Mtor (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: Mtor (mechanistic target of rapamycin kinase) Rattus norvegicus
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
RGD ID: 68371
Description: Enables several functions, including protein kinase binding activity; protein serine/threonine kinase activity; and translation regulator activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular protein metabolic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in cytosol and nucleus. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including middle cerebral artery infarction; obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN mTOR signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Frap1; mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target-1 protein; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25158,884,856 - 158,994,311 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)Ensembl
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (IDA)
Breast Neoplasms  (ISO)
Burns  (IDA)
Cardiomegaly  (IMP)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (IMP)
chondrosarcoma  (IMP)
Chronic Allograft Dysfunction  (IDA)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (IMP)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Nephropathies  (IDA,ISO)
Drug-Induced Dyskinesia  (IMP)
end stage renal disease  (IMP)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IEP)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (IDA)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (IMP)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (IMP)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (IMP)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (IDA,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
Mammary Neoplasms, Experimental  (IMP)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IDA,IEP)
muscular atrophy  (IMP)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (IDA)
Neoplasm Metastasis  (IMP)
nephritis  (ISO)
obesity  (IEP)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (IMP)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IMP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (IMP)
schizophrenia  (IMP,ISO)
Schnyder corneal dystrophy  (ISO)
sciatic neuropathy  (IMP)
Sepsis  (IDA)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (IMP)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (IDA,IMP)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (IMP)
Temporomandibular Joint Disorders  (IDA)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (IEP)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
20-hydroxyecdysone  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
AICA ribonucleotide  (EXP,ISO)
Ajugasterone C  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
antroquinonol  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
Asiaticoside  (EXP)
astragaloside IV  (EXP)
atrazine  (ISO)
aucubin  (ISO)
Auriculasin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (ISO)
beta-thujaplicin  (ISO)
betalain  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
celastrol  (EXP)
cepharanthine  (ISO)
chicoric acid  (EXP)
chloroethene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corticosterone  (ISO)
Corynoxine B  (ISO)
creatine  (ISO)
cucurbitacin E  (EXP,ISO)
curcumin  (ISO)
Curcumol  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
everolimus  (EXP,ISO)
fenvalerate  (EXP)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fluoxetine  (EXP)
fulvestrant  (ISO)
Fusaric acid  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
graphene oxide  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP)
icariside II  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kahweol  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
letrozole  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
Lupiwighteone  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (EXP)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP)
navitoclax  (ISO)
Neferine  (EXP)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nobiletin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
p-cresol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
Pentoxifylline  (EXP)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perhexiline  (ISO)
perifosine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
piclamilast  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
pravastatin  (ISO)
progesterone  (EXP,ISO)
promethazine  (ISO)
prostaglandin E2  (ISO)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
radon atom  (ISO)
radon(0)  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
ridaforolimus  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
Salidroside  (EXP)
sarpogrelate  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
serotonin  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sonidegib  (EXP)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
testosterone  (EXP)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
theobromine  (EXP)
thioacetamide  (ISO)
Thiorphan  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
torin 1  (ISO)
trabectedin  (ISO)
trans-piceid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (EXP)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
XL765  (ISO)
Y-27632  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (ISO)
behavioral response to pain  (ISO)
brain development  (IEP)
cardiac cell development  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle contraction  (ISO)
cardiac muscle tissue development  (ISO)
cell aging  (IEP)
cell projection organization  (IGI,ISO)
cellular component organization  (IEA)
cellular response to amino acid starvation  (ISO,ISS)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (ISO,ISS)
cellular response to leucine  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to nutrient levels  (ISO,ISS)
cellular response to starvation  (ISO,ISS)
energy reserve metabolic process  (ISO)
germ cell development  (ISO)
heart morphogenesis  (ISO)
heart valve morphogenesis  (ISO)
inflammatory response  (ISO)
long-term memory  (IMP)
lysosome organization  (ISO,ISS)
maternal process involved in female pregnancy  (IDA)
mRNA stabilization  (IMP)
multicellular organism growth  (ISO)
negative regulation of autophagy  (IMP,ISO,ISS)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of cell size  (IMP,ISO)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of iodide transmembrane transport  (IMP)
negative regulation of macroautophagy  (IBA,ISO)
negative regulation of muscle atrophy  (IMP)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein ubiquitination  (IMP)
neuronal action potential  (ISO)
nucleus localization  (ISO,ISS)
peptidyl-serine phosphorylation  (ISO,ISS)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell death  (IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cellular protein metabolic process  (IEA)
positive regulation of cholangiocyte proliferation  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of eating behavior  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of granulosa cell proliferation  (IMP)
positive regulation of keratinocyte migration  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of lipid biosynthetic process  (ISO,ISS)
positive regulation of myotube differentiation  (ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of neuron death  (IMP)
positive regulation of neuron maturation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of oligodendrocyte differentiation  (IMP,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of sensory perception of pain  (IMP)
positive regulation of skeletal muscle hypertrophy  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase III  (ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (ISO)
positive regulation of translation  (IMP,ISO)
positive regulation of wound healing, spreading of epidermal cells  (ISO)
post-embryonic development  (ISO)
protein autophosphorylation  (IMP,ISO)
protein phosphorylation  (IDA,IEA,IMP,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagy  (ISO,ISS)
regulation of brown fat cell differentiation  (IMP)
regulation of carbohydrate metabolic process  (IDA,IMP)
regulation of carbohydrate utilization  (IDA,IMP)
regulation of cell growth  (ISO)
regulation of cell size  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of fatty acid beta-oxidation  (IDA,IMP)
regulation of glycogen biosynthetic process  (IDA,IMP)
regulation of GTPase activity  (ISO)
regulation of locomotor rhythm  (ISO,ISS)
regulation of membrane permeability  (ISO)
regulation of myelination  (ISO)
regulation of osteoclast differentiation  (ISO,ISS)
regulation of protein kinase activity  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of response to food  (IDA,IMP)
regulation of translation at synapse, modulating synaptic transmission  (EXP,IDA,IMP)
reproductive process  (IEA)
response to activity  (IEP)
response to amino acid  (ISO)
response to cocaine  (IMP)
response to heat  (ISO)
response to insulin  (ISO)
response to morphine  (IMP)
response to nutrient  (ISO)
response to nutrient levels  (ISO,ISS)
rhythmic process  (IEA)
ruffle organization  (ISO)
social behavior  (IMP)
spinal cord development  (IDA)
T-helper 1 cell lineage commitment  (ISO)
TOR signaling  (ISO,ISS)
TORC1 signaling  (IBA,ISO)
visual learning  (IMP)
voluntary musculoskeletal movement  (ISO)
wound healing  (IEP)

Cellular Component


References - curated
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2. Alperovich G, etal., Lupus. 2007;16(1):18-24.
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6. Bolster DR, etal., J Biol Chem 2002 Jul 5;277(27):23977-80.
7. Boluyt MO, etal., Cardiovasc Drugs Ther. 2004 Jul;18(4):257-67.
8. Brunn GJ, etal., Science. 1997 Jul 4;277(5322):99-101.
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10. Chen S, etal., J Neurochem. 2011 Dec;119(5):1108-18. doi: 10.1111/j.1471-4159.2011.07493.x. Epub 2011 Oct 20.
11. Chen Z, etal., Oncogene. 2014 Sep 11;33(37):4548-57. doi: 10.1038/onc.2013.402. Epub 2013 Oct 7.
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25158,884,856 - 158,994,311 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)Ensembl
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl111,106,535 - 11,262,551 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,106,535 - 11,273,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,166,592 - 11,322,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554862,487,642 - 2,599,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,487,642 - 2,599,694 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,349,286 - 81,469,352 (+)NCBI
ROS_Cfam_1.0285,486,181 - 85,601,386 (+)NCBI
ROS_Cfam_1.0 Ensembl285,480,139 - 85,601,386 (+)Ensembl
UMICH_Zoey_3.1282,229,433 - 82,349,483 (+)NCBI
UNSW_CanFamBas_1.0283,231,190 - 83,351,242 (+)NCBI
UU_Cfam_GSD_1.0284,293,674 - 84,413,764 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505834,333,597 - 34,457,567 (-)NCBI
SpeTri2.0NW_004936474158,376 - 282,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120120,522,667 - 120,678,988 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,525,737 - 120,679,020 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605424,431,846 - 24,582,610 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248181,570,155 - 1,698,264 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,994,128 - 158,994,298 (+)MAPPERmRatBN7.2
Rnor_6.05165,373,785 - 165,373,954NCBIRnor6.0
Rnor_5.05169,030,386 - 169,030,555UniSTSRnor5.0
RGSC_v3.45165,640,717 - 165,640,886UniSTSRGSC3.4
Celera5157,270,717 - 157,270,886UniSTS
RH 3.4 Map51106.7UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,986,103 - 158,986,565 (+)MAPPERmRatBN7.2
mRatBN7.25158,986,520 - 158,986,565 (+)MAPPERmRatBN7.2
mRatBN7.25158,986,103 - 158,986,808 (+)MAPPERmRatBN7.2
Rnor_6.05165,365,472 - 165,366,221NCBIRnor6.0
Rnor_6.05165,365,472 - 165,365,933NCBIRnor6.0
Rnor_5.05169,022,073 - 169,022,822UniSTSRnor5.0
Rnor_5.05169,022,073 - 169,022,534UniSTSRnor5.0
RGSC_v3.45165,632,692 - 165,633,153UniSTSRGSC3.4
Celera5157,262,692 - 157,263,153UniSTS
Cytogenetic Map5q36UniSTS

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:112
Interacting mature miRNAs:151
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 41 45 29 19 29 8 11 74 35 41 11 8
Low 2 12 12 12
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014167   ⟹   ENSRNOP00000014167
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)Ensembl
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080751   ⟹   ENSRNOP00000070162
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,884,846 - 158,994,311 (+)Ensembl
Rnor_6.0 Ensembl5165,267,368 - 165,372,472 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113961   ⟹   ENSRNOP00000094256
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,887,995 - 158,994,311 (+)Ensembl
RefSeq Acc Id: NM_019906   ⟹   NP_063971
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,884,856 - 158,994,311 (+)NCBI
Rnor_6.05165,263,813 - 165,373,967 (+)NCBI
Rnor_5.05168,920,414 - 169,030,568 (+)NCBI
RGSC_v3.45165,531,402 - 165,640,899 (+)RGD
Celera5157,161,454 - 157,270,899 (+)RGD
Protein Sequences
Protein RefSeqs NP_063971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20091 (Get FASTA)   NCBI Sequence Viewer  
  AAA65929 (Get FASTA)   NCBI Sequence Viewer  
  EDL81121 (Get FASTA)   NCBI Sequence Viewer  
  P42346 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_063971   ⟸   NM_019906
- UniProtKB: P42346 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070162   ⟸   ENSRNOT00000080751
RefSeq Acc Id: ENSRNOP00000014167   ⟸   ENSRNOT00000014167
RefSeq Acc Id: ENSRNOP00000094256   ⟸   ENSRNOT00000113961
Protein Domains


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694261
Promoter ID:EPDNEW_R4786
Type:multiple initiation site
Description:mechanistic target of rapamycin kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05165,263,742 - 165,263,802EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program