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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mfn2
Name: mitofusin 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mfn2increases expressionISOMFN2 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of MFN2 mRNAPMID:34032870
Mfn2multiple interactionsISOMFN2 (Homo sapiens)6480464CTDMFN2 protein affects the reaction [sodium arsenite results in decreased expression of GPX4 protein]; MFN2 protein affects the reaction [sodium arsenite results in increased expression of IL1B protein]; MFN2 protein affects the reaction [sodium arsenite results in increased expression of IL6 protein]; MFN2 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]; MFN2 protein affects the reaction [sodium arsenite results in increased expression of TNF protein]; sodium arsenite promotes the reaction [MFN2 protein binds to ERN1 protein]PMID:32593899
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