Mfn2 (mitofusin 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Mfn2 (mitofusin 2) Rattus norvegicus
Analyze
Symbol: Mfn2
Name: mitofusin 2
RGD ID: 628843
Description: Exhibits several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including mitochondrion organization; negative regulation of cell death; and positive regulation of anion transport. Localizes to cytosol and intrinsic component of mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); fatty liver disease (multiple); obesity; prediabetes syndrome; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,4-dinitrotoluene; 2-tert-butylhydroquinone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: HSG; hypertension-related protein; mitochondrial transmembrane GTPase FZO1A; mitofusin-2; transmembrane GTPase MFN2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: GeneIDs: 64476 and 100911485 are annotated independently on Rnor_6.0 but may be redundant loci. [09 Feb 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,304,285 - 158,335,502 (-)NCBI
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Celera5156,587,853 - 156,617,496 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
alopecia  (ISO)
Alzheimer's disease  (IEP,ISO)
Blister  (ISO)
Cardiac Fibrosis  (IEP)
Cardiomegaly  (IEP,ISO)
carotid stenosis  (IMP)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth Disease Type 2A2  (ISO)
Charcot-Marie-Tooth disease type 2A2A  (ISO)
Charcot-Marie-Tooth disease type 2A2B  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 6  (ISO)
Charcot-Marie-Tooth Disease Type 6A  (ISO)
Charcot-Marie-Tooth Disease, Type 2A  (ISO)
Cicatrix  (ISO)
Diabetic Nephropathies  (IEP,IMP,ISO)
diabetic retinopathy  (IEP)
dilated cardiomyopathy  (ISO)
distal hereditary motor neuronopathy type 7B  (ISO)
distal myopathy  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP)
Failure to Thrive  (ISO)
fatty liver disease  (IEP)
genetic disease  (ISO)
Hyperalgesia  (IEP,ISO)
hypertension  (IEP)
Insulin Resistance  (IEP)
Liver Reperfusion Injury  (IEP)
Manganese Poisoning  (IEP)
mental depression  (IEP)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (IEP)
Myocardial Reperfusion Injury  (IEP)
non-alcoholic fatty liver disease  (IEP)
nonprogressive cerebellar ataxia with mental retardation  (ISO)
nonsyndromic congenital nail disorder 9  (ISO)
obesity  (IEP,ISO)
prediabetes syndrome  (IEP)
Pulmonary Edema of Mountaineers  (IEP)
pulmonary fibrosis  (IEP)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
Sarcopenia  (IEP)
Sepsis  (IEP)
Spinal Cord Injuries  (IEP)
Tooth Abnormalities  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-DAMP(1+)  (EXP)
5-fluorouracil  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
alloxan  (EXP)
alpha-D-galactose  (EXP,ISO)
AM-251  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
azide  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
Calpeptin  (EXP,ISO)
Candesartan cilexetil  (EXP)
carnosic acid  (ISO)
CCCP  (EXP,ISO)
cinnamic acid  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (EXP,ISO)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
entinostat  (ISO)
ethanol  (ISO)
excitatory amino acid agonist  (EXP,ISO)
ferulic acid  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
galactose  (EXP,ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glucose  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
isoprenaline  (EXP)
lamivudine  (ISO)
linuron  (EXP)
lovastatin  (ISO)
mabuterol  (EXP)
manganese(II) chloride  (ISO)
melatonin  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-hexadecanoylsphingosine  (ISO)
nitrogen dioxide  (ISO)
NSC 23766  (ISO)
okadaic acid  (EXP)
oxidopamine  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenethyl caffeate  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
pyrroloquinoline quinone  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
ruthenium red  (EXP)
Salvianolic acid A  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP)
streptozocin  (EXP)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trans-cinnamic acid  (EXP)
trichloroethene  (EXP)
Triptolide  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
blastocyst formation  (ISO)
camera-type eye morphogenesis  (ISO)
cell cycle arrest  (IDA)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to ionizing radiation  (IEP)
cellular response to L-glutamate  (IEP)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to manganese ion  (IEP)
