Icmt (isoprenylcysteine carboxyl methyltransferase)

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Gene: Icmt (isoprenylcysteine carboxyl methyltransferase) Rattus norvegicus

Analyze

Symbol:

Icmt

Name:

isoprenylcysteine carboxyl methyltransferase

RGD ID:

621618

Description:

Enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; S-adenosylhomocysteine metabolic process; and S-adenosylmethioninamine metabolic process. Located in membrane. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

farnesyl cysteine carboxyl methyltransferase; fcmt; MGC95322; pcCMT; PPMT; prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methlytransferase; prenylcysteine carboxyl methyltransferase; protein-S-isoprenylcysteine O-methyltransferase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ICMT (isoprenylcysteine carboxyl methyltransferase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Icmt (isoprenylcysteine carboxyl methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Icmt (isoprenylcysteine carboxyl methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ICMT (isoprenylcysteine carboxyl methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR153 (G protein-coupled receptor 153)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ICMT (isoprenylcysteine carboxyl methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ICMT (isoprenylcysteine carboxyl methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Icmt (isoprenylcysteine carboxyl methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Icmt (isoprenylcysteine carboxyl methyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ICMT (isoprenylcysteine carboxyl methyltransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	icmt (isoprenylcysteine carboxyl methyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	M01E11.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	STE14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ste14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	icmt-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	162,804,368 - 162,811,129 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	162,804,368 - 162,811,128 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	165,507,381 - 165,514,154 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	167,328,981 - 167,335,754 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	167,291,181 - 167,297,954 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	169,475,270 - 169,482,031 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	169,475,270 - 169,482,030 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	173,027,895 - 173,035,370 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	169,526,961 - 169,533,722 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	169,537,360 - 169,543,425 (+)	NCBI
Celera	5	161,035,644 - 161,042,405 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

nephronophthisis (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

Enterolactone (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

hydralazine (ISO)

hydrogen cyanide (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (EXP)

mitomycin C (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

potassium cyanide (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

Salinomycin (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (ISO)

C-terminal protein methylation (IBA,IMP,ISO)

determination of adult lifespan (ISO)

fibroblast proliferation (ISO)

in utero embryonic development (ISO)

liver development (ISO)

multicellular organism growth (ISO)

neuromuscular process (ISO)

positive regulation of fibroblast proliferation (ISO)

protein localization (ISO)

protein methylation (ISO)

regulation of cellular senescence (ISO)

regulation of protein localization (ISO)

regulation of Ras protein signal transduction (ISO)

S-adenosylhomocysteine metabolic process (IMP)

S-adenosylmethioninamine metabolic process (IMP)

TOR signaling (ISO)

Cellular Component

cytoplasmic side of rough endoplasmic reticulum membrane (ISO)

endoplasmic reticulum (IBA,ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

large ribosomal subunit (ISO)

membrane (IDA)

Molecular Function

cAMP response element binding protein binding (ISO)

protein binding (ISO)

protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity (IBA,IMP,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

homocysteine metabolic pathway (ISS)

methionine cycle/metabolic pathway (ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt).	Baron RA and Casey PJ, BMC Biochem 2004 Dec 29;5(1):19.
2.	Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.	Bergo MO, etal., J Biol Chem 2000 Jun 9;275(23):17605-10.
3.	Essential arginine residues in isoprenylcysteine protein carboxyl methyltransferase.	Boivin D, etal., Biochem Cell Biol. 1997;75(1):63-9.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7673206	PMID:9614111	PMID:10441503	PMID:11121396	PMID:12105862	PMID:12477932	PMID:12631708	PMID:14966563	PMID:21346419	PMID:23686339

Genomics

Comparative Map Data

Icmt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	162,804,368 - 162,811,129 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	162,804,368 - 162,811,128 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	165,507,381 - 165,514,154 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	167,328,981 - 167,335,754 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	167,291,181 - 167,297,954 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	169,475,270 - 169,482,031 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	169,475,270 - 169,482,030 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	173,027,895 - 173,035,370 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	169,526,961 - 169,533,722 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	169,537,360 - 169,543,425 (+)	NCBI
Celera	5	161,035,644 - 161,042,405 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

ICMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	6,221,193 - 6,235,964 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	6,221,193 - 6,235,972 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	6,281,253 - 6,296,024 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	6,203,840 - 6,218,631 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	5,395,764 - 5,410,546 (-)	NCBI		Celera
Cytogenetic Map	1	p36.31	NCBI
HuRef	1	5,429,524 - 5,444,303 (-)	NCBI		HuRef
CHM1_1	1	6,269,895 - 6,284,684 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	5,746,837 - 5,761,608 (-)	NCBI		T2T-CHM13v2.0

