Mfn1 (mitofusin 1) - Rat Genome Database

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Gene: Mfn1 (mitofusin 1) Rattus norvegicus
Analyze
Symbol: Mfn1
Name: mitofusin 1
RGD ID: 621460
Description: Enables identical protein binding activity. Involved in several processes, including regulation of mitochondrion organization; response to glucocorticoid; and response to hypoxia. Located in mitochondrial inner membrane and mitochondrial outer membrane. Biomarker of several diseases, including adult respiratory distress syndrome; dental fluorosis; kidney failure (multiple); pulmonary hypertension; and status epilepticus. Orthologous to human MFN1 (mitofusin 1); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-methylglutaric acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fzo1b; mitochondrial transmembrane GTPase FZO1B; mitofusin-1; transmembrane GTPase MFN1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,240,525 - 117,288,017 (+)NCBIGRCr8
mRatBN7.22115,313,380 - 115,359,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,929,637 - 121,971,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02120,042,271 - 120,083,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,743,136 - 114,785,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,929,738 - 118,971,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,929,738 - 118,973,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,586,943 - 138,627,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,739,155 - 118,783,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,684,116 - 118,727,999 (+)NCBI
Celera2110,426,431 - 110,467,687 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylglutaric acid  (EXP)
3-nitropropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-DAMP(1+)  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
aconitine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (EXP,ISO)
azide  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bupivacaine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbidopa  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
fructose  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
glucose  (EXP,ISO)
hemin  (EXP)
heptanal  (ISO)
hexadecanoic acid  (ISO)
hexanal  (ISO)
Honokiol  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
isoprenaline  (EXP)
ketoconazole  (ISO)
lamivudine  (ISO)
lanthanum trichloride  (EXP)
leflunomide  (ISO)
lenvatinib  (EXP)
lipopolysaccharide  (EXP)
melatonin  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrogen dioxide  (ISO)
nonanal  (ISO)
octanal  (ISO)
okadaic acid  (EXP)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
regorafenib  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
Salvianolic acid A  (EXP,ISO)
sarin  (ISO)
sarpogrelate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sulfur dioxide  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
zidovudine  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
GTP binding  (IEA)
GTPase activity  (IBA,IEA,ISO,ISS)
identical protein binding  (IEA,IPI,ISO)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
2. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
3. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
4. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Chen H, etal., J Cell Biol 2003 Jan 20;160(2):189-200. Epub 2003 Jan 13.
5. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Chen Y, etal., Circ Res. 2011 Dec 9;109(12):1327-31. doi: 10.1161/CIRCRESAHA.111.258723. Epub 2011 Nov 3.
6. Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model. Córdova-Dávalos L, etal., Epilepsy Res. 2016 Jul;123:11-9. doi: 10.1016/j.eplepsyres.2016.03.007. Epub 2016 Mar 29.
7. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
8. Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle. Ding H, etal., Biochim Biophys Acta. 2010 Mar;1800(3):250-6. doi: 10.1016/j.bbagen.2009.08.007. Epub 2009 Aug 28.
9. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine. Dong X, etal., Neurosci Lett. 2017 Jan 1;636:127-133. doi: 10.1016/j.neulet.2016.10.054. Epub 2016 Oct 29.
10. Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling. Eisner V, etal., J Cell Biol. 2014 Apr 28;205(2):179-95. doi: 10.1083/jcb.201312066. Epub 2014 Apr 21.
11. Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. Eura Y, etal., J Biochem (Tokyo) 2003 Sep;134(3):333-44.
12. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Fields JA, etal., Neurobiol Dis. 2016 Feb;86:154-69. doi: 10.1016/j.nbd.2015.11.015. Epub 2015 Nov 22.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Calcium-induced alteration of mitochondrial morphology and mitochondrial-endoplasmic reticulum contacts in rat brown adipocytes. Golic I, etal., Eur J Histochem. 2014 Sep 9;58(3):2377. doi: 10.4081/ejh.2014.2377.
15. PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
16. Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1. Hernández-Alvarez MI, etal., Antioxid Redox Signal. 2013 Aug 1;19(4):366-78. doi: 10.1089/ars.2011.4269. Epub 2012 Aug 6.
17. Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. Honda S and Hirose S, Biochem Biophys Res Commun. 2003 Nov 14;311(2):424-32.
18. Time representation of mitochondrial morphology and function after acute spinal cord injury. Jia ZQ, etal., Neural Regen Res. 2016 Jan;11(1):137-43. doi: 10.4103/1673-5374.175061.
19. MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension. Joshi SR, etal., Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H689-98. doi: 10.1152/ajpheart.00264.2016. Epub 2016 Jul 15.
20. Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle. Kitaoka Y, etal., Appl Physiol Nutr Metab. 2015 Nov;40(11):1137-42. doi: 10.1139/apnm-2015-0184. Epub 2015 Jul 14.
21. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Koltai E, etal., Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15;303(2):R127-34. doi: 10.1152/ajpregu.00337.2011. Epub 2012 May 9.
22. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
23. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
24. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. Liu Q, etal., PLoS One. 2015 Oct 19;10(10):e0140906. doi: 10.1371/journal.pone.0140906. eCollection 2015.
25. Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. Liu W and Zhou C, Psychoneuroendocrinology. 2012 Jul;37(7):1057-70. doi: 10.1016/j.psyneuen.2011.12.003. Epub 2012 Jan 14.
26. The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain. Lou DD, etal., Arch Toxicol. 2013 Mar;87(3):449-57. doi: 10.1007/s00204-012-0942-z. Epub 2012 Sep 25.
27. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
31. Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. Park KS, etal., J Biol Chem. 2008 Nov 28;283(48):33347-56. doi: 10.1074/jbc.M806251200. Epub 2008 Oct 2.
32. The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress. Qin SL, etal., J Trace Elem Med Biol. 2015 Jan;29:263-8. doi: 10.1016/j.jtemb.2014.06.001. Epub 2014 Jun 9.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Sun W, etal., Neuropharmacology. 2017 Feb;113(Pt A):556-566. doi: 10.1016/j.neuropharm.2016.11.010. Epub 2016 Nov 12.
36. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
37. Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway. Wang Y, etal., Cell Death Dis. 2017 May 18;8(5):e2799. doi: 10.1038/cddis.2017.193.
38. Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. Wappler EA, etal., PLoS One. 2013 May 2;8(5):e63206. doi: 10.1371/journal.pone.0063206. Print 2013.
39. Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKß/AMPK pathway in isoproterenol-induced myocardial ischaemia. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
40. Sevoflurane postconditioning attenuates cardiomyocyte hypoxia/reoxygenation injury via restoring mitochondrial morphology. Yu J, etal., PeerJ. 2016 Nov 3;4:e2659. eCollection 2016.
41. Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats. Yu J, etal., Sci Rep. 2016 Nov 10;6:36530. doi: 10.1038/srep36530.
42. Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chloride. Zhang S, etal., Toxicol Appl Pharmacol. 2005 Jan 1;202(1):13-7.
43. Acetyl-L-carnitine ameliorates mitochondrial damage and apoptosis following spinal cord injury in rats. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
44. Dihydromyricetin improves physical performance under simulated high altitude. Zou D, etal., Med Sci Sports Exerc. 2014 Nov;46(11):2077-84. doi: 10.1249/MSS.0000000000000336.
Additional References at PubMed
PMID:12477932   PMID:12589796   PMID:12759376   PMID:15899901   PMID:18614015   PMID:20436456   PMID:20594982   PMID:20871098   PMID:23921378   PMID:24513856   PMID:24615014   PMID:25801171  
PMID:26316108   PMID:27920125   PMID:28114303   PMID:28593577   PMID:29382326   PMID:29445732   PMID:29483649   PMID:31975567   PMID:33347533   PMID:35192161   PMID:36689810  


Genomics

Comparative Map Data
Mfn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,240,525 - 117,288,017 (+)NCBIGRCr8
mRatBN7.22115,313,380 - 115,359,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,929,637 - 121,971,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02120,042,271 - 120,083,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,743,136 - 114,785,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,929,738 - 118,971,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,929,738 - 118,973,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,586,943 - 138,627,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,739,155 - 118,783,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,684,116 - 118,727,999 (+)NCBI
Celera2110,426,431 - 110,467,687 (+)NCBICelera
Cytogenetic Map2q24NCBI
MFN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,347,709 - 179,394,936 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,347,709 - 179,394,936 (+)EnsemblGRCh38hg38GRCh38
GRCh373179,065,497 - 179,112,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,548,174 - 180,593,708 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,548,181 - 180,593,708NCBI
Celera3177,496,491 - 177,542,028 (+)NCBICelera
Cytogenetic Map3q26.33NCBI
HuRef3176,468,758 - 176,514,186 (+)NCBIHuRef
CHM1_13179,028,464 - 179,074,130 (+)NCBICHM1_1
T2T-CHM13v2.03182,151,549 - 182,198,775 (+)NCBIT2T-CHM13v2.0
Mfn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,583,594 - 32,633,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,583,614 - 32,633,388 (+)EnsemblGRCm39 Ensembl
GRCm38332,529,443 - 32,579,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,529,465 - 32,579,239 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,428,404 - 32,478,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,721,035 - 32,769,225 (+)NCBIMGSCv36mm8
Celera332,439,720 - 32,489,477 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.75NCBI
Mfn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,541,936 - 8,594,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,541,547 - 8,596,494 (+)NCBIChiLan1.0ChiLan1.0
MFN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,214,053 - 177,261,639 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,218,770 - 177,266,371 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,378,175 - 176,423,943 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,552,108 - 184,596,763 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,552,108 - 184,596,763 (+)Ensemblpanpan1.1panPan2
MFN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,785,799 - 12,816,881 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,785,856 - 12,815,994 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,928,972 - 16,960,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,682,636 - 12,715,445 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,682,734 - 12,758,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,735,233 - 12,767,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,717,513 - 12,749,787 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,956,997 - 12,989,281 (+)NCBIUU_Cfam_GSD_1.0
Mfn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,444,823 - 109,485,343 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,737,315 - 3,775,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,737,315 - 3,775,894 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,404,699 - 117,442,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,404,637 - 117,441,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,050,616 - 10,093,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,047,599 - 10,093,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606318,929,780 - 18,974,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473057,110,807 - 57,153,989 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473057,110,669 - 57,154,924 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfn1
265 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:56
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000065144
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH134722  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22115,357,745 - 115,357,928 (+)MAPPERmRatBN7.2
Rnor_6.02118,971,802 - 118,971,984NCBIRnor6.0
Rnor_5.02138,627,393 - 138,627,575UniSTSRnor5.0
RGSC_v3.42118,783,150 - 118,783,332UniSTSRGSC3.4
Celera2110,467,800 - 110,467,982UniSTS
RH 3.4 Map2688.7UniSTS
Cytogenetic Map2q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000065144   ⟹   ENSRNOP00000060265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)Ensembl
Rnor_6.0 Ensembl2118,929,738 - 118,971,689 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077170   ⟹   ENSRNOP00000073448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)Ensembl
Rnor_6.0 Ensembl2118,932,209 - 118,973,698 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098575   ⟹   ENSRNOP00000087684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2115,322,216 - 115,359,640 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116019   ⟹   ENSRNOP00000087917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)Ensembl
RefSeq Acc Id: NM_138976   ⟹   NP_620432
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,241,758 - 117,288,017 (+)NCBI
mRatBN7.22115,313,384 - 115,359,651 (+)NCBI
Rnor_6.02118,929,738 - 118,971,689 (+)NCBI
Rnor_5.02138,586,943 - 138,627,280 (+)NCBI
RGSC_v3.42118,739,155 - 118,783,037 (+)RGD
Celera2110,426,431 - 110,467,687 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101679   ⟹   XP_038957607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,240,525 - 117,288,017 (+)NCBI
mRatBN7.22115,313,666 - 115,359,651 (+)NCBI
RefSeq Acc Id: XM_039101680   ⟹   XP_038957608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,240,652 - 117,288,017 (+)NCBI
mRatBN7.22115,313,380 - 115,359,651 (+)NCBI
RefSeq Acc Id: XM_039101681   ⟹   XP_038957609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,240,652 - 117,288,017 (+)NCBI
mRatBN7.22115,313,380 - 115,359,651 (+)NCBI
RefSeq Acc Id: XM_063281273   ⟹   XP_063137343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,242,018 - 117,288,017 (+)NCBI
RefSeq Acc Id: NP_620432   ⟸   NM_138976
- UniProtKB: Q8R4Z9 (UniProtKB/Swiss-Prot),   A0A0G2K5J3 (UniProtKB/TrEMBL),   A6IHP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060265   ⟸   ENSRNOT00000065144
Ensembl Acc Id: ENSRNOP00000073448   ⟸   ENSRNOT00000077170
RefSeq Acc Id: XP_038957608   ⟸   XM_039101680
- Peptide Label: isoform X2
- UniProtKB: Q8R4Z9 (UniProtKB/Swiss-Prot),   D3ZR27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957609   ⟸   XM_039101681
- Peptide Label: isoform X3
- UniProtKB: Q8R4Z9 (UniProtKB/Swiss-Prot),   A0A8I6GGI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957607   ⟸   XM_039101679
- Peptide Label: isoform X1
- UniProtKB: Q8R4Z9 (UniProtKB/Swiss-Prot),   A0A0G2K5J3 (UniProtKB/TrEMBL),   A6IHP3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087684   ⟸   ENSRNOT00000098575
Ensembl Acc Id: ENSRNOP00000087917   ⟸   ENSRNOT00000116019
RefSeq Acc Id: XP_063137343   ⟸   XM_063281273
- Peptide Label: isoform X3
- UniProtKB: Q8R4Z9 (UniProtKB/Swiss-Prot),   A0A8I6GGI5 (UniProtKB/TrEMBL)
Protein Domains
Dynamin-type G   Fzo/mitofusin HR2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4Z9-F1-model_v2 AlphaFold Q8R4Z9 1-741 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691279
Promoter ID:EPDNEW_R1804
Type:single initiation site
Name:Mfn1_1
Description:mitofusin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02118,929,680 - 118,929,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621460 AgrOrtholog
BioCyc Gene G2FUF-53429 BioCyc
Ensembl Genes ENSRNOG00000011057 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065144.4 UniProtKB/TrEMBL
  ENSRNOT00000077170.2 UniProtKB/TrEMBL
  ENSRNOT00000098575.1 UniProtKB/TrEMBL
  ENSRNOT00000116019.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192647 UniProtKB/Swiss-Prot
NCBI Gene 192647 ENTREZGENE
PANTHER PTHR10465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10465:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mfn1 PhenoGen
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011057 RatGTEx
Superfamily-SCOP Fzo-like conserved region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5J3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6C1_RAT UniProtKB/TrEMBL
  A0A8I6GGI5 ENTREZGENE, UniProtKB/TrEMBL
  A6IHP3 ENTREZGENE, UniProtKB/TrEMBL
  A6IHP5_RAT UniProtKB/TrEMBL
  A6IHP6_RAT UniProtKB/TrEMBL
  D3ZR27 ENTREZGENE, UniProtKB/TrEMBL
  MFN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Mfn1  mitofusin 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mfn1  mitofusin 1      Symbol and Name status set to provisional 70820 PROVISIONAL