cellular response to mercaptoethanol  (IEP)
cellular response to oxygen-glucose deprivation  (IEP)
cellular response to testosterone stimulus  (IEP)
intracellular distribution of mitochondria  (IMP)
male gonad development  (IEP)
mitochondrial calcium ion homeostasis  (IMP)
mitochondrial fusion  (IBA,IEA,IMP,ISO,ISS)
mitochondrial membrane organization  (ISO,ISS)
mitochondrion localization  (IBA,ISO)
mitochondrion morphogenesis  (IMP)
mitochondrion organization  (IMP)
mitotic cell cycle  (IEP)
mitotic cell cycle arrest  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell cycle  (IMP)
negative regulation of cell death  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of cell size  (IMP)
negative regulation of glial cell proliferation  (IMP)
negative regulation of mitochondrial fission  (IMP)
negative regulation of neuron death  (IMP)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of release of cytochrome c from mitochondria  (IMP)
negative regulation of sarcomere organization  (IMP)
negative regulation of smooth muscle cell proliferation  (IDA,IEA)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (ISO)
positive regulation of cellular respiration  (IMP)
positive regulation of chromatin binding  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of estradiol secretion  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of glucose import  (IMP)
positive regulation of hydrogen peroxide biosynthetic process  (IMP)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of ovarian follicle development  (IMP)
positive regulation of progesterone secretion  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein localization to phagophore assembly site  (ISO)
protein targeting to mitochondrion  (ISO,ISS)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to calcium ion  (IEP)
response to D-galactose  (IEP)
response to electrical stimulus  (IEP)
response to fatty acid  (IEP)
response to flavonoid  (IEP)
response to hypobaric hypoxia  (IEP)
response to L-arginine  (IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
response to testosterone  (IEP)
response to unfolded protein  (IEA)
spermatogenesis  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bach D, etal., Diabetes. 2005 Sep;54(9):2685-93.
2. Bach D, etal., J Biol Chem. 2003 May 9;278(19):17190-7. Epub 2003 Feb 21.
3. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
4. Chen KH, etal., Nat Cell Biol 2004 Sep;6(9):872-83. Epub 2004 Aug 22.
5. Chen Y, etal., Circ Res. 2011 Dec 9;109(12):1327-31. doi: 10.1161/CIRCRESAHA.111.258723. Epub 2011 Nov 3.
6. Chien L, etal., Oncotarget. 2015 Oct 13;6(31):30628-39. doi: 10.18632/oncotarget.5790.
7. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
8. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
9. Ding H, etal., Biochim Biophys Acta. 2010 Mar;1800(3):250-6. doi: 10.1016/j.bbagen.2009.08.007. Epub 2009 Aug 28.
10. Erasso D, etal., Exp Neurol. 2014 Nov;261:646-53. doi: 10.1016/j.expneurol.2014.08.014. Epub 2014 Aug 21.
11. Eura Y, etal., J Biochem (Tokyo) 2003 Sep;134(3):333-44.
12. Fang X, etal., J Cardiovasc Pharmacol. 2016 Feb;67(2):164-74. doi: 10.1097/FJC.0000000000000333.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Ge L, etal., Oncotarget. 2017 Mar 3. doi: 10.18632/oncotarget.15876.
15. GOA data from the GO Consortium
16. Golic I, etal., Eur J Histochem. 2014 Sep 9;58(3):2377. doi: 10.4081/ejh.2014.2377.
17. Gonzalez AS, etal., Free Radic Res. 2014 Jul;48(7):769-83. doi: 10.3109/10715762.2014.906592. Epub 2014 Apr 10.
18. Guan X, etal., J Mol Cell Cardiol. 2016 Oct;99:207-217. doi: 10.1016/j.yjmcc.2016.08.016. Epub 2016 Aug 23.
19. Hernández-Alvarez MI, etal., Antioxid Redox Signal. 2013 Aug 1;19(4):366-78. doi: 10.1089/ars.2011.4269. Epub 2012 Aug 6.
20. Honda S and Hirose S, Biochem Biophys Res Commun. 2003 Nov 14;311(2):424-32.
21. Hu M, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Jun;26(6):388-93. doi: 10.3760/cma.j.issn.2095-4352.2014.06.005.
22. Hu X, etal., Exp Ther Med. 2014 Sep;8(3):731-736. Epub 2014 Jul 9.
23. Javadov S, etal., Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.
24. Kang JW, etal., J Pineal Res. 2016 May;60(4):383-93. doi: 10.1111/jpi.12319. Epub 2016 Mar 7.
25. Kitaoka Y, etal., Appl Physiol Nutr Metab. 2015 Nov;40(11):1137-42. doi: 10.1139/apnm-2015-0184. Epub 2015 Jul 14.
26. Koncsos G, etal., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H927-H943. doi: 10.1152/ajpheart.00049.2016. Epub 2016 Aug 12.
27. Kou X, etal., J Appl Physiol (1985). 2017 Jun 1;122(6):1462-1469. doi: 10.1152/japplphysiol.00018.2017. Epub 2017 Mar 16.
28. Li D, etal., Acta Biochim Biophys Sin (Shanghai). 2015 Jun;47(6):441-50. doi: 10.1093/abbs/gmv035. Epub 2015 Apr 29.
29. Li J, etal., J Cell Mol Med. 2014 Sep;18(9):1863-73. doi: 10.1111/jcmm.12320. Epub 2014 Jun 4.
30. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
31. Lin KP, etal., PLoS One. 2011;6(12):e29393. doi: 10.1371/journal.pone.0029393. Epub 2011 Dec 19.
32. Lin YZ, etal., J Surg Res. 2016 Jun 15;203(2):268-74. doi: 10.1016/j.jss.2016.02.013. Epub 2016 Feb 19.
33. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
34. Liu T, etal., Neurosci Lett. 2014 Sep 5;579:24-9. doi: 10.1016/j.neulet.2014.07.002. Epub 2014 Jul 11.
35. Liu W and Zhou C, Psychoneuroendocrinology. 2012 Jul;37(7):1057-70. doi: 10.1016/j.psyneuen.2011.12.003. Epub 2012 Jan 14.
36. Liu X, etal., Neurochem Int. 2017 Feb 21. pii: S0197-0186(16)30405-3. doi: 10.1016/j.neuint.2017.02.008.
37. Liu X, etal., Zhonghua Gan Zang Bing Za Zhi. 2014 Sep;22(9):671-5. doi: 10.3760/cma.j.issn.1007-3418.2014.09.008.
38. Mahdaviani K, etal., EMBO Rep. 2017 Jul;18(7):1123-1138. doi: 10.15252/embr.201643827. Epub 2017 May 24.
39. Maimaitijiang A, etal., Biochem Biophys Res Commun. 2016 Mar 18;471(4):474-8. doi: 10.1016/j.bbrc.2016.02.051. Epub 2016 Feb 20.
40. Martorell-Riera A, etal., EMBO J. 2014 Oct 16;33(20):2388-407. doi: 10.15252/embj.201488327. Epub 2014 Aug 21.
41. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
42. MGD data from the GO Consortium
43. Mi X, etal., J Mol Endocrinol. 2016 Nov;57(4):233-249. doi: 10.1530/JME-16-0031.
44. Nair AR, etal., Arch Toxicol. 2015 Dec;89(12):2273-89. doi: 10.1007/s00204-014-1401-9. Epub 2014 Nov 12.
45. Nie Q, etal., Mol Biol Rep. 2014 Oct;41(10):6975-83. doi: 10.1007/s11033-014-3584-9. Epub 2014 Jul 18.
46. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
47. OMIM Disease Annotation Pipeline
48. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
49. Parra V, etal., Cardiovasc Res. 2008 Jan 15;77(2):387-97. Epub 2007 Oct 4.
50. Pennanen C, etal., J Cell Sci. 2014 Jun 15;127(Pt 12):2659-71. doi: 10.1242/jcs.139394. Epub 2014 Apr 28.
51. RGD automated data pipeline
52. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. RGD automated import pipeline for gene-chemical interactions
54. Rojo M, etal., J Cell Sci. 2002 Apr 15;115(Pt 8):1663-74.
55. Song A, etal., Int J Mol Med. 2014 Jun;33(6):1671-9. doi: 10.3892/ijmm.2014.1738. Epub 2014 Apr 9.
56. Stancic A, etal., Chem Biol Interact. 2017 Jun 25;272:188-196. doi: 10.1016/j.cbi.2017.05.003. Epub 2017 May 5.
57. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
58. Sun M, etal., Sci Rep. 2015 Dec 22;5:18351. doi: 10.1038/srep18351.
59. Sun W, etal., Neuropharmacology. 2017 Feb;113(Pt A):556-566. doi: 10.1016/j.neuropharm.2016.11.010. Epub 2016 Nov 12.
60. Tang H, etal., Int J Biochem Cell Biol. 2017 May 5;88:55-59. doi: 10.1016/j.biocel.2017.05.006.
61. Wang F, etal., J Endocrinol. 2015 May;225(2):101-11. doi: 10.1530/JOE-14-0638. Epub 2015 Mar 13.
62. Wang W, etal., J Biol Chem. 2015 Jan 2;290(1):168-82. doi: 10.1074/jbc.M114.617167. Epub 2014 Nov 21.
63. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
64. Wang Y, etal., Cell Death Dis. 2017 May 18;8(5):e2799. doi: 10.1038/cddis.2017.193.
65. Wang YC, etal., World J Gastroenterol. 2015 Sep 21;21(35):10104-12. doi: 10.3748/wjg.v21.i35.10104.
66. Wang Z, etal., Int J Cardiol. 2015 Jan 15;178:165-7. doi: 10.1016/j.ijcard.2014.10.122. Epub 2014 Oct 22.
67. Wang Z, etal., Int J Cardiol. 2016 Jul 1;214:348-57. doi: 10.1016/j.ijcard.2016.04.007. Epub 2016 Apr 5.
68. Wappler EA, etal., PLoS One. 2013 May 2;8(5):e63206. doi: 10.1371/journal.pone.0063206. Print 2013.
69. Wu L, etal., Mol Cell Endocrinol. 2015 Sep 15;413:1-12. doi: 10.1016/j.mce.2015.06.007. Epub 2015 Jun 27.
70. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
71. Yamashita Y, etal., Neurosci Lett. 2017 Jun 3;653:337-340. doi: 10.1016/j.neulet.2017.05.069.
72. Yang F, etal., Am J Physiol Endocrinol Metab. 2017 Mar 1;312(3):E190-E203. doi: 10.1152/ajpendo.00196.2016. Epub 2016 Dec 20.
73. Zhang R, etal., Mol Cell Endocrinol. 2017 Sep 5;452:33-43. doi: 10.1016/j.mce.2017.05.009. Epub 2017 May 6.
74. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
75. Zhou W, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Apr;30(4):388-90.
76. Zhou W, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Jun;31(6):775-8.
77. Zhu TT, etal., Eur J Pharmacol. 2017 Aug 15;809:42-51. doi: 10.1016/j.ejphar.2017.05.003. Epub 2017 May 3.
78. Zou D, etal., Med Sci Sports Exerc. 2014 Nov;46(11):2077-84. doi: 10.1249/MSS.0000000000000336.
79. Zuchner S, etal., Ann Neurol. 2006 Feb;59(2):276-81.
80. Zuchner S, etal., Nat Genet. 2004 May;36(5):449-51. Epub 2004 Apr 4.
Additional References at PubMed
PMID:11181170   PMID:12527753   PMID:12589796   PMID:15899901   PMID:16083859   PMID:16104381   PMID:16936636   PMID:17035996   PMID:17093923   PMID:17499311   PMID:17532093   PMID:17562700  
PMID:17901359   PMID:18614015   PMID:18931719   PMID:19961739   PMID:20303493   PMID:20671748   PMID:20711222   PMID:20871098   PMID:21106870   PMID:21245373   PMID:22282241   PMID:22493254  
PMID:22771393   PMID:23383258   PMID:23455425   PMID:23494933   PMID:23592132   PMID:23620051   PMID:23652351   PMID:23815800   PMID:23921378   PMID:24513856   PMID:26593335   PMID:27640178  
PMID:28013092   PMID:29097872   PMID:29445732   PMID:29762821   PMID:31017259   PMID:31247293   PMID:31295012   PMID:31322244   PMID:31557386   PMID:31829064   PMID:32313015   PMID:32593899  


Genomics

Comparative Map Data
Mfn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,304,285 - 158,335,502 (-)NCBI
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Celera5156,587,853 - 156,617,496 (-)NCBICelera
Cytogenetic Map5q36NCBI
MFN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,980,181 - 12,013,514 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl111,980,181 - 12,015,211 (+)EnsemblGRCh38hg38GRCh38
GRCh38111,980,215 - 12,013,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,040,501 - 12,073,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,962,956 - 11,996,152 (+)NCBINCBI36hg18NCBI36
Build 34111,974,634 - 12,007,833NCBI
Celera111,153,903 - 11,187,236 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,195,001 - 11,228,266 (+)NCBIHuRef
CHM1_1112,028,020 - 12,061,326 (+)NCBICHM1_1
Mfn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394147,958,043 - 147,989,527 (-)NCBIGRCm39mm39
GRCm39 Ensembl4147,958,056 - 147,989,161 (-)Ensembl
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBImm8
Celera4150,136,809 - 150,169,620 (-)NCBICelera
Cytogenetic Map4E1NCBI
Mfn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,937,802 - 1,962,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,937,873 - 1,962,577 (-)NCBIChiLan1.0ChiLan1.0
MFN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,945,849 - 11,981,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0panPan3
MFN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl284,284,719 - 84,308,225 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1284,284,719 - 84,310,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mfn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936474767,754 - 795,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,026,722 - 72,056,439 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,026,512 - 72,056,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,936,375 - 65,955,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,787,700 - 119,818,455 (-)NCBI
ChlSab1.1 Ensembl20119,787,370 - 119,816,693 (-)Ensembl
Mfn2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,041,371 - 1,065,061 (-)NCBI

Position Markers
RH128167  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05164,561,548 - 164,561,749NCBIRnor6.0
Rnor_6.05164,685,355 - 164,685,556NCBIRnor6.0
Rnor_5.05168,343,818 - 168,344,019UniSTSRnor5.0
Rnor_5.05168,228,411 - 168,228,612UniSTSRnor5.0
RGSC_v3.45164,952,099 - 164,952,300UniSTSRGSC3.4
Celera5156,588,700 - 156,588,901UniSTS
RH 3.4 Map51089.21UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5149568588167739697Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149832180164807402Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5150360936167946134Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5157212422167739539Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5157319671171194163Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5157319671173707219Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5161084664173707219Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:175
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000055680, ENSRNOT00000065985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055680   ⟹   ENSRNOP00000052539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091132   ⟹   ENSRNOP00000070746
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5164,685,956 - 164,709,441 (-)Ensembl
RefSeq Acc Id: NM_130894   ⟹   NP_570964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,304,549 - 158,334,190 (-)NCBI
Rnor_6.05164,684,508 - 164,714,145 (-)NCBI
Rnor_5.05168,342,707 - 168,373,926 (-)NCBI
RGSC_v3.45164,951,252 - 164,980,763 (-)RGD
Celera5156,587,853 - 156,617,496 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239402   ⟹   XP_006239464
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,304,285 - 158,335,502 (-)NCBI
Rnor_6.05164,684,244 - 164,715,414 (-)NCBI
Rnor_5.05168,342,707 - 168,373,926 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239403   ⟹   XP_006239465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,304,285 - 158,335,241 (-)NCBI
Rnor_6.05164,684,244 - 164,715,236 (-)NCBI
Rnor_5.05168,342,707 - 168,373,926 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764288   ⟹   XP_008762510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,304,285 - 158,335,457 (-)NCBI
Rnor_6.05164,684,244 - 164,715,414 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593611   ⟹   XP_017449100
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,684,244 - 164,715,015 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_570964   ⟸   NM_130894
- UniProtKB: Q6IRL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239464   ⟸   XM_006239402
- Peptide Label: isoform X1
- UniProtKB: Q6IRL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239465   ⟸   XM_006239403
- Peptide Label: isoform X1
- UniProtKB: Q6IRL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762510   ⟸   XM_008764288
- Peptide Label: isoform X1
- UniProtKB: Q6IRL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449100   ⟸   XM_017593611
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000052539   ⟸   ENSRNOT00000055680
RefSeq Acc Id: ENSRNOP00000070746   ⟸   ENSRNOT00000091132
Protein Domains
Dynamin-type G

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694250
Promoter ID:EPDNEW_R4775
Type:single initiation site
Name:LOC100911485_1
Description:mitofusin-2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,714,147 - 164,714,207EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628843 AgrOrtholog
Ensembl Genes ENSRNOG00000046424 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046447 UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052539 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000059463 UniProtKB/TrEMBL
  ENSRNOP00000070746 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055680 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000065985 UniProtKB/TrEMBL
  ENSRNOT00000091132 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096620 IMAGE-MGC_LOAD
InterPro Dynamin_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitofusin-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100911485 UniProtKB/TrEMBL
  rno:64476 UniProtKB/TrEMBL
MGC_CLONE MGC:91421 IMAGE-MGC_LOAD
NCBI Gene 64476 ENTREZGENE
PANTHER PTHR10465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10465:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mfn2 PhenoGen
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7FHF7_RAT UniProtKB/TrEMBL
  MFN2_RAT UniProtKB/Swiss-Prot
  Q6IRL2 ENTREZGENE, UniProtKB/TrEMBL
  Q8R500 ENTREZGENE
UniProt Secondary D4A9N3 UniProtKB/TrEMBL
  O09013 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Mfn2  mitofusin 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Mfn2  mitofusin 2      Symbol and Name status set to provisional 70820 PROVISIONAL