Icmt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	152,381,671 - 152,391,583 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	152,381,684 - 152,391,578 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	152,297,214 - 152,307,126 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	152,297,227 - 152,307,121 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	151,671,460 - 151,681,231 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	151,141,151 - 151,150,922 (+)	NCBI		MGSCv36	mm8
Celera	4	154,584,683 - 154,594,454 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI

Icmt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	6,280,125 - 6,289,584 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	6,280,838 - 6,289,584 (+)	NCBI	ChiLan1.0	ChiLan1.0

ICMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	6,242,672 - 6,256,102 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	6,246,570 - 6,258,746 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	4,987,384 - 5,002,213 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GPR153
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	60,119,793 - 60,128,531 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	60,123,054 - 60,149,027 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	60,129,410 - 60,138,127 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	60,335,150 - 60,344,074 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	60,335,160 - 60,365,596 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	60,334,692 - 60,343,406 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	60,201,501 - 60,210,215 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	60,602,948 - 60,611,676 (-)	NCBI		UU_Cfam_GSD_1.0

ICMT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	67,116,946 - 67,123,810 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	67,116,943 - 67,125,908 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	62,023,966 - 62,032,925 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ICMT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	125,504,240 - 125,516,749 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	125,504,325 - 125,515,160 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	29,609,720 - 29,624,581 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Icmt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	5,165,876 - 5,174,828 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	5,165,923 - 5,174,761 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Icmt
15 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	320
Count of miRNA genes:	176
Interacting mature miRNAs:	206
Transcripts:	ENSRNOT00000014625
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat

Markers in Region

BF416448

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	162,808,690 - 162,808,935 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	169,479,593 - 169,479,837	NCBI	Rnor6.0
Rnor_5.0	5	173,032,932 - 173,033,176	UniSTS	Rnor5.0
RGSC_v3.4	5	169,531,284 - 169,531,528	UniSTS	RGSC3.4
Celera	5	161,039,967 - 161,040,211	UniSTS
RH 3.4 Map	5	1139.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	30	32	17	18	17			74	35	41	11
Low		13	25	24	1	24	8	11					8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF075595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF075596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB616023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000014625 ⟹ ENSRNOP00000014625

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	162,804,368 - 162,811,128 (+)	Ensembl
Rnor_6.0 Ensembl	5	169,475,270 - 169,482,030 (+)	Ensembl

RefSeq Acc Id:

NM_133310 ⟹ NP_579844

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	162,804,368 - 162,811,129 (+)	NCBI
Rnor_6.0	5	169,475,270 - 169,482,031 (+)	NCBI
Rnor_5.0	5	173,027,895 - 173,035,370 (+)	NCBI
RGSC_v3.4	5	169,526,961 - 169,533,722 (+)	RGD
Celera	5	161,035,644 - 161,042,405 (+)	RGD

Sequence:

