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Gene: Tnfrsf1b (TNF receptor superfamily member 1B) Rattus norvegicus
Symbol: Tnfrsf1b
Name: TNF receptor superfamily member 1B
RGD ID: 621238
Description: Exhibits tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Localizes to several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and varicosity. Used to study visual epilepsy. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including acne; bone disease (multiple); glomerulonephritis (multiple); lung disease (multiple); and pre-eclampsia. Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; amyotrophic lateral sclerosis pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: p75; p80 TNF-alpha receptor; TNF-R2; TNF-RII; TNFR-II; Tnfr2; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1b; tumor necrosis factor receptor type II
Homo sapiens (human) : TNFRSF1B (TNF receptor superfamily member 1B)  HGNC  Alliance
Mus musculus (house mouse) : Tnfrsf1b (tumor necrosis factor receptor superfamily, member 1b)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfrsf1b (TNF receptor superfamily member 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFRSF1B (TNF receptor superfamily member 1B)
Canis lupus familiaris (dog) : TNFRSF1B (TNF receptor superfamily member 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfrsf1b (TNF receptor superfamily member 1B)
Sus scrofa (pig) : TNFRSF1B (TNF receptor superfamily member 1B)
Chlorocebus sabaeus (African green monkey) : TNFRSF1B (TNF receptor superfamily member 1B)
Heterocephalus glaber (naked mole-rat) : Tnfrsf1b (TNF receptor superfamily member 1B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05163,136,390 - 163,167,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,815,372 - 166,845,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45163,666,541 - 163,697,484 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15163,674,328 - 163,707,672 (-)NCBI
Celera5155,362,574 - 155,393,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tnfrsf1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621238
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.