Cenps (centromere protein S) - Rat Genome Database

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Gene: Cenps (centromere protein S) Rattus norvegicus
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Symbol: Cenps
Name: centromere protein S
RGD ID: 5128728
Description: Predicted to enable DNA binding activity and chromatin binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in interstrand cross-link repair; replication fork processing; and resolution of meiotic recombination intermediates. Predicted to be located in chromatin. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. Orthologous to human CENPS (centromere protein S); INTERACTS WITH acetamide; fipronil; ochratoxin A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Apitd1; apoptosis-inducing, TAF9-like domain 1; FANCM associated histone fold protein 1; Mhf1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,847,009 - 164,856,705 (-)NCBIGRCr8
mRatBN7.25159,563,917 - 159,573,534 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5162,280,626 - 162,290,243 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,101,318 - 164,110,806 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,057,690 - 164,067,178 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,946,106 - 165,955,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,596,287 - 169,605,817 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5157,834,868 - 157,844,482 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:20347428   PMID:20347429  


Genomics

Comparative Map Data
Cenps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,847,009 - 164,856,705 (-)NCBIGRCr8
mRatBN7.25159,563,917 - 159,573,534 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5162,280,626 - 162,290,243 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,101,318 - 164,110,806 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,057,690 - 164,067,178 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,946,106 - 165,955,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,596,287 - 169,605,817 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5157,834,868 - 157,844,482 (-)NCBICelera
Cytogenetic Map5q36NCBI
CENPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,430,433 - 10,442,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,430,433 - 10,442,808 (+)EnsemblGRCh38hg38GRCh38
GRCh37110,490,490 - 10,502,865 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,412,746 - 10,434,797 (+)NCBINCBI36Build 36hg18NCBI36
Celera19,601,550 - 9,623,464 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef19,643,798 - 9,656,502 (+)NCBIHuRef
CHM1_1110,477,737 - 10,490,612 (+)NCBICHM1_1
T2T-CHM13v2.019,974,048 - 9,986,421 (+)NCBIT2T-CHM13v2.0
Cenps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,212,806 - 149,222,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,211,578 - 149,222,086 (-)EnsemblGRCm39 Ensembl
GRCm384149,128,349 - 149,137,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,127,121 - 149,137,629 (-)EnsemblGRCm38mm10GRCm38
MGSCv374148,502,458 - 148,511,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,972,149 - 147,981,350 (-)NCBIMGSCv36mm8
Celera4151,394,399 - 151,403,592 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.89NCBI
Cenps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554863,157,535 - 3,167,397 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554863,157,535 - 3,167,424 (-)NCBIChiLan1.0ChiLan1.0
CENPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,775,591 - 217,797,122 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11216,421,508 - 216,443,031 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,190,303 - 9,211,812 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1110,415,778 - 10,436,977 (+)NCBIpanpan1.1PanPan1.1panPan2
APITD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,701,694 - 70,711,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1670,700,802 - 70,711,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,634,440 - 64,644,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cenps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248182,249,369 - 2,256,834 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248182,244,114 - 2,256,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cenps
86 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_001204879   ⟹   NP_001191808
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,847,009 - 164,856,626 (-)NCBI
mRatBN7.25159,563,917 - 159,573,534 (-)NCBI
Rnor_6.05165,946,106 - 165,955,723 (-)NCBI
Rnor_5.05169,596,287 - 169,605,817 (-)NCBI
Celera5157,834,868 - 157,844,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063287046   ⟹   XP_063143116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,848,898 - 164,856,705 (-)NCBI
RefSeq Acc Id: XM_063287047   ⟹   XP_063143117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,849,986 - 164,856,705 (-)NCBI
RefSeq Acc Id: XM_063287048   ⟹   XP_063143118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,847,015 - 164,856,705 (-)NCBI
RefSeq Acc Id: XM_063287049   ⟹   XP_063143119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,850,635 - 164,856,705 (-)NCBI
RefSeq Acc Id: XM_063287050   ⟹   XP_063143120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,847,425 - 164,856,705 (-)NCBI
RefSeq Acc Id: XM_063287051   ⟹   XP_063143121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,847,425 - 164,856,705 (-)NCBI
RefSeq Acc Id: NP_001191808   ⟸   NM_001204879
- UniProtKB: A6IUA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063143118   ⟸   XM_063287048
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143120   ⟸   XM_063287050
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143121   ⟸   XM_063287051
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063143116   ⟸   XM_063287046
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143117   ⟸   XM_063287047
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143119   ⟸   XM_063287049
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:5128728 AgrOrtholog
BioCyc Gene G2FUF-39142 BioCyc
Gene3D-CATH Histone, subunit A UniProtKB/TrEMBL
InterPro CENP-S/Mhf1 UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
KEGG Report rno:100534597 UniProtKB/TrEMBL
NCBI Gene 100534597 ENTREZGENE
PANTHER CENTROMERE PROTEIN S UniProtKB/TrEMBL
  CORTISTATIN UniProtKB/TrEMBL
Pfam CENP-S UniProtKB/TrEMBL
PhenoGen Cenps PhenoGen
Superfamily-SCOP Histone-fold UniProtKB/TrEMBL
UniProt A6IUA1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-09 Cenps  centromere protein S  Apitd1  apoptosis-inducing, TAF9-like domain 1  Name and Symbol changed 629549 APPROVED
2011-03-15 Apitd1  apoptosis-inducing, TAF9-like domain 1      Symbol and Name status set to provisional 70820 PROVISIONAL