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Gene: Icmt (isoprenylcysteine carboxyl methyltransferase) Rattus norvegicus
Symbol: Icmt
Name: isoprenylcysteine carboxyl methyltransferase
Description: Exhibits protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; S-adenosylhomocysteine metabolic process; and S-adenosylmethioninamine metabolic process. Localizes to membrane. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: farnesyl cysteine carboxyl methyltransferase; fcmt; MGC95322; pcCMT; PPMT; prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methlytransferase; prenylcysteine carboxyl methyltransferase; protein-S-isoprenylcysteine O-methyltransferase
Homo sapiens (human) : ICMT (isoprenylcysteine carboxyl methyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Icmt (isoprenylcysteine carboxyl methyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Icmt (isoprenylcysteine carboxyl methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Canis lupus familiaris (dog) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Icmt (isoprenylcysteine carboxyl methyltransferase)
Sus scrofa (pig) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Chlorocebus sabaeus (African green monkey) : ICMT (isoprenylcysteine carboxyl methyltransferase)
Heterocephalus glaber (naked mole-rat) : Icmt (isoprenylcysteine carboxyl methyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05169,475,270 - 169,482,031 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,475,270 - 169,482,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05173,027,895 - 173,035,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,526,961 - 169,533,722 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15169,537,360 - 169,543,425 (+)NCBI
Celera5161,035,644 - 161,042,405 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Icmt
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621618
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.