Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ccnl2 | Rat | (S)-nicotine | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | Ccnl2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of CCNL2 mRNA | CTD | PMID:22206623 | Ccnl2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of CCNL2 mRNA] | CTD | PMID:22206623 | Ccnl2 | Rat | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | Ccnl2 | Rat | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | Ccnl2 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of CCNL2 mRNA | CTD | PMID:35192832 | Ccnl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CCNL2 mRNA | CTD | PMID:20702594 | Ccnl2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | affects expression | ISO | Ccnl2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:20702594 | Ccnl2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CCNL2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CCNL2 mRNA | CTD | PMID:28628672 | Ccnl2 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of CCNL2 mRNA | CTD | PMID:18648102 | Ccnl2 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of CCNL2 mRNA | CTD | PMID:30723492 | Ccnl2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CCNL2 mRNA | CTD | PMID:28628672 | Ccnl2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CCNL2 mRNA | CTD | PMID:30047161 | Ccnl2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of CCNL2 mRNA | CTD | PMID:31881176 | Ccnl2 | Rat | aflatoxin B1 | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of CCNL2 mRNA | CTD | PMID:19770486 | Ccnl2 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | CCNL2 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of CCNL2 polyA tail | CTD | PMID:30157460 | Ccnl2 | Rat | benzo[b]fluoranthene | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of CCNL2 mRNA | CTD | PMID:26377693 | Ccnl2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CCNL2 mRNA | CTD | PMID:25181051 | Ccnl2 | Rat | bisphenol A | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of CCNL2 mRNA | CTD | PMID:32156529 | Ccnl2 | Rat | bisphenol A | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CCNL2 gene | CTD | PMID:31601247 | Ccnl2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CCNL2 mRNA | CTD | PMID:34947998 | Ccnl2 | Rat | bisphenol A | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CCNL2 mRNA | CTD | PMID:33221593 | Ccnl2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CCNL2 mRNA | CTD | PMID:30816183 more ... | Ccnl2 | Rat | bisphenol A | affects expression | ISO | CCNL2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of CCNL2 mRNA | CTD | PMID:30903817 | Ccnl2 | Rat | bisphenol F | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CCNL2 mRNA | CTD | PMID:28628672 | Ccnl2 | Rat | butanal | decreases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of CCNL2 mRNA | CTD | PMID:26079696 | Ccnl2 | Rat | cadmium dichloride | decreases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of CCNL2 mRNA | CTD | PMID:38568856 | Ccnl2 | Rat | caffeine | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | Ccnl2 | Rat | carbon nanotube | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Ccnl2 | Rat | CGP 52608 | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CCNL2 gene] | CTD | PMID:28238834 | Ccnl2 | Rat | choline | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CCNL2 gene | CTD | PMID:20938992 | Ccnl2 | Rat | chrysene | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | chrysene results in increased expression of CCNL2 mRNA | CTD | PMID:26377693 | Ccnl2 | Rat | ciguatoxin CTX1B | affects expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of CCNL2 mRNA | CTD | PMID:18353800 | Ccnl2 | Rat | copper atom | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of CCNL2 mRNA | CTD | PMID:20971185 | Ccnl2 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of CCNL2 mRNA | CTD | PMID:30556269 | Ccnl2 | Rat | copper(0) | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of CCNL2 mRNA | CTD | PMID:20971185 | Ccnl2 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of CCNL2 mRNA | CTD | PMID:30556269 | Ccnl2 | Rat | copper(II) sulfate | increases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of CCNL2 mRNA | CTD | PMID:19549813 | Ccnl2 | Rat | crocidolite asbestos | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in increased expression of CCNL2 mRNA | CTD | PMID:29279043 | Ccnl2 | Rat | cyclosporin A | increases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CCNL2 mRNA | CTD | PMID:22147139 | Ccnl2 | Rat | dexamethasone | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CCNL2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CCNL2 mRNA | CTD | PMID:28628672 | Ccnl2 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of CCNL2 mRNA | CTD | PMID:24893172 | Ccnl2 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of CCNL2 mRNA | CTD | PMID:21551480 | Ccnl2 | Rat | doxorubicin | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Doxorubicin results in increased expression of CCNL2 mRNA | CTD | PMID:25896364 | Ccnl2 | Rat | enniatin | increases expression | EXP | | 6480464 | enniatins results in increased expression of CCNL2 mRNA | CTD | PMID:27163883 | Ccnl2 | Rat | folic acid | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CCNL2 gene more ... | CTD | PMID:20938992 and PMID:22206623 | Ccnl2 | Rat | FR900359 | increases phosphorylation | ISO | CCNL2 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of CCNL2 protein | CTD | PMID:37730182 | Ccnl2 | Rat | fulvestrant | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CCNL2 gene | CTD | PMID:31601247 | Ccnl2 | Rat | indometacin | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CCNL2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CCNL2 mRNA | CTD | PMID:28628672 | Ccnl2 | Rat | L-methionine | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CCNL2 gene | CTD | PMID:20938992 | Ccnl2 | Rat | lead diacetate | decreases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | lead acetate results in decreased expression of CCNL2 mRNA | CTD | PMID:38568856 | Ccnl2 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of CCNL2 mRNA | CTD | PMID:24136188 | Ccnl2 | Rat | lipopolysaccharide | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of CCNL2 mRNA] | CTD | PMID:28070326 | Ccnl2 | Rat | lipopolysaccharide | affects expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Lipopolysaccharides affects the expression of CCNL2 mRNA | CTD | PMID:28070326 | Ccnl2 | Rat | methamphetamine | increases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of CCNL2 mRNA | CTD | PMID:26307267 | Ccnl2 | Rat | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of CCNL2 mRNA | CTD | PMID:22484513 | Ccnl2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of CCNL2 mRNA | CTD | PMID:30047161 | Ccnl2 | Rat | miconazole | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Miconazole results in decreased expression of CCNL2 mRNA | CTD | PMID:27462272 | Ccnl2 | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of CCNL2 mRNA | CTD | PMID:24136188 | Ccnl2 | Rat | nicotine | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | Ccnl2 | Rat | ozone | multiple interactions | ISO | Ccnl2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CCNL2 mRNA | CTD | PMID:34911549 | Ccnl2 | Rat | paracetamol | affects expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of CCNL2 mRNA | CTD | PMID:17562736 | Ccnl2 | Rat | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of CCNL2 mRNA | CTD | PMID:22484513 | Ccnl2 | Rat | pirinixic acid | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CCNL2 mRNA | CTD | PMID:18445702 | Ccnl2 | Rat | potassium dichromate | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of CCNL2 mRNA | CTD | PMID:23608068 | Ccnl2 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of CCNL2 mRNA | CTD | PMID:30047161 | Ccnl2 | Rat | propiconazole | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of CCNL2 mRNA | CTD | PMID:21278054 | Ccnl2 | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of CCNL2 mRNA | CTD | PMID:28374803 | Ccnl2 | Rat | sodium arsenite | decreases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CCNL2 mRNA | CTD | PMID:34032870 | Ccnl2 | Rat | sodium arsenite | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [CCNL2 protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | Ccnl2 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of CCNL2 mRNA | CTD | PMID:30047161 | Ccnl2 | Rat | testosterone | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Testosterone results in decreased expression of CCNL2 mRNA | CTD | PMID:21669218 | Ccnl2 | Rat | tetraphene | affects expression | ISO | Ccnl2 (Mus musculus) | 6480464 | benz(a)anthracene affects the expression of CCNL2 mRNA | CTD | PMID:26377693 | Ccnl2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of CCNL2 mRNA | CTD | PMID:22659510 and PMID:23411599 | Ccnl2 | Rat | thiram | decreases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Thiram results in decreased expression of CCNL2 mRNA | CTD | PMID:38568856 | Ccnl2 | Rat | tolcapone | increases expression | EXP | | 6480464 | tolcapone results in increased expression of CCNL2 mRNA | CTD | PMID:24136188 | Ccnl2 | Rat | triphenyl phosphate | affects expression | ISO | CCNL2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CCNL2 mRNA | CTD | PMID:37042841 | Ccnl2 | Rat | valproic acid | decreases expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CCNL2 mRNA | CTD | PMID:29154799 | Ccnl2 | Rat | valproic acid | affects expression | ISO | CCNL2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CCNL2 mRNA | CTD | PMID:25979313 | Ccnl2 | Rat | valproic acid | decreases expression | ISO | Ccnl2 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of CCNL2 mRNA | CTD | PMID:19136453 | Ccnl2 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of CCNL2 mRNA | CTD | PMID:23034163 | Ccnl2 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of CCNL2 mRNA | CTD | PMID:23034163 | Ccnl2 | Rat | zidovudine | multiple interactions | ISO | CCNL2 (Homo sapiens) | 6480464 | [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA | CTD | PMID:20370541 | |