Mtor (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: Mtor (mechanistic target of rapamycin kinase) Rattus norvegicus
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Symbol: Mtor
Name: mechanistic target of rapamycin kinase
RGD ID: 68371
Description: Enables protein domain specific binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular biosynthetic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including cerebrovascular disease (multiple); obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN mTOR signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Frap1; mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target-1 protein; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,167,985 - 164,277,438 (+)NCBIGRCr8
mRatBN7.25158,884,856 - 158,994,311 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,601,607 - 161,711,017 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,423,732 - 163,533,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,380,079 - 163,489,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
atherosclerosis  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (IDA)
Breast Neoplasms  (ISO)
Burns  (IDA)
Cardiomegaly  (IMP)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (IMP)
Charcot-Marie-Tooth disease type 2  (ISO)
chondrosarcoma  (IMP)
chromosome 1p36 deletion syndrome  (ISO)
Chronic Allograft Dysfunction  (IDA)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (IMP)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IDA,ISO)
Drug-Induced Dyskinesia  (IMP)
end stage renal disease  (IMP)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IEP)
Experimental Mammary Neoplasms  (IMP)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (IDA)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (IMP)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (IMP)
idiopathic interstitial pneumonia  (ISO)
immunodeficiency 14  (ISO)
Inflammation  (IMP)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (IDA,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IDA,IEP)
muscular atrophy  (IMP)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (IDA)
Neoplasm Metastasis  (IMP)
nephritis  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IEP)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (IMP)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IMP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (IMP)
schizophrenia  (IMP,ISO)
sciatic neuropathy  (IMP)
Sepsis  (IDA)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (IMP)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (IDA,IMP)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (IMP)
Temporomandibular Joint Disorders  (IDA)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
20-hydroxyecdysone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
acrylonitrile  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
Ajugasterone C  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (EXP)
alpha-amanitin  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alternariol  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
angelicin  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
Asiaticoside  (EXP)
astragaloside IV  (EXP,ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
aucubin  (ISO)
Auriculasin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-thujaplicin  (ISO)
betalain  (ISO)
Betanin  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butachlor  (ISO)
butan-1-ol  (ISO)
butein  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
carteolol  (ISO)
celastrol  (EXP)
cepharanthine  (ISO)
chicoric acid  (EXP)
chloroethene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
Corynoxine B  (ISO)
coumarin  (ISO)
creatine  (ISO)
cucurbitacin E  (EXP,ISO)
curcumin  (ISO)
Curcumol  (EXP)
cyclosporin A  (EXP)
cyfluthrin  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
Doramectin  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
eugenol  (EXP)
everolimus  (EXP,ISO)
fenvalerate  (EXP,ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fluoxetine  (EXP)
fluvastatin  (EXP)
formoterol fumarate  (ISO)
FR900359  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
Fusaric acid  (ISO)
gabapentin  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
graphene oxide  (ISO)
hesperetin  (EXP)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
icariin  (EXP)
icariside II  (ISO)
idelalisib  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kahweol  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
letrozole  (ISO)
levetiracetam  (EXP)
linagliptin  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loperamide  (ISO)
Lupiwighteone  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (EXP)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mirtazapine  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-succinylsulfathiazole  (ISO)
naringin  (EXP)
navitoclax  (ISO)
Neferine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nobiletin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP)
palmatine  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
Pentoxifylline  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
perhexiline  (ISO)
perifosine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
piclamilast  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
progesterone  (EXP,ISO)
promethazine  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
prothioconazole  (ISO)
psoralen  (ISO)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
ridaforolimus  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
roxarsone  (EXP)
ruthenium atom  (ISO)
Salidroside  (EXP)
Sanggenon C  (EXP)
sarpogrelate  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
serotonin  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sonidegib  (EXP)
Sophoricoside  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
sulfadiazine  (ISO)
sulfamethizole  (ISO)
swainsonine  (ISO)
T-2 toxin  (EXP)
tadalafil  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
theobromine  (EXP)
thioacetamide  (ISO)
Thiorphan  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
torin 1  (ISO)
trabectedin  (ISO)
trans-piceid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (EXP)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
XL765  (ISO)
Y-27632  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP)
zinc oxide  (EXP,ISO)
zinc pyrithione  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IEA,ISO)
behavioral response to pain  (IEA,ISO)
calcineurin-NFAT signaling cascade  (IEA,ISO)
cardiac cell development  (ISO)
cardiac muscle cell development  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cardiac muscle tissue development  (ISO)
cell projection organization  (IGI,ISO)
cellular component organization  (IEA)
cellular response to amino acid starvation  (ISO,ISS)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IEA,ISO,ISS)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to leucine  (IEA,ISO)
cellular response to leucine starvation  (IEA,ISO)
cellular response to nutrient  (IEA,ISO)
cellular response to nutrient levels  (ISO,ISS)
cellular response to starvation  (ISO,ISS)
energy reserve metabolic process  (IEA,ISO)
germ cell development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
heart valve morphogenesis  (IEA,ISO)
inflammatory response  (IEA,ISO)
long-term memory  (IMP)
lysosome organization  (IEA,ISO,ISS)
macroautophagy  (IEA,ISO)
maternal process involved in female pregnancy  (IDA)
mRNA stabilization  (IMP)
multicellular organism growth  (IEA,ISO)
negative regulation of autophagy  (IMP,ISO,ISS)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
negative regulation of cell size  (IEA,IMP,ISO)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of iodide transmembrane transport  (IMP)
negative regulation of lysosome organization  (IEA,ISO,ISS)
negative regulation of macroautophagy  (IBA,IEA,ISO)
negative regulation of muscle atrophy  (IMP)
negative regulation of protein localization to nucleus  (IEA,ISO,ISS)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein ubiquitination  (IMP)
neuronal action potential  (IEA,ISO)
nucleus localization  (IEA,ISO,ISS)
oligodendrocyte differentiation  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cellular senescence  (IMP)
positive regulation of cholangiocyte proliferation  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of eating behavior  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of granulosa cell proliferation  (IMP)
positive regulation of keratinocyte migration  (IEA,ISO)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO,ISS)
positive regulation of myotube differentiation  (IEA,ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron maturation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of oligodendrocyte differentiation  (IEA,IMP,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle hypertrophy  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase III  (IEA,ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (IEA,ISO)
positive regulation of translation  (IMP,ISO)
positive regulation of translational initiation  (IEA,ISO)
positive regulation of wound healing, spreading of epidermal cells  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein autophosphorylation  (IMP)
protein destabilization  (IEA,ISO,ISS)
protein phosphorylation  (IDA,IMP)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagosome assembly  (IEA,ISO)
regulation of autophagy  (ISO,ISS)
regulation of brown fat cell differentiation  (IMP)
regulation of carbohydrate metabolic process  (IDA,IMP)
regulation of carbohydrate utilization  (IDA,IMP)
regulation of cell growth  (IEA,ISO)
regulation of cell size  (ISO)
regulation of cellular component organization  (IEA)
regulation of circadian rhythm  (ISO,ISS)
regulation of fatty acid beta-oxidation  (IDA,IMP)
regulation of glycogen biosynthetic process  (IDA,IMP)
regulation of locomotor rhythm  (IEA,ISO,ISS)
regulation of membrane permeability  (IEA,ISO)
regulation of myelination  (IEA,ISO)
regulation of osteoclast differentiation  (IEA,ISO,ISS)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
regulation of response to food  (IDA,IMP)
regulation of translation at synapse, modulating synaptic transmission  (EXP,IDA,IEP,IMP)
reproductive process  (IEA)
response to activity  (IEP)
response to amino acid  (ISO)
response to cocaine  (IMP)
response to heat  (IEA,ISO)
response to insulin  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO,ISS)
rhythmic process  (IEA)
ruffle organization  (IEA,ISO)
social behavior  (IMP)
spinal cord development  (IDA)
T-helper 1 cell lineage commitment  (IEA,ISO)
TOR signaling  (IBA,IEA,ISO,ISS)
TORC1 signaling  (IEA,ISO,ISS)
visual learning  (IMP)
voluntary musculoskeletal movement  (IEA,ISO)

Cellular Component

References

References - curated
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103. Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock. Xia X, etal., PLoS One. 2013 Oct 28;8(10):e77823. doi: 10.1371/journal.pone.0077823. eCollection 2013.
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109. The mechanisms of EGFR in the regulation of axon regeneration. Xu MF, etal., Cell Biochem Funct. 2014 Jan;32(1):101-5. doi: 10.1002/cbf.2977. Epub 2013 May 17.
110. Anti-angiogenic effects of mammalian target of rapamycin inhibitors in a mouse model of oxygen-induced retinopathy. Yagasaki R, etal., Biol Pharm Bull. 2014;37(11):1838-42.
111. Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic alpha2A receptor through the mTOR (mammalian target of rapamycin) pathway: implication in new-onset diabetes in renal transplantation. Yang J, etal., J Biol Chem. 2012 Jul 13;287(29):24795-806. doi: 10.1074/jbc.M112.344259. Epub 2012 May 29.
112. Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. Yang W, etal., BJU Int. 2012 Dec;110(11 Pt C):E1138-46. doi: 10.1111/j.1464-410X.2012.11299.x. Epub 2012 Jun 28.
113. Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation. Yu J, etal., Reprod Sci. 2012 Feb;19(2):143-51. doi: 10.1177/1933719111424447.
114. mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy. Zeidan A, etal., Mol Cell Biochem. 2011 Jun;352(1-2):99-108. doi: 10.1007/s11010-011-0744-2. Epub 2011 Feb 13.
115. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. Zeng LH, etal., J Neurosci. 2009 May 27;29(21):6964-72. doi: 10.1523/JNEUROSCI.0066-09.2009.
116. Abeta40 modulates GABA(A) receptor alpha6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway. Zhan XQ, etal., J Neurochem. 2014 Feb;128(3):350-62. doi: 10.1111/jnc.12471. Epub 2013 Oct 24.
117. [Tsc1 promoter methylation rate, mTOR expression in food-induced obese rat hypothalamus]. Zhang L, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Jan;46(1):47-50.
118. Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways. Zhang L, etal., Transplantation. 2013 Nov 15;96(9):782-90. doi: 10.1097/TP.0b013e3182a2034f.
119. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, etal., Apoptosis. 2013 Apr;18(4):423-34. doi: 10.1007/s10495-013-0811-0.
120. Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1. Zhang W, etal., Exp Physiol. 2013 Dec;98(12):1696-704. doi: 10.1113/expphysiol.2013.074930. Epub 2013 Aug 16.
121. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Zhang Y, etal., Ann Rheum Dis. 2014 Mar 20. doi: 10.1136/annrheumdis-2013-204599.
122. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1alpha through mTOR-dependent pathway. Zhao Y, etal., Fitoterapia. 2014 Dec;99:318-27. doi: 10.1016/j.fitote.2014.10.009. Epub 2014 Oct 16.
123. Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia. Zhu Y, etal., Neurol Sci. 2013 Jul;34(7):1093-7. doi: 10.1007/s10072-012-1209-4. Epub 2012 Oct 9.
124. Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging. Zhuo L, etal., Mech Ageing Dev. 2009 Oct;130(10):700-8. doi: 10.1016/j.mad.2009.08.005. Epub 2009 Aug 19.
Additional References at PubMed
PMID:10325225   PMID:10471835   PMID:11438723   PMID:11707573   PMID:12140361   PMID:12150926   PMID:12522136   PMID:12718876   PMID:12766174   PMID:12881204   PMID:12935885   PMID:12937293  
PMID:14610086   PMID:14679009   PMID:14769825   PMID:15001544   PMID:15010853   PMID:15185396   PMID:15292249   PMID:15304378   PMID:15389631   PMID:15467718   PMID:15494402   PMID:15591312  
PMID:15604215   PMID:15613684   PMID:15692808   PMID:15886222   PMID:16027121   PMID:16079186   PMID:16344552   PMID:16408196   PMID:16455781   PMID:16507764   PMID:16597691   PMID:16710051  
PMID:16714284   PMID:16717100   PMID:16885218   PMID:16885413   PMID:16915281   PMID:17005863   PMID:17023663   PMID:17028174   PMID:17074751   PMID:17203200   PMID:17284572   PMID:17374702  
PMID:17429052   PMID:17510244   PMID:17556672   PMID:17698034   PMID:17885021   PMID:17897319   PMID:17950100   PMID:18097751   PMID:18160036   PMID:18221855   PMID:18247380   PMID:18262357  
PMID:18265001   PMID:18347059   PMID:18347658   PMID:18365011   PMID:18377870   PMID:18381428   PMID:18410586   PMID:18466337   PMID:18497260   PMID:18556237   PMID:18593953   PMID:18620060  
PMID:18641049   PMID:18651560   PMID:18660503   PMID:18663086   PMID:18670866   PMID:18695678   PMID:18722381   PMID:18762023   PMID:18842593   PMID:18925875   PMID:19297425   PMID:19340459  
PMID:19348060   PMID:19401455   PMID:19403715   PMID:19440205   PMID:19453943   PMID:19509187   PMID:19515910   PMID:19539716   PMID:19547753   PMID:19622787   PMID:19648118   PMID:19704009  
PMID:19734277   PMID:19818818   PMID:19846571   PMID:19883644   PMID:19884565   PMID:19940197   PMID:19946888   PMID:19961888   PMID:20019183   PMID:20152809   PMID:20187447   PMID:20206401  
PMID:20233713   PMID:20352108   PMID:20368999   PMID:20381137   PMID:20399760   PMID:20466002   PMID:20473743   PMID:20513425   PMID:20517583   PMID:20526321   PMID:20537536   PMID:20538043  
PMID:20543138   PMID:20890458   PMID:20976781   PMID:21041654   PMID:21045808   PMID:21208419   PMID:21258367   PMID:21285325   PMID:21289215   PMID:21368105   PMID:21371020   PMID:21404070  
PMID:21439355   PMID:21472380   PMID:21478152   PMID:21525000   PMID:21602475   PMID:21613414   PMID:21720156   PMID:21750711   PMID:21858874   PMID:21876538   PMID:21925170   PMID:21949366  
PMID:22021677   PMID:22104347   PMID:22170591   PMID:22178140   PMID:22205374   PMID:22242835   PMID:22275758   PMID:22294347   PMID:22341316   PMID:22343943   PMID:22378614   PMID:22424946  
PMID:22467681   PMID:22513717   PMID:22567115   PMID:22576015   PMID:22577289   PMID:22684415   PMID:22692423   PMID:22768106   PMID:22802527   PMID:22848442   PMID:22875481   PMID:22889863  
PMID:22899279   PMID:22999929   PMID:23056530   PMID:23142719   PMID:23167446   PMID:23193052   PMID:23197407   PMID:23197706   PMID:23239524   PMID:23265586   PMID:23274896   PMID:23342106  
PMID:23372143   PMID:23395931   PMID:23429704   PMID:23566837   PMID:23583278   PMID:23607966   PMID:23618858   PMID:23707523   PMID:23726960   PMID:23728790   PMID:23788393   PMID:23836929  
PMID:23852509   PMID:23920219   PMID:23994018   PMID:24006279   PMID:24011591   PMID:24036451   PMID:24040371   PMID:24067463   PMID:24068000   PMID:24101522   PMID:24127984   PMID:24131573  
PMID:24194502   PMID:24270265   PMID:24374752   PMID:24462113   PMID:24576152   PMID:24667246   PMID:24670654   PMID:24797554   PMID:24801387   PMID:24889507   PMID:24889758   PMID:24976516  
PMID:25001019   PMID:25017576   PMID:25029414   PMID:25040634   PMID:25047835   PMID:25056347   PMID:25057926   PMID:25139234   PMID:25146548   PMID:25218136   PMID:25288788   PMID:25294810  
PMID:25304210   PMID:25327288   PMID:25358492   PMID:25411504   PMID:25428129   PMID:25471136   PMID:25479925   PMID:25674207   PMID:25706655   PMID:25759412   PMID:25816157   PMID:25871970  
PMID:25888508   PMID:25918725   PMID:25924882   PMID:25936802   PMID:25944900   PMID:26018084   PMID:26120832   PMID:26160071   PMID:26164831   PMID:26181632   PMID:26271595   PMID:26362885  
PMID:26400964   PMID:26409044   PMID:26410627   PMID:26449613   PMID:26558695   PMID:26572647   PMID:26636543   PMID:26648565   PMID:26695882   PMID:26706460   PMID:26770837   PMID:26823769  
PMID:26847932   PMID:27035760   PMID:27049295   PMID:27105917   PMID:27163752   PMID:27217700   PMID:27223630   PMID:27235551   PMID:27367537   PMID:27423593   PMID:27458160   PMID:27502839  
PMID:27631411   PMID:27762461   PMID:27791458   PMID:27891586   PMID:27919618   PMID:27997905   PMID:28025572   PMID:28041982   PMID:28084108   PMID:28130174   PMID:28147330   PMID:28161641  
PMID:28198521   PMID:28213972   PMID:28223137   PMID:28320092   PMID:28320103   PMID:28340591   PMID:28686615   PMID:28689409   PMID:28759157   PMID:28855439   PMID:28928406   PMID:28939765  
PMID:29084578   PMID:29127238   PMID:29137981   PMID:29237506   PMID:29277549   PMID:29278652   PMID:29287199   PMID:29311141   PMID:29315934   PMID:29353374   PMID:29466698   PMID:29506051  
PMID:29509258   PMID:29563162   PMID:29674181   PMID:29695414   PMID:29719042   PMID:29737948   PMID:29750193   PMID:29750810   PMID:29762821   PMID:29786755   PMID:29803175   PMID:29916537  
PMID:29956767   PMID:29975938   PMID:30030400   PMID:30041644   PMID:30050390   PMID:30066841   PMID:30089868   PMID:30317878   PMID:30391592   PMID:30444896   PMID:30541899   PMID:30704899  
PMID:30755615   PMID:30789219   PMID:30887674   PMID:30905926   PMID:30940563   PMID:30956113   PMID:31274018   PMID:31309116   PMID:31368880   PMID:31462148   PMID:31517703   PMID:31534118  
PMID:31593688   PMID:31698999   PMID:31759056   PMID:31899964   PMID:31994822   PMID:32003536   PMID:32061737   PMID:32124939   PMID:32236586   PMID:32383265   PMID:32572931   PMID:32651677  
PMID:32712090   PMID:32713334   PMID:32715402   PMID:32867795   PMID:32940340   PMID:33086033   PMID:33212156   PMID:33245682   PMID:33378666   PMID:33537831   PMID:33990769   PMID:33992580  
PMID:34071043   PMID:34138410   PMID:34265467   PMID:34278477   PMID:34338399   PMID:34338758   PMID:34374900   PMID:34655015   PMID:34736532   PMID:34874016   PMID:34926690   PMID:35030973  
PMID:35276811   PMID:35727683   PMID:35904584   PMID:35926274   PMID:36527650   PMID:36586551   PMID:36767264   PMID:36917311   PMID:37191448   PMID:37200987   PMID:37308416   PMID:37511214  
PMID:37633909   PMID:37644373   PMID:37653221   PMID:37702892   PMID:37858960   PMID:38325289  


Genomics

Comparative Map Data
Mtor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,167,985 - 164,277,438 (+)NCBIGRCr8
mRatBN7.25158,884,856 - 158,994,311 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,601,607 - 161,711,017 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,423,732 - 163,533,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,380,079 - 163,489,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
MTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,106,535 - 11,262,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,106,535 - 11,262,556 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,166,592 - 11,322,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
T2T-CHM13v2.0110,648,106 - 10,804,142 (-)NCBIT2T-CHM13v2.0
Mtor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)EnsemblGRCm39 Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBIMGSCv36mm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
Mtor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,487,642 - 2,599,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,487,642 - 2,599,694 (+)NCBIChiLan1.0ChiLan1.0
MTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,957,987 - 217,115,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,604,358 - 215,761,670 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
MTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,349,286 - 81,469,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,486,181 - 85,601,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,480,139 - 85,601,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,229,433 - 82,349,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,231,190 - 83,351,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,293,674 - 84,413,764 (+)NCBIUU_Cfam_GSD_1.0
Mtor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,333,597 - 34,457,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474157,590 - 282,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474158,376 - 282,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,522,667 - 120,678,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,525,737 - 120,679,020 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605424,431,846 - 24,582,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,570,276 - 1,698,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,570,155 - 1,698,264 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtor
273 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:112
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000014167
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH134710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,994,128 - 158,994,298 (+)MAPPERmRatBN7.2
Rnor_6.05165,373,785 - 165,373,954NCBIRnor6.0
Rnor_5.05169,030,386 - 169,030,555UniSTSRnor5.0
RGSC_v3.45165,640,717 - 165,640,886UniSTSRGSC3.4
Celera5157,270,717 - 157,270,886UniSTS
RH 3.4 Map51106.7UniSTS
Cytogenetic Map5q36UniSTS
MARC_7131-7132:996687522:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,986,103 - 158,986,565 (+)MAPPERmRatBN7.2
mRatBN7.25158,986,520 - 158,986,565 (+)MAPPERmRatBN7.2
mRatBN7.25158,986,103 - 158,986,808 (+)MAPPERmRatBN7.2
Rnor_6.05165,365,472 - 165,366,221NCBIRnor6.0
