Fbxo2 (F-box protein 2) - Rat Genome Database

Name: Fbxo2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fbxo2 (F-box protein 2) Rattus norvegicus

Analyze

Symbol:

Fbxo2

Name:

F-box protein 2

RGD ID:

621751

Description:

Predicted to enable amyloid-beta binding activity; carbohydrate binding activity; and denatured protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in negative regulation of cell population proliferation. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human FBXO2 (F-box protein 2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

F-box only protein 2; neural F box protein NFB42

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBXO2 (F-box protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FBXO2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbxo2 (F-box protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CIC (capicua transcriptional repressor)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	FBXO2 (F-box protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fbxo2 (F-box protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:175088	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C14B1.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	158,592,926 - 158,598,355 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,592,925 - 158,598,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	161,309,703 - 161,315,130 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,131,494 - 163,136,941 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	163,087,839 - 163,093,286 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	164,972,483 - 164,977,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,972,480 - 164,977,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	168,630,521 - 168,635,950 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	165,239,080 - 165,244,509 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	165,249,267 - 165,254,697 (+)	NCBI
Celera	5	156,871,142 - 156,876,571 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

chromosome 1p36 deletion syndrome (ISO)

Familial Atrial Fibrillation 6 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methoxyethanol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

chrysene (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

dextran sulfate (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dieldrin (EXP)

dorsomorphin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

flavonoids (EXP)

folic acid (ISO)

gentamycin (EXP)

isobutanol (ISO)

ivermectin (ISO)

ketamine (EXP)

lead(0) (ISO)

lead(2+) (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel dichloride (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

propanal (ISO)

quercetin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycoprotein catabolic process (IBA,ISO)

negative regulation of cell population proliferation (IDA)

protein ubiquitination (ISO)

regulation of protein catabolic process at postsynapse, modulating synaptic transmission (ISO)

regulation of protein ubiquitination (ISO)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IBA,ISO)

ubiquitin-dependent ERAD pathway (IBA,ISO)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (ISO)

dendritic spine (ISO)

extrinsic component of postsynaptic membrane (IDA,IMP)

glutamatergic synapse (IDA,IMP,ISO)

postsynapse (ISO)

SCF ubiquitin ligase complex (IBA,ISO)

Molecular Function

amyloid-beta binding (ISO)

carbohydrate binding (ISO)

denatured protein binding (ISO)

protein binding (ISO)

ubiquitin protein ligase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest.	Erhardt JA, etal., J Biol Chem 1998 Dec 25;273(52):35222-7.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination.	Kato A, etal., Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5600-5. doi: 10.1073/pnas.0501769102. Epub 2005 Apr 4.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9173930	PMID:12140560	PMID:12939278	PMID:14701835	PMID:15723043	PMID:19028597	PMID:21378169	PMID:23376485

Genomics

Comparative Map Data

Fbxo2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	158,592,926 - 158,598,355 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,592,925 - 158,598,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	161,309,703 - 161,315,130 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,131,494 - 163,136,941 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	163,087,839 - 163,093,286 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	164,972,483 - 164,977,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,972,480 - 164,977,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	168,630,521 - 168,635,950 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	165,239,080 - 165,244,509 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	165,249,267 - 165,254,697 (+)	NCBI
Celera	5	156,871,142 - 156,876,571 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

FBXO2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	11,648,387 - 11,654,429 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	11,637,018 - 11,655,785 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	11,708,444 - 11,714,486 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	11,631,035 - 11,637,326 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	11,642,715 - 11,649,005	NCBI
Celera	1	10,820,505 - 10,826,801 (-)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	10,862,510 - 10,868,984 (-)	NCBI		HuRef
CHM1_1	1	11,696,402 - 11,702,875 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,192,423 - 11,198,481 (-)	NCBI		T2T-CHM13v2.0

Fbxo2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	148,244,605 - 148,250,874 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	148,245,078 - 148,250,881 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	148,160,198 - 148,166,420 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,160,621 - 148,166,424 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	147,534,777 - 147,540,526 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	147,004,468 - 147,010,217 (+)	NCBI		MGSCv36	mm8
Celera	4	150,422,125 - 150,427,887 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	78.68	NCBI

Fbxo2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,212,001 - 2,218,017 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	2,212,001 - 2,217,260 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBXO2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	215,217,956 - 215,224,017 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,408,853 - 10,415,174 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	11,626,713 - 11,633,171 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	11,626,713 - 11,633,171 (-)	Ensembl	panpan1.1		panPan2

