MFN2 (mitofusin 2) - Rat Genome Database
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Gene: MFN2 (mitofusin 2) Pan paniscus
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Symbol: MFN2
Name: mitofusin 2
RGD ID: 11968415
Description: ENCODES a protein that exhibits GTP binding (ortholog); GTPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN blastocyst formation (ortholog); camera-type eye morphogenesis (ortholog); cell cycle arrest (ortholog); PARTICIPATES IN mitochondria fusion pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); alopecia (ortholog); Alzheimer's disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); intrinsic component of mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mitofusin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,945,849 - 11,981,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
Blister  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
carotid stenosis  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth Disease Type 2A2  (ISO)
Charcot-Marie-Tooth disease type 2A2A  (ISO)
Charcot-Marie-Tooth disease type 2A2B  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 6  (ISO)
Charcot-Marie-Tooth Disease Type 6A  (ISO)
Charcot-Marie-Tooth Disease, Type 2A  (ISO)
Cicatrix  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
distal hereditary motor neuronopathy type 7B  (ISO)
distal myopathy  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Failure to Thrive  (ISO)
fatty liver disease  (ISO)
genetic disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
Liver Reperfusion Injury  (ISO)
Manganese Poisoning  (ISO)
mental depression  (ISO)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
non-alcoholic fatty liver disease  (ISO)
nonprogressive cerebellar ataxia with mental retardation  (ISO)
nonsyndromic congenital nail disorder 9  (ISO)
obesity  (ISO)
prediabetes syndrome  (ISO)
Pulmonary Edema of Mountaineers  (ISO)
pulmonary fibrosis  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
Sarcopenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Tooth Abnormalities  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blastocyst formation  (ISO)
camera-type eye morphogenesis  (ISO)
cell cycle arrest  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to manganese ion  (ISO)
cellular response to mercaptoethanol  (ISO)
cellular response to oxygen-glucose deprivation  (ISO)
cellular response to testosterone stimulus  (ISO)
intracellular distribution of mitochondria  (ISO)
male gonad development  (ISO)
mitochondrial calcium ion homeostasis  (ISO)
mitochondrial fusion  (ISO)
mitochondrial membrane organization  (ISO)
mitochondrion localization  (ISO)
mitochondrion morphogenesis  (ISO)
mitochondrion organization  (ISO)
mitotic cell cycle  (ISO)
mitotic cell cycle arrest  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell size  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of sarcomere organization  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chromatin binding  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of estradiol secretion  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of progesterone secretion  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein localization to phagophore assembly site  (ISO)
protein targeting to mitochondrion  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to calcium ion  (ISO)
response to D-galactose  (ISO)
response to electrical stimulus  (ISO)
response to fatty acid  (ISO)
response to flavonoid  (ISO)
response to hypobaric hypoxia  (ISO)
response to L-arginine  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
response to testosterone  (ISO)
spermatogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MFN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,945,849 - 11,981,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0panPan3
MFN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,980,181 - 12,013,514 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl111,980,181 - 12,015,211 (+)EnsemblGRCh38hg38GRCh38
GRCh38111,980,215 - 12,013,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,040,238 - 12,073,572 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37112,040,501 - 12,073,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,962,956 - 11,996,152 (+)NCBINCBI36hg18NCBI36
Build 34111,974,634 - 12,007,833NCBI
Celera111,153,903 - 11,187,236 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,195,001 - 11,228,266 (+)NCBIHuRef
CHM1_1112,028,020 - 12,061,326 (+)NCBICHM1_1
Mfn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394147,958,043 - 147,989,527 (-)NCBIGRCm39mm39
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBImm8
Celera4150,136,809 - 150,169,620 (-)NCBICelera
Cytogenetic Map4E1NCBI
Mfn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,304,285 - 158,335,502 (-)NCBI
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Celera5156,587,853 - 156,617,496 (-)NCBICelera
Cytogenetic Map5q36NCBI
Mfn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,937,802 - 1,962,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,937,873 - 1,962,577 (-)NCBIChiLan1.0ChiLan1.0
MFN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl284,284,719 - 84,308,225 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1284,284,719 - 84,310,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mfn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936474767,754 - 795,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,026,722 - 72,056,439 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,026,512 - 72,056,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,936,375 - 65,955,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,787,700 - 119,818,455 (-)NCBI
ChlSab1.1 Ensembl20119,787,370 - 119,816,693 (-)Ensembl
Mfn2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,041,371 - 1,065,061 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032485   ⟹   ENSPPAP00000009840
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032504   ⟹   ENSPPAP00000009858
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,954,967 - 11,979,133 (+)Ensembl
RefSeq Acc Id: XM_003822063   ⟹   XP_003822111
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1111,945,849 - 11,981,077 (+)NCBI
Mhudiblu_PPA_v0110,729,984 - 10,764,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003822064   ⟹   XP_003822112
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1111,945,849 - 11,981,075 (+)NCBI
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975582   ⟹   XP_008973830
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1111,945,877 - 11,980,759 (+)NCBI
Mhudiblu_PPA_v0110,729,984 - 10,764,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975583   ⟹   XP_008973831
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1111,945,880 - 11,980,759 (+)NCBI
Mhudiblu_PPA_v0110,729,983 - 10,764,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034955611   ⟹   XP_034811502
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0110,729,983 - 10,764,865 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_003822111   ⟸   XM_003822063
- Sequence:
RefSeq Acc Id: XP_003822112   ⟸   XM_003822064
- Sequence:
RefSeq Acc Id: XP_008973830   ⟸   XM_008975582
- Sequence:
RefSeq Acc Id: XP_008973831   ⟸   XM_008975583
- Sequence:
RefSeq Acc Id: XP_034811502   ⟸   XM_034955611
RefSeq Acc Id: ENSPPAP00000009840   ⟸   ENSPPAT00000032485
RefSeq Acc Id: ENSPPAP00000009858   ⟸   ENSPPAT00000032504
Protein Domains
Dynamin-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000009840 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000009858 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032485 UniProtKB/TrEMBL
  ENSPPAT00000032504 UniProtKB/TrEMBL
InterPro Dynamin_SF UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  Mitofusin-2 UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report pps:100973903 UniProtKB/TrEMBL
NCBI Gene MFN2 ENTREZGENE
PANTHER PTHR10465 UniProtKB/TrEMBL
  PTHR10465:SF1 UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/TrEMBL
PROSITE G_DYNAMIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R8ZXY7_PANPA UniProtKB/TrEMBL
  A0A2R9A1T4_PANPA UniProtKB/TrEMBL