Agrn (agrin) - Rat Genome Database

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Gene: Agrn (agrin) Rattus norvegicus
Analyze
Symbol: Agrn
Name: agrin
RGD ID: 2067
Description: Enables calcium ion binding activity; cytokine binding activity; and dystroglycan binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of plasma membrane bounded cell projection organization; and synapse organization. Acts upstream of or within receptor clustering. Located in axonal growth cone; basement membrane; and synapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AGR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,031,528 - 172,064,429 (-)NCBIGRCr8
mRatBN7.25166,749,306 - 166,782,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,749,310 - 166,786,003 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,451,492 - 169,472,811 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,272,883 - 171,294,202 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,235,444 - 171,256,763 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,589,910 - 173,622,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,589,819 - 173,622,645 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05177,063,797 - 177,096,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,999,420 - 173,020,764 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15173,009,918 - 173,031,259 (-)NCBI
Celera5164,949,181 - 164,970,209 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
Allylamine  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
reactive oxygen species  (EXP)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
chemical synaptic transmission  (IMP,ISO)
circadian rhythm  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
motor neuron apoptotic process  (ISO)
negative regulation of P-type sodium:potassium-exchanging transporter activity  (ISO)
negative regulation of sodium ion export across plasma membrane  (ISO)
neuromuscular junction development  (IBA,ISO,TAS)
plasma membrane organization  (ISO)
positive regulation of filopodium assembly  (IDA)
positive regulation of GTPase activity  (IDA)
positive regulation of motor neuron apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of protein geranylgeranylation  (ISO)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of synaptic assembly at neuromuscular junction  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
protein transport  (ISO)
receptor clustering  (IBA,IDA,IEA,ISO,ISS)
regulation of axon guidance  (IDA)
regulation of cardiac muscle cell membrane potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of microtubule cytoskeleton organization  (IDA)
regulation of protein phosphorylation  (IDA)
regulation of synapse organization  (IDA,IMP)
regulation of synaptic activity  (ISO)
regulation of synaptic assembly at neuromuscular junction  (IEA)
skeletal muscle acetylcholine-gated channel clustering  (IDA,IMP)
synapse assembly  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Agrin binds BMP2, BMP4 and TGFbeta1. Banyai L, etal., PLoS One. 2010 May 21;5(5):e10758. doi: 10.1371/journal.pone.0010758.
2. Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Bergstrom RA, etal., Neuroscience. 2007 Nov 9;149(3):527-36. Epub 2007 Aug 14.
3. Agrin requires specific proteins to selectively activate ¿-aminobutyric acid neurons for pain suppression. Erasso D, etal., Exp Neurol. 2014 Nov;261:646-53. doi: 10.1016/j.expneurol.2014.08.014. Epub 2014 Aug 21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor. Gee SH, etal., Cell. 1994 Jun 3;77(5):675-86.
6. Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder. Gingras J, etal., Cell Tissue Res. 2005 Apr;320(1):115-25. Epub 2005 Feb 16.
7. Agrin acts via a MuSK receptor complex. Glass DJ, etal., Cell 1996 May 17;85(4):513-23.
8. Alpha3Na+/K+-ATPase is a neuronal receptor for agrin. Hilgenberg LG, etal., Cell. 2006 Apr 21;125(2):359-69.
9. The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons. Hoover CL, etal., J Cell Biol. 2003 Jun 9;161(5):923-32.
10. Lrp4 is a receptor for Agrin and forms a complex with MuSK. Kim N, etal., Cell. 2008 Oct 17;135(2):334-42. doi: 10.1016/j.cell.2008.10.002. Epub 2008 Oct 9.
11. Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases. Lin L, etal., Exp Cell Res. 2010 Aug 15;316(14):2260-77. doi: 10.1016/j.yexcr.2010.05.006. Epub 2010 May 13.
12. Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis. Martin AO, etal., J Cell Biol. 2005 May 9;169(3):503-14.
13. Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures. McCroskery S, etal., Neuroscience. 2009 Sep 29;163(1):168-79. doi: 10.1016/j.neuroscience.2009.06.012. Epub 2009 Jun 10.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering. Moransard M, etal., J Biol Chem. 2003 Feb 28;278(9):7350-9. Epub 2002 Dec 16.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Targeting of recombinant agrin to axonal growth cones. Neuhuber B and Daniels MP, Mol Cell Neurosci. 2003 Dec;24(4):1180-96.
18. Alternative splicing of agrin regulates its binding to heparin alpha-dystroglycan, and the cell surface. O'Toole JJ, etal., Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7369-74.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Structure and expression of a rat agrin. Rupp F, etal., Neuron 1991 May;6(5):811-23.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Neuregulin inhibits acetylcholine receptor aggregation in myotubes. Trinidad JC and Cohen JB, J Biol Chem. 2004 Jul 23;279(30):31622-8. Epub 2004 May 20.
26. Asparagine of z8 insert is critical for the affinity, conformation, and acetylcholine receptor-clustering activity of neural agrin. Tseng CN, etal., J Biol Chem. 2010 Sep 3;285(36):27641-51. doi: 10.1074/jbc.M110.130625. Epub 2010 Jun 21.
27. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
28. LRP4 serves as a coreceptor of agrin. Zhang B, etal., Neuron. 2008 Oct 23;60(2):285-97. doi: 10.1016/j.neuron.2008.10.006.
29. Structural basis of agrin-LRP4-MuSK signaling. Zong Y, etal., Genes Dev. 2012 Feb 1;26(3):247-58. doi: 10.1101/gad.180885.111.
Additional References at PubMed
PMID:1326608   PMID:7670489   PMID:8653788   PMID:9151673   PMID:9405491   PMID:9422725   PMID:10402191   PMID:11018052   PMID:11312299   PMID:11395002   PMID:12165471   PMID:12773545  
PMID:12955494   PMID:14622576   PMID:15210115   PMID:15340048   PMID:16274639   PMID:16635246   PMID:16860570   PMID:17119023   PMID:17628813   PMID:18003748   PMID:18230682   PMID:18627255  
PMID:18639611   PMID:18757743   PMID:19199708   PMID:19285050   PMID:19376779   PMID:19940118   PMID:20458337   PMID:20551380   PMID:21068333   PMID:21969364   PMID:23056392   PMID:23117006  
PMID:23376485   PMID:23533145   PMID:23658023   PMID:24006456   PMID:27068509   PMID:27559042   PMID:31055156   PMID:31454080  


Genomics

Comparative Map Data
Agrn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,031,528 - 172,064,429 (-)NCBIGRCr8
mRatBN7.25166,749,306 - 166,782,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,749,310 - 166,786,003 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,451,492 - 169,472,811 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,272,883 - 171,294,202 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,235,444 - 171,256,763 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,589,910 - 173,622,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,589,819 - 173,622,645 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05177,063,797 - 177,096,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,999,420 - 173,020,764 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15173,009,918 - 173,031,259 (-)NCBI
Celera5164,949,181 - 164,970,209 (-)NCBICelera
Cytogenetic Map5q36NCBI
AGRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,020,120 - 1,056,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,020,120 - 1,056,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371955,500 - 991,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,366 - 981,355 (+)NCBINCBI36Build 36hg18NCBI36
Celera11,597,136 - 1,631,462 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1226,888 - 263,237 (+)NCBIHuRef
CHM1_11942,522 - 978,540 (+)NCBICHM1_1
T2T-CHM13v2.01450,247 - 486,181 (+)NCBIT2T-CHM13v2.0
Agrn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394156,249,747 - 156,281,997 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4156,249,747 - 156,281,945 (-)EnsemblGRCm39 Ensembl
GRCm384156,165,290 - 156,197,533 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4156,165,290 - 156,197,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,539,399 - 155,559,244 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364155,009,090 - 155,028,935 (-)NCBIMGSCv36mm8
Celera4158,419,989 - 158,441,614 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map488.55NCBI
Agrn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,675,214 - 9,704,991 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,674,103 - 9,704,994 (-)NCBIChiLan1.0ChiLan1.0
AGRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,197,744 - 227,232,423 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,893,486 - 225,928,339 (-)NCBINHGRI_mPanPan1
PanPan1.11953,977 - 967,946 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1936,000 - 966,808 (+)Ensemblpanpan1.1panPan2
AGRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,239,621 - 56,273,679 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,239,701 - 56,272,745 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,317,660 - 56,351,511 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,443,168 - 56,477,026 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,443,113 - 56,476,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,434,207 - 56,468,062 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,326,114 - 56,359,961 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,716,182 - 56,750,025 (+)NCBIUU_Cfam_GSD_1.0
Agrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,426,638 - 27,455,302 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367372,011,724 - 2,039,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367372,010,647 - 2,041,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,365,983 - 63,398,309 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,366,017 - 63,398,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2657,851,241 - 57,880,816 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,383,226 - 130,416,926 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,383,220 - 130,416,933 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,009,405 - 35,044,463 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agrn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,476,562 - 8,508,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248188,475,453 - 8,508,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agrn
122 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1178
Count of miRNA genes:262
Interacting mature miRNAs:325
Transcripts:ENSRNOT00000042726, ENSRNOT00000045678, ENSRNOT00000046315, ENSRNOT00000047854
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
RH127796  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85172,031,689 - 172,031,878 (+)Marker Load Pipeline
mRatBN7.25166,749,466 - 166,749,656 (+)MAPPERmRatBN7.2
Rnor_6.05173,590,071 - 173,590,260NCBIRnor6.0
Rnor_5.05177,063,958 - 177,064,147UniSTSRnor5.0
RGSC_v3.45172,999,581 - 172,999,770UniSTSRGSC3.4
Celera5164,949,342 - 164,949,531UniSTS
RH 3.4 Map51172.9UniSTS
Cytogenetic Map5q36UniSTS
RH94447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,750,028 - 166,750,202 (+)MAPPERmRatBN7.2
Rnor_6.05173,590,633 - 173,590,806NCBIRnor6.0
Rnor_5.05177,064,520 - 177,064,693UniSTSRnor5.0
RGSC_v3.45173,000,143 - 173,000,316UniSTSRGSC3.4
Celera5164,949,904 - 164,950,077UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_175754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF250032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S44194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045678   ⟹   ENSRNOP00000050623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,749,310 - 166,786,003 (-)Ensembl
Rnor_6.0 Ensembl5173,589,819 - 173,622,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047854   ⟹   ENSRNOP00000040828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,749,310 - 166,786,003 (-)Ensembl
Rnor_6.0 Ensembl5173,589,914 - 173,611,202 (-)Ensembl
RefSeq Acc Id: NM_175754   ⟹   NP_786930
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,052,825 (-)NCBI
mRatBN7.25166,749,306 - 166,770,603 (-)NCBI
Rnor_6.05173,589,910 - 173,611,202 (-)NCBI
Rnor_5.05177,063,797 - 177,096,674 (-)NCBI
RGSC_v3.45172,999,420 - 173,020,764 (-)RGD
Celera5164,949,181 - 164,970,209 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239541   ⟹   XP_006239603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
mRatBN7.25166,749,306 - 166,782,211 (-)NCBI
Rnor_6.05173,589,910 - 173,622,813 (-)NCBI
Rnor_5.05177,063,797 - 177,096,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239542   ⟹   XP_006239604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
mRatBN7.25166,749,306 - 166,782,211 (-)NCBI
Rnor_6.05173,589,910 - 173,622,813 (-)NCBI
Rnor_5.05177,063,797 - 177,096,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593166   ⟹   XP_017448655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
mRatBN7.25166,749,306 - 166,782,211 (-)NCBI
Rnor_6.05173,589,910 - 173,622,813 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593167   ⟹   XP_017448656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
mRatBN7.25166,749,306 - 166,782,211 (-)NCBI
Rnor_6.05173,589,910 - 173,622,813 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593168   ⟹   XP_017448657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
mRatBN7.25166,749,306 - 166,782,211 (-)NCBI
Rnor_6.05173,589,910 - 173,622,813 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593169   ⟹   XP_017448658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
mRatBN7.25166,749,306 - 166,782,212 (-)NCBI
Rnor_6.05173,589,910 - 173,622,813 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593170   ⟹   XP_017448659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,053,699 (-)NCBI
mRatBN7.25166,749,306 - 166,771,490 (-)NCBI
Rnor_6.05173,589,910 - 173,612,677 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109320   ⟹   XP_038965248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,044,775 (-)NCBI
mRatBN7.25166,749,306 - 166,763,068 (-)NCBI
RefSeq Acc Id: XM_063287202   ⟹   XP_063143272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,031,528 - 172,064,429 (-)NCBI
RefSeq Acc Id: NP_786930   ⟸   NM_175754
- UniProtKB: A6IUW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239604   ⟸   XM_006239542
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006239603   ⟸   XM_006239541
- Peptide Label: isoform X5
- UniProtKB: D4A2F1 (UniProtKB/TrEMBL),   A6IUW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448658   ⟸   XM_017593169
- Peptide Label: isoform X4
- UniProtKB: Q63034 (UniProtKB/Swiss-Prot),   P25304 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448656   ⟸   XM_017593167
- Peptide Label: isoform X2
- UniProtKB: Q63034 (UniProtKB/Swiss-Prot),   P25304 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448657   ⟸   XM_017593168
- Peptide Label: isoform X3
- UniProtKB: Q63034 (UniProtKB/Swiss-Prot),   P25304 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448655   ⟸   XM_017593166
- Peptide Label: isoform X1
- UniProtKB: Q63034 (UniProtKB/Swiss-Prot),   P25304 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448659   ⟸   XM_017593170
- Peptide Label: isoform X8
- UniProtKB: Q63034 (UniProtKB/Swiss-Prot),   P25304 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040828   ⟸   ENSRNOT00000047854
Ensembl Acc Id: ENSRNOP00000050623   ⟸   ENSRNOT00000045678
RefSeq Acc Id: XP_038965248   ⟸   XM_039109320
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063143272   ⟸   XM_063287202
- Peptide Label: isoform X7
- UniProtKB: A6IUW3 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   Kazal-like   Laminin EGF-like   Laminin G   Laminin G-like   NtA   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25304-F1-model_v2 AlphaFold P25304 1-1959 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2067 AgrOrtholog
BioCyc Gene G2FUF-38860 BioCyc
Ensembl Genes ENSRNOG00000020205 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045678 ENTREZGENE
  ENSRNOT00000045678.6 UniProtKB/TrEMBL
  ENSRNOT00000047854 ENTREZGENE
  ENSRNOT00000047854.4 UniProtKB/TrEMBL
  ENSRNOT00000126412 ENTREZGENE
  ENSRNOT00000150948 ENTREZGENE
  ENSRNOT00000154534 ENTREZGENE
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Agrin_NtA UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FacI_MAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurexin-related_CASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report rno:25592 UniProtKB/Swiss-Prot
NCBI Gene 25592 ENTREZGENE
PANTHER AGRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKACHURIN-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NtA UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Agrn PhenoGen
PRINTS EGFLAMININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTA UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020205 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Lam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIMAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_like UniProtKB/TrEMBL
TIGR TC229521
UniProt A6IUW3 ENTREZGENE, UniProtKB/TrEMBL
  AGRIN_RAT UniProtKB/Swiss-Prot
  D4A2F1 ENTREZGENE, UniProtKB/TrEMBL
  F1LPF2 ENTREZGENE, UniProtKB/TrEMBL
  P25304 ENTREZGENE
  Q63034 ENTREZGENE
UniProt Secondary Q63034 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Agrn  Agrin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
null contains141 cysteine residues 632164
gene_cellular_localization localized to synapses 632164
gene_expression expressed in embryonic spinal cord and muscle 632164
gene_process may play a role in synaptic development and regeneration 632164
gene_protein protein sequence contains1940 amino acid residues 632164