Ttc34 (tetratricopeptide repeat domain 34) - Rat Genome Database

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Gene: Ttc34 (tetratricopeptide repeat domain 34) Rattus norvegicus
Analyze
Symbol: Ttc34
Name: tetratricopeptide repeat domain 34
RGD ID: 1304840
Description: Orthologous to human TTC34 (tetratricopeptide repeat domain 34); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102550274; LOC366517; RGD1304840; similar to RIKEN cDNA B230396O12; tetratricopeptide repeat protein 34; uncharacterized LOC102550274
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,693,410 - 170,711,215 (+)NCBIGRCr8
mRatBN7.25165,411,063 - 165,428,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,253,257 - 172,271,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,714,925 - 175,724,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,658,968 - 171,668,759 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,643,843 - 171,679,156 (+)NCBI
Celera5163,617,537 - 163,635,393 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttc34Ratchromosome 1p36 deletion syndrome  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1p36 deletion syndromeClinVar 
Ttc34Ratdilated cardiomyopathy 1LL  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Left ventricular noncompaction 8ClinVarPMID:28492532
Ttc34RatEhlers-Danlos syndrome spondylodysplastic type 2  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome more ...ClinVarPMID:10862081 more ...
Ttc34RatGoldberg-Shprintzen syndrome  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Shprintzen-Goldberg syndromeClinVarPMID:23892090 more ...
Ttc34Ratimmunodeficiency 16  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiency due to OX40 deficiencyClinVarPMID:10862081 more ...
Ttc34Ratimmunodeficiency 38  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiencyClinVarPMID:10862081 more ...
Ttc34RatJoubert syndrome 25  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Joubert syndrome 25ClinVarPMID:10862081 more ...
Ttc34RatNeurodevelopmental Disorders  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Ttc34RatPeroxisome Biogenesis Disorder, Complementation Group 7  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder and complementation group 7ClinVarPMID:10862081 more ...
Ttc34RatShprintzen-Goldberg Craniosynostosis  ISOTTC34 (Homo sapiens)8554872ClinVar Annotator: match by term: Shprintzen-Goldberg syndromeClinVarPMID:23892090 more ...
1 to 10 of 10 rows

1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttc34Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TTC34 mRNACTDPMID:32109520
Ttc34Rat4,4'-sulfonyldiphenol decreases methylationISOTtc34 (Mus musculus)6480464bisphenol S results in decreased methylation of TTC34 exonCTDPMID:33297965
Ttc34Rataflatoxin B1 decreases methylationISOTTC34 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TTC34 intronCTDPMID:30157460
Ttc34Ratbenzo[e]pyrene increases methylationISOTTC34 (Homo sapiens)6480464benzo(e)pyrene results in increased methylation of TTC34 exonCTDPMID:30157460
Ttc34Ratbis(2-ethylhexyl) phthalate multiple interactionsISOTTC34 (Homo sapiens)6480464[Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of TTC34 geneCTDPMID:33872906
Ttc34Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of TTC34 mRNACTDPMID:25181051
Ttc34Ratbisphenol A decreases methylationISOTTC34 (Homo sapiens)6480464bisphenol A results in decreased methylation of TTC34 geneCTDPMID:31601247
Ttc34Ratbisphenol A decreases methylationISOTtc34 (Mus musculus)6480464bisphenol A results in decreased methylation of TTC34 promoterCTDPMID:27312807
Ttc34RatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of TTC34 mRNACTDPMID:19167457
Ttc34Ratcadmium dichloride increases expressionEXP 6480464Cadmium Chloride results in increased expression of TTC34 mRNACTDPMID:33453195
Ttc34Ratcadmium dichloride increases expressionISOTTC34 (Homo sapiens)6480464Cadmium Chloride results in increased expression of TTC34 mRNACTDPMID:38382870
Ttc34Ratcarbon nanotube decreases expressionISOTtc34 (Mus musculus)6480464Nanotubes more ...CTDPMID:25554681
Ttc34Ratcholine multiple interactionsISOTtc34 (Mus musculus)6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TTC34 geneCTDPMID:20938992
Ttc34RatCuprizon increases expressionEXP 6480464Cuprizone results in increased expression of TTC34 mRNACTDPMID:26577399
Ttc34RatDibutyl phosphate affects expressionISOTTC34 (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of TTC34 mRNACTDPMID:37042841
Ttc34Ratfolic acid multiple interactionsISOTtc34 (Mus musculus)6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TTC34 geneCTDPMID:20938992
Ttc34RatL-methionine multiple interactionsISOTtc34 (Mus musculus)6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TTC34 geneCTDPMID:20938992
Ttc34Ratmethapyrilene increases methylationISOTTC34 (Homo sapiens)6480464Methapyrilene results in increased methylation of TTC34 exonCTDPMID:30157460
Ttc34Ratmono(2-ethylhexyl) phthalate multiple interactionsISOTTC34 (Homo sapiens)6480464[Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of TTC34 geneCTDPMID:33872906
Ttc34Ratozone multiple interactionsISOTTC34 (Homo sapiens)6480464[Air Pollutants results in increased abundance of Ozone] which affects the expression of TTC34 mRNACTDPMID:35430440

