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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mfn2
Name: mitofusin 2
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mfn2multiple interactionsEXP 6480464CTDMFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased chemical synthesis of Reactive Oxygen Species]PMID:24898700
Mfn2decreases chemical synthesisISOMfn2 (Mus musculus)6480464CTDMFN2 protein results in decreased chemical synthesis of Reactive Oxygen SpeciesPMID:25416777
Mfn2multiple interactionsISOMFN2 (Homo sapiens)6480464CTDMFN2 protein inhibits the reaction [TNF protein results in increased chemical synthesis of Reactive Oxygen Species]PMID:24898700
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