Tnfrsf1b (TNF receptor superfamily member 1B) - Rat Genome Database

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Gene: Tnfrsf1b (TNF receptor superfamily member 1B) Rattus norvegicus
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Symbol: Tnfrsf1b
Name: TNF receptor superfamily member 1B
RGD ID: 621238
Description: Enables tumor necrosis factor receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in neuronal cell body; perinuclear region of cytoplasm; and varicosity. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; amyotrophic lateral sclerosis pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: p75; p80 TNF-alpha receptor; TNF-R2; TNF-RII; TNFR-II; Tnfr2; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1b; tumor necrosis factor receptor type II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,356,250 - 162,387,411 (-)NCBIGRCr8
mRatBN7.25157,070,642 - 157,104,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5159,775,748 - 159,806,642 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,549,033 - 161,579,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,505,389 - 161,536,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05163,136,390 - 163,167,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,815,372 - 166,845,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45163,666,541 - 163,697,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15163,674,328 - 163,707,672 (-)NCBI
Celera5155,362,574 - 155,393,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Tnfrsf1bRatacne susceptibilityISOTNFRSF1B (Homo sapiens)8553023DNA:polymorphism:cds:p.M196R(human)RGD 
Tnfrsf1bRatacquired immunodeficiency syndrome  ISOTNFRSF1B (Homo sapiens)12904035 RGD 
Tnfrsf1bRatAcute Experimental Pancreatitis  IEP 1580295protein:increased expression:serumRGD 
Tnfrsf1bRatacute kidney failure  ISOTnfrsf1b (Mus musculus)7245532 RGD 
Tnfrsf1bRatacute kidney failure  ISOTNFRSF1B (Homo sapiens)5128661associated with Acute Lung InjuryRGD 
Tnfrsf1bRatacute kidney failure  ISOTNFRSF1B (Homo sapiens)7245534associated with Shock more ...RGD 
Tnfrsf1bRatadult respiratory distress syndrome  ISOTnfrsf1b (Mus musculus)5131206protein:increased expression:lung (mouse)RGD 
Tnfrsf1bRatadult respiratory distress syndrome  ISOTNFRSF1B (Homo sapiens)5131423human protein in rat modelRGD 
Tnfrsf1bRatadult respiratory distress syndrome severityISOTnfrsf1b (Mus musculus)5131147 RGD 
Tnfrsf1bRatAlzheimer's disease  ISOTNFRSF1B (Homo sapiens)13825268protein:increased expression:cerebrospinal fluid:RGD 
Tnfrsf1bRatAlzheimer's disease  ISOTNFRSF1B (Homo sapiens)13825249protein:decreased expression:brain:RGD 
Tnfrsf1bRatankylosing spondylitis  ISOTNFRSF1B (Homo sapiens)5131280 RGD 
Tnfrsf1bRatAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis severityISOTNFRSF1B (Homo sapiens)7245518protein:increased expression:serum and granulocyteRGD 
Tnfrsf1bRatbacterial pneumonia  ISOTnfrsf1b (Mus musculus)5131429protein:increased expression:serum (mouse)RGD 
Tnfrsf1bRatBronchial Spasm  ISOTNFRSF1B (Homo sapiens)5131441associated with Arthritis and RheumatoidRGD 
Tnfrsf1bRatcerebral malaria  ISOTnfrsf1b (Mus musculus)5131158 RGD 
Tnfrsf1bRatchronic obstructive pulmonary disease severityISOTNFRSF1B (Homo sapiens)5131154protein:increased expression:sputum (human)RGD 
Tnfrsf1bRatcolon carcinoma  ISOTNFRSF1B (Homo sapiens)5131434protein:increased expression:serum (human)RGD 
Tnfrsf1bRatcongestive heart failure  ISOTNFRSF1B (Homo sapiens)5131262human protein in rat modelRGD 
Tnfrsf1bRatCrohn's disease  IEP 5130893protein:increased expression:large intestine mucosa (rat)RGD 
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Tnfrsf1bRatCharcot-Marie-Tooth disease type 2  ISOTNFRSF1B (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 2ClinVarPMID:28492532
Tnfrsf1bRatchromosome 1p36 deletion syndrome  ISOTNFRSF1B (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1p36 deletion syndromeClinVar 
