Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Agrn (agrin) Mus musculus
Analyze
Symbol: Agrn
Name: agrin
Description: Exhibits anion binding activity; ion channel binding activity; and molecular function regulator. Involved in several processes, including negative regulation of sodium ion transmembrane transport; positive regulation of macromolecule metabolic process; and positive regulation of synaptic growth at neuromuscular junction. Localizes to several cellular components, including the cell surface; sarcolemma; and synaptic cleft. Used to study congenital myasthenic syndrome 8. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Is expressed in several structures, including nervous system; notochord; oral region epithelium; retina; and skeletal musculature. Orthologous to human AGRN (agrin); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; cell-extracellular matrix signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: nmf380
Orthologs:
Homo sapiens (human) : AGRN (agrin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Agrn (agrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agrn (agrin)
Pan paniscus (bonobo/pygmy chimpanzee) : AGRN (agrin)
Canis lupus familiaris (dog) : AGRN (agrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agrn (agrin)
Sus scrofa (pig) : AGRN (agrin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm384156,165,290 - 156,197,533 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374155,539,399 - 155,559,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv364155,009,090 - 155,028,935 (-)NCBImm8
Celera4158,419,989 - 158,453,803 (-)NCBICelera
Cytogenetic Map4 E2NCBI
cM Map488.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Agrn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10117
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.