Ttc34 (tetratricopeptide repeat domain 34) - Rat Genome Database

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Gene: Ttc34 (tetratricopeptide repeat domain 34) Rattus norvegicus
Analyze
Symbol: Ttc34
Name: tetratricopeptide repeat domain 34
RGD ID: 1304840
Description: Orthologous to human TTC34 (tetratricopeptide repeat domain 34); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102550274; LOC366517; RGD1304840; similar to RIKEN cDNA B230396O12; tetratricopeptide repeat protein 34; uncharacterized LOC102550274
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,693,410 - 170,711,215 (+)NCBIGRCr8
GRCr8 Ensembl5170,693,402 - 170,710,368 (+)EnsemblGRCr8 Ensembl
mRatBN7.25165,411,063 - 165,428,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,253,257 - 172,271,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,714,925 - 175,724,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,658,968 - 171,668,759 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5163,617,537 - 163,635,393 (+)NCBICelera
RGSC_v3.15171,643,843 - 171,679,156 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ttc34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,693,410 - 170,711,215 (+)NCBIGRCr8
GRCr8 Ensembl5170,693,402 - 170,710,368 (+)EnsemblGRCr8 Ensembl
mRatBN7.25165,411,063 - 165,428,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,253,257 - 172,271,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,714,925 - 175,724,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,658,968 - 171,668,759 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5163,617,537 - 163,635,393 (+)NCBICelera
RGSC_v3.15171,643,843 - 171,679,156 (+)NCBI
Cytogenetic Map5q36NCBI
TTC34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,636,986 - 2,801,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,636,986 - 2,801,693 (-)EnsemblGRCh38hg38GRCh38
GRCh3712,568,425 - 2,718,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,689,996 - 2,707,252 (-)NCBINCBI36Build 36hg18NCBI36
Celera11,898,499 - 1,923,916 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,852,084 - 1,875,285 (-)NCBIHuRef
HuRef11,993,249 - 1,999,306 (-)NCBIHuRef
CHM1_112,559,861 - 2,649,648 (-)NCBICHM1_1
T2T-CHM13v2.012,078,230 - 2,301,463 (-)NCBIT2T-CHM13v2.0
Ttc34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,921,871 - 154,951,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,921,916 - 154,951,584 (+)EnsemblGRCm39 Ensembl
GRCm384154,837,308 - 154,867,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,837,459 - 154,867,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,230,309 - 154,241,236 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,700,148 - 153,710,924 (+)NCBIMGSCv36mm8
Celera4157,122,995 - 157,139,547 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map485.47NCBI
Ttc34
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,620,516 - 8,631,399 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,620,609 - 8,633,069 (+)NCBIChiLan1.0ChiLan1.0
TTC34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,525,787 - 225,611,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,171,630 - 224,271,207 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,374,206 - 1,454,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,512,513 - 2,584,564 (-)NCBIpanpan1.1PanPan1.1panPan2
TTC34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,470,807 - 57,481,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,473,001 - 57,490,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,483,646 - 57,503,595 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,673,967 - 57,693,869 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,674,238 - 57,694,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,665,271 - 57,685,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,557,583 - 57,577,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,947,361 - 57,967,296 (-)NCBIUU_Cfam_GSD_1.0
Ttc34
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,502,832 - 28,531,358 (-)NCBIHiC_Itri_2
TTC34
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,478,408 - 64,499,986 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,478,117 - 64,499,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,035,533 - 59,050,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC34
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Ttc34
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,427,787 - 7,447,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,435,250 - 7,447,905 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000037211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
BF386934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,426,890 - 165,427,063 (+)MAPPERmRatBN7.2
Rnor_6.05172,269,083 - 172,269,255NCBIRnor6.0
Rnor_5.05175,724,736 - 175,724,908UniSTSRnor5.0
RGSC_v3.45171,668,531 - 171,668,703UniSTSRGSC3.4
Celera5163,633,420 - 163,633,592UniSTS
RH 3.4 Map51157.3UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 1 98 18 28 7 4 7 4 25 10 91 7 54 21

Sequence


Ensembl Acc Id: ENSRNOT00000037211   ⟹   ENSRNOP00000029146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,693,402 - 170,710,368 (+)Ensembl
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)Ensembl
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)Ensembl
RefSeq Acc Id: XM_039111371   ⟹   XP_038967299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,693,410 - 170,711,215 (+)NCBI
mRatBN7.25165,411,063 - 165,428,864 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038967299 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81275 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029146
  ENSRNOP00000029146.5
Ensembl Acc Id: ENSRNOP00000029146   ⟸   ENSRNOT00000037211
RefSeq Acc Id: XP_038967299   ⟸   XM_039111371
- UniProtKB: D3ZC99 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC99-F1-model_v2 AlphaFold D3ZC99 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304840 AgrOrtholog
BioCyc Gene G2FUF-38947 BioCyc
Ensembl Genes ENSRNOG00000024526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037211 ENTREZGENE
  ENSRNOT00000037211.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  TTC34 UniProtKB/TrEMBL
NCBI Gene 366517 ENTREZGENE
PANTHER PTHR44874 UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT PROTEIN 34 UniProtKB/TrEMBL
PhenoGen Ttc34 PhenoGen
PROSITE TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024526 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt D3ZC99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ttc34  tetratricopeptide repeat domain 34  LOC102550274  uncharacterized LOC102550274  Data merged from RGD:7732915 737654 PROVISIONAL
2013-12-18 LOC102550274  uncharacterized LOC102550274      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-12 Ttc34  tetratricopeptide repeat domain 34  RGD1304840  similar to RIKEN cDNA B230396O12   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1304840  similar to RIKEN cDNA B230396O12   RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  LOC366517_predicted  similar to RIKEN cDNA B230396O12 (predicted)  Symbol and Name status set to approved 1331353 APPROVED
2005-01-20 RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  LOC366517_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366517_predicted  similar to RIKEN cDNA B230396O12 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL