Acot7 (acyl-CoA thioesterase 7) - Rat Genome Database

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Gene: Acot7 (acyl-CoA thioesterase 7) Rattus norvegicus
Analyze
Symbol: Acot7
Name: acyl-CoA thioesterase 7
RGD ID: 628856
Description: Enables acyl-CoA hydrolase activity. Predicted to be involved in fatty acid biosynthetic process and purine nucleoside bisphosphate metabolic process. Predicted to act upstream of or within fatty acid catabolic process. Located in cytosol. Orthologous to human ACOT7 (acyl-CoA thioesterase 7); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACH1; ACT; Bach; brain acyl-CoA hydrolase; CTE-II; CTE-IIa; CTE-IIb; cytosolic acyl coenzyme A thioester hydrolase; LACH1; long chain acyl-CoA thioester hydrolase; MGC105261; MTE-II; Rbach
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25162,686,562 - 162,779,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,684,645 - 162,779,309 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,389,812 - 165,482,377 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05167,211,405 - 167,303,979 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05167,173,603 - 167,266,173 (+)NCBIRnor_WKY
Rnor_6.05169,357,582 - 169,450,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,357,517 - 169,450,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,912,096 - 173,003,554 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,409,306 - 169,501,907 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,419,590 - 169,512,094 (+)NCBI
Celera5160,918,240 - 161,010,763 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
finasteride  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of cDNA encoding rat brain cytosolic acyl-coenzyme A thioester hydrolase. Broustas CG, etal., J Biol Chem 1996 May 3;271(18):10470-6.
2. Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells. Engberg ST, etal., Biochem J 1997 Apr 15;323 ( Pt 2):525-31.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Molecular cloning and expression of cDNAs encoding rat brain and liver cytosolic long-chain acyl-CoA hydrolases. Yamada J, etal., Biochem Biophys Res Commun 1997 Mar 6;232(1):198-203.
Additional References at PubMed
PMID:7906114   PMID:10578051   PMID:11755680   PMID:11834298   PMID:12435388   PMID:12477932   PMID:15489334   PMID:16103133   PMID:17563367   PMID:18324622   PMID:19056867  


Genomics

Comparative Map Data
Acot7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25162,686,562 - 162,779,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,684,645 - 162,779,309 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,389,812 - 165,482,377 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05167,211,405 - 167,303,979 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05167,173,603 - 167,266,173 (+)NCBIRnor_WKY
Rnor_6.05169,357,582 - 169,450,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,357,517 - 169,450,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,912,096 - 173,003,554 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,409,306 - 169,501,907 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,419,590 - 169,512,094 (+)NCBI
Celera5160,918,240 - 161,010,763 (+)NCBICelera
Cytogenetic Map5q36NCBI
ACOT7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,264,272 - 6,393,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl16,264,269 - 6,393,767 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,324,332 - 6,453,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,246,919 - 6,376,413 (-)NCBINCBI36Build 36hg18NCBI36
Celera15,438,842 - 5,568,337 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,472,303 - 5,601,612 (-)NCBIHuRef
CHM1_116,312,939 - 6,442,400 (-)NCBICHM1_1
T2T-CHM13v2.015,789,916 - 5,919,409 (-)NCBIT2T-CHM13v2.0
Acot7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,258,872 - 152,356,312 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,262,591 - 152,356,312 (+)EnsemblGRCm39 Ensembl
GRCm384152,178,100 - 152,271,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,178,134 - 152,271,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,552,209 - 151,645,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364151,021,934 - 151,115,647 (+)NCBIMGSCv36mm8
Celera4154,464,405 - 154,558,717 (+)NCBICelera
Cytogenetic Map4E2NCBI
Acot7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,188,102 - 6,259,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,188,102 - 6,258,230 (+)NCBIChiLan1.0ChiLan1.0
ACOT7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.116,287,177 - 6,402,767 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v015,030,488 - 5,154,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACOT7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,153,616 - 60,239,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,153,616 - 60,239,239 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,163,440 - 60,265,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,369,414 - 60,471,489 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,369,414 - 60,471,855 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,368,684 - 60,471,165 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,235,482 - 60,337,604 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,637,013 - 60,739,144 (-)NCBIUU_Cfam_GSD_1.0
Acot7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,626,783 - 30,710,871 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366231,112,021 - 1,191,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,152,429 - 67,254,103 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,152,428 - 67,254,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,103,745 - 62,205,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,345,636 - 125,474,650 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,345,670 - 125,474,690 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,408,450 - 29,580,377 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acot7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248185,065,995 - 5,142,558 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248185,048,410 - 5,142,135 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH129039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,779,058 - 162,779,275 (+)MAPPERmRatBN7.2
Rnor_6.05169,449,965 - 169,450,181NCBIRnor6.0
Rnor_5.05173,003,304 - 173,003,520UniSTSRnor5.0
RGSC_v3.45169,501,657 - 169,501,873UniSTSRGSC3.4
Celera5161,010,513 - 161,010,729UniSTS
RH 3.4 Map51139.3UniSTS
Cytogenetic Map5q36UniSTS
AW557066  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,778,914 - 162,779,065 (+)MAPPERmRatBN7.2
Rnor_6.05169,449,821 - 169,449,971NCBIRnor6.0
Rnor_5.05173,003,160 - 173,003,310UniSTSRnor5.0
RGSC_v3.45169,501,513 - 169,501,663UniSTSRGSC3.4
Celera5161,010,369 - 161,010,519UniSTS
Cytogenetic Map5q36UniSTS
D1S2335E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,768,913 - 162,769,030 (+)MAPPERmRatBN7.2
Rnor_6.05169,439,820 - 169,439,936NCBIRnor6.0
Rnor_5.05172,993,159 - 172,993,275UniSTSRnor5.0
RGSC_v3.45169,491,512 - 169,491,628UniSTSRGSC3.4
Celera5161,000,368 - 161,000,484UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:346
Count of miRNA genes:126
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000000079, ENSRNOT00000014213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 36 27 15 27 3 74 29 36 9
Low 7 21 14 4 14 8 8 6 5 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005504373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK469690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY317682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000079   ⟹   ENSRNOP00000000079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,707,818 - 162,779,309 (+)Ensembl
Rnor_6.0 Ensembl5169,357,517 - 169,450,219 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000014213   ⟹   ENSRNOP00000014213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,693,306 - 162,779,309 (+)Ensembl
Rnor_6.0 Ensembl5169,364,306 - 169,450,214 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118204   ⟹   ENSRNOP00000089356
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,684,645 - 162,779,309 (+)Ensembl
RefSeq Acc Id: NM_001146061   ⟹   NP_001139533
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,693,400 - 162,779,309 (+)NCBI
Rnor_6.05169,364,306 - 169,450,215 (+)NCBI
Rnor_5.05172,912,096 - 173,003,554 (+)NCBI
RGSC_v3.45169,409,306 - 169,501,907 (+)RGD
Celera5160,924,964 - 161,010,763 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013214   ⟹   NP_037346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,686,676 - 162,779,309 (+)NCBI
Rnor_6.05169,357,582 - 169,450,215 (+)NCBI
Rnor_5.05172,912,096 - 173,003,554 (+)NCBI
RGSC_v3.45169,409,306 - 169,501,907 (+)RGD
Celera5160,918,240 - 161,010,763 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239448   ⟹   XP_006239510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,707,899 - 162,779,309 (+)NCBI
Rnor_6.05169,378,805 - 169,450,215 (+)NCBI
Rnor_5.05172,912,096 - 173,003,554 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109339   ⟹   XP_038965267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,693,418 - 162,779,309 (+)NCBI
RefSeq Acc Id: XM_039109340   ⟹   XP_038965268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,686,562 - 162,779,309 (+)NCBI
RefSeq Acc Id: XM_039109341   ⟹   XP_038965269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,710,283 - 162,779,309 (+)NCBI
RefSeq Acc Id: XM_039109342   ⟹   XP_038965270
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,693,066 - 162,779,309 (+)NCBI
RefSeq Acc Id: XM_039109343   ⟹   XP_038965271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,733,399 - 162,779,309 (+)NCBI
RefSeq Acc Id: XR_005504373
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,693,409 - 162,779,309 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037346   ⟸   NM_013214
- Peptide Label: isoform 2
- UniProtKB: Q64559 (UniProtKB/Swiss-Prot),   F8WG67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139533   ⟸   NM_001146061
- Peptide Label: isoform 1
- UniProtKB: O09041 (UniProtKB/Swiss-Prot),   Q64559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239510   ⟸   XM_006239448
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000000079   ⟸   ENSRNOT00000000079
RefSeq Acc Id: ENSRNOP00000014213   ⟸   ENSRNOT00000014213
RefSeq Acc Id: XP_038965268   ⟸   XM_039109340
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965270   ⟸   XM_039109342
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965267   ⟸   XM_039109339
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965269   ⟸   XM_039109341
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965271   ⟸   XM_039109343
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000089356   ⟸   ENSRNOT00000118204
Protein Domains
HotDog ACOT-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64559-F1-model_v2 AlphaFold Q64559 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694303
Promoter ID:EPDNEW_R4824
Type:initiation region
Name:Acot7_1
Description:acyl-CoA thioesterase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4825  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,357,614 - 169,357,674EPDNEW
RGD ID:13694301
Promoter ID:EPDNEW_R4825
Type:initiation region
Name:Acot7_2
Description:acyl-CoA thioesterase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4824  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,364,301 - 169,364,361EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628856 AgrOrtholog
BioCyc Gene G2FUF-39018 BioCyc
BioCyc Pathway PWY-5148 [acyl-CoA hydrolysis] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY-8042 [acylceramide biosynthesis] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
Ensembl Genes ENSRNOG00000010580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000079 ENTREZGENE
  ENSRNOP00000000079.7 UniProtKB/TrEMBL
  ENSRNOP00000014213 ENTREZGENE
  ENSRNOP00000014213.3 UniProtKB/TrEMBL
  ENSRNOP00000089356 ENTREZGENE
  ENSRNOP00000089356.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000079 ENTREZGENE
  ENSRNOT00000000079.9 UniProtKB/TrEMBL
  ENSRNOT00000014213 ENTREZGENE
  ENSRNOT00000014213.5 UniProtKB/TrEMBL
  ENSRNOT00000118204 ENTREZGENE
  ENSRNOT00000118204.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7316866 IMAGE-MGC_LOAD
InterPro Cytosol_ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOTDOG_ACOT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HotDog_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioestr_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26759 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105261 IMAGE-MGC_LOAD
NCBI Gene 26759 ENTREZGENE
PANTHER PTHR11049 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 4HBT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acot7 PhenoGen
PROSITE HOTDOG_ACOT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54637 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ACH7_RAT UniProtKB/TrEMBL
  A0A8L2Q6N9_RAT UniProtKB/TrEMBL
  BACH_RAT UniProtKB/Swiss-Prot
  F8WG67 ENTREZGENE, UniProtKB/TrEMBL
  O09041 ENTREZGENE
  Q64559 ENTREZGENE
UniProt Secondary O08652 UniProtKB/Swiss-Prot
  O09041 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Acot7  acyl-CoA thioesterase 7  Bach  brain acyl-CoA hydrolase  Symbol and Name updated 1299863 APPROVED
2005-01-20 Bach  brain acyl-CoA hydrolase      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Bach  brain acyl-CoA hydrolase      Symbol and Name status set to provisional 70820 PROVISIONAL