MFN2 (mitofusin 2) - Rat Genome Database

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Gene: MFN2 (mitofusin 2) Pan paniscus
Analyze
Symbol: MFN2
Name: mitofusin 2
RGD ID: 11968415
Description: ENCODES a protein that exhibits GTP binding (ortholog); GTPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN blastocyst formation (ortholog); camera-type eye morphogenesis (ortholog); cellular response to dexamethasone stimulus (ortholog); PARTICIPATES IN apoptotic cell death pathway; mitochondria fusion pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitofusin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,221,413 - 216,256,365 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,868,444 - 214,903,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,945,849 - 11,981,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
axonal neuropathy  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
carotid stenosis  (ISO)
cerebellar ataxia  (ISO)
cerebral palsy  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth Disease Type 2A2  (ISO)
Charcot-Marie-Tooth disease type 2A2A  (ISO)
Charcot-Marie-Tooth disease type 2A2B  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 6  (ISO)
Charcot-Marie-Tooth Disease Type 6A  (ISO)
Charcot-Marie-Tooth Disease, Type 2A  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
Cicatrix  (ISO)
depressive disorder  (ISO)
Developmental Disabilities  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
distal myopathy  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Failure to Thrive  (ISO)
genetic disease  (ISO)
Hyperalgesia  (ISO)
Hyperpigmentation  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
Liver Reperfusion Injury  (ISO)
Manganese Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
multiple symmetric lipomatosis  (ISO)
multiple system atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
neuropathy  (ISO)
nonprogressive cerebellar ataxia with mental retardation  (ISO)
obesity  (ISO)
peripheral nervous system disease  (ISO)
prediabetes syndrome  (ISO)
primary pulmonary hypertension  (ISO)
Pulmonary Edema of Mountaineers  (ISO)
pulmonary fibrosis  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
Sarcopenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aerobic respiration  (IEA)
blastocyst formation  (IEA,ISO)
camera-type eye morphogenesis  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to manganese ion  (ISO)
cellular response to mercaptoethanol  (ISO)
cellular response to testosterone stimulus  (ISO)
intracellular distribution of mitochondria  (ISO)
male gonad development  (ISO)
mitochondrial calcium ion homeostasis  (ISO)
mitochondrial fusion  (IEA,ISO)
mitochondrial membrane organization  (IEA)
mitochondrion localization  (IEA)
mitochondrion organization  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of Ras protein signal transduction  (IEA)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of sarcomere organization  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (IEA)
positive regulation of cellular respiration  (ISO)
positive regulation of chromatin binding  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of estradiol secretion  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of progesterone secretion  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IEA)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
protein localization to phagophore assembly site  (IEA,ISO)
protein targeting to mitochondrion  (IEA)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to calcium ion  (ISO)
response to D-galactose  (ISO)
response to electrical stimulus  (ISO)
response to fatty acid  (ISO)
response to flavonoid  (ISO)
response to hypobaric hypoxia  (ISO)
response to L-arginine  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
response to testosterone  (ISO)
spermatogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MFN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,221,413 - 216,256,365 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,868,444 - 214,903,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,945,849 - 11,981,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensemblpanpan1.1panPan2
MFN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,980,444 - 12,013,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,980,181 - 12,015,211 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,040,501 - 12,073,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,962,956 - 11,996,152 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,974,634 - 12,007,833NCBI
Celera111,153,903 - 11,187,236 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,195,001 - 11,228,266 (+)NCBIHuRef
CHM1_1112,028,020 - 12,061,326 (+)NCBICHM1_1
T2T-CHM13v2.0111,524,563 - 11,557,644 (+)NCBIT2T-CHM13v2.0
Mfn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394147,958,043 - 147,989,527 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4147,958,056 - 147,989,161 (-)EnsemblGRCm39 Ensembl
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBIMGSCv36mm8
Celera4150,136,809 - 150,169,620 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.56NCBI
Mfn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,587,463 - 163,617,363 (-)NCBIGRCr8
