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Gene: BMP2 (bone morphogenetic protein 2) Homo sapiens
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Symbol: BMP2
Name: bone morphogenetic protein 2
Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDA2; BMP-2A; BMP2A; bone morphogenetic protein 2A; SSFSC
Orthologs:
Mus musculus (house mouse) : Bmp2 (bone morphogenetic protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bmp2 (bone morphogenetic protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmp2 (bone morphogenetic protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BMP2 (bone morphogenetic protein 2)
Canis lupus familiaris (dog) : BMP2 (bone morphogenetic protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bmp2 (bone morphogenetic protein 2)
Sus scrofa (pig) : BMP2 (bone morphogenetic protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38206,768,098 - 6,780,280 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37206,748,745 - 6,760,910 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,696,745 - 6,708,910 (+)NCBINCBI36hg18NCBI36
Build 34206,697,206 - 6,707,769NCBI
Celera206,819,903 - 6,832,070 (+)NCBI
Cytogenetic Map20p12.3NCBI
HuRef206,705,637 - 6,717,811 (+)NCBIHuRef
CHM1_1206,748,804 - 6,760,987 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated
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Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on BMP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733110
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.