Acot7 (acyl-CoA thioesterase 7) - Rat Genome Database
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Gene: Acot7 (acyl-CoA thioesterase 7) Rattus norvegicus
Analyze
Symbol: Acot7
Name: acyl-CoA thioesterase 7
RGD ID: 628856
Description: Exhibits acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process and purine nucleoside bisphosphate metabolic process. Localizes to cytosol. Orthologous to human ACOT7 (acyl-CoA thioesterase 7); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ACH1; ACT; Bach; brain acyl-CoA hydrolase; CTE-II; CTE-IIa; CTE-IIb; cytosolic acyl coenzyme A thioester hydrolase; LACH1; long chain acyl-CoA thioester hydrolase; MGC105261; MTE-II; Rbach
Orthologs:
Homo sapiens (human) : ACOT7 (acyl-CoA thioesterase 7)  HGNC  Alliance
Mus musculus (house mouse) : Acot7 (acyl-CoA thioesterase 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acot7 (acyl-CoA thioesterase 7)
Pan paniscus (bonobo/pygmy chimpanzee) : ACOT7 (acyl-CoA thioesterase 7)
Canis lupus familiaris (dog) : ACOT7 (acyl-CoA thioesterase 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acot7 (acyl-CoA thioesterase 7)
Sus scrofa (pig) : ACOT7 (acyl-CoA thioesterase 7)
Chlorocebus sabaeus (African green monkey) : ACOT7 (acyl-CoA thioesterase 7)
Heterocephalus glaber (naked mole-rat) : Acot7 (acyl-CoA thioesterase 7)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05169,357,582 - 169,450,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,357,517 - 169,450,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,912,096 - 173,003,554 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,409,306 - 169,501,907 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15169,419,590 - 169,512,094 (+)NCBI
Celera5160,918,240 - 161,010,763 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
folic acid  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell body  (ISO)
cytoplasm  (ISO)
cytosol  (IBA,IDA,ISO)
neuron projection  (ISO)
nucleoplasm  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7906114   PMID:10578051   PMID:11755680   PMID:11834298   PMID:12435388   PMID:12477932   PMID:15489334   PMID:16103133   PMID:17563367   PMID:18324622   PMID:19056867  


Genomics

Comparative Map Data
Acot7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05169,357,582 - 169,450,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,357,517 - 169,450,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,912,096 - 173,003,554 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,409,306 - 169,501,907 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15169,419,590 - 169,512,094 (+)NCBI
Celera5160,918,240 - 161,010,763 (+)NCBICelera
Cytogenetic Map5q36NCBI
ACOT7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl16,264,269 - 6,394,391 (-)EnsemblGRCh38hg38GRCh38
GRCh3816,264,272 - 6,393,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716,324,332 - 6,453,826 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,246,919 - 6,376,413 (-)NCBINCBI36hg18NCBI36
Celera15,438,842 - 5,568,337 (-)NCBI
Cytogenetic Map1p36.31NCBI
HuRef15,472,303 - 5,601,612 (-)NCBIHuRef
CHM1_116,312,939 - 6,442,400 (-)NCBICHM1_1
Acot7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,258,872 - 152,356,312 (+)NCBI
GRCm384152,178,100 - 152,271,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,178,134 - 152,271,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,552,209 - 151,645,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv364151,021,934 - 151,115,647 (+)NCBImm8
Celera4154,464,405 - 154,558,717 (+)NCBICelera
Cytogenetic Map4E2NCBI
Acot7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,188,102 - 6,259,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,188,102 - 6,258,230 (+)NCBIChiLan1.0ChiLan1.0
ACOT7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.116,287,177 - 6,402,767 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v015,030,488 - 5,154,800 (-)NCBIMhudiblu_PPA_v0panPan3
ACOT7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl560,153,616 - 60,239,239 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1560,153,616 - 60,239,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Acot7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366231,112,021 - 1,191,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,152,428 - 67,254,103 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,152,428 - 67,254,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,103,745 - 62,205,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20125,345,670 - 125,474,690 (+)Ensembl
ChlSab1.120125,345,636 - 125,474,650 (+)NCBI
Acot7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248185,048,410 - 5,142,135 (+)NCBI

