Gene: Agrn (agrin) Rattus norvegicus
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Symbol: Agrn
Name: agrin
Description: ENCODES a protein that exhibits BMP binding; calcium ion binding; dystroglycan binding; INVOLVED IN chemical synaptic transmission; positive regulation of filopodium assembly; positive regulation of GTPase activity; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; cell-extracellular matrix signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 8 (ortholog); FOUND IN axonal growth cone; basement membrane; glutamatergic synapse; INTERACTS WITH (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol
AGR Description: Exhibits calcium ion binding activity, cytokine binding activity, and dystroglycan binding activity; involved in several processes, including chemical synaptic transmission, nervous system development, and positive regulation of cellular metabolic process; localizes to the axonal growth cone, basement membrane, and glutamatergic synapse; orthologous to human AGRN (agrin).
Merged Description: Exhibits calcium ion binding activity, cytokine binding activity, and dystroglycan binding activity; involved in several processes, including chemical synaptic transmission, nervous system development, and positive regulation of cellular metabolic process; localizes to the axonal growth cone, basement membrane, and glutamatergic synapse; orthologous to human AGRN (agrin); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AGR
Orthologs:
Homo sapiens (human) : AGRN (agrin)  HGNC  Alliance
Mus musculus (house mouse) : Agrn (agrin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agrn (agrin)
Pan paniscus (bonobo/pygmy chimpanzee) : AGRN (agrin)
Canis lupus familiaris (dog) : AGRN (agrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agrn (agrin)
Sus scrofa (pig) : AGRN (agrin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05173,589,910 - 173,622,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05177,063,797 - 177,096,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,999,420 - 173,020,764 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15173,009,918 - 173,031,259 (-)NCBI
Celera5164,949,181 - 164,970,209 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Agrn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2067
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.