RGD Reference Report - Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. - Rat Genome Database

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Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria.

Authors: Stoelcker, B  Hehlgans, T  Weigl, K  Bluethmann, H  Grau, GE  Mannel, DN 
Citation: Stoelcker B, etal., Infect Immun. 2002 Oct;70(10):5857-9.
RGD ID: 5131158
Pubmed: PMID:12228317   (View Abstract at PubMed)
PMCID: PMC128326   (View Article at PubMed Central)

Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.



Disease Annotations    
cerebral malaria  (IMP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf1b  (TNF receptor superfamily member 1B)

Genes (Mus musculus)
Tnfrsf1b  (tumor necrosis factor receptor superfamily, member 1b)

Genes (Homo sapiens)
TNFRSF1B  (TNF receptor superfamily member 1B)


Additional Information