Position Markers
RH129039  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05169,449,965 - 169,450,181NCBIRnor6.0
Rnor_5.05173,003,304 - 173,003,520UniSTSRnor5.0
RGSC_v3.45169,501,657 - 169,501,873UniSTSRGSC3.4
Celera5161,010,513 - 161,010,729UniSTS
Cytogenetic Map5q36UniSTS
RH 3.4 Map51139.3UniSTS
AW557066  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05169,449,821 - 169,449,971NCBIRnor6.0
Rnor_5.05173,003,160 - 173,003,310UniSTSRnor5.0
RGSC_v3.45169,501,513 - 169,501,663UniSTSRGSC3.4
Celera5161,010,369 - 161,010,519UniSTS
Cytogenetic Map5q36UniSTS
D1S2335E  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05169,439,820 - 169,439,936NCBIRnor6.0
Rnor_5.05172,993,159 - 172,993,275UniSTSRnor5.0
RGSC_v3.45169,491,512 - 169,491,628UniSTSRGSC3.4
Celera5161,000,368 - 161,000,484UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5157319671173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5157319671171194163Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5161084664173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:346
Count of miRNA genes:126
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000000079, ENSRNOT00000014213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 36 27 15 27 3 74 29 36 9
Low 7 21 14 4 14 8 8 6 5 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07050551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07050552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07073195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01040997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01040998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01040999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01041000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK469690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY317682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000079   ⟹   ENSRNOP00000000079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5169,357,517 - 169,450,219 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000014213   ⟹   ENSRNOP00000014213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5169,364,306 - 169,450,214 (+)Ensembl
RefSeq Acc Id: NM_001146061   ⟹   NP_001139533
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,364,306 - 169,450,215 (+)NCBI
Rnor_5.05172,912,096 - 173,003,554 (+)NCBI
RGSC_v3.45169,409,306 - 169,501,907 (+)RGD
Celera5160,924,964 - 161,010,763 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013214   ⟹   NP_037346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,357,582 - 169,450,215 (+)NCBI
Rnor_5.05172,912,096 - 173,003,554 (+)NCBI
RGSC_v3.45169,409,306 - 169,501,907 (+)RGD
Celera5160,918,240 - 161,010,763 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239448   ⟹   XP_006239510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,378,805 - 169,450,215 (+)NCBI
Rnor_5.05172,912,096 - 173,003,554 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037346   ⟸   NM_013214
- Peptide Label: isoform 2
- UniProtKB: Q64559 (UniProtKB/Swiss-Prot),   F8WG67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139533   ⟸   NM_001146061
- Peptide Label: isoform 1
- UniProtKB: Q64559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239510   ⟸   XM_006239448
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000000079   ⟸   ENSRNOT00000000079
RefSeq Acc Id: ENSRNOP00000014213   ⟸   ENSRNOT00000014213
Protein Domains
HotDog ACOT-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694303
Promoter ID:EPDNEW_R4824
Type:initiation region
Name:Acot7_1
Description:acyl-CoA thioesterase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4825  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,357,614 - 169,357,674EPDNEW
RGD ID:13694301
Promoter ID:EPDNEW_R4825
Type:initiation region
Name:Acot7_2
Description:acyl-CoA thioesterase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4824  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,364,301 - 169,364,361EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628856 AgrOrtholog
Ensembl Genes ENSRNOG00000010580 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000079 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000014213 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000079 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000014213 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7316866 IMAGE-MGC_LOAD
InterPro Cytosol_ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOTDOG_ACOT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HotDog_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioestr_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26759 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105261 IMAGE-MGC_LOAD
NCBI Gene 26759 ENTREZGENE
PANTHER PTHR11049 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 4HBT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acot7 PhenoGen
PROSITE HOTDOG_ACOT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54637 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.6024 ENTREZGENE
UniProt BACH_RAT UniProtKB/Swiss-Prot
  F8WG67 ENTREZGENE, UniProtKB/TrEMBL
  Q64559 ENTREZGENE
UniProt Secondary O08652 UniProtKB/Swiss-Prot
  O09041 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Acot7  acyl-CoA thioesterase 7  Bach  brain acyl-CoA hydrolase  Symbol and Name updated 1299863 APPROVED
2005-01-20 Bach  brain acyl-CoA hydrolase      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Bach  brain acyl-CoA hydrolase      Symbol and Name status set to provisional 70820 PROVISIONAL