FBXO2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,563,256 - 84,568,507 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,556,547 - 84,568,491 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	81,095,467 - 81,100,690 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	85,226,074 - 85,231,298 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	85,226,182 - 85,231,052 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,975,039 - 81,980,259 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,975,760 - 82,980,978 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	84,038,529 - 84,043,752 (+)	NCBI		UU_Cfam_GSD_1.0

Fbxo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	34,696,457 - 34,701,333 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	521,123 - 526,959 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936474	521,235 - 526,151 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXO2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	71,740,677 - 71,748,923 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	71,740,647 - 71,747,265 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	65,660,557 - 65,663,671 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXO2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	120,136,630 - 120,144,119 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	120,136,702 - 120,144,258 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	24,005,047 - 24,011,590 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxo2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	1,299,067 - 1,309,667 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	1,300,191 - 1,311,245 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fbxo2
30 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	221
Count of miRNA genes:	153
Interacting mature miRNAs:	169
Transcripts:	ENSRNOT00000012670
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat

Markers in Region

RH136768

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	158,598,218 - 158,598,317 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	164,977,776 - 164,977,874	NCBI	Rnor6.0
Rnor_5.0	5	168,635,814 - 168,635,912	UniSTS	Rnor5.0
RGSC_v3.4	5	165,244,373 - 165,244,471	UniSTS	RGSC3.4
Celera	5	156,876,435 - 156,876,533	UniSTS
RH 3.4 Map	5	1103.9	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									36		9
Low	3		20	4	8	4			26	35	30
Below cutoff		19	20	20	8	20	3	3	12		2	11	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF098301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000012670 ⟹ ENSRNOP00000012670

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	158,592,926 - 158,598,355 (+)	Ensembl
Rnor_6.0 Ensembl	5	164,972,480 - 164,977,916 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115135 ⟹ ENSRNOP00000076638

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	158,595,706 - 158,598,355 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119733 ⟹ ENSRNOP00000090623

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	158,592,925 - 158,598,355 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119831 ⟹ ENSRNOP00000089724

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	158,593,933 - 158,598,355 (+)	Ensembl

RefSeq Acc Id:

NM_053511 ⟹ NP_445963

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	158,592,926 - 158,598,355 (+)	NCBI
Rnor_6.0	5	164,972,483 - 164,977,912 (+)	NCBI
Rnor_5.0	5	168,630,521 - 168,635,950 (+)	NCBI
RGSC_v3.4	5	165,239,080 - 165,244,509 (+)	RGD
Celera	5	156,871,142 - 156,876,571 (+)	RGD

Sequence:

show sequence

CGGCACGAGCTCCAGGACTCGCCACCCGCAGCGCTCAGGCTCCACTCTCGTCAGCGCCGCACGG
ATGGATGGAGATGGTGATCCAGAGAGTGTGAGCCACCCCGAAGAGGCGAGCCCGGAGGAGCAGC
CTGAGGAGGCGGGCGCCAGGGCGAGTGCGGAGGAGGAGCAGCCCAGGGAGGAGGAGGAGGAAGA
GACAGAGGCCGTGGAGTACCTTGCCGAGTTGCCTGAGCCACTGCTGCTGCGCGTGCTGGCAGAG
CTGCCCGCTACGGAGCTAGTGCAAGCCTGCCGCCTGGTGTGCCTGCGCTGGAAGGAGCTGGTGG
ACGGCGCCCCACTGTGGCTGCTCAAGTGTCAGCAGGAGGGGCTGGTGCCTGAGGGCAGCGCTGA
TGACGAGCGGGACCACTGGCAACAGTTCTACTTTCTGAGCAAGAGGAGGCGCAACCTGCTGCGT
AACCCGTGTGGGGAAGAGGACTTGGAGGGCTGGTGCGACGTGGAGCACGGTGGGGACGGCTGGA
GAGTGGAGGAACTGCCCGGAGACAGTGGGGTGGAATTTACCCACGACGACAGCGTTAAGAAGTA
CTTCGCCTCCTCCTTCGAGTGGTGTCGCAAAGCGCAGGTCATTGATCTGCAGGCTGAGGGCTAC
TGGGAGGAGCTACTGGACACCACCCAGCCCGCCATCGTGGTGAAGGACTGGTACTCGGGCCGCA
CGGATGCCGGCAGCCTGTATGAGCTCACTGTGAGGCTGCTGTCGGAGCATGAAGATGTGCTGGC
GGAGTTCAATACGGGACAGGTGGCTGTGCCAGAGGATGGCAGCTGGATGGAGATCTCCCACACT
TTCACCGACTACGGGCCAGGCGTCCGCTACGTCCGCTTCGAGCACGGAGGGCAGGACTCGGTCT
ACTGGAAGGGCTGGTTCGGGGCCCGGGTGACCAACAGTAGCGTGTGGGTGGAACCCTGAGGGAC
CTCCCCTATCCCCACCATCTGCCCTCTAGGGCAGAATCCTGGAGTAGAATGGCCTTAATTTAGT
TGGTAGCGTCCTCACCTGCCTCGTCTACGCCTTGCACCTGCCTCTCTCCCGCCCCTTCCTCCAG
TCTGGAACCCGAGAGAGAAGGATTTGTTGCTTTTACTGTGGGATCGGCTTCCATTTGCATCCCA
TGGGCAGTCGCTTCTAGAATGTACGATCCGATCCGAGGGGGGAATGGGGCTGCTGCTGGATCCG
CGCACCTAGCATTGTGCCTGCCTCAGAGTGGGCAGTCAATAAATATTTGTCCAAAGAAGGCAAC
AATGGAAGCGCAGATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_445963	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC97505	(Get FASTA)	NCBI Sequence Viewer
	EDL81115	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_445963 ⟸ NM_053511

