RGD Reference Report - Regression of endometrial autografts in a rat model of endometriosis treated with etanercept. - Rat Genome Database

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Regression of endometrial autografts in a rat model of endometriosis treated with etanercept.

Authors: Islimye, M  Kilic, S  Zulfikaroglu, E  Topcu, O  Zergeroglu, S  Batioglu, S 
Citation: Islimye M, etal., Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):184-9. doi: 10.1016/j.ejogrb.2011.06.029. Epub 2011 Jul 7.
RGD ID: 7247423
Pubmed: PMID:21741153   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejogrb.2011.06.029   (Journal Full-text)

OBJECTIVE: To determine the efficacy of anti-tumor necrosis factor therapy (etanercept) for treating endometriosis in the rat endometriosis model. STUDY DESIGN: A randomized, placebo-controlled, blinded study using rat endometriosis model. After the peritoneal implantation of endometrial tissue, twenty-eight Wistar female rats were randomized to two equal intervention groups: the control group and the etanercept-treated group. After measuring implant volume, pretreatment blood and peritoneal fluid samples were obtained. A vehicle treatment of 2 mL saline to the rats in control group and 0. 4 mg/kg etanercept SC once weekly were administered in the etanercept-treated group. After four weeks treatment period, the volumes and histopathological properties of the implants were evaluated. A scoring system was used to evaluate preservation of epithelia. Endometrial explants were evaluated immunohistochemically for tumor necrosis factor receptor type 2 (TNFR2). A scoring system was used to evaluate expression grade of TNFR2. RESULTS: There was not a significant difference in spherical volume between control (131.0 (60.3-501.2)) and treatment groups (72.8 (31.2-149.6)) (p>0.025). There was a significant change in between the volumes of implants before and after treatment in etanercept group (p<0.05). At the end of the treatment significant differences among the groups were found in histopathological and immunohistochemical parameters (p<0.05) also histologic scores and HSCORES were decreased in the treatment group significantly (p<0.05). CONCLUSION: These results indicate that etanercept was found to effectively reduce the development of endometriosis in this experimental rat model.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometriosis treatmentISOTnf (Rattus norvegicus)7247423; 7247423 RGD 
endometriosis treatmentIDA 7247423; 7247423 RGD 
endometriosis treatmentISOTNFRSF1B (Homo sapiens)7247423; 7247423 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)
Tnfrsf1b  (TNF receptor superfamily member 1B)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)
Tnfrsf1b  (tumor necrosis factor receptor superfamily, member 1b)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)
TNFRSF1B  (TNF receptor superfamily member 1B)


Additional Information