Rac1 (Rac family small GTPase 1) - Rat Genome Database
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Gene: Rac1 (Rac family small GTPase 1) Rattus norvegicus
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Symbol: Rac1
Name: Rac family small GTPase 1
RGD ID: 619755
Description: Exhibits several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including Rac protein signal transduction; bone resorption; and regulation of cellular biosynthetic process. Localizes to several cellular components, including Golgi membrane; cytosol; and dendritic spine. Predicted to colocalize with actin filament. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; 11-deoxycorticosterone; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21211,037,028 - 11,057,251 (+)NCBI
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxycoumarin  (ISO)
4-tert-Octylphenol  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B2  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
azathioprine  (ISO)
azithromycin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
Deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
farnesyl diphosphate  (ISO)
felodipine  (ISO)
flavonoids  (ISO)
flubendazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geranylgeraniol  (ISO)
glucose  (EXP,ISO)
graphene oxide  (ISO)
GTP  (EXP,ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (EXP)
heparin  (EXP)
irbesartan  (ISO)
kainic acid  (EXP)
kanamycin A  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
mebendazole  (ISO)
melittin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methohexital  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
mevastatin  (ISO)
ML-7  (EXP)
mycophenolic acid  (EXP)
N-acetyl-L-cysteine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nebivolol  (EXP)
nitrofen  (EXP)
NSC 23766  (ISO)
oxaliplatin  (EXP)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
PD 0325901  (ISO)
pentobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
plitidepsin  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
Risedronate sodium  (ISO)
rotenone  (EXP)
secobarbital  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
styrene oxide  (ISO)
sucrose  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (ISO)
thiamylal  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (EXP)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA,ISO)
actin filament organization  (IBA,IMP)
actin filament polymerization  (ISO)
anatomical structure arrangement  (ISO)
auditory receptor cell morphogenesis  (ISO)
axon guidance  (ISO)
bone resorption  (IDA)
cell adhesion  (ISO)
cell migration  (ISO)
cell motility  (ISO,ISS)
cell population proliferation  (IMP)
cell projection assembly  (IBA)
cell-cell junction organization  (ISO)
cellular response to mechanical stimulus  (IDA)
cerebral cortex GABAergic interneuron development  (ISO)
cerebral cortex radially oriented cell migration  (ISO)
chemotaxis  (IMP)
cochlea morphogenesis  (ISO)
cortical cytoskeleton organization  (IBA)
cytoskeleton organization  (ISO)
dendrite development  (ISO)
dendrite morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic olfactory bulb interneuron precursor migration  (ISO)
endocytosis  (ISO)
engulfment of apoptotic cell  (IBA,ISO)
epithelial cell morphogenesis  (ISO)
establishment or maintenance of cell polarity  (IBA)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
homeostasis of number of cells within a tissue  (ISO)
hyperosmotic response  (ISO)
lamellipodium assembly  (ISO)
localization within membrane  (ISO)
mast cell chemotaxis  (IMP)
midbrain dopaminergic neuron differentiation  (ISO)
motor neuron axon guidance  (IBA)
negative regulation of fibroblast migration  (IEA,ISO)
negative regulation of interleukin-23 production  (ISO)
neuron migration  (ISO,ISS)
neuron projection morphogenesis  (ISO)
non-canonical Wnt signaling pathway  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP,ISO)
positive regulation of lamellipodium assembly  (IMP,ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
protein localization to plasma membrane  (ISO)
Rac protein signal transduction  (IBA,IDA,TAS)
regulation of actin cytoskeleton organization  (IBA)
regulation of cell adhesion involved in heart morphogenesis  (ISO)
regulation of cell migration  (ISO,ISS)
regulation of cell morphogenesis  (ISO)
regulation of cell shape  (IBA)
regulation of cell size  (ISO)
regulation of fibroblast migration  (ISO)
regulation of lamellipodium assembly  (ISO)
regulation of neuron maturation  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neutrophil migration  (IBA)
