385   ⟸   XM_038476457
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038332387   ⟸   XM_038476459
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038457691   ⟸   XM_038601763
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038457690   ⟸   XM_038601762
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038457692   ⟸   XM_038601764
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038522263   ⟸   XM_038666335
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038522262   ⟸   XM_038666334
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038522264   ⟸   XM_038666336
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038393532   ⟸   XM_038537604
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038393530   ⟸   XM_038537602
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038393533   ⟸   XM_038537605
- Peptide Label: isoform X3
Protein Domains
DEP   DIX   PDZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000028442 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030605 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.10.20.380 UniProtKB/TrEMBL
InterPro DEP_dom UniProtKB/TrEMBL
  Dishevelled_C-dom UniProtKB/TrEMBL
  Dishevelled_fam UniProtKB/TrEMBL
  Dishevelled_protein_dom UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/TrEMBL
  Dsh/Dvl-rel UniProtKB/TrEMBL
  DVL-1 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene DVL1 ENTREZGENE
PANTHER PTHR10878 UniProtKB/TrEMBL
  PTHR10878:SF5 UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  Dishevelled UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  Dsh_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PRINTS DISHEVELLED UniProtKB/TrEMBL
PROSITE DEP UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
SMART DAX UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt E2QY91 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53355 ENTREZGENE