1 to 20 of 20 rows

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Reference Title
Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Ttc34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,693,410 - 170,711,215 (+)NCBIGRCr8
mRatBN7.25165,411,063 - 165,428,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,253,257 - 172,271,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,714,925 - 175,724,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,658,968 - 171,668,759 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,643,843 - 171,679,156 (+)NCBI
Celera5163,617,537 - 163,635,393 (+)NCBICelera
Cytogenetic Map5q36NCBI
TTC34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,636,986 - 2,801,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,636,986 - 2,801,693 (-)EnsemblGRCh38hg38GRCh38
GRCh3712,568,425 - 2,718,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,689,996 - 2,707,252 (-)NCBINCBI36Build 36hg18NCBI36
Celera11,898,499 - 1,923,916 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,852,084 - 1,875,285 (-)NCBIHuRef
HuRef11,993,249 - 1,999,306 (-)NCBIHuRef
CHM1_112,559,861 - 2,649,648 (-)NCBICHM1_1
T2T-CHM13v2.012,078,230 - 2,301,463 (-)NCBIT2T-CHM13v2.0
Ttc34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,921,871 - 154,951,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,921,916 - 154,951,584 (+)EnsemblGRCm39 Ensembl
GRCm384154,837,308 - 154,867,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,837,459 - 154,867,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,230,309 - 154,241,236 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,700,148 - 153,710,924 (+)NCBIMGSCv36mm8
Celera4157,122,995 - 157,139,547 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map485.47NCBI
Ttc34
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,620,516 - 8,631,399 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,620,609 - 8,633,069 (+)NCBIChiLan1.0ChiLan1.0
TTC34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,525,787 - 225,611,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,171,630 - 224,271,207 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,374,206 - 1,454,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,512,513 - 2,584,564 (-)NCBIpanpan1.1PanPan1.1panPan2
TTC34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,470,807 - 57,481,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,473,001 - 57,490,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,483,646 - 57,503,595 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,673,967 - 57,693,869 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,674,238 - 57,694,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,665,271 - 57,685,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,557,583 - 57,577,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,947,361 - 57,967,296 (-)NCBIUU_Cfam_GSD_1.0
Ttc34
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,502,832 - 28,531,358 (-)NCBIHiC_Itri_2
TTC34
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,478,408 - 64,499,986 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,478,117 - 64,499,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,035,533 - 59,050,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ttc34
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,427,787 - 7,447,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,435,250 - 7,447,905 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ttc34
52 total Variants

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000037211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat

1 to 10 of 18 rows
BF386934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,426,890 - 165,427,063 (+)MAPPERmRatBN7.2
Rnor_6.05172,269,083 - 172,269,255NCBIRnor6.0
Rnor_5.05175,724,736 - 175,724,908UniSTSRnor5.0
RGSC_v3.45171,668,531 - 171,668,703UniSTSRGSC3.4
Celera5163,633,420 - 163,633,592UniSTS
RH 3.4 Map51157.3UniSTS
Cytogenetic Map5q36UniSTS




appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 1 98 18 28 7 4 7 4 25 10 91 7 54 21



Ensembl Acc Id: ENSRNOT00000037211   ⟹   ENSRNOP00000029146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,411,058 - 165,428,857 (+)Ensembl
Rnor_6.0 Ensembl5172,259,520 - 172,269,213 (+)Ensembl
RefSeq Acc Id: XM_039111371   ⟹   XP_038967299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,693,410 - 170,711,215 (+)NCBI
mRatBN7.25165,411,063 - 165,428,864 (+)NCBI
Protein RefSeqs XP_038967299 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81275 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029146
  ENSRNOP00000029146.5
Ensembl Acc Id: ENSRNOP00000029146   ⟸   ENSRNOT00000037211
RefSeq Acc Id: XP_038967299   ⟸   XM_039111371
- UniProtKB: D3ZC99 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC99-F1-model_v2 AlphaFold D3ZC99 1-554 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 17 of 17 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38947 BioCyc
Ensembl Genes ENSRNOG00000024526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037211 ENTREZGENE
  ENSRNOT00000037211.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  TTC34 UniProtKB/TrEMBL
NCBI Gene 366517 ENTREZGENE
PANTHER PTHR44874 UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT PROTEIN 34 UniProtKB/TrEMBL
PhenoGen Ttc34 PhenoGen
PROSITE TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024526 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt D3ZC99 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ttc34  tetratricopeptide repeat domain 34  LOC102550274  uncharacterized LOC102550274  Data merged from RGD:7732915 737654 PROVISIONAL
2013-12-18 LOC102550274  uncharacterized LOC102550274      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-12 Ttc34  tetratricopeptide repeat domain 34  RGD1304840  similar to RIKEN cDNA B230396O12   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1304840  similar to RIKEN cDNA B230396O12   RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  LOC366517_predicted  similar to RIKEN cDNA B230396O12 (predicted)  Symbol and Name status set to approved 1331353 APPROVED
2005-01-20 RGD1304840_predicted  similar to RIKEN cDNA B230396O12 (predicted)  LOC366517_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366517_predicted  similar to RIKEN cDNA B230396O12 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL