Pik3cd (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta) - Rat Genome Database

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Gene: Pik3cd (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta) Rattus norvegicus
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Symbol: Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
RGD ID: 1310990
Description: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in negative regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: catalytic phosphatidylinositol 3-kinase delta; LOC366508; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphoinositide-3-kinase, catalytic, delta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,094,952 - 160,142,962 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5160,094,952 - 160,120,930 (-)Ensembl
Rnor_6.05166,602,053 - 166,628,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,602,053 - 166,628,028 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,248,202 - 170,274,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,735,274 - 166,761,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15166,747,134 - 166,774,251 (-)NCBI
Celera5158,364,393 - 158,390,431 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
celastrol  (ISO)
chlormequat chloride  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fonofos  (ISO)
gedunin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
lead diacetate  (ISO)
LY294002  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
phenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway  (IEA)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
inositol phosphate metabolic pathway  (IEA)
insulin signaling pathway  (IEA)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway  (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway  (ISO)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (ISO)
type 2 diabetes mellitus pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
5. Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis. Khadem F, etal., J Antimicrob Chemother. 2017 Feb;72(2):467-477. doi: 10.1093/jac/dkw448. Epub 2016 Dec 20.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Deficiency of Phosphatidylinositol 3-Kinase δ Signaling Leads to Diminished Numbers of Regulatory T Cells and Increased Neutrophil Activity Resulting in Mortality Due to Endotoxic Shock. Okeke EB, etal., J Immunol. 2017 Aug 1;199(3):1086-1095. doi: 10.4049/jimmunol.1600954. Epub 2017 Jun 28.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. Pearce VQ, etal., J Immunol. 2015 Oct 1;195(7):3206-17. doi: 10.4049/jimmunol.1501227. Epub 2015 Aug 26.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. The p110δ isoforme of phosphatidylinositol 3-kinase plays an important role in host defense against chlamydial lung infection through influencing CD4+ T-cell function. Qiao S, etal., Pathog Dis. 2018 Aug 1;76(6). pii: 5035814. doi: 10.1093/femspd/fty053.
14. Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Primate-specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma. Shi Y, etal., Clin Cancer Res. 2014 Apr 1;20(7):1803-13. doi: 10.1158/1078-0432.CCR-13-2284. Epub 2014 Feb 12.
19. PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Stark AK, etal., Nat Commun. 2018 Aug 9;9(1):3174. doi: 10.1038/s41467-018-05674-8.
20. Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer. Szmida E, etal., J Appl Genet. 2015 May;56(2):185-92. doi: 10.1007/s13353-014-0253-6. Epub 2014 Nov 1.
21. PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer. Urick ME, etal., Cancer Res. 2011 Jun 15;71(12):4061-7. doi: 10.1158/0008-5472.CAN-11-0549. Epub 2011 Apr 8.
Additional References at PubMed
PMID:12235209   PMID:12477932   PMID:22079609   PMID:22391142   PMID:24009720   PMID:25327288   PMID:25339672  


Genomics

Comparative Map Data
Pik3cd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,094,952 - 160,142,962 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5160,094,952 - 160,120,930 (-)Ensembl
Rnor_6.05166,602,053 - 166,628,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,602,053 - 166,628,028 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,248,202 - 170,274,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,735,274 - 166,761,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15166,747,134 - 166,774,251 (-)NCBI
Celera5158,364,393 - 158,390,431 (-)NCBICelera
Cytogenetic Map5q36NCBI
PIK3CD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,627,258 - 9,729,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl19,629,889 - 9,729,114 (+)EnsemblGRCh38hg38GRCh38
GRCh3719,711,789 - 9,789,172 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,634,377 - 9,711,759 (+)NCBINCBI36hg18NCBI36
Build 3419,646,068 - 9,723,240NCBI
Celera18,862,699 - 8,900,443 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef18,867,937 - 8,945,277 (+)NCBIHuRef
CHM1_119,700,330 - 9,777,708 (+)NCBICHM1_1
T2T-CHM13v2.019,194,503 - 9,271,897 (+)NCBI
Pik3cd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,733,625 - 149,787,023 (-)NCBIGRCm39mm39
GRCm39 Ensembl4149,733,625 - 149,787,028 (-)Ensembl
GRCm384149,649,168 - 149,702,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,649,168 - 149,702,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,023,277 - 149,075,738 (-)NCBIGRCm37mm9NCBIm37
MGSCv364148,492,968 - 148,542,489 (-)NCBImm8
Celera4151,915,787 - 151,968,568 (-)NCBICelera
Cytogenetic Map4E2NCBI
Pik3cd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554863,813,923 - 3,838,119 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554863,813,923 - 3,837,563 (-)NCBIChiLan1.0ChiLan1.0
PIK3CD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.119,683,626 - 9,724,641 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,686,208 - 9,724,633 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v018,418,570 - 8,495,435 (+)NCBIMhudiblu_PPA_v0panPan3
PIK3CD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,884,596 - 62,936,882 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,909,009 - 62,935,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,900,181 - 62,953,014 (+)NCBI
ROS_Cfam_1.0563,111,143 - 63,163,978 (+)NCBI
ROS_Cfam_1.0 Ensembl563,093,394 - 63,164,766 (+)Ensembl
UMICH_Zoey_3.1563,132,926 - 63,185,725 (+)NCBI
UNSW_CanFamBas_1.0562,972,335 - 63,025,149 (+)NCBI
UU_Cfam_GSD_1.0563,376,064 - 63,428,899 (+)NCBI
Pik3cd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,167,388 - 33,211,355 (+)NCBI
SpeTri2.0NW_0049366233,672,201 - 3,696,959 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,026,373 - 70,084,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1670,026,254 - 70,086,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,031,598 - 64,091,037 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,040,131 - 122,111,397 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,041,963 - 122,078,504 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605426,005,112 - 26,077,450 (-)NCBIVero_WHO_p1.0
Pik3cd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248182,751,724 - 2,779,999 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248182,751,724 - 2,789,145 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH133425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,095,082 - 160,095,287 (+)MAPPERmRatBN7.2
Rnor_6.05166,602,184 - 166,602,388NCBIRnor6.0
Rnor_5.05170,248,333 - 170,248,537UniSTSRnor5.0
RGSC_v3.45166,735,405 - 166,735,609UniSTSRGSC3.4
Celera5158,364,524 - 158,364,728UniSTS
RH 3.4 Map51115.8UniSTS
Cytogenetic Map5q36UniSTS
RH142729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,112,028 - 160,112,136 (+)MAPPERmRatBN7.2
Rnor_6.05166,619,130 - 166,619,237NCBIRnor6.0
Rnor_5.05170,265,279 - 170,265,386UniSTSRnor5.0
RGSC_v3.45166,752,291 - 166,752,398UniSTSRGSC3.4
Celera5158,381,533 - 158,381,640UniSTS
RH 3.4 Map51115.5UniSTS
Cytogenetic Map5q36UniSTS
BE109926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,097,539 - 160,097,715 (+)MAPPERmRatBN7.2
Rnor_6.05166,604,641 - 166,604,816NCBIRnor6.0
Rnor_5.05170,250,790 - 170,250,965UniSTSRnor5.0
RGSC_v3.45166,737,862 - 166,738,037UniSTSRGSC3.4
Celera5158,366,981 - 158,367,156UniSTS
RH 3.4 Map51114.6UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir384rno-miR-384-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23315007

Predicted Target Of
Summary Value
Count of predictions:387
Count of miRNA genes:230
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000066179
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 1 4 47 1 14 11 1
Low 1 43 49 41 41 7 7 27 34 27 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000066179   ⟹   ENSRNOP00000061674
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,094,952 - 160,120,930 (-)Ensembl
Rnor_6.0 Ensembl5166,602,053 - 166,628,028 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095643   ⟹   ENSRNOP00000076811
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,095,016 - 160,120,930 (-)Ensembl
RefSeq Acc Id: NM_001108978   ⟹   NP_001102448
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,094,952 - 160,120,930 (-)NCBI
Rnor_6.05166,602,053 - 166,628,028 (-)NCBI
Rnor_5.05170,248,202 - 170,274,177 (-)NCBI
RGSC_v3.45166,735,274 - 166,761,189 (-)RGD
Celera5158,364,393 - 158,390,431 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110494   ⟹   XP_038966422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110495   ⟹   XP_038966423
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,962 (-)NCBI
RefSeq Acc Id: XM_039110496   ⟹   XP_038966424
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,126,805 (-)NCBI
RefSeq Acc Id: XM_039110497   ⟹   XP_038966425
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,123,156 (-)NCBI
RefSeq Acc Id: XM_039110498   ⟹   XP_038966426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,835 (-)NCBI
RefSeq Acc Id: XM_039110499   ⟹   XP_038966427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110500   ⟹   XP_038966428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110501   ⟹   XP_038966429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110502   ⟹   XP_038966430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110503   ⟹   XP_038966431
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110504   ⟹   XP_038966432
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
RefSeq Acc Id: XM_039110505   ⟹   XP_038966433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,095,015 - 160,142,961 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102448   ⟸   NM_001108978
- UniProtKB: D4A5Q1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061674   ⟸   ENSRNOT00000066179
RefSeq Acc Id: XP_038966423   ⟸   XM_039110495
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966433   ⟸   XM_039110505
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038966432   ⟸   XM_039110504
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038966429   ⟸   XM_039110501
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038966428   ⟸   XM_039110500
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038966431   ⟸   XM_039110503
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038966430   ⟸   XM_039110502
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038966427   ⟸   XM_039110499
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038966422   ⟸   XM_039110494
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966426   ⟸   XM_039110498
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966424   ⟸   XM_039110496
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966425   ⟸   XM_039110497
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000076811   ⟸   ENSRNOT00000095643
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5Q1-F1-model_v2 AlphaFold D4A5Q1 1-944 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310990 AgrOrtholog
BioCyc Gene G2FUF-39122 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000016846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000061674 ENTREZGENE
  ENSRNOP00000061674.2 UniProtKB/TrEMBL
  ENSRNOP00000076811 ENTREZGENE
  ENSRNOP00000076811.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066179 ENTREZGENE
  ENSRNOT00000066179.3 UniProtKB/TrEMBL
  ENSRNOT00000095643 ENTREZGENE
  ENSRNOT00000095643.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/TrEMBL
  PI3K_p85-bd UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/TrEMBL
  PI3Kdelta_dom UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:366508 UniProtKB/TrEMBL
NCBI Gene 366508 ENTREZGENE
PANTHER PI_Kinase UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
PhenoGen Pik3cd PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5Y949_RAT UniProtKB/TrEMBL
  D4A5Q1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3cd  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta  Pik3cd  phosphoinositide-3-kinase, catalytic, delta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Pik3cd  phosphoinositide-3-kinase, catalytic, delta polypeptide  Pik3cd  phosphatidylinositol 3-kinase catalytic delta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pik3cd  phosphatidylinositol 3-kinase catalytic delta polypeptide   Pik3cd_predicted  phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pik3cd_predicted  phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED