Pank4 (pantothenate kinase 4) - Rat Genome Database

Name: Pank4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pank4 (pantothenate kinase 4) Rattus norvegicus

Analyze

Symbol:

Pank4

Name:

pantothenate kinase 4

RGD ID:

628857

Description:

Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)); PARTICIPATES IN pantothenic acid metabolic pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

4'-phosphopantetheine phosphatase; Fang1; hypothetical protein Fang1; inactive pantothenic acid kinase 4; pantothenate kinase 4 (inactive); pantothenic acid kinase 4; rPanK4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PANK4 (pantothenate kinase 4 (inactive))	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Pank4 (pantothenate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pank4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PANK4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PANK4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pank4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PANK4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PANK4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pank4 (pantothenate kinase 4 (inactive))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PANK4 (pantothenate kinase 4 (inactive))	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pank4 (pantothenate kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pank4 (pantothenate kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CAB1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pnk-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	pnk-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5828	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pank4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	165,525,340 - 165,542,139 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	165,525,402 - 165,542,135 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	168,230,846 - 168,247,308 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,052,260 - 170,068,722 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,014,792 - 170,031,254 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	172,367,593 - 172,384,077 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	172,367,398 - 172,384,269 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	175,823,564 - 175,840,048 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	171,767,041 - 171,783,525 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	171,777,535 - 171,794,011 (+)	NCBI
Celera	5	163,731,885 - 163,748,343 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cataract (ISS)

Cataract 49 (ISO)

chromosome 1p36 deletion syndrome (ISO)

dilated cardiomyopathy 1LL (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

Goldberg-Shprintzen syndrome (ISO)

immunodeficiency 16 (ISO)

immunodeficiency 38 (ISO)

Joubert syndrome 25 (ISO)

Neurodevelopmental Disorders (ISO)

Peroxisome Biogenesis Disorder, Complementation Group 7 (ISO)

Shprintzen-Goldberg Craniosynostosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butanal (ISO)

caffeine (ISO)

chrysene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

gentamycin (EXP)

ivermectin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

tetraphene (ISO)

tributylstannane (EXP)

undecane (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

coenzyme A biosynthetic process (IBA,IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IBA)

nucleus (IBA)

Molecular Function

ATP binding (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

pantothenate kinase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

pantothenic acid metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16132722	PMID:17971806	PMID:28755400	PMID:30927326

Genomics

Comparative Map Data

Pank4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	165,525,340 - 165,542,139 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	165,525,402 - 165,542,135 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	168,230,846 - 168,247,308 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,052,260 - 170,068,722 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,014,792 - 170,031,254 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	172,367,593 - 172,384,077 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	172,367,398 - 172,384,269 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	175,823,564 - 175,840,048 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	171,767,041 - 171,783,525 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	171,777,535 - 171,794,011 (+)	NCBI
Celera	5	163,731,885 - 163,748,343 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

PANK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	2,508,537 - 2,526,596 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	2,508,537 - 2,526,597 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	2,439,976 - 2,458,035 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	2,429,835 - 2,447,895 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	2,472,136 - 2,490,197	NCBI
Celera	1	127,937 - 146,325 (+)	NCBI		Celera
Cytogenetic Map	1	p36.32	NCBI
HuRef	1	1,718,423 - 1,731,652 (-)	NCBI		HuRef
CHM1_1	1	2,426,721 - 2,444,792 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	1,949,626 - 1,968,240 (-)	NCBI		T2T-CHM13v2.0

Pank4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	155,048,580 - 155,065,395 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	155,048,580 - 155,065,395 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	154,964,123 - 154,980,940 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	154,964,123 - 154,980,938 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	154,338,242 - 154,355,047 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	153,807,933 - 153,824,673 (+)	NCBI		MGSCv36	mm8
Celera	4	157,236,178 - 157,253,016 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI

Pank4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	8,702,909 - 8,716,377 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	8,703,236 - 8,716,017 (+)	NCBI	ChiLan1.0	ChiLan1.0

PANK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	224,381,893 - 224,402,477 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	1,238,821 - 1,259,139 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	2,378,116 - 2,391,642 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	2,378,116 - 2,395,738 (-)	Ensembl	panpan1.1		panPan2

