Mfn2 (mitofusin 2) - Rat Genome Database

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Gene: Mfn2 (mitofusin 2) Mus musculus
Analyze
Symbol: Mfn2
Name: mitofusin 2
RGD ID: 732570
MGI Page MGI
Description: Predicted to enable several functions, including GTP binding activity; GTPase activity; and enzyme binding activity. Involved in mitochondrial fusion; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; and positive regulation of cold-induced thermogenesis. Acts upstream of or within blastocyst formation and camera-type eye morphogenesis. Located in microtubule cytoskeleton and mitochondrion. Is expressed in several structures, including brain; early conceptus; eye; heart; and oocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D630023P19Rik; Fz; Fzo; HSG protein; hypertension related protein 1; hypertension-related protein 1; mitochondrial assembly regulatory factor; mitofusin-2; transmembrane GTPase MFN2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394147,958,043 - 147,989,527 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4147,958,056 - 147,989,161 (-)EnsemblGRCm39 Ensembl
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBIMGSCv36mm8
Celera4150,136,809 - 150,169,620 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
axonal neuropathy  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (IEP,ISO)
carotid stenosis  (ISO)
cerebellar ataxia  (ISO)
cerebral palsy  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth Disease Type 2A2  (ISO)
Charcot-Marie-Tooth disease type 2A2A  (ISO)
Charcot-Marie-Tooth disease type 2A2B  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 6  (ISO)
Charcot-Marie-Tooth Disease Type 6A  (ISO)
Charcot-Marie-Tooth Disease, Type 2A  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
Cicatrix  (ISO)
depressive disorder  (ISO)
Developmental Disabilities  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IMP)
distal myopathy  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Failure to Thrive  (ISO)
genetic disease  (ISO)
Hyperalgesia  (ISO)
Hyperpigmentation  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
Liver Reperfusion Injury  (ISO)
Manganese Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
multiple symmetric lipomatosis  (ISO)
multiple system atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
neuropathy  (ISO)
nonprogressive cerebellar ataxia with mental retardation  (ISO)
obesity  (ISO)
peripheral nervous system disease  (ISO)
prediabetes syndrome  (ISO)
primary pulmonary hypertension  (ISO)
Pulmonary Edema of Mountaineers  (ISO)
pulmonary fibrosis  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
Sarcopenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-DAMP(1+)  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (ISO)
alpha-D-galactose  (ISO)
AM-251  (ISO)
amiodarone  (EXP)
amlodipine  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
ATP  (EXP,ISO)
azide  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calpeptin  (EXP,ISO)
Candesartan cilexetil  (ISO)
carnosic acid  (ISO)
Carnosol  (EXP)
CCCP  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
excitatory amino acid agonist  (EXP,ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
ferulic acid  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fructose  (ISO)
galactose  (ISO)
Genipin  (EXP)
genistein  (ISO)
gentamycin  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glucose  (ISO)
GW 4064  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lamivudine  (EXP)
lenvatinib  (ISO)
linuron  (ISO)
lipoic acid  (EXP)
lovastatin  (EXP)
mabuterol  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-hexadecanoylsphingosine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nitrogen dioxide  (EXP)
NSC 23766  (EXP)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenethyl caffeate  (EXP)
phenylephrine  (ISO)
pirinixic acid  (EXP)
ponasterone A  (ISO)
potassium dichromate  (ISO)
pyrroloquinoline quinone  (ISO)
reactive oxygen species  (EXP,ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
Salvianolic acid A  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulfur dioxide  (EXP)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (EXP)
trans-cinnamic acid  (ISO)
trans-piceid  (ISO)
tricalcium bis(phosphate)  (EXP)
trichloroethene  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vanillic acid  (ISO)
vinclozolin  (ISO)
XAV939  (EXP)
zearalenone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aerobic respiration  (ISO)
apoptotic process  (IEA)
autophagy  (IEA)
blastocyst formation  (IMP)
camera-type eye morphogenesis  (IMP)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to manganese ion  (ISO)
cellular response to mercaptoethanol  (ISO)
cellular response to testosterone stimulus  (ISO)
intracellular distribution of mitochondria  (ISO)
