TNFRSF1B (TNF receptor superfamily member 1B) - Rat Genome Database

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Pathways
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Gene: TNFRSF1B (TNF receptor superfamily member 1B) Chlorocebus sabaeus
Analyze
Symbol: TNFRSF1B
Name: TNF receptor superfamily member 1B
RGD ID: 18432607
Description: ENCODES a protein that exhibits tumor necrosis factor receptor activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN aortic valve development (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH acne (ortholog); acquired immunodeficiency syndrome (ortholog); Acute Experimental Pancreatitis (ortholog); FOUND IN axon (ortholog); membrane raft (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor necrosis factor receptor superfamily member 1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,590,621 - 119,633,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,590,325 - 119,633,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,447,248 - 23,490,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acquired immunodeficiency syndrome  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Bone Fractures  (ISO)
brain ischemia  (ISO)
Bronchial Spasm  (ISO)
cerebral malaria  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
congestive heart failure  (ISO)
Crohn's disease  (ISO)
cryptogenic organizing pneumonia  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrinsic allergic alveolitis  (ISO)
Fatigue  (ISO)
Fetal Death  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Headache  (ISO)
Hyperalgesia  (ISO)
Hypoalbuminemia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
Intervertebral Disc Displacement  (ISO)
kidney failure  (ISO)
Legionnaires' disease  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
Nasal Polyps  (ISO)
Neurogenic Inflammation  (ISO)
nonprogressive cerebellar ataxia with mental retardation  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
pre-eclampsia  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
retinal detachment  (ISO)
sciatic neuropathy  (ISO)
Sciatica  (ISO)
Sezary's disease  (ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNFRSF1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,590,621 - 119,633,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,590,325 - 119,633,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,447,248 - 23,490,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TNFRSF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,166,991 - 12,209,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,166,991 - 12,209,228 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,227,048 - 12,269,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,149,647 - 12,191,864 (+)NCBINCBI36Build 36hg18NCBI36
Build 34112,161,325 - 12,203,542NCBI
Celera111,340,352 - 11,382,470 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,380,310 - 11,422,542 (+)NCBIHuRef
CHM1_1112,214,947 - 12,257,256 (+)NCBICHM1_1
T2T-CHM13v2.0111,711,114 - 11,753,352 (+)NCBIT2T-CHM13v2.0
Tnfrsf1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394144,938,938 - 144,973,453 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4144,940,033 - 144,973,440 (-)EnsemblGRCm39 Ensembl
GRCm384145,212,368 - 145,246,870 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4145,213,463 - 145,246,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv374144,802,271 - 144,836,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364144,479,055 - 144,513,557 (-)NCBIMGSCv36mm8
Celera4146,801,795 - 146,837,140 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.17NCBI
Tnfrsf1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85162,356,250 - 162,387,411 (-)NCBIGRCr8
mRatBN7.25157,070,642 - 157,104,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,070,642 - 157,104,206 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5159,775,748 - 159,806,642 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05161,549,033 - 161,579,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05161,505,389 - 161,536,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05163,136,390 - 163,167,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5163,136,390 - 163,167,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,815,372 - 166,845,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45163,666,541 - 163,697,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15163,674,328 - 163,707,672 (-)NCBI
Celera5155,362,574 - 155,393,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
Tnfrsf1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,792,115 - 1,818,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554861,790,531 - 1,817,986 (-)NCBIChiLan1.0ChiLan1.0
TNFRSF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,028,254 - 216,070,267 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,675,232 - 214,717,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,915,743 - 10,957,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,130,663 - 12,172,646 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,130,663 - 12,172,646 (+)Ensemblpanpan1.1panPan2
TNFRSF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,140,179 - 84,151,219 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,141,911 - 84,157,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,674,178 - 80,701,012 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,802,376 - 84,828,308 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,801,328 - 84,828,324 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,551,315 - 81,578,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,551,181 - 82,578,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,616,667 - 83,643,630 (-)NCBIUU_Cfam_GSD_1.0
Tnfrsf1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505835,083,616 - 35,110,985 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474908,485 - 934,177 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474908,414 - 935,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,195,435 - 72,231,147 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1672,195,420 - 72,231,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Tnfrsf1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624818896,150 - 922,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624818894,470 - 922,806 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20
Low 36 60
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000017725   ⟹   ENSCSAP00000017197
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20119,590,325 - 119,633,497 (-)Ensembl
RefSeq Acc Id: XM_007980504   ⟹   XP_007978695
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120119,592,352 - 119,633,561 (-)NCBI
Vero_WHO_p1.0NW_02366605423,447,248 - 23,490,475 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007980506   ⟹   XP_007978697
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120119,590,621 - 119,633,561 (-)NCBI
Vero_WHO_p1.0NW_02366605423,447,248 - 23,490,475 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007978695 (Get FASTA)   NCBI Sequence Viewer  
  XP_007978697 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017197.1
Reference Protein Sequences
RefSeq Acc Id: XP_007978697   ⟸   XM_007980506
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S8K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007978695   ⟸   XM_007980504
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S8K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017197   ⟸   ENSCSAT00000017725


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000809 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017725.1 UniProtKB/TrEMBL
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFR_1B UniProtKB/TrEMBL
  TNFRSF1B_N UniProtKB/TrEMBL
NCBI Gene TNFRSF1B ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B UniProtKB/TrEMBL
Pfam TNFR_c6 UniProtKB/TrEMBL
PRINTS TNFACTORR1B UniProtKB/TrEMBL
PROSITE TNFR_NGFR_1 UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
SMART TNFR UniProtKB/TrEMBL
Superfamily-SCOP TNF receptor-like UniProtKB/TrEMBL
UniProt A0A0D9S8K8 ENTREZGENE, UniProtKB/TrEMBL