PANK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	57,370,624 - 57,386,095 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	57,370,946 - 57,386,089 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	5	57,574,838 - 57,590,295 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	57,574,838 - 57,590,279 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	57,566,341 - 57,581,652 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	57,458,666 - 57,473,975 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	57,848,372 - 57,863,687 (-)	NCBI		UU_Cfam_GSD_1.0

Pank4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	28,401,402 - 28,416,483 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	1,048,597 - 1,065,364 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936737	1,049,467 - 1,064,548 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PANK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	64,393,102 - 64,407,448 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	64,393,092 - 64,407,443 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	58,615,182 - 58,629,220 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PANK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	129,030,853 - 129,050,944 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	129,030,904 - 129,050,636 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	33,377,617 - 33,396,652 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pank4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	7,519,382 - 7,532,108 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	7,519,347 - 7,532,116 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pank4
27 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	193
Count of miRNA genes:	141
Interacting mature miRNAs:	157
Transcripts:	ENSRNOT00000019028
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat

Markers in Region

RH128493

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	165,523,425 - 165,523,644 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	172,365,613 - 172,365,831	NCBI	Rnor6.0
Rnor_5.0	5	175,821,584 - 175,821,802	UniSTS	Rnor5.0
RGSC_v3.4	5	171,765,061 - 171,765,279	UniSTS	RGSC3.4
Celera	5	163,729,905 - 163,730,123	UniSTS
RH 3.4 Map	5	1153.9	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	34	18	19	18	8	11	74	35	36	11	8
Low			23	23		23					5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC134160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF399873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000019028 ⟹ ENSRNOP00000019028

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	165,525,402 - 165,542,135 (+)	Ensembl
Rnor_6.0 Ensembl	5	172,367,398 - 172,384,269 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094361 ⟹ ENSRNOP00000080157

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	165,525,402 - 165,542,135 (+)	Ensembl

RefSeq Acc Id:

NM_133531 ⟹ NP_598215

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	165,525,406 - 165,541,891 (+)	NCBI
Rnor_6.0	5	172,367,593 - 172,384,077 (+)	NCBI
Rnor_5.0	5	175,823,564 - 175,840,048 (+)	NCBI
RGSC_v3.4	5	171,767,041 - 171,783,525 (+)	RGD
Celera	5	163,731,885 - 163,748,343 (+)	RGD

Sequence:

show sequence

CAAAATGGCGGAGTGCCGGGCGAGTGGCGGCGGGAGCGGCGGGGACAGTCTGGACAAGAGCATC
ACGCTGCCCCCCGACGAGATCTTCCGAAACCTGGAGAACGCCAAGCGCTTCGCCATTGATATAG
GTGGATCACTGACCAAGTTGGCATACTATTCCACAGTACAGCACAAAGTGGCCAAAGTGAGGTC
TTTTGACCACCCAGGAAAGGACGCAGAACAGGACCATGAGCCGCCCTATGAGATCTCAGTTCAG
GAGGAGATCACAGCTCGTCTGCATTTCATCAAGTTTGAGAACACCTACATGGAAGCCTGCCTGG
ACTTTATCAGAGACCACCTTGTCAACACTGAGACCAAGGTCATCCAGGCCACAGGGGGTGGAGC
CTACAAGTTCAAGGACCTCATCGAGGAGAAGCTGCGTCTGAAGGTGGACAAAGAGGATGTGATG
ACCTGCTTGATTAAGGGGTGCAACTTCGTGCTGAAGAACATCCCACATGAGGCCTTCATGTACC
AGAAAGACTCAGACCCAGAGTTTCGGTTTCAGACAAATCACCCGAACATCTTCCCCTACCTCCT
AGTCAACATTGGCTCTGGAGTCTCCATCGTGAAGGTGGAGACAGAGGACCGGTTCGAGTGGATT
GGTGGGAGCTCCATTGGAGGAGGCACCTTCTGGGGGCTTGGGGCTCTGCTCACCAAAACAAAGA
AGTTTGATGAGCTGCTGCAGCTGGCTTCCAGAGGCCGGCACGCCAATGTTGACATGCTGGTACA
AGACATCTATGGAGGGGCCCACCAGACCCTGGGGCTGAGCGGCAATCTCATCGCAAGCAGTTTT
GGGAAGTCAGCCACTGCTGACAGAGAGTTCTCCAAAGAAGACATGGCCAAGAGCCTGCTGCACA
TGATCAGCAATGACATTGGACAGCTCGCCTGTCTCTACGCCAAGCTTCATGGCCTAGACAGGGT
CTACTTTGGGGGTTTCTTCATCCGGGGTCACCCTGTGACCATGCGCACCATCACCTACAGCATT
AACTTCTTCTCTAAGGGTGAAGTCCAGGCACTCTTCCTGAGACATGAAGGCTACCTGGGAGCCA
TCGGGGCATTTTTGAAAGGAGCCGAGCAAGATAATCCTAACCAGTACAGCTGGGGTGAGAACTA
CGCGGCCAGCTCCGGGCTGATGAGCACGGCGCCGGAGCTGTGCCCGACACAGCGGGCAAGGAGC
GGCACATTTGACCTGCTGGAAATGGACCGCCTGGAGAGACCCCTGGTCAACCTGCCCCTCCTCC
TGGACCCATCCTCCTATGTGCCCGACACGGTAGACCTCACTGACGATGCTCTGGCCCGACAGTA
CTGGCTCACATGCTTTGAGGAGGCTCTGGATGGGGTGGTGAAGCGAGCTGTGGCCAGCCAGCCA
GAATCCGTGGATGCAGCTGAGAGGGCAGAGAAGTTCCGTCAGAAGTACTGGGGCAAACTTCAGA
CTCTGAGGCACCAGCCCTTTGCTTATGGGACGCTGACTGTGCGCAGCCTGTTGGACACAAGAGA
GCACTGTTTGAATGAGTTCAACTTCCCAGACCCCTACTCCAAGGTGAAGCAGAAAGAAAACGGC
CTCGCGCTAAAGTGCTTTCAGAGCGTGACTCGCTCGCTGGACTCACTAGGCTGGGAGGAGCGGC
AGCTGGCCCTGGTGAAGGGGCTGTTAGCTGGGAATGTCTTTGACTGGGGAGCCAAGGCTGTGTC
TGACGTCCTGGAATCGGACCCCCAGTTTGGGTTTGAAGAAGCAAAGAGAAAATTGCAAGAACGG
CCCTGGCTGGTGGATTCCTACACCAAGTGGCTCCAGAGGTTAAAGGGGCCCCCTCATAAATGTG
CCTTAATTTTCGCAGATAACAGTGGAATAGACATCATTTTGGGAGTCTTCCCCTTTGTCAGGGA
GCTACTCTGTAGAGGGATAGAGGTCATCTTGGCATGCAACTCAGGCCCTGCCCTGAACGATGTG
ACCTACAGTGAGTCTCTCATTGTGGCAGAACGCATTGCAGCCATGGACCCCATCATCTGCACTG
CACTCAGAGAAGACAGGCTACTGCTGGTGCAGACCGGTTCCAGTCCCCCATGCCTAGATCTCAG
CCGCCTAGATAAGGGACTGGCTGTGCTGGTGCGGGAGCGTGGTGCCGACCTGGTGGTCATCGAG
GGAATGGGCCGTGCTGTCCACACCAACTACCATGCTTTGCTGCGATGTGAGAGTCTCAAGCTGG
CCGTGGTGAAGAACGCCTGGCTGGCTGAGCGTCTGGGTGGCCAGCTCTTCAGTGTCATCTTCAA
GTACGAGGTCCCAGCCGAGTGAG

hide sequence

RefSeq Acc Id:

XM_039109220 ⟹ XP_038965148

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	165,525,340 - 165,542,139 (+)	NCBI

RefSeq Acc Id:

XR_005504359

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	165,525,340 - 165,542,136 (+)	NCBI

RefSeq Acc Id:

XR_005504360

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	165,525,340 - 165,538,489 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_598215	(Get FASTA)	NCBI Sequence Viewer
	XP_038965148	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK94009	(Get FASTA)	NCBI Sequence Viewer
	EDL81281	(Get FASTA)	NCBI Sequence Viewer
	Q923S8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598215 ⟸ NM_133531

- UniProtKB:

Q923S8 (UniProtKB/Swiss-Prot), A6IUN0 (UniProtKB/TrEMBL), G3V7T3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAECRASGGGSGGDSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVAKVRSF
DHPGKDAEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVIQATGGGAY
KFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQKDSDPEFRFQTNHPNIFPYLLV
NIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQD
IYGGAHQTLGLSGNLIASSFGKSATADREFSKEDMAKSLLHMISNDIGQLACLYAKLHGLDRVY
FGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYA
ASSGLMSTAPELCPTQRARSGTFDLLEMDRLERPLVNLPLLLDPSSYVPDTVDLTDDALARQYW
LTCFEEALDGVVKRAVASQPESVDAAERAEKFRQKYWGKLQTLRHQPFAYGTLTVRSLLDTREH
CLNEFNFPDPYSKVKQKENGLALKCFQSVTRSLDSLGWEERQLALVKGLLAGNVFDWGAKAVSD
VLESDPQFGFEEAKRKLQERPWLVDSYTKWLQRLKGPPHKCALIFADNSGIDIILGVFPFVREL
LCRGIEVILACNSGPALNDVTYSESLIVAERIAAMDPIICTALREDRLLLVQTGSSPPCLDLSR
LDKGLAVLVRERGADLVVIEGMGRAVHTNYHALLRCESLKLAVVKNAWLAERLGGQLFSVIFKY
EVPAE

hide sequence

RefSeq Acc Id:

ENSRNOP00000019028 ⟸ ENSRNOT00000019028

RefSeq Acc Id:	XP_038965148 ⟸ XM_039109220
- Peptide Label:	isoform X1
- UniProtKB:	A6IUN0 (UniProtKB/TrEMBL), G3V7T3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000080157 ⟸ ENSRNOT00000094361

Protein Domains

Damage-control phosphatase ARMT1-like metal-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q923S8-F1-model_v2	AlphaFold	Q923S8	1-773	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628857	AgrOrtholog
BioCyc Gene	G2FUF-38942	BioCyc
Ensembl Genes	ENSRNOG00000014044	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019028	ENTREZGENE
	ENSRNOP00000019028.2	UniProtKB/TrEMBL
	ENSRNOP00000080157.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019028	ENTREZGENE
	ENSRNOT00000019028.5	UniProtKB/TrEMBL
	ENSRNOT00000094361.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1700.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.420.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.420.510	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Uncharacterised protein PF01937, DUF89, domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Uncharacterised protein PF01937, DUF89, domain 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AF1104-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	At2g17340_3_helix_bundle	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_NBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DUF89	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PanK_long	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Type_II_PanK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171053	UniProtKB/Swiss-Prot
NCBI Gene	171053	ENTREZGENE
PANTHER	4'-PHOSPHOPANTETHEINE PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12280	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUF89	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fumble	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pank4	PhenoGen
PIRSF	PanK_long	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF111321	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF53067	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZQ29_RAT	UniProtKB/TrEMBL
	A6IUN0	ENTREZGENE, UniProtKB/TrEMBL
	G3V7T3	ENTREZGENE, UniProtKB/TrEMBL
	PANK4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-04-29	Pank4	pantothenate kinase 4	Pank4	pantothenate kinase 4 (inactive)	Name changed	629549	APPROVED
2021-10-22	Pank4	pantothenate kinase 4 (inactive)	Pank4	pantothenate kinase 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Pank4	pantothenate kinase 4			Symbol and Name updated	629477	APPROVED
2003-03-06	Pank4	pantothenate kinase 4	Fang1	hypothetical protein Fang1	Data Merged	628472	PROVISIONAL
2003-02-27	Pank4	pantothenate kinase 4			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-08-07	Fang1	hypothetical protein Fang1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Annotations - KEGG (archival)