Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Agrn (agrin) Mus musculus
Symbol: Agrn
Name: agrin
RGD ID: 10117
Description: Exhibits anion binding activity; ion channel binding activity; and molecular function regulator. Involved in several processes, including negative regulation of sodium ion transmembrane transport; positive regulation of nitrogen compound metabolic process; and positive regulation of synaptic growth at neuromuscular junction. Localizes to several cellular components, including cell surface; sarcolemma; and synaptic cleft. Is expressed in several structures, including lower jaw; nervous system; notochord; retina; and skeletal musculature. Used to study congenital myasthenic syndrome 8. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; cell-extracellular matrix signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; NMF38; nmf380
Homo sapiens (human) : AGRN (agrin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Agrn (agrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agrn (agrin)
Pan paniscus (bonobo/pygmy chimpanzee) : AGRN (agrin)
Canis lupus familiaris (dog) : AGRN (agrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agrn (agrin)
Sus scrofa (pig) : AGRN (agrin)
Chlorocebus sabaeus (African green monkey) : AGRN (agrin)
Heterocephalus glaber (naked mole-rat) : Agrn (agrin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394156,249,747 - 156,281,997 (-)NCBI
GRCm384156,165,290 - 156,197,533 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4156,165,290 - 156,197,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,539,399 - 155,559,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv364155,009,090 - 155,028,935 (-)NCBImm8
Celera4158,419,989 - 158,441,614 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map488.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Agrn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10117
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.