male gonad development  (ISO)
mitochondrial calcium ion homeostasis  (ISO)
mitochondrial fusion  (IBA,IGI,IMP,ISO)
mitochondrial membrane organization  (ISO)
mitochondrion localization  (IBA,ISO)
mitochondrion organization  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of sarcomere organization  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (IMP)
positive regulation of cellular respiration  (ISO)
positive regulation of chromatin binding  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of estradiol secretion  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of progesterone secretion  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein localization to phagophore assembly site  (ISO)
protein targeting to mitochondrion  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to calcium ion  (ISO)
response to D-galactose  (ISO)
response to electrical stimulus  (ISO)
response to fatty acid  (ISO)
response to flavonoid  (ISO)
response to hypobaric hypoxia  (ISO)
response to L-arginine  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
response to testosterone  (ISO)
response to unfolded protein  (IEA)
spermatogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal axon morphology  (IAGP)
abnormal axonal transport  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal endoplasmic reticulum morphology  (IAGP)
abnormal gait  (IAGP)
abnormal innervation  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal male germ cell physiology  (IAGP)
abnormal male meiosis  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal mitochondrial shape  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal neuron mitochondrial morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal sperm head morphology  (IAGP)
abnormal sperm mitochondrial sheath morphology  (IAGP)
abnormal sperm nucleus morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
absent sperm head  (IAGP)
arrest of male meiosis  (IAGP)
bradykinesia  (IAGP)
coiled sperm flagellum  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased embryo size  (IAGP)
decreased lean body mass  (IEA)
decreased locomotor activity  (IAGP)
decreased male germ cell number  (IAGP)
decreased mitochondrial number  (IAGP)
decreased testis weight  (IAGP)
decreased trophoblast giant cell number  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased vertical activity  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
hunched posture  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
impaired righting response  (IAGP)
increased fetal cardiomyocyte apoptosis  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased mitochondrial DNA content  (IAGP)
increased mitochondrial fission  (IAGP)
increased mitochondrial size  (IAGP)
increased neuron apoptosis  (IAGP)
increased response of heart to induced stress  (IAGP)
increased serotonin level  (IAGP)
increased testis apoptosis  (IAGP)
kinked sperm flagellum  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lipofuscinosis  (IAGP)
loss of dopaminergic neurons  (IAGP)
male infertility  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
Purkinje cell degeneration  (IAGP)
seminiferous tubule degeneration  (IAGP)
small cerebellum  (IAGP)
small epididymis  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
teratozoospermia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Bach D, etal., Diabetes. 2005 Sep;54(9):2685-93.
2. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. Bach D, etal., J Biol Chem. 2003 May 9;278(19):17190-7. Epub 2003 Feb 21.
3. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
4. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
5. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Chen H, etal., J Cell Biol 2003 Jan 20;160(2):189-200. Epub 2003 Jan 13.
6. Dysregulation of HSG triggers vascular proliferative disorders. Chen KH, etal., Nat Cell Biol 2004 Sep;6(9):872-83. Epub 2004 Aug 22.
7. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Chen Y, etal., Circ Res. 2011 Dec 9;109(12):1327-31. doi: 10.1161/CIRCRESAHA.111.258723. Epub 2011 Nov 3.
8. Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
9. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
10. Mitofusin 2 Downregulation Triggers Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis Imbalance in Rats With Hypoxic Pulmonary Hypertension Via the PI3K/Akt and Mitochondrial Apoptosis Pathways. Fang X, etal., J Cardiovasc Pharmacol. 2016 Feb;67(2):164-74. doi: 10.1097/FJC.0000000000000333.
11. Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. Ge L, etal., Oncotarget. 2017 Mar 3. doi: 10.18632/oncotarget.15876.
12. Abnormal mitochondrial fusion-fission balance contributes to the progression of experimental sepsis. Gonzalez AS, etal., Free Radic Res. 2014 Jul;48(7):769-83. doi: 10.3109/10715762.2014.906592. Epub 2014 Apr 10.