Tnfrsf1bRatnonprogressive cerebellar ataxia with mental retardation  ISOTNFRSF1B (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebellar dysfunction with variable cognitive and behavioral abnormalitiesClinVarPMID:25741868
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Tnfrsf1bRatallergic disease  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
Tnfrsf1bRatautistic disorder  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16139734
Tnfrsf1bRatBone Fractures  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15071724
Tnfrsf1bRatbrain ischemia  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15829914
Tnfrsf1bRatHypoalbuminemia  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15044820
Tnfrsf1bRatliver cirrhosis  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20353583
Tnfrsf1bRatmetabolic dysfunction-associated steatotic liver disease  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20353583
Tnfrsf1bRatmycosis fungoides  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26258847
Tnfrsf1bRatobesity  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11782876
Tnfrsf1bRatpneumonia  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
Tnfrsf1bRatSezary's disease  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26258847
Tnfrsf1bRattype 2 diabetes mellitus  ISOTNFRSF1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11882518
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Tnfrsf1bRat(1->4)-beta-D-glucan multiple interactionsISOTnfrsf1b (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TNFRSF1B mRNACTDPMID:36331819
Tnfrsf1bRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionEXP 6480464o and p'-DDT analog results in decreased expression of TNFRSF1B mRNACTDPMID:22937105
Tnfrsf1bRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o more ...CTDPMID:22937105
Tnfrsf1bRat1,1-dichloroethene increases expressionISOTnfrsf1b (Mus musculus)6480464vinylidene chloride results in increased expression of TNFRSF1B mRNACTDPMID:26682919
Tnfrsf1bRat1,2-dimethylhydrazine increases expressionISOTnfrsf1b (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of TNFRSF1B mRNACTDPMID:22206623
Tnfrsf1bRat1-naphthyl isothiocyanate multiple interactionsISOTNFRSF1B (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TNFRSF1B mRNACTDPMID:27344345
Tnfrsf1bRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of TNFRSF1B mRNACTDPMID:17557909
Tnfrsf1bRat17beta-estradiol multiple interactionsISOTNFRSF1B (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of TNFRSF1B mRNACTDPMID:20660070
Tnfrsf1bRat17beta-estradiol decreases expressionISOTnfrsf1b (Mus musculus)6480464Estradiol results in decreased expression of TNFRSF1B mRNACTDPMID:39298647
Tnfrsf1bRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TNFRSF1B mRNACTDPMID:32741896
Tnfrsf1bRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TNFRSF1B mRNACTDPMID:32741896
Tnfrsf1bRat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOTnfrsf1b (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOTnfrsf1b (Mus musculus)6480464AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFRSF1B mRNA]CTDPMID:16891777
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TNFRSF1B mRNACTDPMID:34747641
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine decreases response to substanceISOTnfrsf1b (Mus musculus)6480464TNFRSF1B gene mutant form results in decreased susceptibility to TetrachlorodibenzodioxinCTDPMID:24718703
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTNFRSF1B (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of TNFRSF1B mRNACTDPMID:22298810
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTnfrsf1b (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of TNFRSF1B mRNACTDPMID:12167310 more ...
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TNFRSF1B mRNACTDPMID:19520675
Tnfrsf1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTnfrsf1b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TNFRSF1B mRNACTDPMID:20702594
Tnfrsf1bRat2,3,7,8-Tetrachlorodibenzofuran affects expressionISOTnfrsf1b (Mus musculus)64804642 more ...CTDPMID:20702594

