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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mfn2
Name: mitofusin 2
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mfn2decreases expressionEXP 6480464CTDRotenone results in decreased expression of MFN2 mRNA; Rotenone results in decreased expression of MFN2 proteinPMID:26770656 PMID:30240821
Mfn2increases expressionEXP 6480464CTDRotenone results in increased expression of MFN2 proteinPMID:35544339
Mfn2multiple interactionsEXP 6480464CTDPQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of MFN2 protein]PMID:26770656 PMID:30240821
Mfn2affects localizationISOMFN2 (Homo sapiens)6480464CTDRotenone affects the localization of MFN2 proteinPMID:30240821
Mfn2decreases expressionISOMFN2 (Homo sapiens)6480464CTDRotenone results in decreased expression of MFN2 mRNA; Rotenone results in decreased expression of MFN2 proteinPMID:24792327 PMID:30240821
Mfn2decreases expressionISOMfn2 (Mus musculus)6480464CTDRotenone results in decreased expression of MFN2 mRNAPMID:23186747
Mfn2increases expressionISOMFN2 (Homo sapiens)6480464CTDRotenone results in increased expression of MFN2 proteinPMID:31926197
Mfn2multiple interactionsISOMFN2 (Homo sapiens)6480464CTDpolydatin inhibits the reaction [Rotenone results in increased expression of MFN2 protein]; PQQ Cofactor inhibits the reaction [Rotenone affects the localization of MFN2 protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA]; Rotenone results in decreased expression of and affects the localization of MFN2 proteinPMID:28940366 PMID:30240821 PMID:31926197
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