Prkcz (protein kinase C, zeta) - Rat Genome Database

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Gene: Prkcz (protein kinase C, zeta) Rattus norvegicus
Symbol: Prkcz
Name: protein kinase C, zeta
RGD ID: 3399
Description: Enables several functions, including 14-3-3 protein binding activity; enzyme binding activity; and protein kinase C activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of cell communication; and regulation of protein localization. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta); PARTICIPATES IN angiotensin II signaling pathway; epidermal growth factor/neuregulin signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 2-methoxyethanol.
Type: protein-coding
Previously known as: 14 - 3 - 3 - zeta isoform; 14-3-3-zetaisoform; nPKC-zeta; Pkcz; protein kinase C zeta type; r14-3-3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25165,817,786 - 165,930,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,819,466 - 165,930,367 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,525,295 - 168,635,221 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05170,346,708 - 170,456,637 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,309,234 - 170,419,166 (-)NCBIRnor_WKY
Rnor_6.05172,658,071 - 172,769,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,658,748 - 172,769,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,116,787 - 176,228,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,061,825 - 172,172,793 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,072,319 - 172,179,534 (-)NCBI
Celera5164,023,257 - 164,132,959 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromochloroacetic acid  (EXP)
butan-1-ol  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cocaine  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
dapagliflozin  (EXP)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dimethylarsinic acid  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
glucose  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methoxyacetic acid  (EXP)
methylazoxymethanol  (ISO)
mitomycin C  (ISO)
myriocin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenylephrine  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (EXP,ISO)
quercetin  (ISO)
raloxifene  (ISO)
riddelliine  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase D activity  (IMP)
activation of protein kinase B activity  (IMP)
cell migration  (IMP)
cell surface receptor signaling pathway  (IMP)
cellular response to insulin stimulus  (IMP)
establishment of cell polarity  (IMP)
inflammatory response  (IEA)
intracellular signal transduction  (IBA,IDA)
long-term memory  (IMP)
long-term synaptic potentiation  (IMP)
membrane depolarization  (IMP)
membrane hyperpolarization  (IMP)
microtubule cytoskeleton organization  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of hydrolase activity  (IDA)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
neuron projection extension  (ISO)
peptidyl-serine phosphorylation  (IBA,IDA,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO,ISS)
positive regulation of excitatory postsynaptic potential  (IDA)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of interleukin-10 production  (ISO,ISS)
positive regulation of interleukin-13 production  (ISO,ISS)
positive regulation of interleukin-4 production  (ISO,ISS)
positive regulation of interleukin-5 production  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of protein transport  (IMP)
positive regulation of synaptic transmission  (IMP)
positive regulation of T-helper 2 cell cytokine production  (ISO,ISS)
positive regulation of T-helper 2 cell differentiation  (ISO,ISS)
protein kinase C signaling  (IMP)
protein localization  (IMP)
protein localization to plasma membrane  (ISO)
protein phosphorylation  (IDA,ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IMP)
signal transduction  (IDA)
vesicle transport along microtubule  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. cDNA cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol. Alam R, etal., J Biochem (Tokyo) 1994 Aug;116(2):416-25.
2. Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport. Barros SA, etal., J Biol Chem. 2009 Jan 30;284(5):2672-9. Epub 2008 Nov 21.
3. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. Berra E, etal., EMBO J. 1995 Dec 15;14(24):6157-63.
4. PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production. Charruyer A, etal., Biochem J. 2007 Jul 1;405(1):77-83.
5. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Chou MM, etal., Curr Biol. 1998 Sep 24;8(19):1069-77.
6. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, etal., J Biol Chem 2003 Feb 21;278(8):6128-35.
7. Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B. Esteve PO, etal., J Biol Chem 2002 Sep 20;277(38):35150-5.
8. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Etienne-Manneville S and Hall A, Cell. 2001 Aug 24;106(4):489-98.
9. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. Fox TE, etal., J Biol Chem. 2007 Apr 27;282(17):12450-7. Epub 2007 Feb 17.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Gong J, etal., Science. 1999 Sep 3;285(5433):1565-9.
13. Regulation of the expression of prostate apoptosis response protein 4 (Par-4) in rat granulosa cells. Gonzalez IH, etal., Apoptosis. 2007 Apr;12(4):769-79.
14. PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38. Hennige AM, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):85-90.
15. Cellular and subcellular localization of PKM¿. Hernández AI, etal., Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130140. doi: 10.1098/rstb.2013.0140. Print 2014 Jan 5.
16. Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. Hodgkinson CP, etal., Biochem J. 2005 Jun 15;388(Pt 3):785-93.
17. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
18. Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells. Kim Y, etal., Neuroscience. 2004;125(2):359-68.
19. Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. Kim YB, etal., Diabetes. 2003 Aug;52(8):1935-42.
20. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. Kim YB, etal., J Biol Chem 2002 Sep 6;277(36):32915-22.
21. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. Kuroda S, etal., J Cell Biol 1999 Feb 8;144(3):403-11.
22. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. Lamark T, etal., J Biol Chem. 2003 Sep 5;278(36):34568-81. Epub 2003 Jun 17.
23. Protein kinase Mzeta is necessary and sufficient for LTP maintenance. Ling DS, etal., Nat Neurosci. 2002 Apr;5(4):295-6.
24. The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells. Liu LZ, etal., Cell Signal. 2010 Oct;22(10):1513-22. Epub 2010 Jun 4.
25. Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells. Liu LZ, etal., Mol Biol Cell. 2006 May;17(5):2322-30. Epub 2006 Mar 8.
26. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
27. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. McConkey M, etal., J Biol Chem. 2004 May 14;279(20):20882-8. Epub 2004 Mar 8.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Inhibitory effect of ceramide on insulin-induced protein kinase Czeta translocation in rat adipocytes. Miura A, etal., Metabolism 2003 Jan;52(1):19-24.
30. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
31. The structure, expression, and properties of additional members of the protein kinase C family. Ono Y, etal., J Biol Chem 1988 May 15;263(14):6927-32.
32. Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Ono Y, etal., Proc Natl Acad Sci U S A 1989 May;86(9):3099-103.
33. ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy. Parmentier JH, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H46-54. Epub 2005 Aug 19.
34. Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury. Parmentier JH, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1602-13. Epub 2006 May 5.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Tumor necrosis factor alpha and ceramide depolarise the resting membrane potential of thyroid FRTL-5 cells via a protein kinase Czeta-dependent regulation of K+ channels. Ramstrom C, etal., Cell Signal. 2004 Dec;16(12):1417-24.
39. Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. Ravichandran LV, etal., J Biol Chem. 2001 Feb 2;276(5):3543-9. Epub 2000 Nov 3.
40. GOA pipeline RGD automated data pipeline
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Cloning, expression and characterization of an A6-related protein. Rohwer A, etal., Eur J Biochem. 1999 Jul;263(2):518-25.
43. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3.
44. Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91. Ryu J, etal., Arch Biochem Biophys 2002 Jul 1;403(1):71-82.
45. PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. Sarkar S, etal., Traffic. 2006 Aug;7(8):1078-91. Epub 2006 May 25.
46. Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes. Seed Ahmed M, etal., PLoS One. 2015 Sep 23;10(9):e0135781. doi: 10.1371/journal.pone.0135781. eCollection 2015.
47. Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload. Sentex E, etal., Can J Physiol Pharmacol. 2006 Feb;84(2):227-38.
48. Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. Serrano P, etal., J Neurosci. 2005 Feb 23;25(8):1979-84.
49. Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta. Shema R, etal., Science. 2007 Aug 17;317(5840):951-3.
50. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. Standaert ML, etal., J Biol Chem. 1997 Nov 28;272(48):30075-82.
51. Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Steiler TL, etal., Endocrinology. 2003 Dec;144(12):5259-67. Epub 2003 Aug 21.
52. The PAR-aPKC system: lessons in polarity. Suzuki A and Ohno S, J Cell Sci. 2006 Mar 15;119(Pt 6):979-87.
53. Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Tokunaga C, etal., Biochem Biophys Res Commun 1998 Mar 17;244(2):353-9.
54. Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. Vohra BP, etal., J Neurosci. 2007 Aug 29;27(35):9458-68.
55. PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Yao Y, etal., J Neurosci. 2008 Jul 30;28(31):7820-7. doi: 10.1523/JNEUROSCI.0223-08.2008.