13. miR-106a promotes cardiac hypertrophy by targeting mitofusin 2. Guan X, etal., J Mol Cell Cardiol. 2016 Oct;99:207-217. doi: 10.1016/j.yjmcc.2016.08.016. Epub 2016 Aug 23.
14. [The interventional effect of Xuebijing injection on expression of mitochondrial fusion protein 2 and the ultrastructure changes in lung tissues in rats with paraquat poisoning]. Hu M, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Jun;26(6):388-93. doi: 10.3760/cma.j.issn.2095-4352.2014.06.005.
15. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Javadov S, etal., Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.
16. Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. Kang JW, etal., J Pineal Res. 2016 May;60(4):383-93. doi: 10.1111/jpi.12319. Epub 2016 Mar 7.
17. Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress. Koncsos G, etal., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H927-H943. doi: 10.1152/ajpheart.00049.2016. Epub 2016 Aug 12.
18. Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. Kou X, etal., J Appl Physiol (1985). 2017 Jun 1;122(6):1462-1469. doi: 10.1152/japplphysiol.00018.2017. Epub 2017 Mar 16.
19. Tumour necrosis factor-a promotes liver ischaemia-reperfusion injury through the PGC-1a/Mfn2 pathway. Li J, etal., J Cell Mol Med. 2014 Sep;18(9):1863-73. doi: 10.1111/jcmm.12320. Epub 2014 Jun 4.
20. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
21. The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan. Lin KP, etal., PLoS One. 2011;6(12):e29393. doi: 10.1371/journal.pone.0029393. Epub 2011 Dec 19.
22. Effect of breviscapine against hepatic ischemia reperfusion injury. Lin YZ, etal., J Surg Res. 2016 Jun 15;203(2):268-74. doi: 10.1016/j.jss.2016.02.013. Epub 2016 Feb 19.
23. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
24. Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. Liu W and Zhou C, Psychoneuroendocrinology. 2012 Jul;37(7):1057-70. doi: 10.1016/j.psyneuen.2011.12.003. Epub 2012 Jan 14.
25. Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells. Liu X, etal., Neurochem Int. 2017 Feb 21. pii: S0197-0186(16)30405-3. doi: 10.1016/j.neuint.2017.02.008.
26. [Changes in mitochondria fusion protein-2 hepatic expression in conditions of liver cirrhosis and acute on chronic liver failure]. Liu X, etal., Zhonghua Gan Zang Bing Za Zhi. 2014 Sep;22(9):671-5. doi: 10.3760/cma.j.issn.1007-3418.2014.09.008.
27. Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. Martorell-Riera A, etal., EMBO J. 2014 Oct 16;33(20):2388-407. doi: 10.15252/embj.201488327. Epub 2014 Aug 21.
28. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
29. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
30. MGDs mouse GO annotations MGD data from the GO Consortium
31. MGD IEA MGD IEA
32. Mitofusin 2 attenuates the histone acetylation at collagen IV promoter in diabetic nephropathy. Mi X, etal., J Mol Endocrinol. 2016 Nov;57(4):233-249. doi: 10.1530/JME-16-0031.
33. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
34. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
37. Mouse MP Annotation Import Pipeline RGD automated import pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Swimming improves high-fat induced insulin resistance by regulating lipid and energy metabolism and the insulin pathway in rats. Song A, etal., Int J Mol Med. 2014 Jun;33(6):1671-9. doi: 10.3892/ijmm.2014.1738. Epub 2014 Apr 9.
41. Early energy metabolism-related molecular events in skeletal muscle of diabetic rats: The effects of l-arginine and SOD mimic. Stancic A, etal., Chem Biol Interact. 2017 Jun 25;272:188-196. doi: 10.1016/j.cbi.2017.05.003. Epub 2017 May 5.
42. MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts. Sun M, etal., Sci Rep. 2015 Dec 22;5:18351. doi: 10.1038/srep18351.
43. Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Sun W, etal., Neuropharmacology. 2017 Feb;113(Pt A):556-566. doi: 10.1016/j.neuropharm.2016.11.010. Epub 2016 Nov 12.
44. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
45. Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. Wang YC, etal., World J Gastroenterol. 2015 Sep 21;21(35):10104-12. doi: 10.3748/wjg.v21.i35.10104.
46. Mitofusin 2 ameliorates aortic remodeling by suppressing ras/raf/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells. Wang Z, etal., Int J Cardiol. 2015 Jan 15;178:165-7. doi: 10.1016/j.ijcard.2014.10.122. Epub 2014 Oct 22.
47. Candesartan cilexetil attenuated cardiac remodeling by improving expression and function of mitofusin 2 in SHR. Wang Z, etal., Int J Cardiol. 2016 Jul 1;214:348-57. doi: 10.1016/j.ijcard.2016.04.007. Epub 2016 Apr 5.
48. Activation of FoxO1/ PGC-1alpha prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats. Wu L, etal., Mol Cell Endocrinol. 2015 Sep 15;413:1-12. doi: 10.1016/j.mce.2015.06.007. Epub 2015 Jun 27.
49. Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKß/AMPK pathway in isoproterenol-induced myocardial ischaemia. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
50. Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats. Yamashita Y, etal., Neurosci Lett. 2017 Jun 3;653:337-340. doi: 10.1016/j.neulet.2017.05.069.
51. Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes. Yang F, etal., Am J Physiol Endocrinol Metab. 2017 Mar 1;312(3):E190-E203. doi: 10.1152/ajpendo.00196.2016. Epub 2016 Dec 20.
52. Upregulation of miR-195 accelerates oxidative stress-induced retinal endothelial cell injury by targeting mitofusin 2 in diabetic rats. Zhang R, etal., Mol Cell Endocrinol. 2017 Sep 5;452:33-43. doi: 10.1016/j.mce.2017.05.009. Epub 2017 May 6.
53. Acetyl-L-carnitine ameliorates mitochondrial damage and apoptosis following spinal cord injury in rats. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
54. [Atorvastatin inhibits cardiomyocyte apoptosis via down-cegulation the expression mitofusin 2 after myocardial ischemia/reperfusion injury in rats]. Zhou W, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Apr;30(4):388-90.
55. Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2. Zuchner S, etal., Ann Neurol. 2006 Feb;59(2):276-81.
56. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Zuchner S, etal., Nat Genet. 2004 May;36(5):449-51. Epub 2004 Apr 4.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11950885   PMID:12477932   PMID:12693553   PMID:14610273   PMID:15297672   PMID:15489334   PMID:15782199  
PMID:15899901   PMID:15985463   PMID:16083859   PMID:16104381   PMID:16141072   PMID:16141073   PMID:16731843   PMID:17035996   PMID:17093923   PMID:17296794   PMID:17499311   PMID:17606912  
PMID:17693261   PMID:18614015   PMID:18722178   PMID:18974884   PMID:19052620   PMID:19075228   PMID:19168699   PMID:19265701   PMID:19269351   PMID:19360003   PMID:19445933   PMID:19477917  
PMID:19578372   PMID:19690333   PMID:20037808   PMID:20335458   PMID:20403324   PMID:20671748   PMID:21160028   PMID:21220420   PMID:21245373   PMID:21255726   PMID:21267068   PMID:21285398  
PMID:21285412   PMID:21394548   PMID:21647385   PMID:21677750   PMID:21873635   PMID:22292091   PMID:22427360   PMID:22493254   PMID:22509026   PMID:22511781   PMID:22549180   PMID:22619176  
PMID:22777004   PMID:22794259   PMID:22859504   PMID:22904094   PMID:22914740   PMID:22957060   PMID:23029466   PMID:23620051   PMID:23727017   PMID:23921556   PMID:23941871   PMID:23954742  
PMID:24074867   PMID:24074868   PMID:24081906   PMID:24091702   PMID:24127597   PMID:24379352   PMID:24469638   PMID:24513856   PMID:24710686   PMID:24813948   PMID:24874428   PMID:24876927  
PMID:25201884   PMID:25352671   PMID:25359615   PMID:25387754   PMID:25416777   PMID:25477138   PMID:25574749   PMID:25600785   PMID:25688136   PMID:25870285   PMID:25978725   PMID:26166568  
PMID:26184910   PMID:26210454   PMID:26230519   PMID:26327438   PMID:26375863   PMID:26434502   PMID:26472072   PMID:26603188   PMID:26638184   PMID:26711011   PMID:26785495   PMID:26789249  
PMID:27060252   PMID:27166947   PMID:27206984   PMID:27228353   PMID:27239030   PMID:27315062   PMID:27334614   PMID:27404125   PMID:27469431   PMID:27485634   PMID:27647893   PMID:27693395  
