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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mfn2
Name: mitofusin 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mfn2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of MFN2 mRNA; Acetaminophen results in decreased expression of MFN2 proteinPMID:27792760 PMID:33387578
Mfn2multiple interactionsEXP 6480464CTDAICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN2 protein]PMID:27792760
Mfn2affects expressionISOMfn2 (Mus musculus)6480464CTDAcetaminophen affects the expression of MFN2 mRNAPMID:17562736
Mfn2decreases expressionISOMFN2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of MFN2 mRNAPMID:21420995
Mfn2multiple interactionsISOMfn2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of and results in increased cleavage of MFN2 protein; acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in decreased expression of and results in increased cleavage of MFN2 protein]; calpeptin inhibits the reaction [Acetaminophen results in decreased expression of and results in increased cleavage of MFN2 protein]PMID:35713544
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