Additional References at PubMed
PMID:3691811   PMID:7575416   PMID:8026469   PMID:8180127   PMID:8694767   PMID:9177193   PMID:10770950   PMID:10882525   PMID:11035106   PMID:11463795   PMID:11699875   PMID:11795668  
PMID:11805100   PMID:12169270   PMID:12242277   PMID:12391145   PMID:12527732   PMID:12551925   PMID:12590138   PMID:12857744   PMID:12871585   PMID:14499501   PMID:14500723   PMID:14580237  
PMID:14711829   PMID:14730360   PMID:15069075   PMID:15081397   PMID:15134463   PMID:15371429   PMID:15723051   PMID:15775979   PMID:15802290   PMID:15882626   PMID:15950600   PMID:15958741  
PMID:15987782   PMID:16085361   PMID:16316329   PMID:16455755   PMID:16510873   PMID:17284668   PMID:17313651   PMID:17416458   PMID:17531159   PMID:17558396   PMID:17653813   PMID:17699685  
PMID:17711990   PMID:17724026   PMID:17728398   PMID:17786270   PMID:17878344   PMID:17893151   PMID:17899301   PMID:17940884   PMID:17941087   PMID:18568943   PMID:18577579   PMID:18636965  
PMID:18640115   PMID:18662671   PMID:18702941   PMID:18815554   PMID:18984560   PMID:19056867   PMID:19088082   PMID:19108606   PMID:19241483   PMID:19254952   PMID:19273501   PMID:19380482  
PMID:19523145   PMID:19625676   PMID:19634944   PMID:19668197   PMID:19806657   PMID:19819945   PMID:20013954   PMID:20237282   PMID:20307614   PMID:20332120   PMID:20383136   PMID:20551175  
PMID:20979579   PMID:21131967   PMID:21248226   PMID:21257729   PMID:21258326   PMID:21385716   PMID:21633338   PMID:21949908   PMID:21975456   PMID:22054645   PMID:22123937   PMID:22153887  
PMID:22185613   PMID:22333836   PMID:22348011   PMID:22378786   PMID:22482911   PMID:22531886   PMID:22659643   PMID:22674720   PMID:22967481   PMID:23035087   PMID:23432726   PMID:24117625  
PMID:24141945   PMID:24312324   PMID:24691733   PMID:25713101   PMID:25722116   PMID:25781645   PMID:25822413   PMID:25948265   PMID:26199377   PMID:26205888   PMID:27076427   PMID:27094369  
PMID:27133433   PMID:27417578   PMID:27498875   PMID:27918276   PMID:28258221   PMID:29202853   PMID:29288797   PMID:30622166   PMID:31026567   PMID:34968669  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25165,817,786 - 165,930,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,819,466 - 165,930,367 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,525,295 - 168,635,221 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05170,346,708 - 170,456,637 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,309,234 - 170,419,166 (-)NCBIRnor_WKY
Rnor_6.05172,658,071 - 172,769,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,658,748 - 172,769,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,116,787 - 176,228,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,061,825 - 172,172,793 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,072,319 - 172,179,534 (-)NCBI
Celera5164,023,257 - 164,132,959 (-)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812,048,504 - 2,185,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12,050,411 - 2,185,395 (+)EnsemblGRCh38hg38GRCh38
GRCh3711,981,850 - 2,116,834 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,971,769 - 2,106,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412,014,070 - 2,148,996NCBI
Celera1476,373 - 611,123 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef11,259,190 - 1,392,660 (+)NCBIHuRef
CHM1_111,969,035 - 2,101,756 (+)NCBICHM1_1
T2T-CHM13v2.011,485,930 - 1,620,370 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394155,344,575 - 155,445,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,344,586 - 155,445,818 (-)EnsemblGRCm39 Ensembl
GRCm384155,260,118 - 155,361,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,260,129 - 155,361,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,634,229 - 154,735,500 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,103,920 - 154,205,191 (-)NCBIMGSCv36mm8
Celera4157,534,125 - 157,635,425 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.17NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554868,947,579 - 9,021,702 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,947,579 - 9,021,702 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.111,918,653 - 2,046,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,920,219 - 2,045,855 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01763,942 - 901,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1557,012,020 - 57,113,346 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,012,070 - 57,112,664 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,089,028 - 57,190,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,215,092 - 57,316,595 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,214,279 - 57,316,691 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,206,002 - 57,307,319 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,098,518 - 57,199,838 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,488,367 - 57,589,745 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505828,082,811 - 28,162,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,303,887 - 1,321,944 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367371,303,502 - 1,383,135 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl664,068,577 - 64,163,472 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,073,343 - 64,159,187 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,385,685 - 58,460,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120129,367,309 - 129,502,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,365,679 - 129,485,818 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605433,720,444 - 33,872,633 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248187,759,770 - 7,847,208 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,758,192 - 7,846,950 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkcz
496 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:146
Interacting mature miRNAs:165
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,856,505 - 165,856,681 (+)MAPPERmRatBN7.2
Rnor_6.05172,695,873 - 172,696,048NCBIRnor6.0
Rnor_5.05176,154,587 - 176,154,762UniSTSRnor5.0
RGSC_v3.45172,097,807 - 172,097,982UniSTSRGSC3.4
Celera5164,059,333 - 164,059,508UniSTS
RH 3.4 Map51157.0UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,864,617 - 165,864,738 (+)MAPPERmRatBN7.2
Rnor_6.05172,703,775 - 172,703,895NCBIRnor6.0
Rnor_5.05176,162,489 - 176,162,609UniSTSRnor5.0
RGSC_v3.45172,106,891 - 172,107,011UniSTSRGSC3.4
Celera5164,067,325 - 164,067,445UniSTS
RH 3.4 Map51155.1UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,885,784 - 165,885,981 (+)MAPPERmRatBN7.2
Rnor_6.05172,724,910 - 172,725,105NCBIRnor6.0
Rnor_5.05176,183,624 - 176,183,819UniSTSRnor5.0
RGSC_v3.45172,128,239 - 172,128,434UniSTSRGSC3.4
Celera5164,088,355 - 164,088,550UniSTS
RH 3.4 Map51157.2UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,820,203 - 165,820,573 (+)MAPPERmRatBN7.2
Rnor_6.05172,660,489 - 172,660,858NCBIRnor6.0
Rnor_5.05176,119,203 - 176,119,572UniSTSRnor5.0
RGSC_v3.45172,062,563 - 172,062,932UniSTSRGSC3.4
Celera5164,023,995 - 164,024,364UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,819,856 - 165,820,078 (+)MAPPERmRatBN7.2
Rnor_6.05172,660,142 - 172,660,363NCBIRnor6.0
Rnor_5.05176,118,856 - 176,119,077UniSTSRnor5.0
RGSC_v3.45172,062,216 - 172,062,437UniSTSRGSC3.4
Celera5164,023,648 - 164,023,869UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 68 29 18 11
Low 43 57 41 19 41 8 11 6 6 23 8
Below cutoff


Nucleotide Sequences
RefSeq Transcripts NM_022507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH009282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L23321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000021285   ⟹   ENSRNOP00000021285
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,819,466 - 165,930,367 (-)Ensembl
Rnor_6.0 Ensembl5172,658,748 - 172,769,421 (-)Ensembl
RefSeq Acc Id: NM_022507   ⟹   NP_071952
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,819,466 - 165,930,367 (-)NCBI
Rnor_6.05172,659,751 - 172,769,492 (-)NCBI
Rnor_5.05176,116,787 - 176,228,206 (-)NCBI
RGSC_v3.45172,061,825 - 172,172,793 (-)RGD
Celera5164,023,257 - 164,132,959 (-)RGD
RefSeq Acc Id: XM_006239536   ⟹   XP_006239598
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,817,786 - 165,912,473 (-)NCBI
Rnor_6.05172,658,071 - 172,752,236 (-)NCBI
Rnor_5.05176,116,787 - 176,228,206 (-)NCBI
RefSeq Acc Id: XM_039109309   ⟹   XP_038965237
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,817,786 - 165,930,386 (-)NCBI
RefSeq Acc Id: XM_039109310   ⟹   XP_038965238
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,817,786 - 165,865,727 (-)NCBI
RefSeq Acc Id: XM_039109311   ⟹   XP_038965239
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,817,786 - 165,911,500 (-)NCBI
RefSeq Acc Id: XM_039109312   ⟹   XP_038965240
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,817,786 - 165,912,473 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071952   ⟸   NM_022507
- UniProtKB: P09217 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239598   ⟸   XM_006239536
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000021285   ⟸   ENSRNOT00000021285
RefSeq Acc Id: XP_038965237   ⟸   XM_039109309
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965240   ⟸   XM_039109312
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038965239   ⟸   XM_039109311
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965238   ⟸   XM_039109310
- Peptide Label: isoform X2
Protein Domains
AGC-kinase C-terminal   PB1   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09217-F1-model_v2 AlphaFold P09217 1-592 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694319
Promoter ID:EPDNEW_R4843
Type:initiation region
Description:protein kinase C, zeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05172,769,430 - 172,769,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3399 AgrOrtholog
BioCyc Gene G2FUF-38930 BioCyc
Ensembl Genes ENSRNOG00000015480 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000021285 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021285 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PB1_aPKC UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PKC UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:25522 UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PB1 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Prkcz PhenoGen
PIRSF PKC_zeta UniProtKB/Swiss-Prot
  PB1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
SMART PB1 UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-07-23 Prkcz  protein kinase C, zeta      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Prkcz  14 - 3 - 3 - zeta isoform      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pancreatic islets 70640
gene_process mediates basal and IGF-1-dependent mitogenesis 61695
gene_process mediates basal and IGF-1-dependent mitogenesis 70640
gene_process enhances PDX-1 transcription factor binding activity after stimulation of IGF-1 in RIN 1046-38 cells 61695
gene_process enhances PDX-1 transcription factor binding activity after stimulation of IGF-1 in RIN 1046-38 cells 70640
gene_regulation induced by IL-1 and TNF-alpha; calcium- and diacylglycerol-insensitive 729628