Tnfrsf1b (TNF receptor superfamily member 1B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tnfrsf1b (TNF receptor superfamily member 1B) Rattus norvegicus
Analyze
Symbol: Tnfrsf1b
Name: TNF receptor superfamily member 1B
RGD ID: 621238
Description: Enables tumor necrosis factor receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in neuronal cell body; perinuclear region of cytoplasm; and varicosity. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; amyotrophic lateral sclerosis pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: p75; p80 TNF-alpha receptor; TNF-R2; TNF-RII; TNFR-II; Tnfr2; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1b; tumor necrosis factor receptor type II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,356,250 - 162,387,411 (-)NCBIGRCr8
mRatBN7.25157,070,642 - 157,104,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5159,775,748 - 159,806,642 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,549,033 - 161,579,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,505,389 - 161,536,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05163,136,390 - 163,167,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,815,372 - 166,845,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45163,666,541 - 163,697,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15163,674,328 - 163,707,672 (-)NCBI
Celera5155,362,574 - 155,393,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acquired immunodeficiency syndrome  (ISO)
Acute Experimental Pancreatitis  (IEP)
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Bone Fractures  (ISO)
brain ischemia  (ISO)
Bronchial Spasm  (ISO)
cerebral malaria  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
congestive heart failure  (ISO)
Crohn's disease  (IEP)
cryptogenic organizing pneumonia  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Arthritis  (IDA,IEP,ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Seizures  (IEP)
extrinsic allergic alveolitis  (ISO)
Fatigue  (ISO)
Fetal Death  (ISO)
focal segmental glomerulosclerosis  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Headache  (ISO)
Hyperalgesia  (IMP,ISO)
Hypoalbuminemia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
Intervertebral Disc Displacement  (ISO)
kidney failure  (ISO)
Legionnaires' disease  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (IEP)
Nasal Polyps  (ISO)
nonprogressive cerebellar ataxia with mental retardation  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
pre-eclampsia  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
retinal detachment  (ISO)
sciatic neuropathy  (IEP)
Sciatica  (IDA)
Sezary's disease  (ISO)
silicosis  (ISO)
Spinal Cord Compression  (IEP,ISO)
Systemic Inflammatory Response Syndrome  (IEP)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (IEP)
tuberculosis  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucosamine  (ISO)
alfacalcidol  (ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
Brevianamide A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dichromium trioxide  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fluoranthene  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
gefitinib  (ISO)
glyphosate  (EXP)
Heliotrine  (EXP)
hopane  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
ionomycin  (ISO)
ketoconazole  (EXP,ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (ISO)
melatonin  (ISO)
methyl methanesulfonate  (ISO)
Mitotane  (EXP)
monosodium L-glutamate  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
obeticholic acid  (ISO)
octreotide  (EXP)
oleanolic acid  (ISO)
osthole  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prenyl diphosphate  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium stibogluconate  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfur dioxide  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
WR-1065  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Aderka D, etal., Arthritis Rheum. 1993 Aug;36(8):1111-20.
2. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Aderka D, etal., Cancer Res. 1991 Oct 15;51(20):5602-7.
3. Tumor necrosis factor receptor expression and signaling in renal cell carcinoma. Al-Lamki RS, etal., Am J Pathol. 2010 Aug;177(2):943-54. doi: 10.2353/ajpath.2010.091218. Epub 2010 Jun 21.
4. The thalidomide analgesic effect is associated with differential TNF-alpha receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. Andrade P, etal., Brain Res. 2012 Apr 23;1450:24-32. doi: 10.1016/j.brainres.2012.02.033. Epub 2012 Feb 22.
5. Tumor necrosis factor-alpha modulates the expression of its p60 receptor and several cytokines in rat tracheal epithelial cells. Bader T and Nettesheim P, J Immunol 1996 Oct 1;157(7):3089-96.
6. Anti-tumor necrosis factor alpha treatment of interferon-alpha-induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation. Bethunaickan R, etal., Arthritis Rheum. 2012 Oct;64(10):3399-408. doi: 10.1002/art.34553.
7. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Bower JE, etal., Psychosom Med. 2002 Jul-Aug;64(4):604-11.
8. TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. Bruggeman LA, etal., Lab Invest. 2011 Mar;91(3):413-25. doi: 10.1038/labinvest.2010.199. Epub 2011 Jan 10.
9. The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. Cayci T, etal., J Obstet Gynaecol Res. 2011 Apr 12. doi: 10.1111/j.1447-0756.2010.01482.x.
10. Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis. Chen B, etal., Eur Respir J. 2005 Jun;25(6):1039-43.
11. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-alpha, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. Chen H, etal., Rheumatol Int. 2013 May;33(5):1223-7. doi: 10.1007/s00296-012-2529-7. Epub 2012 Oct 2.
12. Tumor Necrosis Factor-Alpha Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury. Chen KB, etal., Spine (Phila Pa 1976). 2011 Jan 8.
13. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. Cheng X, etal., J Alzheimers Dis. 2010;19(2):621-30. doi: 10.3233/JAD-2010-1253.
14. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Cho HY, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L537-46.
15. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. Constantin CE, etal., J Neurosci. 2008 May 7;28(19):5072-81.
16. Circulating levels of TNF-alpha and its soluble receptors in the plasma of patients with epithelial ovarian cancer. Dobrzycka B, etal., Eur Cytokine Netw. 2009 Sep;20(3):131-4.
17. Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. Dorr AD, etal., J Appl Physiol. 2011 Apr 21.
18. Efficacy of etanercept on rheumatic signs and pulmonary function tests in advanced ankylosing spondylitis: results of a randomised double-blind placebo-controlled study (SPINE). Dougados M, etal., Ann Rheum Dis. 2011 May;70(5):799-804. Epub 2011 Feb 13.
19. Bronchospasm associated with anti-TNF treatment. Dubey S, etal., Clin Rheumatol. 2009 Aug;28(8):989-92. Epub 2009 Apr 2.
20. Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome. Fernandez R, etal., Respir Physiol Neurobiol. 2011 Mar 15;175(3):336-48. Epub 2010 Dec 30.
21. TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice. Fujita M, etal., Cytokine. 2008 Nov;44(2):298-303. Epub 2008 Oct 5.
22. Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. Gadducci A, etal., Anticancer Res. 1996 Sep-Oct;16(5B):3125-8.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
25. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. Gohda T, etal., J Am Soc Nephrol. 2012 Mar;23(3):516-24. doi: 10.1681/ASN.2011060628. Epub 2012 Jan 19.
26. Circulating TNF-alpha and its soluble receptors during experimental acute pancreatitis. Granell S, etal., Cytokine. 2004 Feb 21;25(4):187-91.
27. Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Guo G, etal., Am J Physiol. 1999 Nov;277(5 Pt 2):F766-72.
28. Early subcutaneous administration of etanercept (Enbrel) prevents from hyperoxia-induced lung injury. Guthmann F, etal., Exp Lung Res. 2009 Nov;35(9):770-80.
29. Changes in cardiac structure in hypertension produced by placental ischemia in pregnant rats: effect of tumor necrosis factor blockade. Gutkowska J, etal., J Hypertens. 2011 Apr 17.
30. Methamphetamine-induced dopamine transporter complex formation and dopaminergic deficits: the role of D2 receptor activation. Hadlock GC, etal., J Pharmacol Exp Ther. 2010 Oct;335(1):207-12. Epub 2010 Jul 9.
31. The role of TNFalpha in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats. Hao S, etal., Neuropsychopharmacology. 2011 Feb;36(3):664-76. Epub 2010 Nov 10.
32. Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Hasegawa M, etal., Nephron Clin Pract. 2009;113(3):c222-33. doi: 10.1159/000235242. Epub 2009 Aug 18.
33. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
34. Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection. Hoffmann U, etal., Am J Transplant. 2009 Apr;9(4):675-86. doi: 10.1111/j.1600-6143.2008.02536.x. Epub 2008 Mar 2.
35. Direct application of the tumor necrosis factor-alpha inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons. Horii M, etal., Spine (Phila Pa 1976). 2011 Jan 15;36(2):E80-5.
36. Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. Hwang DY, etal., J Neurochem. 2009 Dec;111(5):1202-12. Epub 2009 Sep 24.
37. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Iglesias J, etal., Am J Kidney Dis. 2003 Jan;41(1):62-75.
38. Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus. Ingaramo PI, etal., Mol Immunol. 2011 Apr 8.
39. Differences between tumor necrosis factor-alpha receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model. Ishikawa T, etal., Spine (Phila Pa 1976). 2013 Jan 1;38(1):11-6. doi: 10.1097/BRS.0b013e3182610fa9.
40. Regression of endometrial autografts in a rat model of endometriosis treated with etanercept. Islimye M, etal., Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):184-9. doi: 10.1016/j.ejogrb.2011.06.029. Epub 2011 Jul 7.
41. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Jiang H, etal., Mol Neurodegener. 2011 Oct 6;6:69. doi: 10.1186/1750-1326-6-69.
42. TNF-alpha in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters. Kang YM, etal., Tohoku J Exp Med. 2010;222(4):251-63.
43. Serum cytokine profile in patients with active lupus nephritis. Koenig KF, etal., Cytokine. 2012 Nov;60(2):410-6. doi: 10.1016/j.cyto.2012.07.004. Epub 2012 Jul 28.
44. Roles of TNF-alpha and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. Kong SS, etal., Clin Exp Pharmacol Physiol. 2011 Mar 1. doi: 10.1111/j.1440-1681.2011.05505.x.
45. The association of serum lipids and inflammatory biomarkers with renal function in men with type II diabetes mellitus. Lin J, etal., Kidney Int. 2006 Jan;69(2):336-42.
46. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Liu KD, etal., Crit Care Med. 2007 Dec;35(12):2755-61.
47. Inflammatory profile and response to anti-TNF therapy in patients with chronic pulmonary sarcoidosis. Loza MJ, etal., Clin Vaccine Immunol. 2011 Apr 20.
48. Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate. Lu Y, etal., Arthritis Res Ther. 2011 Apr 4;13(2):R56.
49. Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-alpha in rat primary astrocytes. Lung HL, etal., Life Sci. 2001 Mar 23;68(18):2081-91.
50. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
51. Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats. Misaki T, etal., Am J Pathol. 2009 Jul;175(1):74-83. doi: 10.2353/ajpath.2009.080884. Epub 2009 Jun 18.
52. A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. Moller M, etal., Am J Respir Crit Care Med. 2010 Feb 15;181(4):388-93. Epub 2009 Dec 10.
53. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Nakazawa T, etal., Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1384-91. Print 2011 Mar.
54. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
55. Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis. Nemec A, etal., Exp Lung Res. 2009 Sep;35(7):605-20.
56. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Niewczas MA, etal., Clin J Am Soc Nephrol. 2009 Jan;4(1):62-70. Epub 2008 Dec 10.
57. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. Niewczas MA, etal., J Am Soc Nephrol. 2012 Mar;23(3):507-15. doi: 10.1681/ASN.2011060627. Epub 2012 Jan 19.
58. Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood-brain barrier of the rat. Osburg B, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E899-908.
59. Mechanisms of immune complex-mediated experimental glomerulonephritis: possible role of the balance between endogenous TNF and soluble TNF receptor type 2. Pfeifer E, etal., Eur Cytokine Netw. 2012 Mar 1;23(1):15-20. doi: 10.1684/ecn.2012.0299.
60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
62. MicroRNA Expression in Induced Sputum of Smokers and Patients with Chronic Obstructive Pulmonary Disease. Pottelberge GR, etal., Am J Respir Crit Care Med. 2011 Apr 1;183(7):898-906. Epub 2010 Oct 29.
63. TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. Ramesh G and Reeves WB, Am J Physiol Renal Physiol. 2003 Oct;285(4):F610-8. Epub 2003 Jul 15.
64. Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. Renaud SJ, etal., J Immunol. 2011 Feb 1;186(3):1799-808. Epub 2010 Dec 27.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity. Riezzo I, etal., J Neurosci Res. 2010 Mar;88(4):905-16.
69. Quantification of the mRNA encoding Tumor Necrosis Factor alpha (TNFalpha) and its receptors in human nasal polyps. Rostkowska-Nadolska B, etal., Adv Med Sci. 2008;53(2):263-9.
70. Imbalances in serum proinflammatory cytokines and their soluble receptors: a putative role in the progression of idiopathic IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis, and a potential target of immunoglobulin therapy? Rostoker G, etal., Clin Exp Immunol. 1998 Dec;114(3):468-76.
71. Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease. Safranow K, etal., Tissue Antigens. 2009 Nov;74(5):386-92.
72. Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats. Sama DM, etal., PLoS One. 2012;7(5):e38170. doi: 10.1371/journal.pone.0038170. Epub 2012 May 29.
73. Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats. Shen CH, etal., Anesth Analg. 2011 Feb;112(2):454-9. Epub 2010 Nov 16.
74. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn's disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2. Shi Y, etal., Chin J Integr Med. 2011 Mar;17(3):212-7. Epub 2011 Feb 27.
75. Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. Shimizu T, etal., Clin Rheumatol. 2000;19(5):352-9.
76. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. Shubayev VI and Myers RR, J Neuroimmunol. 2001 Mar 1;114(1-2):48-56.
77. TNF-alpha type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice. Singh P, etal., Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F991-9. doi: 10.1152/ajprenal.00525.2012. Epub 2013 Feb 6.
78. Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. Sippy BD, etal., J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):511-21.
79. [Interleukin-6, tumor necrosis factor alpha and their soluble receptors in Bence-Jones nephropathy. Possible role in pathogenesis andthe importance in the determination of prognosis in renal insufficiency]. Spicka I, etal., Cas Lek Cesk. 1998 May 4;137(9):267-70.
80. Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Stoelcker B, etal., Infect Immun. 2002 Oct;70(10):5857-9.
81. Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Sunil VR, etal., Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55. Epub 2010 Nov 9.
82. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Tian LM, etal., Dermatology. 2010;221(3):276-84. doi: 10.1159/000319851.
83. Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Tsuchiya N, etal., Genes Immun. 2001 Oct;2(6):317-22.
84. Segregation of the classical transmitters norepinephrine and acetylcholine and the neuropeptide Y in sympathetic neurons: modulation by ciliary neurotrophic factor or prolonged growth in culture. Vega A, etal., Dev Neurobiol. 2010 Dec;70(14):913-28. doi: 10.1002/dneu.20834.
85. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. Vielhauer V, etal., J Clin Invest. 2005 May;115(5):1199-209. Epub 2005 Apr 1.
86. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
87. Opposing actions of hippocampus TNFalpha receptors on limbic seizure susceptibility. Weinberg MS, etal., Exp Neurol. 2013 Jan 16. pii: S0014-4886(13)00024-1. doi: 10.1016/j.expneurol.2013.01.011.
88. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
89. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Yan P, etal., Exp Neurol 2003 Oct;183(2):286-97.
90. The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. Yanik GA, etal., Blood. 2008 Oct 15;112(8):3073-81. Epub 2008 Jul 29.
91. Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia. Ye Q, etal., Respir Med. 2011 Feb;105(2):292-7. Epub 2010 Dec 8.
92. [Effect of intra-articular ozone injection on serum and synovial TNF-alpha, TNFR I, and TNFR II contents in rats with rheumatoid arthritis]. Yu B, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(6):1055-8.
93. Tumor necrosis factor-alpha induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Zhang XC, etal., Pain. 2011 Jan;152(1):140-9. Epub 2010 Oct 30.
94. Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor. Zhou QH, etal., J Pharmacol Exp Ther. 2011 Nov;339(2):618-23. doi: 10.1124/jpet.111.185876. Epub 2011 Aug 10.
95. Predictive value of conjointly examined IL-1ra, TNF-R I, TNF-R II, and RANTES in patients with primary glomerulonephritis. Zwiech R J Korean Med Sci. 2013 Feb;28(2):261-7. doi: 10.3346/jkms.2013.28.2.261. Epub 2013 Jan 29.
96. [Prognostic values of serum concentration and urinary excretion of interleukin-1 receptor antagonist and tumor necrosis factor receptors type I and II in patients with IGA nephropathy]. Zwiech R, etal., Pol Arch Med Wewn. 2005 Apr;113(4):326-33.
Additional References at PubMed
PMID:1645445   PMID:7990930   PMID:9435233   PMID:9551933   PMID:10747083   PMID:11279055   PMID:11588035   PMID:12849708   PMID:15509749   PMID:15987482   PMID:17010968   PMID:17049356  
PMID:17242187   PMID:17873366   PMID:17917074   PMID:18205044   PMID:18990246   PMID:21692635   PMID:21871121   PMID:22480688   PMID:25378394   PMID:26491108   PMID:26504355   PMID:26732833  
PMID:27147664   PMID:27979472   PMID:28052249   PMID:29975930   PMID:30988334  


Genomics

Comparative Map Data
Tnfrsf1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,356,250 - 162,387,411 (-)NCBIGRCr8
mRatBN7.25157,070,642 - 157,104,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5159,775,748 - 159,806,642 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,549,033 - 161,579,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,505,389 - 161,536,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05163,136,390 - 163,167,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,815,372 - 166,845,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45163,666,541 - 163,697,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15163,674,328 - 163,707,672 (-)NCBI
Celera5155,362,574 - 155,393,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
TNFRSF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,166,991 - 12,209,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,166,991 - 12,209,228 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,227,048 - 12,269,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,149,647 - 12,191,864 (+)NCBINCBI36Build 36hg18NCBI36
Build 34112,161,325 - 12,203,542NCBI
Celera111,340,352 - 11,382,470 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,380,310 - 11,422,542 (+)NCBIHuRef
CHM1_1112,214,947 - 12,257,256 (+)NCBICHM1_1
T2T-CHM13v2.0111,711,114 - 11,753,352 (+)NCBIT2T-CHM13v2.0
Tnfrsf1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394144,938,938 - 144,973,453 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4144,940,033 - 144,973,440 (-)EnsemblGRCm39 Ensembl
GRCm384145,212,368 - 145,246,870 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4145,213,463 - 145,246,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv374144,802,271 - 144,836,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364144,479,055 - 144,513,557 (-)NCBIMGSCv36mm8
Celera4146,801,795 - 146,837,140 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.17NCBI
Tnfrsf1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,792,115 - 1,818,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,790,531 - 1,817,986 (-)NCBIChiLan1.0ChiLan1.0
TNFRSF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,028,254 - 216,070,267 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,675,232 - 214,717,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,915,743 - 10,957,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,130,663 - 12,172,646 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,130,663 - 12,172,646 (+)Ensemblpanpan1.1panPan2
TNFRSF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,140,179 - 84,151,219 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,141,911 - 84,157,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,674,178 - 80,701,012 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,802,376 - 84,828,308 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,801,328 - 84,828,324 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,551,315 - 81,578,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,551,181 - 82,578,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,616,667 - 83,643,630 (-)NCBIUU_Cfam_GSD_1.0
Tnfrsf1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505835,083,616 - 35,110,985 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474908,485 - 934,177 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474908,414 - 935,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,195,435 - 72,231,147 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,195,420 - 72,231,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TNFRSF1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,590,621 - 119,633,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,590,325 - 119,633,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,447,248 - 23,490,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfrsf1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624818896,150 - 922,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624818894,470 - 922,806 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnfrsf1b
302 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:530
Count of miRNA genes:258
Interacting mature miRNAs:340
Transcripts:ENSRNOT00000022478
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat

Markers in Region
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022478   ⟹   ENSRNOP00000022478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)Ensembl
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103500   ⟹   ENSRNOP00000094197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,070,642 - 157,087,912 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119924   ⟹   ENSRNOP00000078858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)Ensembl
RefSeq Acc Id: NM_130426   ⟹   NP_569110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85162,356,250 - 162,387,411 (-)NCBI
mRatBN7.25157,073,045 - 157,104,206 (-)NCBI
Rnor_6.05163,136,390 - 163,167,299 (-)NCBI
Rnor_5.05166,815,372 - 166,845,910 (-)NCBI
RGSC_v3.45163,666,541 - 163,697,484 (-)RGD
Celera5155,362,574 - 155,393,443 (-)RGD
Sequence:
RefSeq Acc Id: NP_569110   ⟸   NM_130426
- Peptide Label: precursor
- UniProtKB: Q5YLP0 (UniProtKB/Swiss-Prot),   Q80WY6 (UniProtKB/Swiss-Prot),   A6IU15 (UniProtKB/TrEMBL),   A0A8I5ZLM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022478   ⟸   ENSRNOT00000022478
Ensembl Acc Id: ENSRNOP00000078858   ⟸   ENSRNOT00000119924
Ensembl Acc Id: ENSRNOP00000094197   ⟸   ENSRNOT00000103500
Protein Domains
TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80WY6-F1-model_v2 AlphaFold Q80WY6 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694248
Promoter ID:EPDNEW_R4773
Type:multiple initiation site
Name:Tnfrsf1b_1
Description:TNF receptor superfamily member 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05163,167,299 - 163,167,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621238 AgrOrtholog
BioCyc Gene G2FUF-39251 BioCyc
Ensembl Genes ENSRNOG00000016575 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022478 ENTREZGENE
  ENSRNOT00000022478.5 UniProtKB/Swiss-Prot
  ENSRNOT00000103500.1 UniProtKB/TrEMBL
  ENSRNOT00000119924.1 UniProtKB/TrEMBL
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF_chemokine_rcpt-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF1B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:156767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 156767 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/Swiss-Prot
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/Swiss-Prot
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/TrEMBL
Pfam TNFR_c6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TNFRSF1B RGD
PhenoGen Tnfrsf1b PhenoGen
PRINTS TNFACTORR1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016575 RatGTEx
SMART TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP TNF receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJ16_RAT UniProtKB/TrEMBL
  A6IU15 ENTREZGENE, UniProtKB/TrEMBL
  Q5YLP0 ENTREZGENE
  Q80WY6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5YLP0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 Tnfrsf1b  TNF receptor superfamily member 1B  Tnfrsf1b  tumor necrosis factor receptor superfamily, member 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnfrsf1b  tumor necrosis factor receptor superfamily, member 1b      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tnfrsf1b  tumor necrosis factor receptor superfamily, member 1b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function binds to tumor necrosis factor (TNF)-alpha 628388