Ski (Ski proto-oncogene) - Rat Genome Database

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Gene: Ski (Ski proto-oncogene) Rattus norvegicus
Analyze
Symbol: Ski
Name: Ski proto-oncogene
RGD ID: 1565591
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding activity; and histone deacetylase inhibitor activity. Involved in cardiac muscle cell proliferation. Predicted to be located in PML body and centrosome. Predicted to be part of transcription repressor complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKI (SKI proto-oncogene); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH bisphenol A; cadmium dichloride; chlormequat chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-ski; hypothetical protein LOC313757; LOC313757; RGD1565591; similar to Ski protein; ski oncogene; ski sarcoma viral oncogene homolog; Sloan-Kettering viral oncogene homolog; uncharacterized protein LOC313757; v-ski avian sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,995,851 - 171,064,957 (-)NCBIGRCr8
mRatBN7.25165,713,525 - 165,782,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,714,093 - 165,782,733 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,556,196 - 172,623,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,559,135 - 172,623,899 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,014,988 - 176,083,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,953,650 - 171,987,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5163,919,213 - 163,986,092 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle. Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7659522   PMID:7823166   PMID:8514802   PMID:9284043   PMID:11430826   PMID:11441023   PMID:11731796   PMID:11781823   PMID:12419246   PMID:12435627   PMID:12874272   PMID:14699069  
PMID:15107821   PMID:15312649   PMID:17003410   PMID:17054724   PMID:17352741   PMID:17469184   PMID:17510063   PMID:17725545   PMID:18695043   PMID:19008232   PMID:19049980   PMID:19379700  
PMID:20386537   PMID:20943957   PMID:21600873   PMID:21937600   PMID:22277932   PMID:22986000   PMID:23052247   PMID:23610558   PMID:24155330   PMID:27039037   PMID:28059863   PMID:28844002  
PMID:29236326   PMID:29551367   PMID:29950153   PMID:30488595   PMID:33349993   PMID:33847835   PMID:35007896   PMID:35339646  