Rnor_6.05165,365,472 - 165,365,933NCBIRnor6.0
Rnor_5.05169,022,073 - 169,022,822UniSTSRnor5.0
Rnor_5.05169,022,073 - 169,022,534UniSTSRnor5.0
RGSC_v3.45165,632,692 - 165,633,153UniSTSRGSC3.4
Celera5157,262,692 - 157,263,153UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 45 29 19 29 8 11 74 35 41 11 8
Low 2 12 12 12
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000014167   ⟹   ENSRNOP00000014167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)Ensembl
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080751   ⟹   ENSRNOP00000070162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,884,846 - 158,994,311 (+)Ensembl
Rnor_6.0 Ensembl5165,267,368 - 165,372,472 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113961   ⟹   ENSRNOP00000094256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,887,995 - 158,994,311 (+)Ensembl
RefSeq Acc Id: NM_019906   ⟹   NP_063971
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,167,985 - 164,277,438 (+)NCBI
mRatBN7.25158,884,856 - 158,994,311 (+)NCBI
Rnor_6.05165,263,813 - 165,373,967 (+)NCBI
Rnor_5.05168,920,414 - 169,030,568 (+)NCBI
RGSC_v3.45165,531,402 - 165,640,899 (+)RGD
Celera5157,161,454 - 157,270,899 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_063971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20091 (Get FASTA)   NCBI Sequence Viewer  
  AAA65929 (Get FASTA)   NCBI Sequence Viewer  
  EDL81121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014167.5
  ENSRNOP00000070162.2
  ENSRNOP00000094256
  ENSRNOP00000094256.1
GenBank Protein P42346 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_063971   ⟸   NM_019906
- UniProtKB: P42346 (UniProtKB/Swiss-Prot),   A6IU70 (UniProtKB/TrEMBL),   A0A8I6APT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070162   ⟸   ENSRNOT00000080751
RefSeq Acc Id: ENSRNOP00000014167   ⟸   ENSRNOT00000014167
RefSeq Acc Id: ENSRNOP00000094256   ⟸   ENSRNOT00000113961
Protein Domains
FAT   FATC   PI3K/PI4K catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42346-F1-model_v2 AlphaFold P42346 1-2549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694261
Promoter ID:EPDNEW_R4786
Type:multiple initiation site
Name:Mtor_1
Description:mechanistic target of rapamycin kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05165,263,742 - 165,263,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68371 AgrOrtholog
BioCyc Gene G2FUF-39164 BioCyc
Ensembl Genes ENSRNOG00000009615 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014167.8 UniProtKB/TrEMBL
  ENSRNOT00000080751.2 UniProtKB/TrEMBL
  ENSRNOT00000113961 ENTREZGENE
  ENSRNOT00000113961.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3385_TOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FRB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FRB_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56718 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 56718 ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11139:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FRB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FRAP1 RGD
PhenoGen Mtor PhenoGen
PROSITE FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009615 RatGTEx
SMART DUF3385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rapamycin_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47212 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218708
UniProt A0A0G2JX74_RAT UniProtKB/TrEMBL
  A0A8I6APT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q797_RAT UniProtKB/TrEMBL
  A6IU70 ENTREZGENE, UniProtKB/TrEMBL
  MTOR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Mtor  mechanistic target of rapamycin kinase  Mtor  mechanistic target of rapamycin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-17 Mtor  mechanistic target of rapamycin  Mtor  mechanistic target of rapamycin (serine/threonine kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Mtor  mechanistic target of rapamycin (serine/threonine kinase)  Frap1  FK506 binding protein 12-rapamycin associated protein 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Frap1  FK506 binding protein 12-rapamycin associated protein 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference