Symbol:
Acot7
Name:
acyl-CoA thioesterase 7
Description:
Exhibits acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process and purine nucleoside bisphosphate metabolic process. Localizes to the cytosol. Orthologous to human ACOT7 (acyl-CoA thioesterase 7); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (RS)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
ACH1; ACT; Bach; brain acyl-CoA hydrolase; CTE-II; CTE-IIa; CTE-IIb; cytosolic acyl coenzyme A thioester hydrolase; LACH1; long chain acyl-CoA thioester hydrolase; MGC105261; MTE-II; Rbach
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACOT7 (acyl-CoA thioesterase 7) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Acot7 (acyl-CoA thioesterase 7) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Acot7 (acyl-CoA thioesterase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ACOT7 (acyl-CoA thioesterase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ACOT7 (acyl-CoA thioesterase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Acot7 (acyl-CoA thioesterase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACOT7 (acyl-CoA thioesterase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ACOT7 (acyl-CoA thioesterase 7)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Acot7 (acyl-CoA thioesterase 7)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
acot7 (acyl-CoA thioesterase 7)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 169,357,582 - 169,450,215 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 169,357,517 - 169,450,219 (+) Ensembl Rnor_5.0 5 172,912,096 - 173,003,554 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 169,409,306 - 169,501,907 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 169,419,590 - 169,512,094 (+) NCBI Celera 5 160,918,240 - 161,010,763 (+) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(RS)-amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of ACOT7 mRNA CTD PMID:30779732 17alpha-ethynylestradiol affects expression ISO RGD:1558456 6480464 Ethinyl Estradiol affects the expression of BACH mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO RGD:733878 6480464 Estradiol results in increased expression of ACOT7 mRNA CTD PMID:19167446 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733878 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACOT7 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1558456 6480464 Tetrachlorodibenzodioxin affects the expression of ACOT7 mRNA CTD PMID:18343893 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1558456 6480464 Tetrachlorodibenzodioxin results in increased expression of ACOT7 mRNA CTD PMID:15328365 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACOT7 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733878 6480464 Tetrachlorodibenzodioxin results in increased expression of ACOT7 mRNA CTD PMID:19684285 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO RGD:1558456 6480464 2 more ... CTD PMID:18343893 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of ACOT7 mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:1558456 6480464 3 more ... CTD PMID:23994337 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1558456 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ACOT7 mRNA CTD PMID:26251327 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of ACOT7 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:733878 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACOT7 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACOT7 mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide increases expression ISO RGD:1558456 6480464 Fenretinide results in increased expression of ACOT7 mRNA CTD PMID:28973697 5-fluorouracil affects response to substance ISO RGD:733878 6480464 ACOT7 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime multiple interactions ISO RGD:733878 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases expression ISO RGD:733878 6480464 6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 aflatoxin B1 decreases expression ISO RGD:733878 6480464 Aflatoxin B1 results in decreased expression of ACOT7 mRNA CTD PMID:22100608 aflatoxin B1 increases methylation ISO RGD:733878 6480464 Aflatoxin B1 results in increased methylation of ACOT7 gene CTD PMID:27153756 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ACOT7 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:733878 6480464 Arsenic affects the methylation of ACOT7 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:733878 6480464 Arsenic affects the methylation of ACOT7 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:733878 6480464 Arsenic affects the methylation of ACOT7 gene CTD PMID:25304211 atrazine decreases expression ISO RGD:733878 6480464 Atrazine results in decreased expression of ACOT7 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression ISO RGD:1558456 6480464 Benzo(a)pyrene results in increased expression of ACOT7 mRNA CTD PMID:22228805 beta-naphthoflavone increases expression ISO RGD:1558456 6480464 beta-Naphthoflavone results in increased expression of ACOT7 mRNA CTD PMID:23994337 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ACOT7 mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ACOT7 gene CTD PMID:28505145 bisphenol A decreases methylation ISO RGD:1558456 6480464 bisphenol A results in decreased methylation of ACOT7 promoter CTD PMID:27312807 bisphenol A increases methylation ISO RGD:1558456 6480464 bisphenol A results in increased methylation of ACOT7 promoter CTD PMID:27312807 bisphenol A multiple interactions ISO RGD:733878 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACOT7 mRNA CTD PMID:28628672 bisphenol F multiple interactions ISO RGD:733878 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACOT7 mRNA CTD PMID:28628672 bortezomib decreases expression ISO RGD:733878 6480464 Bortezomib results in decreased expression of ACOT7 mRNA CTD PMID:20977926 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of ACOT7 mRNA CTD PMID:22110744 carbon nanotube increases expression ISO RGD:733878 6480464 Nanotubes, Carbon results in increased expression of ACOT7 mRNA CTD PMID:28673683 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ACOT7 mRNA CTD PMID:17602206 cobalt dichloride increases expression ISO RGD:733878 6480464 cobaltous chloride results in increased expression of ACOT7 mRNA CTD PMID:19320972 coumestrol increases expression ISO RGD:733878 6480464 Coumestrol results in increased expression of ACOT7 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:733878 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 crocidolite asbestos increases expression ISO RGD:733878 6480464 Asbestos, Crocidolite results in increased expression of ACOT7 mRNA CTD PMID:29523930 cyclosporin A decreases expression ISO RGD:733878 6480464 Cyclosporine results in decreased expression of ACOT7 mRNA CTD PMID:27989131 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of ACOT7 mRNA CTD PMID:14618091 dexamethasone multiple interactions ISO RGD:733878 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACOT7 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACOT7 mRNA CTD PMID:28628672 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] affects the expression of ACOT7 mRNA CTD PMID:18636392 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of ACOT7 mRNA CTD PMID:29391264 Enterolactone multiple interactions ISO RGD:733878 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ACOT7 mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:733878 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ACOT7 protein CTD PMID:23301498 ethanol decreases expression ISO RGD:733878 6480464 Ethanol results in decreased expression of ACOT7 mRNA CTD PMID:23378141 ethanol increases expression ISO RGD:1558456 6480464 Ethanol results in increased expression of ACOT7 mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of ACOT7 mRNA CTD PMID:24136188 GW 4064 increases expression ISO RGD:733878 6480464 GW 4064 results in increased expression of ACOT7 mRNA CTD PMID:30611723 GW 4064 multiple interactions ISO RGD:733878 6480464 [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT7 mRNA CTD PMID:30611723 hydrogen peroxide multiple interactions ISO RGD:733878 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACOT7 protein CTD PMID:18951874 indometacin multiple interactions ISO RGD:733878 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACOT7 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACOT7 mRNA CTD PMID:28628672 lead diacetate increases expression ISO RGD:1558456 6480464 lead acetate results in increased expression of ACOT7 mRNA CTD PMID:21829687 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of ACOT7 mRNA CTD PMID:24136188 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ACOT7 mRNA CTD PMID:17602206 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of ACOT7 mRNA CTD PMID:24136188 nickel atom increases expression ISO RGD:733878 6480464 Nickel results in increased expression of ACOT7 mRNA CTD PMID:25583101 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of ACOT7 mRNA CTD PMID:24136188 oleic acid multiple interactions ISO RGD:733878 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] affects the expression of ACOT7 mRNA CTD PMID:18636392 paracetamol affects expression ISO RGD:1558456 6480464 Acetaminophen affects the expression of ACOT7 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:733878 6480464 Acetaminophen results in increased expression of ACOT7 mRNA CTD PMID:25704631 , PMID:29067470 paracetamol affects response to substance ISO RGD:733878 6480464 ACOT7 gene polymorphism affects the susceptibility to Acetaminophen CTD PMID:26104854 paraquat affects expression EXP 6480464 Paraquat affects the expression of BACH mRNA CTD PMID:15206577 perfluorooctane-1-sulfonic acid increases expression ISO RGD:733878 6480464 perfluorooctane sulfonic acid results in increased expression of ACOT7 mRNA CTD PMID:27153767 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of ACOT7 mRNA CTD PMID:19162173 , PMID:28511854 pirinixic acid multiple interactions ISO RGD:733878 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACOT7 mRNA CTD PMID:19710929 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of ACOT7 mRNA, pirinixic acid results in increased expression of BACH mRNA CTD PMID:16940010 more ... pirinixic acid increases expression ISO RGD:1558456 6480464 pirinixic acid results in increased expression of ACOT7 mRNA CTD PMID:15375163 more ... progesterone affects expression ISO RGD:1558456 6480464 Progesterone affects the expression of ACOT7 mRNA CTD PMID:17251523 quinoline increases expression ISO RGD:733878 6480464 quinoline analog results in increased expression of ACOT7 protein CTD PMID:18645022 resveratrol multiple interactions ISO RGD:733878 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of ACOT7 mRNA CTD PMID:19167446 sodium arsenite increases expression ISO RGD:733878 6480464 sodium arsenite results in increased expression of ACOT7 mRNA CTD PMID:28595984 sodium fluoride increases expression ISO RGD:1558456 6480464 Sodium Fluoride results in increased expression of ACOT7 protein CTD PMID:28918527 tamoxifen affects expression ISO RGD:1558456 6480464 Tamoxifen affects the expression of BACH mRNA CTD PMID:17555576 tert-butyl hydroperoxide increases expression ISO RGD:1558456 6480464 tert-Butylhydroperoxide results in increased expression of ACOT7 mRNA CTD PMID:15003993 Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of ACOT7 mRNA CTD PMID:21515302 thapsigargin decreases expression ISO RGD:733878 6480464 Thapsigargin results in decreased expression of ACOT7 mRNA CTD PMID:22378314 theophylline multiple interactions ISO RGD:733878 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACOT7 protein CTD PMID:18951874 trichloroethene affects expression ISO RGD:1558456 6480464 Trichloroethylene affects the expression of ACOT7 mRNA CTD PMID:29353386 trimellitic anhydride increases expression ISO RGD:1558456 6480464 trimellitic anhydride results in increased expression of ACOT7 mRNA CTD PMID:19042947 trimellitic anhydride decreases methylation ISO RGD:1558456 6480464 trimellitic anhydride results in decreased methylation of ACOT7 promoter CTD PMID:24675093 troglitazone increases expression EXP 6480464 troglitazone results in increased expression of ACOT7 mRNA CTD PMID:21515302 tunicamycin decreases expression ISO RGD:733878 6480464 Tunicamycin results in decreased expression of ACOT7 mRNA CTD PMID:22378314 valproic acid increases expression ISO RGD:733878 6480464 Valproic Acid results in increased expression of ACOT7 mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:733878 6480464 Valproic Acid affects the expression of ACOT7 mRNA CTD PMID:25979313 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of ACOT7 mRNA CTD PMID:11717422 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of ACOT7 mRNA CTD PMID:11717422 
Gene-Chemical Interaction Annotations