show sequence

CTACAGTCGGCGCATCGGCCCGCTAGTCCGCCGCCGGCTCTTCCGCCGCCCTGCGCCATGGCGG
GCTGCGCGGCGCGGGTTCCGCCGGGCTCCGAGGCGCGCCTCAGCCTCGCTACCTTCCTCCTTGG
TGCCTCGGTGCTCGCTCTGCCTCTGCTCACGCGCGCCGGCCTGCAGGGCCGCACCGGGCTGGCG
CTGTACGTGGCCGGACTCAACGCGCTGTTGCTGCTTCTCTACCGGCCGCCGCGCTACCAGATAG
CCATCCGAGCTTGTTTCCTTGGCTTTGTGTTTGGCTGCGGCGTGCTGCTAAGTTTCAGCCAGTC
CTCCTGGAATCACTTCGGCTGGTACGTGTGCTCGCTCTCCCTGTTCCACTACTCTGAGTACCTA
GTGACAGCTGTCAATAATCCCAAAAGTCTGTCCTTGGACTCCTTCCTCCTGAACCACAGTCTGG
AGTACACAGTGGCTGCCCTGTCTTCCTGGATAGAGTTCACCCTTGAAAACATCTTTTGGCCAGA
ACTGAAGCAGATTACCTGGCTCAGTGCCGCTGGGCTGTTGATGGTGATCTTTGGAGAATGCCTG
AGGAAAGTGGCCATGTTTACAGCCGGCTCCAACTTCAACCACGTGGTACAGAGTGAAAAGTCAG
ACACCCACACTCTCGTGACAAGTGGGGTATACGCTTGGTGCCGGCACCCCTCCTATGTGGGCTG
GTTTTACTGGAGTATTGGAACCCAGGTGATGCTGTGTAATCCCATCTGTGGTGTGGTCTATGCC
CTGACGGTGTGGCGCTTCTTCCGTGATCGCACAGAGGAGGAGGAGATCTCGCTGATTCACTTCT
TTGGGGAAGAATACTTGGACTATAAGAAGAGGGTGCCCACAGGCCTGCCTTTCATAAAGGGGGT
CAAGGTGGGGCTATGACAGGAAGAGGCCCCGTGGGACCAGGGACCTCTGGCCCTGCGCAGCCTA
GGACAAAACTATTTAAAGTTGGGCACACAGAGTGAGTTTTCTTAATTGTTTTATATGTCACTAA
TTACTCCTCAGAATGTCACCCAGGACCTAATATTGAGGCGATGTTAGGTCCAAAGGAGCCACGG
CAGCTGTCTCCTGCACTGAAGGCAGGTGGGGCAAGGAGTGTGTCCAGGTGTTCATCGACGCCTC
TTCTACCATGGCAGGGGGATGACTCAAGCCACAGCCTCACACCCCCTCAGGCTAGAGTGTGTTT
GCATGGTGACCAGGATGCTTGGGAGAGGTGGACACCGCCCTTTGGAGTGGTCAGAGCTGCCAAG
TGTCAGCATTGGAAATGCACCAAACCCTTCTATTTAACTCCCACACAACCCAGCTTTACCCTTT
GTCGTCCATGAGTGCGTGAACATCTGCATAAACTGGGAAGACTTGTACCCTTGGGCTCATACAG
AAACCTATTTACACTCCAGTTCTATACGCAGAGCAGTGTAGATTCTGAGGGACATCGAGCCTCT
CTGCCTCGAGCGTCCAGGTCCAGCTTTCACGTGGCAACAGGTAGCACAGACCCTTGGGCGCTCT
GCAGCTTTTGAGTAGCCACTGGACCTGGGCTGAAGATGTGGGCCCAGGGTTCTCCCATGGTCCT
GGTCTCAGCTCTTCTGTTCCCCTGGGAAGTAATGTCCTAACTTCTGTGCTAACGCCGAGAAATG
CTGCCCTCCCTGTGTTTGGGATCAGTGTTCTCATTTATCATAGCTTCTGATTTTTATTTCCGTG
TTGCAACAAGTCTGTCAAATTAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_579844	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD42926	(Get FASTA)	NCBI Sequence Viewer
	AAD43000	(Get FASTA)	NCBI Sequence Viewer
	EDL81231	(Get FASTA)	NCBI Sequence Viewer
	Q9WVM4	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_579844 ⟸ NM_133310

- UniProtKB:

G3V7G5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGCAARVPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRY
QIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNH
SLEYTVAALSSWIEFTLENIFWPELKQITWLSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSE
KSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLI
HFFGEEYLDYKKRVPTGLPFIKGVKVGL

hide sequence

RefSeq Acc Id:

ENSRNOP00000014625 ⟸ ENSRNOT00000014625

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WVM4-F1-model_v2	AlphaFold	Q9WVM4	1-284	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694304

Promoter ID:

EPDNEW_R4827

Type:

initiation region

Name:

Icmt_1

Description:

isoprenylcysteine carboxyl methyltransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	169,475,254 - 169,475,314	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621618	AgrOrtholog
BioCyc Gene	G2FUF-39015	BioCyc
Ensembl Genes	ENSRNOG00000010953	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000014625	ENTREZGENE
	ENSRNOP00000014625.3	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000014625	ENTREZGENE
	ENSRNOT00000014625.6	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.120.1630	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7135269	IMAGE-MGC_LOAD
InterPro	ICMT_MeTrfase	UniProtKB/Swiss-Prot
	PPMT_MeTrfase	UniProtKB/Swiss-Prot
KEGG Report	rno:170818	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95322	IMAGE-MGC_LOAD
NCBI Gene	170818	ENTREZGENE
PANTHER	PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE	UniProtKB/Swiss-Prot
	PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE	UniProtKB/Swiss-Prot
Pfam	ICMT	UniProtKB/Swiss-Prot
PhenoGen	Icmt	PhenoGen
PROSITE	SAM_ICMT	UniProtKB/Swiss-Prot
UniProt	G3V7G5	ENTREZGENE
	ICMT_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	G3V7G5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Icmt	isoprenylcysteine carboxyl methyltransferase			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Icmt	isoprenylcysteine carboxyl methyltransferase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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