mRatBN7.25158,304,285 - 158,335,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,304,287 - 158,335,342 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,021,313 - 161,050,945 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,848,902 - 162,878,457 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,805,236 - 162,834,795 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Celera5156,587,853 - 156,617,496 (-)NCBICelera
Cytogenetic Map5q36NCBI
Mfn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,937,802 - 1,962,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,937,873 - 1,962,577 (-)NCBIChiLan1.0ChiLan1.0
MFN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,284,719 - 84,310,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,284,719 - 84,308,225 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,817,285 - 80,840,793 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,945,233 - 84,971,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,940,926 - 84,971,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,694,915 - 81,718,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,694,894 - 82,718,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,760,479 - 83,784,201 (-)NCBIUU_Cfam_GSD_1.0
Mfn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,943,043 - 34,970,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474767,671 - 796,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474767,754 - 795,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,028,499 - 72,056,438 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,026,512 - 72,056,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,936,375 - 65,955,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,787,700 - 119,818,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,787,370 - 119,816,693 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,645,802 - 23,677,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,041,369 - 1,065,023 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,041,371 - 1,065,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032485   ⟹   ENSPPAP00000009840
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032504   ⟹   ENSPPAP00000009858
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,954,967 - 11,979,133 (+)Ensembl
RefSeq Acc Id: XM_003822063   ⟹   XP_003822111
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,221,413 - 216,256,365 (-)NCBI
NHGRI_mPanPan11214,868,444 - 214,903,510 (-)NCBI
Mhudiblu_PPA_v0110,729,984 - 10,764,865 (+)NCBI
PanPan1.1111,945,849 - 11,981,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003822064   ⟹   XP_003822112
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,221,413 - 216,256,300 (-)NCBI
NHGRI_mPanPan11214,868,444 - 214,903,442 (-)NCBI
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBI
PanPan1.1111,945,849 - 11,981,075 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975582   ⟹   XP_008973830
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,221,413 - 216,256,341 (-)NCBI
NHGRI_mPanPan11214,868,444 - 214,903,486 (-)NCBI
Mhudiblu_PPA_v0110,729,984 - 10,764,865 (+)NCBI
PanPan1.1111,945,877 - 11,980,759 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975583   ⟹   XP_008973831
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,221,413 - 216,256,308 (-)NCBI
NHGRI_mPanPan11214,868,444 - 214,903,453 (-)NCBI
Mhudiblu_PPA_v0110,729,983 - 10,764,865 (+)NCBI
PanPan1.1111,945,880 - 11,980,759 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055098319   ⟹   XP_054954294
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,221,413 - 216,256,300 (-)NCBI
NHGRI_mPanPan11214,868,444 - 214,903,443 (-)NCBI
RefSeq Acc Id: XM_055098324   ⟹   XP_054954299
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,221,413 - 216,256,300 (-)NCBI
NHGRI_mPanPan11214,868,444 - 214,903,443 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003822111   ⟸   XM_003822063
- UniProtKB: A0A2R8ZXY7 (UniProtKB/TrEMBL),   A0A2R9A1T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003822112   ⟸   XM_003822064
- UniProtKB: A0A2R8ZXY7 (UniProtKB/TrEMBL),   A0A2R9A1T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008973830   ⟸   XM_008975582
- UniProtKB: A0A2R8ZXY7 (UniProtKB/TrEMBL),   A0A2R9A1T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008973831   ⟸   XM_008975583
- UniProtKB: A0A2R8ZXY7 (UniProtKB/TrEMBL),   A0A2R9A1T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000009840   ⟸   ENSPPAT00000032485
RefSeq Acc Id: ENSPPAP00000009858   ⟸   ENSPPAT00000032504
RefSeq Acc Id: XP_054954299   ⟸   XM_055098324
- UniProtKB: A0A2R8ZXY7 (UniProtKB/TrEMBL),   A0A2R9A1T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054954294   ⟸   XM_055098319
- UniProtKB: A0A2R8ZXY7 (UniProtKB/TrEMBL),   A0A2R9A1T4 (UniProtKB/TrEMBL)
Protein Domains
Dynamin-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032485.1 UniProtKB/TrEMBL
  ENSPPAT00000032504.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Dynamin_N UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report pps:100973903 UniProtKB/TrEMBL
NCBI Gene MFN2 ENTREZGENE
PANTHER PTHR10465 UniProtKB/TrEMBL
  PTHR10465:SF1 UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/TrEMBL
PROSITE G_DYNAMIN_2 UniProtKB/TrEMBL
Superfamily-SCOP Fzo-like conserved region UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R8ZXY7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A1T4 ENTREZGENE, UniProtKB/TrEMBL