PMID:27775718   PMID:27907123   PMID:27997827   PMID:28110471   PMID:28132466   PMID:28348166   PMID:28539390   PMID:28671696   PMID:28684211   PMID:28904083   PMID:29097872   PMID:29107503  
PMID:29367651   PMID:29391029   PMID:29688375   PMID:29734176   PMID:29774638   PMID:29787809   PMID:29981809   PMID:30017354   PMID:30084972   PMID:30136162   PMID:30260752   PMID:30333037  
PMID:30690319   PMID:30694178   PMID:30865877   PMID:30882371   PMID:30936207   PMID:31051106   PMID:31064883   PMID:31104361   PMID:31134519   PMID:31138677   PMID:31170154   PMID:31204051  
PMID:31204316   PMID:31281507   PMID:31341888   PMID:31358769   PMID:31431479   PMID:31525456   PMID:31575649   PMID:31596236   PMID:31639106   PMID:31659282   PMID:31675497   PMID:31937559  
PMID:31947766   PMID:32165499   PMID:32220306   PMID:32236517   PMID:32281181   PMID:32325033   PMID:32330448   PMID:32437795   PMID:32560809   PMID:32788232   PMID:32846136   PMID:32923630  
PMID:33074106   PMID:33479369   PMID:33602894   PMID:33674260   PMID:33749882   PMID:33813068   PMID:33980844   PMID:34048907   PMID:34110411   PMID:34570766   PMID:34575944   PMID:34624325  
PMID:34948301   PMID:35154486   PMID:35172139   PMID:35293971   PMID:35318101   PMID:35472764   PMID:35493072   PMID:35716948   PMID:36050466   PMID:36125902   PMID:36167966   PMID:36283455  
PMID:36473917   PMID:36598990   PMID:36656708   PMID:36682578   PMID:36754021   PMID:36781680   PMID:36808153   PMID:37060270   PMID:37331409   PMID:37347868   PMID:37378422   PMID:37401731  
PMID:37440411   PMID:37493331   PMID:37495895   PMID:37537600   PMID:37633049   PMID:37910431   PMID:38142958   PMID:38156445   PMID:38187761  


Genomics

Comparative Map Data
Mfn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394147,958,043 - 147,989,527 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4147,958,056 - 147,989,161 (-)EnsemblGRCm39 Ensembl
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBIMGSCv36mm8
Celera4150,136,809 - 150,169,620 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.56NCBI
MFN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,980,444 - 12,013,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,980,181 - 12,015,211 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,040,501 - 12,073,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,962,956 - 11,996,152 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,974,634 - 12,007,833NCBI
Celera111,153,903 - 11,187,236 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,195,001 - 11,228,266 (+)NCBIHuRef
CHM1_1112,028,020 - 12,061,326 (+)NCBICHM1_1
T2T-CHM13v2.0111,524,563 - 11,557,644 (+)NCBIT2T-CHM13v2.0
Mfn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,587,463 - 163,617,363 (-)NCBIGRCr8
mRatBN7.25158,304,285 - 158,335,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,304,287 - 158,335,342 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,021,313 - 161,050,945 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,848,902 - 162,878,457 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,805,236 - 162,834,795 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Celera5156,587,853 - 156,617,496 (-)NCBICelera
Cytogenetic Map5q36NCBI
Mfn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,937,802 - 1,962,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,937,873 - 1,962,577 (-)NCBIChiLan1.0ChiLan1.0
MFN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,221,413 - 216,256,365 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,868,444 - 214,903,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,945,849 - 11,981,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)Ensemblpanpan1.1panPan2
MFN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,284,719 - 84,310,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,284,719 - 84,308,225 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,817,285 - 80,840,793 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,945,233 - 84,971,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,940,926 - 84,971,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,694,915 - 81,718,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,694,894 - 82,718,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,760,479 - 83,784,201 (-)NCBIUU_Cfam_GSD_1.0
