Gpr157 (G protein-coupled receptor 157) - Rat Genome Database

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Gene: Gpr157 (G protein-coupled receptor 157) Rattus norvegicus
Analyze
Symbol: Gpr157
Name: G protein-coupled receptor 157
RGD ID: 1311096
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; circadian behavior; and radial glial cell differentiation. Predicted to be located in ciliary membrane. Predicted to be active in plasma membrane. Orthologous to human GPR157 (G protein-coupled receptor 157); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 157; LOC313725; MGC109533; probable G-protein coupled receptor 157
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,833,651 - 165,849,376 (+)NCBIGRCr8
mRatBN7.25160,550,703 - 160,566,432 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,550,713 - 160,566,432 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,267,195 - 163,282,912 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,089,378 - 165,105,226 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,045,749 - 165,061,597 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,109,691 - 167,125,380 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,109,691 - 167,125,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,750,442 - 170,766,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,205,605 - 167,223,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,215,792 - 167,233,933 (+)NCBI
Celera5158,812,331 - 158,828,028 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:27142930  


Genomics

Comparative Map Data
Gpr157
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,833,651 - 165,849,376 (+)NCBIGRCr8
mRatBN7.25160,550,703 - 160,566,432 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,550,713 - 160,566,432 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,267,195 - 163,282,912 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,089,378 - 165,105,226 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,045,749 - 165,061,597 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,109,691 - 167,125,380 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,109,691 - 167,125,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,750,442 - 170,766,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,205,605 - 167,223,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,215,792 - 167,233,933 (+)NCBI
Celera5158,812,331 - 158,828,028 (+)NCBICelera
Cytogenetic Map5q36NCBI
GPR157
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,100,305 - 9,129,102 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,100,305 - 9,129,102 (-)EnsemblGRCh38hg38GRCh38
GRCh3719,160,364 - 9,189,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,087,063 - 9,111,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419,098,741 - 9,123,495NCBI
Celera18,273,844 - 8,298,831 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,314,669 - 8,339,557 (-)NCBIHuRef
CHM1_119,154,653 - 9,179,610 (-)NCBICHM1_1
T2T-CHM13v2.018,634,357 - 8,663,346 (-)NCBIT2T-CHM13v2.0
Gpr157
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,171,960 - 150,190,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,171,822 - 150,190,384 (+)EnsemblGRCm39 Ensembl
GRCm384150,087,503 - 150,105,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,087,365 - 150,105,927 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,461,612 - 149,480,036 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,931,165 - 148,948,167 (+)NCBIMGSCv36mm8
Celera4152,363,542 - 152,381,935 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.89NCBI
Gpr157
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,172,515 - 4,189,137 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,172,515 - 4,188,887 (+)NCBIChiLan1.0ChiLan1.0
GPR157
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21219,104,545 - 219,133,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,749,151 - 217,778,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017,857,904 - 7,884,669 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119,093,479 - 9,117,743 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,093,493 - 9,117,748 (-)Ensemblpanpan1.1panPan2
GPR157
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,453,338 - 62,471,614 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,454,921 - 62,508,970 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,470,724 - 62,489,028 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,680,187 - 62,698,261 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,682,328 - 62,698,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,678,315 - 62,696,346 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,541,859 - 62,560,054 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,946,549 - 62,964,604 (-)NCBIUU_Cfam_GSD_1.0
Gpr157
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,780,436 - 32,796,613 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,264,403 - 3,281,931 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,264,409 - 3,281,857 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR157
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,557,701 - 69,581,643 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,558,940 - 69,581,656 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GPR157
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,631,383 - 122,650,163 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,632,218 - 122,649,115 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605426,596,694 - 26,671,603 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr157
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,109,407 - 3,123,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,109,457 - 3,123,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr157
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:115
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000055536
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
AA944747  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,563,129 - 160,563,323 (+)MAPPERmRatBN7.2
Rnor_6.05167,122,078 - 167,122,271NCBIRnor6.0
Rnor_5.05170,762,767 - 170,762,960UniSTSRnor5.0
RGSC_v3.45167,219,708 - 167,219,901UniSTSRGSC3.4
Celera5158,824,726 - 158,824,919UniSTS
RH 3.4 Map51120.8UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3
Low 3 43 57 41 19 41 8 9 50 35 41 8 8
Below cutoff 24

Sequence


RefSeq Acc Id: ENSRNOT00000055536   ⟹   ENSRNOP00000052398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,550,713 - 160,566,432 (+)Ensembl
Rnor_6.0 Ensembl5167,109,691 - 167,125,380 (+)Ensembl
RefSeq Acc Id: NM_001012107   ⟹   NP_001012107
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,833,661 - 165,849,376 (+)NCBI
mRatBN7.25160,550,713 - 160,566,432 (+)NCBI
Rnor_6.05167,109,691 - 167,125,380 (+)NCBI
Rnor_5.05170,750,442 - 170,766,069 (+)NCBI
RGSC_v3.45167,205,605 - 167,223,745 (+)RGD
Celera5158,812,331 - 158,828,028 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110103   ⟹   XP_038966031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,833,651 - 165,847,631 (+)NCBI
mRatBN7.25160,550,703 - 160,564,687 (+)NCBI
RefSeq Acc Id: XR_005504463
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,833,651 - 165,847,627 (+)NCBI
mRatBN7.25160,550,703 - 160,564,682 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012107 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966031 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH90013 (Get FASTA)   NCBI Sequence Viewer  
  EDL81177 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052398
  ENSRNOP00000052398.1
  ENSRNOP00055021023
  ENSRNOP00060034537
  ENSRNOP00065014006
GenBank Protein Q5FVG1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012107   ⟸   NM_001012107
- UniProtKB: Q5FVG1 (UniProtKB/Swiss-Prot),   A6IUC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052398   ⟸   ENSRNOT00000055536
RefSeq Acc Id: XP_038966031   ⟸   XM_039110103
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVG1-F1-model_v2 AlphaFold Q5FVG1 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311096 AgrOrtholog
BioCyc Gene G2FUF-39082 BioCyc
Ensembl Genes ENSRNOG00000017528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055015068 UniProtKB/Swiss-Prot
  ENSRNOG00060024082 UniProtKB/Swiss-Prot
  ENSRNOG00065011302 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000055536 ENTREZGENE
  ENSRNOT00000055536.2 UniProtKB/Swiss-Prot
  ENSRNOT00055025766 UniProtKB/Swiss-Prot
  ENSRNOT00060041673 UniProtKB/Swiss-Prot
  ENSRNOT00065018334 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324631 IMAGE-MGC_LOAD
InterPro GCR1-cAMP_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:313725 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109533 IMAGE-MGC_LOAD
NCBI Gene 313725 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR 157-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 157 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr157 PhenoGen
PRINTS GCR1CAMPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017528 RatGTEx
  ENSRNOG00055015068 RatGTEx
  ENSRNOG00060024082 RatGTEx
  ENSRNOG00065011302 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IUC6 ENTREZGENE, UniProtKB/TrEMBL
  GP157_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Gpr157  G protein-coupled receptor 157  Gpr157_predicted  G protein-coupled receptor 157 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gpr157_predicted  G protein-coupled receptor 157 (predicted)      Symbol and Name status set to approved 70820 APPROVED