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Gene: Mtor (mechanistic target of rapamycin kinase) Rattus norvegicus
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Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Description: Exhibits several functions, including protein kinase binding activity; protein serine/threonine kinase activity; and translation regulator activity. Involved in several processes, including negative regulation of cellular metabolic process; positive regulation of cell development; and positive regulation of cell population proliferation. Localizes to several cellular components, including the TORC1 complex; glutamatergic synapse; and postsynaptic cytosol. Colocalizes with the dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); crescentic glomerulonephritis; epilepsy (multiple); kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including middle cerebral artery infarction; obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN mTOR signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Frap1; mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target-1 protein; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
Orthologs:
Homo sapiens (human) : MTOR (mechanistic target of rapamycin kinase)  HGNC  Alliance
Mus musculus (house mouse) : Mtor (mechanistic target of rapamycin kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mtor (mechanistic target of rapamycin kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTOR (mechanistic target of rapamycin kinase)
Canis lupus familiaris (dog) : MTOR (mechanistic target of rapamycin kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mtor (mechanistic target of rapamycin kinase)
Sus scrofa (pig) : MTOR (mechanistic target of rapamycin kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mtor
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68371
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.