Mfn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,943,043 - 34,970,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474767,671 - 796,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474767,754 - 795,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,028,499 - 72,056,438 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,026,512 - 72,056,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,936,375 - 65,955,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,787,700 - 119,818,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,787,370 - 119,816,693 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,645,802 - 23,677,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,041,369 - 1,065,023 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,041,371 - 1,065,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfn2
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3267
Count of miRNA genes:714
Interacting mature miRNAs:919
Transcripts:ENSMUST00000030884, ENSMUST00000105714, ENSMUST00000105715, ENSMUST00000105716, ENSMUST00000124646, ENSMUST00000134172, ENSMUST00000150881
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse

Markers in Region
D4Mit206  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384147,877,342 - 147,877,489UniSTSGRCm38
MGSCv374147,251,451 - 147,251,598UniSTSGRCm37
Celera4150,140,244 - 150,140,405UniSTS
Cytogenetic Map4E2UniSTS
cM Map471.0UniSTS
Whitehead Genetic471.0UniSTS
Whitehead_YAC4 UniSTS
D4Nimr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384147,895,316 - 147,895,539UniSTSGRCm38
MGSCv374147,269,425 - 147,269,648UniSTSGRCm37
Celera4150,160,116 - 150,160,339UniSTS
Cytogenetic Map4E2UniSTS
cM Map4 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001285920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB048831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF384100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL607066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY028170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY123975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY062931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY085386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY105143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY123199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY131209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY151666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY474604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ152973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000030884   ⟹   ENSMUSP00000030884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,958,056 - 147,989,161 (-)Ensembl
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105714   ⟹   ENSMUSP00000101339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,965,951 - 147,989,155 (-)Ensembl
GRCm38.p6 Ensembl4147,881,494 - 147,904,698 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105715   ⟹   ENSMUSP00000101340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,958,473 - 147,989,155 (-)Ensembl
GRCm38.p6 Ensembl4147,874,016 - 147,904,698 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105716   ⟹   ENSMUSP00000101341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,958,056 - 147,989,144 (-)Ensembl
GRCm38.p6 Ensembl4147,873,599 - 147,904,687 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,970,165 - 147,971,980 (-)Ensembl
GRCm38.p6 Ensembl4147,885,708 - 147,887,523 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134172   ⟹   ENSMUSP00000123021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,971,791 - 147,987,852 (-)Ensembl
GRCm38.p6 Ensembl4147,887,334 - 147,903,395 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150881   ⟹   ENSMUSP00000117758
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4147,979,040 - 147,989,115 (-)Ensembl
GRCm38.p6 Ensembl4147,894,583 - 147,904,658 (-)Ensembl
RefSeq Acc Id: NM_001285920   ⟹   NP_001272849
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,366 (-)NCBI
GRCm384147,873,586 - 147,904,909 (-)NCBI
Celera4150,136,809 - 150,169,710 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001285921   ⟹   NP_001272850
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,366 (-)NCBI
GRCm384147,873,586 - 147,904,909 (-)NCBI
Celera4150,136,809 - 150,169,710 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001285922   ⟹   NP_001272851
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,366 (-)NCBI
GRCm384147,873,586 - 147,904,909 (-)NCBI
Celera4150,136,809 - 150,169,710 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001285923   ⟹   NP_001272852
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,155 (-)NCBI
GRCm384147,873,586 - 147,904,698 (-)NCBI
Celera4150,136,809 - 150,169,710 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355590   ⟹   NP_001342519
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,118 (-)NCBI
GRCm384147,873,586 - 147,904,661 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355591   ⟹   NP_001342520
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,155 (-)NCBI
GRCm384147,873,586 - 147,904,698 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133201   ⟹   NP_573464
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,043 - 147,989,366 (-)NCBI
GRCm384147,873,586 - 147,904,909 (-)NCBI
MGSCv374147,247,704 - 147,278,928 (-)RGD
Celera4150,136,809 - 150,169,710 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538609   ⟹   XP_006538672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,056 - 147,988,862 (-)NCBI
GRCm384147,873,606 - 147,904,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017320014   ⟹   XP_017175503
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,963,167 - 147,989,527 (-)NCBI
GRCm384147,878,710 - 147,904,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163778   ⟹   XP_036019671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,056 - 147,989,107 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163779   ⟹   XP_036019672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,056 - 147,989,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163780   ⟹   XP_036019673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,056 - 147,989,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163781   ⟹   XP_036019674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394147,958,056 - 147,988,285 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001272849 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272850 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272851 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272852 (Get FASTA)   NCBI Sequence Viewer  
  NP_001342519 (Get FASTA)   NCBI Sequence Viewer  
  NP_001342520 (Get FASTA)   NCBI Sequence Viewer  
  NP_573464 (Get FASTA)   NCBI Sequence Viewer  
  XP_006538672 (Get FASTA)   NCBI Sequence Viewer  
  XP_017175503 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019671 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019672 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019673 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019674 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH46503 (Get FASTA)   NCBI Sequence Viewer  
  AAK27416 (Get FASTA)   NCBI Sequence Viewer  
  AAK66559 (Get FASTA)   NCBI Sequence Viewer  
  AAM88577 (Get FASTA)   NCBI Sequence Viewer  
  BAB39351 (Get FASTA)   NCBI Sequence Viewer  
  BAC33826 (Get FASTA)   NCBI Sequence Viewer  
  BAC35096 (Get FASTA)   NCBI Sequence Viewer  
  BAC65502 (Get FASTA)   NCBI Sequence Viewer  
  BAE20620 (Get FASTA)   NCBI Sequence Viewer  
  BAE28186 (Get FASTA)   NCBI Sequence Viewer  
  BAE41121 (Get FASTA)   NCBI Sequence Viewer  
  EDL14785 (Get FASTA)   NCBI Sequence Viewer  
  EDL14786 (Get FASTA)   NCBI Sequence Viewer  
  EDL14787 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030884
  ENSMUSP00000030884.4
  ENSMUSP00000101339.2
  ENSMUSP00000101340
  ENSMUSP00000101340.2
  ENSMUSP00000101341
  ENSMUSP00000101341.3
  ENSMUSP00000117758.2
  ENSMUSP00000123021.2
GenBank Protein Q80U63 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_573464   ⟸   NM_133201
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272851   ⟸   NM_001285922
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272850   ⟸   NM_001285921
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272849   ⟸   NM_001285920
