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Gene: MFN1 (mitofusin 1) Homo sapiens
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Symbol: MFN1
Name: mitofusin 1
Description: Exhibits GTPase activity and identical protein binding activity. Involved in several processes, including GTP metabolic process; mitochondrial fusion; and mitochondrial membrane fusion. Localizes to integral component of mitochondrial outer membrane and outer mitochondrial membrane protein complex. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp762F247; FLJ20693; fzo homolog; hfzo1; hfzo2; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; mitofusin-1; putative transmembrane GTPase; transmembrane GTPase MFN1
Orthologs:
Mus musculus (house mouse) : Mfn1 (mitofusin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mfn1 (mitofusin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mfn1 (mitofusin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MFN1 (mitofusin 1)
Canis lupus familiaris (dog) : MFN1 (mitofusin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mfn1 (mitofusin 1)
Sus scrofa (pig) : MFN1 (mitofusin 1)
Chlorocebus sabaeus (African green monkey) : MFN1 (mitofusin 1)
Heterocephalus glaber (naked mole-rat) : Mfn1 (mitofusin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3179,347,709 - 179,394,936 (+)EnsemblGRCh38hg38GRCh38
GRCh383179,347,709 - 179,394,936 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373179,065,480 - 179,111,014 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,548,174 - 180,593,708 (+)NCBINCBI36hg18NCBI36
Build 343180,548,181 - 180,593,708NCBI
Celera3177,496,491 - 177,542,028 (+)NCBI
Cytogenetic Map3q26.33NCBI
HuRef3176,468,758 - 176,514,186 (+)NCBIHuRef
CHM1_13179,028,464 - 179,074,130 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MFN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731663
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.