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Biological Process
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Tnfrsf1bRataortic valve development involved_inISOTnfrsf1b (Mus musculus)1624291UniProtKB:P25118 and PMID:26491108RGDPMID:26491108
Tnfrsf1bRatcell surface receptor signaling pathway acts_upstream_of_or_withinISOTnfrsf1b (Mus musculus)1624291MGI:1860087 PMID:9551933RGDPMID:9551933
Tnfrsf1bRatcellular response to growth factor stimulus  IEP 5130921ciliary neurotrophic factorRGD 
Tnfrsf1bRatcellular response to lipopolysaccharide involved_inISOTNFRSF1B (Homo sapiens)1624291 PMID:22480688RGDPMID:22480688
Tnfrsf1bRatcellular response to tumor necrosis factor  IEP 13825430 RGD 
Tnfrsf1bRatextrinsic apoptotic signaling pathway involved_inIBAMGI:1314883 and PANTHER:PTN0029339061600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfrsf1bRatextrinsic apoptotic signaling pathway acts_upstream_of_or_withinISOTnfrsf1b (Mus musculus)1624291MGI:1857262 PMID:7990930RGDPMID:7990930
Tnfrsf1bRatglial cell-neuron signaling involved_inISOTnfrsf1b (Mus musculus)1624291 PMID:27147664RGDPMID:27147664
Tnfrsf1bRatimmune response  IDA 628388 RGD 
Tnfrsf1bRatinflammatory response acts_upstream_of_or_withinISOTnfrsf1b (Mus musculus)1624291MGI:1860087 PMID:9551933RGDPMID:9551933
Tnfrsf1bRatinflammatory response involved_inIEAInterPro:IPR0339961600115GO_REF:0000002InterProGO_REF:0000002
Tnfrsf1bRatintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISOTnfrsf1b (Mus musculus)1624291 PMID:17242187RGDPMID:17242187
Tnfrsf1bRatintrinsic apoptotic signaling pathway in response to DNA damage involved_inIBAMGI:1314883 and PANTHER:PTN0029339061600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfrsf1bRatnegative regulation of cardiac muscle hypertrophy involved_inISOTnfrsf1b (Mus musculus)1624291UniProtKB:P25118 and PMID:26491108RGDPMID:26491108
Tnfrsf1bRatnegative regulation of extracellular matrix constituent secretion involved_inISOTnfrsf1b (Mus musculus)1624291UniProtKB:P25118 and PMID:26491108RGDPMID:26491108
Tnfrsf1bRatnegative regulation of inflammatory response acts_upstream_of_or_withinISOTnfrsf1b (Mus musculus)1624291MGI:1857262 PMID:11588035RGDPMID:11588035
Tnfrsf1bRatnegative regulation of neuroinflammatory response involved_inISOTnfrsf1b (Mus musculus)1624291 PMID:27147664RGDPMID:27147664
Tnfrsf1bRatnegative regulation of neuroinflammatory response involved_inIBAMGI:1314883 and PANTHER:PTN0029339061600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfrsf1bRatpositive regulation of apoptotic process involved in morphogenesis involved_inISOTnfrsf1b (Mus musculus)1624291UniProtKB:P25118 and PMID:26491108RGDPMID:26491108
Tnfrsf1bRatpositive regulation of membrane protein ectodomain proteolysis involved_inISOTNFRSF1B (Homo sapiens)1624291 PMID:22480688RGDPMID:22480688
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Cellular Component
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Tnfrsf1bRataxon  IDA 5130963 RGD 
Tnfrsf1bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Tnfrsf1bRatmembrane located_inISOTnfrsf1b (Mus musculus)1624291 PMID:10747083RGDPMID:10747083
Tnfrsf1bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Tnfrsf1bRatmembrane located_inIEAInterPro:IPR0204111600115GO_REF:0000002InterProGO_REF:0000002
Tnfrsf1bRatmembrane raft located_inISOTnfrsf1b (Mus musculus)1624291 PMID:17010968RGDPMID:17010968
Tnfrsf1bRatmembrane raft located_inISOTNFRSF1B (Homo sapiens)1624291 PMID:17010968RGDPMID:17010968
Tnfrsf1bRatneuronal cell body  IDA 5130921 RGD 
Tnfrsf1bRatperinuclear region of cytoplasm  IDA 5130921 RGD 
Tnfrsf1bRatvaricosity  IDA 5130921 RGD 
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RGD Manual Annotations


  
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Original Reference(s)
Tnfrsf1bRattumor necrosis factor mediated signaling pathway   ISOTNFRSF1B (Homo sapiens)2292150 RGD 

Imported Annotations - KEGG (archival)

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Tnfrsf1bRatamyotrophic lateral sclerosis pathway  IEA 6907045 KEGGrno:05014
Tnfrsf1bRatcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060

Imported Annotations - PID (archival)

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Tnfrsf1bRattumor necrosis factor mediated signaling pathway   ISOTNFRSF1B (Homo sapiens)6484113 PIDPID:200102

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#
Reference Title
Reference Citation
1. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Aderka D, etal., Arthritis Rheum. 1993 Aug;36(8):1111-20.
2. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Aderka D, etal., Cancer Res. 1991 Oct 15;51(20):5602-7.
3. Tumor necrosis factor receptor expression and signaling in renal cell carcinoma. Al-Lamki RS, etal., Am J Pathol. 2010 Aug;177(2):943-54. doi: 10.2353/ajpath.2010.091218. Epub 2010 Jun 21.
4. The thalidomide analgesic effect is associated with differential TNF-alpha receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. Andrade P, etal., Brain Res. 2012 Apr 23;1450:24-32. doi: 10.1016/j.brainres.2012.02.033. Epub 2012 Feb 22.
5. Tumor necrosis factor-alpha modulates the expression of its p60 receptor and several cytokines in rat tracheal epithelial cells. Bader T and Nettesheim P, J Immunol 1996 Oct 1;157(7):3089-96.
6. Anti-tumor necrosis factor alpha treatment of interferon-alpha-induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation. Bethunaickan R, etal., Arthritis Rheum. 2012 Oct;64(10):3399-408. doi: 10.1002/art.34553.
7. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Bower JE, etal., Psychosom Med. 2002 Jul-Aug;64(4):604-11.
8. TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. Bruggeman LA, etal., Lab Invest. 2011 Mar;91(3):413-25. doi: 10.1038/labinvest.2010.199. Epub 2011 Jan 10.
9. The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. Cayci T, etal., J Obstet Gynaecol Res. 2011 Apr 12. doi: 10.1111/j.1447-0756.2010.01482.x.
10. Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis. Chen B, etal., Eur Respir J. 2005 Jun;25(6):1039-43.
11. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-alpha, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. Chen H, etal., Rheumatol Int. 2013 May;33(5):1223-7. doi: 10.1007/s00296-012-2529-7. Epub 2012 Oct 2.
12. Tumor Necrosis Factor-Alpha Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury. Chen KB, etal., Spine (Phila Pa 1976). 2011 Jan 8.
13. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. Cheng X, etal., J Alzheimers Dis. 2010;19(2):621-30. doi: 10.3233/JAD-2010-1253.
14. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Cho HY, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L537-46.
15. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. Constantin CE, etal., J Neurosci. 2008 May 7;28(19):5072-81.
16. Circulating levels of TNF-alpha and its soluble receptors in the plasma of patients with epithelial ovarian cancer. Dobrzycka B, etal., Eur Cytokine Netw. 2009 Sep;20(3):131-4.
17. Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. Dorr AD, etal., J Appl Physiol. 2011 Apr 21.
18. Efficacy of etanercept on rheumatic signs and pulmonary function tests in advanced ankylosing spondylitis: results of a randomised double-blind placebo-controlled study (SPINE). Dougados M, etal., Ann Rheum Dis. 2011 May;70(5):799-804. Epub 2011 Feb 13.
19. Bronchospasm associated with anti-TNF treatment. Dubey S, etal., Clin Rheumatol. 2009 Aug;28(8):989-92. Epub 2009 Apr 2.
20. Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome. Fernandez R, etal., Respir Physiol Neurobiol. 2011 Mar 15;175(3):336-48. Epub 2010 Dec 30.
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PMID:1645445   PMID:7990930   PMID:9435233   PMID:9551933   PMID:10747083   PMID:11279055   PMID:11588035   PMID:12849708   PMID:15509749   PMID:15987482   PMID:17010968   PMID:17049356  
PMID:17242187   PMID:17873366   PMID:17917074   PMID:18205044   PMID:18990246   PMID:21692635   PMID:21871121   PMID:22480688   PMID:25378394   PMID:26491108   PMID:26504355   PMID:26732833  
PMID:27147664   PMID:27979472   PMID:28052249   PMID:29975930   PMID:30988334  



Tnfrsf1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,356,250 - 162,387,411 (-)NCBIGRCr8
mRatBN7.25157,070,642 - 157,104,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5159,775,748 - 159,806,642 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,549,033 - 161,579,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,505,389 - 161,536,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05163,136,390 - 163,167,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,815,372 - 166,845,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45163,666,541 - 163,697,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15163,674,328 - 163,707,672 (-)NCBI
Celera5155,362,574 - 155,393,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
TNFRSF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,166,991 - 12,209,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,166,991 - 12,209,228 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,227,048 - 12,269,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,149,647 - 12,191,864 (+)NCBINCBI36Build 36hg18NCBI36
Build 34112,161,325 - 12,203,542NCBI
Celera111,340,352 - 11,382,470 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,380,310 - 11,422,542 (+)NCBIHuRef
CHM1_1112,214,947 - 12,257,256 (+)NCBICHM1_1
T2T-CHM13v2.0111,711,114 - 11,753,352 (+)NCBIT2T-CHM13v2.0
Tnfrsf1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394144,938,938 - 144,973,453 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4144,940,033 - 144,973,440 (-)EnsemblGRCm39 Ensembl
GRCm384145,212,368 - 145,246,870 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4145,213,463 - 145,246,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv374144,802,271 - 144,836,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364144,479,055 - 144,513,557 (-)NCBIMGSCv36mm8
Celera4146,801,795 - 146,837,140 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.17NCBI
Tnfrsf1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,792,115 - 1,818,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,790,531 - 1,817,986 (-)NCBIChiLan1.0ChiLan1.0
TNFRSF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,028,254 - 216,070,267 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,675,232 - 214,717,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,915,743 - 10,957,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,130,663 - 12,172,646 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,130,663 - 12,172,646 (+)Ensemblpanpan1.1panPan2
TNFRSF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,140,179 - 84,151,219 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,141,911 - 84,157,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,674,178 - 80,701,012 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,802,376 - 84,828,308 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,801,328 - 84,828,324 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,551,315 - 81,578,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,551,181 - 82,578,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,616,667 - 83,643,630 (-)NCBIUU_Cfam_GSD_1.0
Tnfrsf1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505835,083,616 - 35,110,985 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474908,485 - 934,177 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474908,414 - 935,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,195,435 - 72,231,147 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,195,420 - 72,231,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TNFRSF1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,590,621 - 119,633,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,590,325 - 119,633,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,447,248 - 23,490,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfrsf1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624818896,150 - 922,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624818894,470 - 922,806 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tnfrsf1b
302 total Variants


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 157078616 157078617 G C snv GK/FarMcwi (2019NG), European Variation Archive Release 3, WN/N (2020), European Variation Archive Release 6, GK/FarMcwi (2019), European Variation Archive Release 4 View more Information


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 163672112 163672113 G C snv GK/Ox (ICL), WN/N (KNAW) View more Information


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 166821231 166821232 G C snv WN/N (KNAW), ZF (KyushuU), GK/Ox (KNAW) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 163141961 163141962 G C snv WN/N (MCW), WN/N (2020), GK/FarMcwi (2019), GK/Ox (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:530
Count of miRNA genes:258
Interacting mature miRNAs:340
Transcripts:ENSRNOT00000022478
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat

1 to 10 of 26 rows
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000022478   ⟹   ENSRNOP00000022478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)Ensembl
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103500   ⟹   ENSRNOP00000094197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,070,642 - 157,087,912 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119924   ⟹   ENSRNOP00000078858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)Ensembl
RefSeq Acc Id: NM_130426   ⟹   NP_569110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85162,356,250 - 162,387,411 (-)NCBI
mRatBN7.25157,073,045 - 157,104,206 (-)NCBI
Rnor_6.05163,136,390 - 163,167,299 (-)NCBI
Rnor_5.05166,815,372 - 166,845,910 (-)NCBI
RGSC_v3.45163,666,541 - 163,697,484 (-)RGD
Celera5155,362,574 - 155,393,443 (-)RGD
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_569110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52795 (Get FASTA)   NCBI Sequence Viewer  
  AAD30148 (Get FASTA)   NCBI Sequence Viewer  
  AAL16021 (Get FASTA)   NCBI Sequence Viewer  
  AAO61402 (Get FASTA)   NCBI Sequence Viewer  
  AAO61403 (Get FASTA)   NCBI Sequence Viewer  
  AAP33151 (Get FASTA)   NCBI Sequence Viewer  
  AAQ22350 (Get FASTA)   NCBI Sequence Viewer  
  EDL81066 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022478
  ENSRNOP00000022478.3
GenBank Protein Q80WY6 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_569110   ⟸   NM_130426
- Peptide Label: precursor
- UniProtKB: Q5YLP0 (UniProtKB/Swiss-Prot),   Q80WY6 (UniProtKB/Swiss-Prot),   A6IU15 (UniProtKB/TrEMBL),   A0A8I5ZLM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022478   ⟸   ENSRNOT00000022478
Ensembl Acc Id: ENSRNOP00000078858   ⟸   ENSRNOT00000119924
Ensembl Acc Id: ENSRNOP00000094197   ⟸   ENSRNOT00000103500
TNFR-Cys

Name Modeler Protein Id AA Range Protein Structure
AF-Q80WY6-F1-model_v2 AlphaFold Q80WY6 1-474 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694248
Promoter ID:EPDNEW_R4773
Type:multiple initiation site
Name:Tnfrsf1b_1
Description:TNF receptor superfamily member 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05163,167,299 - 163,167,359EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39251 BioCyc
Ensembl Genes ENSRNOG00000016575 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022478 ENTREZGENE
  ENSRNOT00000022478.5 UniProtKB/Swiss-Prot
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro TNF_chemokine_rcpt-like UniProtKB/Swiss-Prot
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot
  TNFR_1B UniProtKB/Swiss-Prot
  TNFRSF1B_N UniProtKB/Swiss-Prot
KEGG Report rno:156767 UniProtKB/Swiss-Prot
NCBI Gene 156767 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/Swiss-Prot
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/Swiss-Prot
Pfam TNFR_c6 UniProtKB/Swiss-Prot
PharmGKB TNFRSF1B RGD
PhenoGen Tnfrsf1b PhenoGen
PRINTS TNFACTORR1B UniProtKB/Swiss-Prot
PROSITE TNFR_NGFR_1 UniProtKB/Swiss-Prot
  TNFR_NGFR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016575 RatGTEx
SMART TNFR UniProtKB/Swiss-Prot
Superfamily-SCOP TNF receptor-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZLM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJ16_RAT UniProtKB/TrEMBL
  A6IU15 ENTREZGENE, UniProtKB/TrEMBL
  Q5YLP0 ENTREZGENE
  Q80WY6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5YLP0 UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 Tnfrsf1b  TNF receptor superfamily member 1B  Tnfrsf1b  tumor necrosis factor receptor superfamily, member 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnfrsf1b  tumor necrosis factor receptor superfamily, member 1b      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tnfrsf1b  tumor necrosis factor receptor superfamily, member 1b      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_function binds to tumor necrosis factor (TNF)-alpha 628388