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272852   ⟸   NM_001285923
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538672   ⟸   XM_006538609
- Peptide Label: isoform X1
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017175503   ⟸   XM_017320014
- Peptide Label: isoform X2
- UniProtKB: Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342520   ⟸   NM_001355591
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001342519   ⟸   NM_001355590
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000117758   ⟸   ENSMUST00000150881
RefSeq Acc Id: ENSMUSP00000101339   ⟸   ENSMUST00000105714
RefSeq Acc Id: ENSMUSP00000101340   ⟸   ENSMUST00000105715
RefSeq Acc Id: ENSMUSP00000101341   ⟸   ENSMUST00000105716
RefSeq Acc Id: ENSMUSP00000123021   ⟸   ENSMUST00000134172
RefSeq Acc Id: ENSMUSP00000030884   ⟸   ENSMUST00000030884
RefSeq Acc Id: XP_036019673   ⟸   XM_036163780
- Peptide Label: isoform X1
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036019671   ⟸   XM_036163778
- Peptide Label: isoform X1
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036019672   ⟸   XM_036163779
- Peptide Label: isoform X1
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036019674   ⟸   XM_036163781
- Peptide Label: isoform X1
- UniProtKB: Q8R535 (UniProtKB/Swiss-Prot),   Q8BKV5 (UniProtKB/Swiss-Prot),   Q8BHF0 (UniProtKB/Swiss-Prot),   Q80XK3 (UniProtKB/Swiss-Prot),   Q80WP4 (UniProtKB/Swiss-Prot),   Q80U63 (UniProtKB/Swiss-Prot),   Q3V3B8 (UniProtKB/Swiss-Prot),   A8Y5E4 (UniProtKB/Swiss-Prot),   A2A7Y7 (UniProtKB/Swiss-Prot),   Q923X2 (UniProtKB/Swiss-Prot),   Q3TEX7 (UniProtKB/TrEMBL),   Q3UGM1 (UniProtKB/TrEMBL)
Protein Domains
Dynamin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80U63-F1-model_v2 AlphaFold Q80U63 1-757 view protein structure

Promoters
RGD ID:6835649
Promoter ID:MM_KWN:40783
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000064437
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,261,381 - 147,262,602 (-)MPROMDB
RGD ID:6835648
Promoter ID:MM_KWN:40785
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   Kidney
Transcripts:OTTMUST00000064436
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,277,331 - 147,278,457 (-)MPROMDB
RGD ID:6835646
Promoter ID:MM_KWN:40786
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:NM_133201,   OTTMUST00000024888,   UC008VTG.1,   UC008VTI.1,   UC008VTJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,278,666 - 147,279,512 (-)MPROMDB
RGD ID:6885480
Promoter ID:EPDNEW_M6191
Type:multiple initiation site
Name:Mfn2_1
Description:Mus musculus mitofusin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384147,904,698 - 147,904,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442230 AgrOrtholog
Ensembl Genes ENSMUSG00000029020 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030884 ENTREZGENE
  ENSMUST00000030884.10 UniProtKB/Swiss-Prot
  ENSMUST00000105714.8 UniProtKB/Swiss-Prot
  ENSMUST00000105715 ENTREZGENE
  ENSMUST00000105715.8 UniProtKB/Swiss-Prot
  ENSMUST00000105716 ENTREZGENE
  ENSMUST00000105716.9 UniProtKB/Swiss-Prot
  ENSMUST00000134172.8 UniProtKB/TrEMBL
  ENSMUST00000150881.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:170731 UniProtKB/Swiss-Prot
MGD MGI:2442230 ENTREZGENE
NCBI Gene 170731 ENTREZGENE
PANTHER PTHR10465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10465:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mfn2 PhenoGen
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Fzo-like conserved region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A7Y7 ENTREZGENE
  A2A7Y8_MOUSE UniProtKB/TrEMBL
  A8Y5E4 ENTREZGENE
  A8Y5E5_MOUSE UniProtKB/TrEMBL
  MFN2_MOUSE UniProtKB/Swiss-Prot
  Q3TEX7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UGM1 ENTREZGENE, UniProtKB/TrEMBL
  Q3V3B8 ENTREZGENE
  Q80U63 ENTREZGENE
  Q80WP4 ENTREZGENE
  Q80XK3 ENTREZGENE
  Q8BHF0 ENTREZGENE
  Q8BKV5 ENTREZGENE
  Q8R535 ENTREZGENE
  Q923X2 ENTREZGENE
UniProt Secondary A2A7Y7 UniProtKB/Swiss-Prot
  A8Y5E4 UniProtKB/Swiss-Prot
  Q3V3B8 UniProtKB/Swiss-Prot
  Q80WP4 UniProtKB/Swiss-Prot
  Q80XK3 UniProtKB/Swiss-Prot
  Q8BHF0 UniProtKB/Swiss-Prot
  Q8BKV5 UniProtKB/Swiss-Prot
  Q8R535 UniProtKB/Swiss-Prot
  Q923X2 UniProtKB/Swiss-Prot