Mtor (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: Mtor (mechanistic target of rapamycin kinase) Rattus norvegicus
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
RGD ID: 68371
Description: Enables protein domain specific binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular biosynthetic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including cerebrovascular disease (multiple); obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN mTOR signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Frap1; mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target-1 protein; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25158,884,856 - 158,994,311 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,601,607 - 161,711,017 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,423,732 - 163,533,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,380,079 - 163,489,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
atherosclerosis  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (IDA)
Breast Neoplasms  (ISO)
Burns  (IDA)
Cardiomegaly  (IMP)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (IMP)
Charcot-Marie-Tooth disease type 2  (ISO)
chondrosarcoma  (IMP)
chromosome 1p36 deletion syndrome  (ISO)
Chronic Allograft Dysfunction  (IDA)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (IMP)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IDA,ISO)
Drug-Induced Dyskinesia  (IMP)
end stage renal disease  (IMP)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IEP)
Experimental Mammary Neoplasms  (IMP)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (IDA)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (IMP)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (IMP)
idiopathic interstitial pneumonia  (ISO)
immunodeficiency 14  (ISO)
Inflammation  (IMP)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (IDA,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IDA,IEP)
muscular atrophy  (IMP)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (IDA)
Neoplasm Metastasis  (IMP)
nephritis  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IEP)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (IMP)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IMP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (IMP)
schizophrenia  (IMP,ISO)
sciatic neuropathy  (IMP)
Sepsis  (IDA)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (IMP)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (IDA,IMP)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (IMP)
Temporomandibular Joint Disorders  (IDA)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
20-hydroxyecdysone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
acrylonitrile  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
Ajugasterone C  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (EXP)
alpha-amanitin  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alternariol  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
Asiaticoside  (EXP)
astragaloside IV  (EXP,ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
aucubin  (ISO)
Auriculasin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-thujaplicin  (ISO)
betalain  (ISO)
Betanin  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butachlor  (ISO)
butan-1-ol  (ISO)
butein  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
carteolol  (ISO)
celastrol  (EXP)
cepharanthine  (ISO)
chicoric acid  (EXP)
chloroethene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
Corynoxine B  (ISO)
coumarin  (ISO)
creatine  (ISO)
cucurbitacin E  (EXP,ISO)
curcumin  (ISO)
Curcumol  (EXP)
cyclosporin A  (EXP)
cyfluthrin  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
Doramectin  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
eugenol  (EXP)
everolimus  (EXP,ISO)
fenvalerate  (EXP,ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fluoxetine  (EXP)
fluvastatin  (EXP)
formoterol fumarate  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
Fusaric acid  (ISO)
gabapentin  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
graphene oxide  (ISO)
hesperetin  (EXP)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
icariin  (EXP)
icariside II  (ISO)
idelalisib  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kahweol  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
letrozole  (ISO)
levetiracetam  (EXP)
linagliptin  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loperamide  (ISO)
Lupiwighteone  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (EXP)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mirtazapine  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-succinylsulfathiazole  (ISO)
naringin  (EXP)
navitoclax  (ISO)
Neferine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nobiletin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP)
palmatine  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
Pentoxifylline  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
perhexiline  (ISO)
perifosine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
piclamilast  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
progesterone  (EXP,ISO)
promethazine  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
prothioconazole  (ISO)
psoralen  (ISO)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
ridaforolimus  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
roxarsone  (EXP)
ruthenium atom  (ISO)
Salidroside  (EXP)
Sanggenon C  (EXP)
sarpogrelate  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
serotonin  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sonidegib  (EXP)
Sophoricoside  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
sulfadiazine  (ISO)
sulfamethizole  (ISO)
swainsonine  (ISO)
T-2 toxin  (EXP)
tadalafil  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
theobromine  (EXP)
thioacetamide  (ISO)
Thiorphan  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
torin 1  (ISO)
trabectedin  (ISO)
trans-piceid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (EXP)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
XL765  (ISO)
Y-27632  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP)
zinc oxide  (EXP,ISO)
zinc pyrithione  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IEA,ISO)
behavioral response to pain  (IEA,ISO)
calcineurin-NFAT signaling cascade  (IEA,ISO)
cardiac cell development  (ISO)
cardiac muscle cell development  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cardiac muscle tissue development  (ISO)
cell projection organization  (IGI,ISO)
cellular component organization  (IEA)
cellular response to amino acid starvation  (ISO,ISS)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IEA,ISO,ISS)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to leucine  (IEA,ISO)
cellular response to leucine starvation  (IEA,ISO)
cellular response to nutrient  (IEA,ISO)
cellular response to nutrient levels  (ISO,ISS)
cellular response to starvation  (ISO,ISS)
energy reserve metabolic process  (IEA,ISO)
germ cell development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
heart valve morphogenesis  (IEA,ISO)
inflammatory response  (IEA,ISO)
long-term memory  (IMP)
lysosome organization  (IEA,ISO,ISS)
macroautophagy  (IEA,ISO)
maternal process involved in female pregnancy  (IDA)
mRNA stabilization  (IMP)
multicellular organism growth  (IEA,ISO)
negative regulation of autophagy  (IMP,ISO,ISS)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
negative regulation of cell size  (IEA,IMP,ISO)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of iodide transmembrane transport  (IMP)
negative regulation of lysosome organization  (IEA,ISO,ISS)
negative regulation of macroautophagy  (IBA,IEA,ISO)
negative regulation of muscle atrophy  (IMP)
negative regulation of protein localization to nucleus  (IEA,ISO,ISS)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein ubiquitination  (IMP)
neuronal action potential  (IEA,ISO)
nucleus localization  (IEA,ISO,ISS)
oligodendrocyte differentiation  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cellular senescence  (IMP)
positive regulation of cholangiocyte proliferation  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of eating behavior  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of granulosa cell proliferation  (IMP)
positive regulation of keratinocyte migration  (IEA,ISO)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO,ISS)
positive regulation of myotube differentiation  (IEA,ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron maturation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of oligodendrocyte differentiation  (IEA,IMP,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle hypertrophy  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase III  (IEA,ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (IEA,ISO)
positive regulation of translation  (IMP,ISO)
positive regulation of translational initiation  (IEA,ISO)
positive regulation of wound healing, spreading of epidermal cells  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein autophosphorylation  (IMP)
protein destabilization  (IEA,ISO,ISS)
protein phosphorylation  (IDA,IMP)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagosome assembly  (IEA,ISO)
regulation of autophagy  (ISO,ISS)
regulation of brown fat cell differentiation  (IMP)
regulation of carbohydrate metabolic process  (IDA,IMP)
regulation of carbohydrate utilization  (IDA,IMP)
regulation of cell growth  (IEA,ISO)
regulation of cell size  (ISO)
regulation of cellular component organization  (IEA)
regulation of circadian rhythm  (ISO,ISS)
regulation of fatty acid beta-oxidation  (IDA,IMP)