RGD Reference Report - Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. - Rat Genome Database

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Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons.

Authors: Bergstrom, RA  Sinjoanu, RC  Ferreira, A 
Citation: Bergstrom RA, etal., Neuroscience. 2007 Nov 9;149(3):527-36. Epub 2007 Aug 14.
RGD ID: 2304008
Pubmed: PMID:17870250   (View Abstract at PubMed)
PMCID: PMC2675609   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuroscience.2007.08.017   (Journal Full-text)

The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of growth cones in hippocampal and spinal neurons, respectively. However, the molecular mechanisms underlying these effects have not been completely elucidated. In the present study, we analyzed the morphological and molecular changes induced by agrin in growth cones of hippocampal neurons that developed in culture. Morphometric analysis showed a significant enlargement of growth cones of hippocampal neurons cultured in the presence of agrin. These agrin-induced growth cone changes were accompanied by the formation of loops of microtubules highly enriched in acetylated tubulin and an increase in the content of the microtubule-associated protein (MAP)1B. Together, these data provide further insights into the potential molecular mechanisms underlying the effects of agrin on neurite outgrowth in rat central neurons.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Map1bRatneuron development  IEP  RGD 
AgrnRatregulation of axon guidance  IDA  RGD 
AgrnRatregulation of microtubule cytoskeleton organization  IDA  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Map1bRatgrowth cone  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agrn  (agrin)
Map1b  (microtubule-associated protein 1B)


Additional Information