Genomics

Comparative Map Data
Ski
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,995,851 - 171,064,957 (-)NCBIGRCr8
mRatBN7.25165,713,525 - 165,782,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,714,093 - 165,782,733 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,556,196 - 172,623,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,559,135 - 172,623,899 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,014,988 - 176,083,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,953,650 - 171,987,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5163,919,213 - 163,986,092 (-)NCBICelera
Cytogenetic Map5q36NCBI
SKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,228,319 - 2,310,213 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,227,388 - 2,310,213 (+)EnsemblGRCh38hg38GRCh38
GRCh3712,159,758 - 2,241,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,149,994 - 2,229,316 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412,192,295 - 2,271,618NCBI
Celera1349,404 - 432,073 (-)NCBICelera
Cytogenetic Map1p36.33-p36.32NCBI
HuRef11,435,430 - 1,516,081 (+)NCBIHuRef
CHM1_112,147,183 - 2,227,893 (+)NCBICHM1_1
T2T-CHM13v2.011,663,728 - 1,746,139 (+)NCBIT2T-CHM13v2.0
Ski
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,238,532 - 155,307,536 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,238,532 - 155,307,049 (-)EnsemblGRCm39 Ensembl
GRCm384155,154,075 - 155,222,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,154,075 - 155,222,592 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,528,184 - 154,596,644 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,001,141 - 154,066,320 (-)NCBIMGSCv36mm8
Celera4157,427,881 - 157,496,342 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.17NCBI
Ski
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,857,693 - 8,921,821 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,857,693 - 8,921,821 (-)NCBIChiLan1.0ChiLan1.0
SKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,951,867 - 226,037,094 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,613,373 - 224,698,166 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01944,428 - 1,029,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,091,620 - 2,174,080 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,091,620 - 2,174,080 (+)Ensemblpanpan1.1panPan2
SKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,144,178 - 57,216,385 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,145,825 - 57,214,403 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,222,188 - 57,292,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,347,931 - 57,418,465 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,347,008 - 57,415,963 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,339,163 - 57,409,707 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,231,570 - 57,302,105 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,621,138 - 57,691,705 (+)NCBIUU_Cfam_GSD_1.0
Ski
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,191,284 - 28,243,439 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,222,341 - 1,276,631 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367371,223,653 - 1,274,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,188,236 - 64,242,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,188,265 - 64,242,596 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,243,033 - 129,324,162 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,242,445 - 129,324,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605433,591,348 - 33,675,241 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ski
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,673,203 - 7,736,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,674,184 - 7,736,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ski
257 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
BE099286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,714,635 - 165,714,790 (+)MAPPERmRatBN7.2
Rnor_6.05172,557,307 - 172,557,461NCBIRnor6.0
Rnor_5.05176,016,099 - 176,016,253UniSTSRnor5.0
RGSC_v3.45171,954,762 - 171,954,916UniSTSRGSC3.4
Celera5163,920,324 - 163,920,478UniSTS
RH 3.4 Map51157.1UniSTS
Cytogenetic Map5q36UniSTS
RH141172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2590,862,753 - 90,862,934 (+)MAPPERmRatBN7.2
mRatBN7.25165,714,865 - 165,715,048 (+)MAPPERmRatBN7.2
Rnor_6.05172,557,537 - 172,557,719NCBIRnor6.0
Rnor_6.0593,684,313 - 93,684,493NCBIRnor6.0
Rnor_5.0597,720,722 - 97,720,902UniSTSRnor5.0
Rnor_5.05176,016,329 - 176,016,511UniSTSRnor5.0
RGSC_v3.45171,954,992 - 171,955,174UniSTSRGSC3.4
RGSC_v3.4594,960,308 - 94,960,488UniSTSRGSC3.4
Celera589,551,813 - 89,551,993UniSTS
Celera5163,920,554 - 163,920,736UniSTS
RH 3.4 Map51143.31UniSTS
Cytogenetic Map5q36UniSTS
RH124969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,714,899 - 165,715,032 (+)MAPPERmRatBN7.2
Rnor_6.05172,557,571 - 172,557,703NCBIRnor6.0
Rnor_5.05176,016,363 - 176,016,495UniSTSRnor5.0
RGSC_v3.45171,955,026 - 171,955,158UniSTSRGSC3.4
Celera5163,920,588 - 163,920,720UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 41 25 19 25 6 9 74 35 34 11 6
Low 1 16 16 16 2 2 7 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000080591   ⟹   ENSRNOP00000073651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,714,093 - 165,782,733 (-)Ensembl
Rnor_6.0 Ensembl5172,559,135 - 172,623,899 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111712   ⟹   ENSRNOP00000083197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,714,093 - 165,782,733 (-)Ensembl
RefSeq Acc Id: NM_001100715   ⟹   NP_001094185
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,995,851 - 171,064,957 (-)NCBI
RefSeq Acc Id: XM_039111374   ⟹   XP_038967302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,995,870 - 171,064,495 (-)NCBI
mRatBN7.25165,713,525 - 165,782,134 (-)NCBI
RefSeq Acc Id: XM_063287837   ⟹   XP_063143907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,995,870 - 171,063,147 (-)NCBI
RefSeq Acc Id: XR_010066403
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,002,588 - 171,064,899 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094185 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967302 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143907 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABD66604 (Get FASTA)   NCBI Sequence Viewer  
  EDL81289 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073651.2
  ENSRNOP00000083197
  ENSRNOP00000083197.1
RefSeq Acc Id: ENSRNOP00000073651   ⟸   ENSRNOT00000080591
RefSeq Acc Id: XP_038967302   ⟸   XM_039111374
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYW7 (UniProtKB/TrEMBL),   A6IUN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083197   ⟸   ENSRNOT00000111712
RefSeq Acc Id: NP_001094185   ⟸   NM_001100715
- UniProtKB: A6IUN8 (UniProtKB/TrEMBL),   A0A0G2K628 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143907   ⟸   XM_063287837
- Peptide Label: isoform X2
Protein Domains
c-SKI SMAD4-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K628-F1-model_v2 AlphaFold A0A0G2K628 1-699 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565591 AgrOrtholog
BioCyc Gene G2FUF-38934 BioCyc
Ensembl Genes ENSRNOG00000055340 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080591.2 UniProtKB/TrEMBL
  ENSRNOT00000111712.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.260.20 UniProtKB/TrEMBL
  3.10.390.10 UniProtKB/TrEMBL
InterPro c-SKI_SMAD4-bd_dom UniProtKB/TrEMBL
  DHD_Ski UniProtKB/TrEMBL
  DNA-bd_dom_put UniProtKB/TrEMBL
  SAND_dom-like UniProtKB/TrEMBL
  Ski_DNA-bd_sf UniProtKB/TrEMBL
  Transform_Ski UniProtKB/TrEMBL
  Tscrpt_reg_SKI_SnoN UniProtKB/TrEMBL
KEGG Report rno:313757 UniProtKB/TrEMBL
NCBI Gene 313757 ENTREZGENE
PANTHER PTHR10005 UniProtKB/TrEMBL
  PTHR10005:SF15 UniProtKB/TrEMBL
Pfam c-SKI_SMAD_bind UniProtKB/TrEMBL
  Ski_Sno UniProtKB/TrEMBL
PhenoGen Ski PhenoGen
RatGTEx ENSRNOG00000055340 RatGTEx
SMART c-SKI_SMAD_bind UniProtKB/TrEMBL
Superfamily-SCOP Putativ_DNA_bind UniProtKB/TrEMBL
  SAND_like UniProtKB/TrEMBL
UniProt A0A0G2K628 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYW7 ENTREZGENE, UniProtKB/TrEMBL
  A6IUN8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-09 Ski  Ski proto-oncogene  Ski  SKI proto-oncogene  Name changed 629549 APPROVED
2014-07-10 Ski  SKI proto-oncogene  Ski  v-ski avian sarcoma viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-07 Ski  v-ski avian sarcoma viral oncogene homolog  RGD1565591  similar to Ski protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565591  similar to Ski protein   RGD1565591_predicted  similar to Ski protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565591_predicted  similar to Ski protein (predicted)  LOC313757  similar to Ski protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313757  similar to Ski protein      Symbol and Name status set to provisional 70820 PROVISIONAL