Aadacl4fm1 (AADACL4 family member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Aadacl4fm1 (AADACL4 family member 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Aadacl4fm1 (Ensembl: RGD1308878)
Name: AADACL4 family member 1 (Ensembl:similar to arylacetamide deacetylase)
RGD ID: 1308878
Description: Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in membrane. Orthologous to human AADACL4 (arylacetamide deacetylase like 4).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Arylacetamide deacetylase-like 4-like; hypothetical protein LOC298623; LOC298623; RGD1308878; similar to arylacetamide deacetylase; uncharacterized protein LOC298623
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85161,640,133 - 161,649,744 (+)NCBIGRCr8
mRatBN7.25156,356,868 - 156,366,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5156,356,868 - 156,366,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5159,068,785 - 159,078,399 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05160,842,113 - 160,851,727 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05160,798,450 - 160,808,064 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05162,506,652 - 162,516,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5162,506,652 - 162,516,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,197,556 - 166,207,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45162,934,217 - 162,943,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15162,944,463 - 162,953,900 (+)NCBI
Celera5154,658,417 - 154,668,028 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Aadacl4fm1
122 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000030001
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system appendage
High
Medium
Low
Below cutoff 1 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000030001   ⟹   ENSRNOP00000031295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5156,356,868 - 156,366,479 (+)Ensembl
Rnor_6.0 Ensembl5162,506,652 - 162,516,264 (+)Ensembl
RefSeq Acc Id: NM_001134522   ⟹   NP_001127994
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85161,640,133 - 161,649,744 (+)NCBI
mRatBN7.25156,356,868 - 156,366,479 (+)NCBI
Rnor_6.05162,506,652 - 162,516,264 (+)NCBI
Rnor_5.05166,197,556 - 166,207,168 (+)NCBI
RGSC_v3.45162,934,217 - 162,943,831 (+)RGD
Celera5154,658,417 - 154,668,028 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001127994 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81058 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031295
  ENSRNOP00000031295.4
Reference Protein Sequences
RefSeq Acc Id: NP_001127994   ⟸   NM_001134522
- UniProtKB: D3ZBA8 (UniProtKB/TrEMBL),   A6IU07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031295   ⟸   ENSRNOT00000030001
Protein Domains
Alpha/beta hydrolase fold-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBA8-F1-model_v2 AlphaFold D3ZBA8 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308878 AgrOrtholog
BioCyc Gene G2FUF-39267 BioCyc
Ensembl Genes ENSRNOG00000026782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030001 ENTREZGENE
  ENSRNOT00000030001.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_3 UniProtKB/TrEMBL
  Arylacetamide_deacetylase UniProtKB/TrEMBL
KEGG Report rno:298623 UniProtKB/TrEMBL
NCBI Gene 298623 ENTREZGENE
PANTHER ARYLACETAMIDE DEACETYLASE UniProtKB/TrEMBL
  ARYLACETAMIDE DEACETYLASE-LIKE 4 UniProtKB/TrEMBL
Pfam Abhydrolase_3 UniProtKB/TrEMBL
PhenoGen Aadacl4fm1 PhenoGen
PIRSF Arylacetamide_deacetylase UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026782 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A6IU07 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Aadacl4fm1  AADACL4 family member 1  RGD1308878  similar to arylacetamide deacetylase  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1308878  similar to arylacetamide deacetylase   RGD1308878_predicted  similar to arylacetamide deacetylase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308878_predicted  similar to arylacetamide deacetylase (predicted)  LOC298623_predicted  similar to arylacetamide deacetylase (predicted)  Symbol and Name status set to approved 1331353 APPROVED
2005-01-20 RGD1308878_predicted  similar to arylacetamide deacetylase (predicted)  LOC298623_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298623_predicted  similar to arylacetamide deacetylase (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL