Slc35e2b (solute carrier family 35, member E2B) - Rat Genome Database

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Gene: Slc35e2b (solute carrier family 35, member E2B) Rattus norvegicus
Analyze
Symbol: Slc35e2b
Name: solute carrier family 35, member E2B
RGD ID: 1309076
Description: Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to several human genes including SLC35E2B (solute carrier family 35 member E2B); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC313765; Slc35e2; solute carrier family 35 member E2; solute carrier family 35 member E2B; solute carrier family 35, member E2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,465,222 - 171,493,317 (+)NCBIGRCr8
mRatBN7.25166,185,166 - 166,211,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,185,166 - 166,207,021 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,890,156 - 168,912,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,711,570 - 170,733,462 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,674,112 - 170,696,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,024,335 - 173,050,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,024,335 - 173,046,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,499,465 - 176,521,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,431,714 - 172,453,709 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,450,317 - 172,464,088 (+)NCBI
Celera5164,386,773 - 164,408,383 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27869233  


Genomics

Comparative Map Data
Slc35e2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,465,222 - 171,493,317 (+)NCBIGRCr8
mRatBN7.25166,185,166 - 166,211,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,185,166 - 166,207,021 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,890,156 - 168,912,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,711,570 - 170,733,462 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,674,112 - 170,696,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,024,335 - 173,050,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,024,335 - 173,046,194 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,499,465 - 176,521,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,431,714 - 172,453,709 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,450,317 - 172,464,088 (+)NCBI
Celera5164,386,773 - 164,408,383 (+)NCBICelera
Cytogenetic Map5q36NCBI
SLC35E2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,661,478 - 1,692,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,659,529 - 1,692,795 (-)EnsemblGRCh38hg38GRCh38
GRCh3711,592,939 - 1,624,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,582,799 - 1,618,022 (-)NCBINCBI36Build 36hg18NCBI36
Celera1953,254 - 984,414 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1869,815 - 900,273 (-)NCBIHuRef
CHM1_111,579,995 - 1,611,162 (-)NCBICHM1_1
T2T-CHM13v2.011,095,940 - 1,127,231 (-)NCBIT2T-CHM13v2.0
Slc35e2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,685,873 - 155,707,797 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,685,873 - 155,707,797 (+)EnsemblGRCm39 Ensembl
GRCm384155,601,416 - 155,623,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,601,416 - 155,623,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,975,525 - 154,997,449 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,445,216 - 154,467,140 (+)NCBIMGSCv36mm8
Celera4157,876,331 - 157,898,350 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.62NCBI
SLC35E2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,521,776 - 226,556,034 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,176,903 - 225,211,985 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01429,954 - 458,052 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,581,352 - 1,613,835 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,581,352 - 1,613,835 (-)Ensemblpanpan1.1panPan2
SLC35E2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,715,798 - 56,739,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,718,550 - 56,738,420 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,791,440 - 56,815,168 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,917,815 - 56,941,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,918,900 - 56,938,978 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,910,752 - 56,932,368 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,800,879 - 56,824,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,190,883 - 57,214,660 (-)NCBIUU_Cfam_GSD_1.0
SLC35E2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,820,812 - 63,835,561 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,820,804 - 63,842,400 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,250,371 - 58,261,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC35E2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,808,281 - 129,843,006 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,824,956 - 129,846,114 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605434,261,891 - 34,301,029 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Slc35e2b
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:42
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000023097
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
AI008692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,197,864 - 166,198,057 (+)MAPPERmRatBN7.2
Rnor_6.05173,037,034 - 173,037,226NCBIRnor6.0
Rnor_5.05176,512,164 - 176,512,356UniSTSRnor5.0
RGSC_v3.45172,444,414 - 172,444,606UniSTSRGSC3.4
Celera5164,399,226 - 164,399,418UniSTS
RH 3.4 Map51144.1UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6 45 29 16 29 74 29 36 9
Low 2 37 12 12 3 12 8 11 6 5 2 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023097   ⟹   ENSRNOP00000023097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,185,166 - 166,207,021 (+)Ensembl
Rnor_6.0 Ensembl5173,024,335 - 173,046,194 (+)Ensembl
RefSeq Acc Id: NM_001107998   ⟹   NP_001101468
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,467,428 - 171,489,283 (+)NCBI
mRatBN7.25166,185,166 - 166,207,021 (+)NCBI
Rnor_6.05173,024,335 - 173,046,194 (+)NCBI
Rnor_5.05176,499,465 - 176,521,588 (+)NCBI
RGSC_v3.45172,431,714 - 172,453,709 (+)RGD
Celera5164,386,773 - 164,408,383 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239572   ⟹   XP_006239634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,465,627 - 171,493,317 (+)NCBI
mRatBN7.25166,185,179 - 166,211,055 (+)NCBI
Rnor_6.05173,024,338 - 173,050,228 (+)NCBI
Rnor_5.05176,499,465 - 176,521,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239573   ⟹   XP_006239635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,465,227 - 171,488,220 (+)NCBI
mRatBN7.25166,185,624 - 166,203,120 (+)NCBI
Rnor_6.05173,024,656 - 173,042,124 (+)NCBI
Rnor_5.05176,499,465 - 176,521,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764361   ⟹   XP_008762583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,465,222 - 171,488,220 (+)NCBI
mRatBN7.25166,185,621 - 166,203,120 (+)NCBI
Rnor_6.05173,024,656 - 173,042,161 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101468 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239634 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239635 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762583 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023097
  ENSRNOP00000023097.2
RefSeq Acc Id: NP_001101468   ⟸   NM_001107998
- UniProtKB: D4A0R5 (UniProtKB/TrEMBL),   A6IUQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239634   ⟸   XM_006239572
- Peptide Label: isoform X1
- UniProtKB: D4A0R5 (UniProtKB/TrEMBL),   A6IUQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239635   ⟸   XM_006239573
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008762583   ⟸   XM_008764361
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000023097   ⟸   ENSRNOT00000023097
Protein Domains
Sugar phosphate transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0R5-F1-model_v2 AlphaFold D4A0R5 1-405 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694321
Promoter ID:EPDNEW_R4846
Type:initiation region
Name:Slc35e2b_1
Description:solute carrier family 35, member E2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,024,806 - 173,024,866EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309076 AgrOrtholog
BioCyc Gene G2FUF-38918 BioCyc
Ensembl Genes ENSRNOG00000017075 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023097 ENTREZGENE
  ENSRNOT00000023097.5 UniProtKB/TrEMBL
InterPro DUF250 UniProtKB/TrEMBL
KEGG Report rno:313765 UniProtKB/TrEMBL
NCBI Gene 313765 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 35 UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 35 MEMBER E2A-RELATED UniProtKB/TrEMBL
Pfam TPT UniProtKB/TrEMBL
PhenoGen Slc35e2b PhenoGen
RatGTEx ENSRNOG00000017075 RatGTEx
Superfamily-SCOP Multidrug resistance efflux transporter EmrE UniProtKB/TrEMBL
UniProt A6IUQ8 ENTREZGENE, UniProtKB/TrEMBL
  D4A0R5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-02 Slc35e2b  solute carrier family 35, member E2B  Slc35e2  solute carrier family 35, member E2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc35e2  solute carrier family 35, member E2   Slc35e2_predicted  solute carrier family 35, member E2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc35e2_predicted  solute carrier family 35, member E2 (predicted)      Symbol and Name status set to approved 70820 APPROVED