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Gene: Mfn1 (mitofusin 1) Rattus norvegicus
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Symbol: Mfn1
Name: mitofusin 1
Description: Exhibits identical protein binding activity. Involved in several processes, including cellular response to decreased oxygen levels; regulation of mitochondrion organization; and response to glucocorticoid. Localizes to the mitochondrial inner membrane and mitochondrial outer membrane. Biomarker of several diseases, including adult respiratory distress syndrome; dental fluorosis; kidney failure (multiple); pulmonary hypertension; and status epilepticus. Orthologous to human MFN1 (mitofusin 1); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,6-dinitrotoluene; 4-DAMP(1+); 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Fzo1b; mitochondrial transmembrane GTPase FZO1B; mitofusin-1; transmembrane GTPase MFN1
Orthologs:
Homo sapiens (human) : MFN1 (mitofusin 1)  HGNC  Alliance
Mus musculus (house mouse) : Mfn1 (mitofusin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mfn1 (mitofusin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MFN1 (mitofusin 1)
Canis lupus familiaris (dog) : MFN1 (mitofusin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mfn1 (mitofusin 1)
Sus scrofa (pig) : MFN1 (mitofusin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02118,929,738 - 118,971,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,929,738 - 118,973,698 (+)Ensembl
Rnor_5.02138,586,943 - 138,627,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,739,155 - 118,783,037 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12118,684,116 - 118,727,999 (+)NCBI
Celera2110,426,431 - 110,467,687 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mfn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621460
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.