- UniProtKB:

G3V774 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDGDGDPESVSHPEEASPEEQPEEAGARASAEEEQPREEEEEETEAVEYLAELPEPLLLRVLAE
LPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADDERDHWQQFYFLSKRRRNLLR
NPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDDSVKKYFASSFEWCRKAQVIDLQAEGY
WEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSEHEDVLAEFNTGQVAVPEDGSWMEISHT
FTDYGPGVRYVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

hide sequence

RefSeq Acc Id:

ENSRNOP00000012670 ⟸ ENSRNOT00000012670

RefSeq Acc Id:

ENSRNOP00000089724 ⟸ ENSRNOT00000119831

RefSeq Acc Id:

ENSRNOP00000076638 ⟸ ENSRNOT00000115135

RefSeq Acc Id:

ENSRNOP00000090623 ⟸ ENSRNOT00000119733

Protein Domains

F-box FBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V774-F1-model_v2	AlphaFold	G3V774	1-296	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694259

Promoter ID:

EPDNEW_R4784

Type:

single initiation site

Name:

Fbxo2_1

Description:

F-box protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	164,972,448 - 164,972,508	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621751	AgrOrtholog
BioCyc Gene	G2FUF-39172	BioCyc
Ensembl Genes	ENSRNOG00000009409	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012670	ENTREZGENE
	ENSRNOP00000012670.1	UniProtKB/TrEMBL
	ENSRNOP00000076638.1	UniProtKB/TrEMBL
	ENSRNOP00000089724.1	UniProtKB/TrEMBL
	ENSRNOP00000090623.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012670	ENTREZGENE
	ENSRNOT00000012670.4	UniProtKB/TrEMBL
	ENSRNOT00000115135.1	UniProtKB/TrEMBL
	ENSRNOT00000119733.1	UniProtKB/TrEMBL
	ENSRNOT00000119831.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1280.50	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
InterPro	F-box-assoc_dom	UniProtKB/TrEMBL
	F-box_dom_cyclin-like	UniProtKB/TrEMBL
	F-box_dom_like	UniProtKB/TrEMBL
	F-box_only	UniProtKB/TrEMBL
	Galactose-bd-like	UniProtKB/TrEMBL
KEGG Report	rno:85273	UniProtKB/TrEMBL
NCBI Gene	85273	ENTREZGENE
PANTHER	F-BOX ONLY PROTEIN 2	UniProtKB/TrEMBL
	PTHR12125	UniProtKB/TrEMBL
Pfam	F-box	UniProtKB/TrEMBL
	FBA	UniProtKB/TrEMBL
PhenoGen	Fbxo2	PhenoGen
PROSITE	FBA	UniProtKB/TrEMBL
	FBOX	UniProtKB/TrEMBL
SMART	FBA	UniProtKB/TrEMBL
Superfamily-SCOP	F-box_dom_Skp2-like	UniProtKB/TrEMBL
	Gal_bind_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZK45_RAT	UniProtKB/TrEMBL
	A0A8I6A9Y7_RAT	UniProtKB/TrEMBL
	A0A8I6AAF5_RAT	UniProtKB/TrEMBL
	G3V774	ENTREZGENE, UniProtKB/TrEMBL
	Q9Z1X8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Fbxo2	F-box protein 2	Fbxo2	F-box only protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Fbxo2	F-box only protein 2		neural F box protein NFB42	Name updated	1299863	APPROVED
2002-08-07	Fbxo2	neural F box protein NFB42			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized primarily to the cytoplasm of neurons	632756
gene_expression	enriched in all major areas of the adult brain	632756

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)