regulation of nitric oxide biosynthetic process  (IGI)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of respiratory burst  (ISO)
regulation of stress fiber assembly  (ISO)
ruffle assembly  (ISO)
ruffle organization  (ISO)
semaphorin-plexin signaling pathway  (IMP)
small GTPase mediated signal transduction  (IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA,ISO)
substrate adhesion-dependent cell spreading  (ISO,ISS)
synaptic transmission, GABAergic  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
amyotrophic lateral sclerosis pathway  (IEA)
Arf family mediated signaling pathway  (ISO)
azathioprine pharmacodynamics pathway  (ISO)
B cell receptor signaling pathway  (IEA)
c-Jun N-terminal kinases MAPK signaling pathway  (ISO)
ceramide signaling pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
eicosanoid signaling pathway  (ISO)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO)
interleukin-6 signaling pathway  (ISO)
mercaptopurine pharmacodynamics pathway  (ISO)
mercaptopurine pharmacokinetics pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
mTOR signaling pathway  (ISO)
myocarditis pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
p38 MAPK signaling pathway  (ISO)
pancreatic cancer pathway  (IEA)
phagocytosis pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
platelet-derived growth factor signaling pathway  (ISO)
renal cell carcinoma pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP,ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
tioguanine pharmacodynamics pathway  (ISO)
Toll-like receptor signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (ISO)
Wnt signaling, the planar cell polarity pathway  (ISO)

References

References - curated
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Additional References at PubMed
PMID:8625410   PMID:8631991   PMID:9312003   PMID:10036235   PMID:10699171   PMID:10934045   PMID:10954424   PMID:12213441   PMID:12446704   PMID:12525493   PMID:12612085   PMID:12699088  
PMID:12719791   PMID:12777392   PMID:12783890   PMID:12853475   PMID:12915445   PMID:14516655   PMID:14570905   PMID:14573547   PMID:14580336   PMID:14657280   PMID:14736704   PMID:15037605  
PMID:15121898   PMID:15210825   PMID:15213258   PMID:15226395   PMID:15249579   PMID:15262848   PMID:15308668   PMID:15308673   PMID:15351707   PMID:15467718   PMID:15494521   PMID:15601624  
PMID:15611338   PMID:15629443   PMID:15634677   PMID:15721239   PMID:15723051   PMID:15728191   PMID:15728722   PMID:15826947   PMID:16092944   PMID:16168664   PMID:16195887   PMID:16283857  
PMID:16291935   PMID:16354758   PMID:16439689   PMID:16515795   PMID:16636067   PMID:16801538   PMID:16954223   PMID:16982892   PMID:17085464   PMID:17088251   PMID:17109063   PMID:17109064  
PMID:17130476   PMID:17183546   PMID:17207463   PMID:17300916   PMID:17350025   PMID:17409253   PMID:17515454   PMID:17515837   PMID:17561310   PMID:17687038   PMID:17702745   PMID:17982273  
PMID:18006851   PMID:18079208   PMID:18156211   PMID:18172037   PMID:18218673   PMID:18316075   PMID:18335519   PMID:18567639   PMID:18599477   PMID:18805958   PMID:18953410   PMID:19007770  
PMID:19027829   PMID:19052208   PMID:19067793   PMID:19085564   PMID:19261846   PMID:19289122   PMID:19356729   PMID:19368836   PMID:19403692   PMID:19581409   PMID:19625648   PMID:19787194  
PMID:19812310   PMID:19850129   PMID:19854265   PMID:19890013   PMID:19923407   PMID:19934221   PMID:20004474   PMID:20016102   PMID:20018732   PMID:20069557   PMID:20097736   PMID:20139976  
PMID:20335472   PMID:20339116   PMID:20363326   PMID:20387077   PMID:20458337   PMID:20519585   PMID:20530489   PMID:20578145   PMID:20691665   PMID:20696841   PMID:20808927   PMID:20817060  
PMID:20830300   PMID:20875796   PMID:20926685   PMID:20943855   PMID:20962234   PMID:21107423   PMID:21131638   PMID:21178006   PMID:21215756   PMID:21346419   PMID:21386710   PMID:21423176  
PMID:21457935   PMID:21460187   PMID:21464391   PMID:21474673   PMID:21483795   PMID:21660950   PMID:21683721   PMID:21765214   PMID:21814770   PMID:21816966   PMID:21963650   PMID:22036506  
PMID:22114025   PMID:22128191   PMID:22157753   PMID:22232135   PMID:22262456   PMID:22322064   PMID:22345572   PMID:22384148   PMID:22467863   PMID:22750946   PMID:22871113   PMID:22890232  
PMID:22959435   PMID:23012366   PMID:23027656   PMID:23109420   PMID:23129259   PMID:23153365   PMID:23184663   PMID:23258346   PMID:23325254   PMID:23376485   PMID:23499910   PMID:23528453  
PMID:23533145   PMID:23533177   PMID:23534605   PMID:23564082   PMID:23620790   PMID:23633677   PMID:23640896   PMID:23686855   PMID:23720743   PMID:23967341   PMID:23979707   PMID:24123220  
PMID:24195795   PMID:24248991   PMID:24297929   PMID:24352656   PMID:24522191   PMID:24553575   PMID:24625528   PMID:24660528   PMID:24752318   PMID:24859002   PMID:24915967   PMID:25074804  
PMID:25164814   PMID:25198505   PMID:25248834   PMID:25298426   PMID:25331951   PMID:25382267   PMID:25479592   PMID:25502873   PMID:25514037   PMID:25613020   PMID:25666619   PMID:25794483  
PMID:25796615   PMID:25820249   PMID:25864429   PMID:25865668   PMID:25957600   PMID:26272757   PMID:26319681   PMID:26323693   PMID:26543024   PMID:26690896   PMID:26700000   PMID:26707876  
PMID:26809475   PMID:26824355   PMID:27050391   PMID:27093550   PMID:27159442   PMID:27163367   PMID:27355516   PMID:27412363   PMID:27662902   PMID:27886395   PMID:27917469   PMID:28013306  
PMID:28119263   PMID:28161375   PMID:28220272   PMID:28274785   PMID:28320863   PMID:28336111   PMID:28630256   PMID:28683507   PMID:28828705   PMID:28849230   PMID:28886345   PMID:28934903  
PMID:29046349   PMID:29191942   PMID:29476059   PMID:29494287   PMID:30013448   PMID:30257103   PMID:30448045   PMID:31202817   PMID:32001733  


Genomics

Comparative Map Data
Rac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21211,037,028 - 11,057,251 (+)NCBI
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
RAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl76,374,527 - 6,403,967 (+)EnsemblGRCh38hg38GRCh38
GRCh3876,374,527 - 6,403,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3776,414,158 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3776,414,126 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,380,651 - 6,410,123 (+)NCBINCBI36hg18NCBI36
Celera76,291,529 - 6,321,004 (-)NCBI
Cytogenetic Map7p22.1NCBI
HuRef76,287,239 - 6,316,490 (+)NCBIHuRef
CHM1_176,413,683 - 6,443,197 (+)NCBICHM1_1
CRA_TCAGchr7v276,460,486 - 6,489,951 (+)NCBI
Rac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,491,236 - 143,513,786 (-)NCBIGRCm39mm39
GRCm385143,505,481 - 143,528,031 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,503,634 - 143,528,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv375144,266,349 - 144,288,861 (-)NCBIGRCm37mm9NCBIm37
MGSCv365143,761,100 - 143,783,611 (-)NCBImm8
Celera5140,552,192 - 140,574,740 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.22NCBI
Rac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,270,159 - 13,311,351 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,270,159 - 13,295,562 (-)NCBIChiLan1.0ChiLan1.0
RAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.176,559,590 - 6,599,814 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v077,039,379 - 7,068,866 (-)NCBIMhudiblu_PPA_v0panPan3
RAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl611,655,494 - 11,757,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1611,726,259 - 11,758,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936750107,689 - 122,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,781,771 - 4,803,687 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,781,776 - 4,803,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,583,609 - 15,610,753 (+)NCBI
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)Ensembl
Rac1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474030,912,841 - 30,933,882 (-)NCBI

Position Markers
RH140831  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01213,110,681 - 13,110,900NCBIRnor6.0
Rnor_5.01215,153,830 - 15,154,049UniSTSRnor5.0
RGSC_v3.41211,400,620 - 11,400,839UniSTSRGSC3.4
Celera1212,851,413 - 12,851,632UniSTS
RH 3.4 Map12145.61UniSTS
Cytogenetic Map12p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12122650917Rat
10450854Stl34Serum triglyceride level QTL 343.50.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)12122853017Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12123035872Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123758197Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12130749723Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12136919844Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12138334225Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)1215081045150810Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1215081045150810Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)1249257845492578Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12247568747475687Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12251344247513442Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12251344247513442Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12421005149210051Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12824960820590080Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12895459327911196Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6922362652716770Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922363052716770Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12978983452716770Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121017588931975590Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)121025689031723732Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)121176499514489679Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)121176499537522089Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:126
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000001417
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001417   ⟹   ENSRNOP00000001417
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,090,367 - 13,111,873 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087094   ⟹   ENSRNOP00000071616
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,097,269 - 13,110,592 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092558   ⟹   ENSRNOP00000075900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,090,172 - 13,109,135 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092628   ⟹   ENSRNOP00000075897
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,102,019 - 13,102,706 (+)Ensembl
RefSeq Acc Id: NM_134366   ⟹   NP_599193
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21211,037,028 - 11,057,251 (+)NCBI
Rnor_6.01213,090,372 - 13,110,592 (+)NCBI
Rnor_5.01215,133,521 - 15,153,741 (+)NCBI
RGSC_v3.41211,380,314 - 11,400,531 (+)RGD
Celera1212,831,091 - 12,851,324 (+)RGD
Sequence:
RefSeq Acc Id: XM_008768986   ⟹   XP_008767208
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,090,316 - 13,111,841 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_599193   ⟸   NM_134366
- UniProtKB: Q6RUV5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767208   ⟸   XM_008768986
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000075897   ⟸   ENSRNOT00000092628
RefSeq Acc Id: ENSRNOP00000075900   ⟸   ENSRNOT00000092558
RefSeq Acc Id: ENSRNOP00000071616   ⟸   ENSRNOT00000087094
RefSeq Acc Id: ENSRNOP00000001417   ⟸   ENSRNOT00000001417

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698441
Promoter ID:EPDNEW_R8962
Type:initiation region
Name:Rac1_1
Description:ras-related C3 botulinum toxin substrate 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,090,171 - 13,090,231EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619755 AgrOrtholog
Ensembl Genes ENSRNOG00000001068 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001417 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071616 UniProtKB/TrEMBL
  ENSRNOP00000075897 UniProtKB/TrEMBL
  ENSRNOP00000075900 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001417 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000087094 UniProtKB/TrEMBL
  ENSRNOT00000092558 UniProtKB/TrEMBL
  ENSRNOT00000092628 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363875 UniProtKB/Swiss-Prot
NCBI Gene 363875 ENTREZGENE
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RAC1 RGD
PhenoGen Rac1 PhenoGen
PROSITE RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0X4_RAT UniProtKB/TrEMBL
  A0A0U1RS18_RAT UniProtKB/TrEMBL
  A0A0U1RS21_RAT UniProtKB/TrEMBL
  Q6RUV5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 Rac1  Rac family small GTPase 1  Rac1  ras-related C3 botulinum toxin substrate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rac1  ras-related C3 botulinum toxin substrate 1    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)  Name updated 1299863 APPROVED
2002-08-07 Rac1  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes at the plasma membrane of RBL-2H3 cells in actin-rich structures with phospholipase D, ARF6, and PKC alpha following antigen stimulation 727254
gene_expression expressed in hippocampus and cerebellum 1299238
gene_process enhanced the expression of a kappaB and induced the degradation of IkappaBalpha 704329
gene_process essential for leukotriene B4 induced production of reactive oxygen species, chemotaxis, and cellular proliferation 1299245
gene_process may play a role in synaptic plasticity in brain 1299238
gene_process may play a role in cellular motility through regulation by stretch tension 1299247
gene_regulation activated by treatment of cells with lipopolysaccharide (LPS) 1299246