Fbxo6 (F-box protein 6) - Rat Genome Database

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Gene: Fbxo6 (F-box protein 6) Rattus norvegicus
Analyze
Symbol: Fbxo6
Name: F-box protein 6
RGD ID: 620418
Description: Predicted to enable carbohydrate binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; glycoprotein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum quality control compartment. Orthologous to human FBXO6 (F-box protein 6); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 6; F-box only protein 6 b; F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2; Fbg2; Fbxo6b
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,576,729 - 158,582,520 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5158,576,759 - 158,582,525 (-)Ensembl
Rnor_6.05164,956,285 - 164,962,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,956,280 - 164,959,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,614,323 - 168,620,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,223,009 - 165,226,420 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,233,196 - 165,236,608 (-)NCBI
Celera5156,856,162 - 156,859,573 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:12939278   PMID:15489334   PMID:15723043   PMID:19028597   PMID:19716789   PMID:21062743   PMID:31505169  


Genomics

Comparative Map Data
Fbxo6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,576,729 - 158,582,520 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5158,576,759 - 158,582,525 (-)Ensembl
Rnor_6.05164,956,285 - 164,962,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,956,280 - 164,959,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,614,323 - 168,620,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,223,009 - 165,226,420 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,233,196 - 165,236,608 (-)NCBI
Celera5156,856,162 - 156,859,573 (-)NCBICelera
Cytogenetic Map5q36NCBI
FBXO6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,664,200 - 11,674,354 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl111,664,200 - 11,674,354 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,724,257 - 11,734,411 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,646,768 - 11,656,998 (+)NCBINCBI36hg18NCBI36
Build 34111,658,446 - 11,668,673NCBI
Celera110,836,207 - 10,846,475 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,878,308 - 10,888,516 (+)NCBIHuRef
CHM1_1111,712,136 - 11,722,413 (+)NCBICHM1_1
Fbxo6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,230,173 - 148,236,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl4148,230,173 - 148,236,597 (-)Ensembl
GRCm384148,145,716 - 148,152,135 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,145,716 - 148,152,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,519,825 - 147,526,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv364146,989,587 - 146,995,624 (-)NCBImm8
Celera4150,407,047 - 150,413,479 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.67NCBI
Fbxo6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,197,467 - 2,201,256 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,197,296 - 2,205,947 (-)NCBIChiLan1.0ChiLan1.0
FBXO6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,549,519 - 84,554,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,549,560 - 84,580,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,081,851 - 81,088,009 (-)NCBI
ROS_Cfam_1.0285,212,668 - 85,218,810 (-)NCBI
ROS_Cfam_1.0 Ensembl285,212,675 - 85,218,790 (-)Ensembl
UMICH_Zoey_3.1281,961,418 - 81,967,576 (-)NCBI
UNSW_CanFamBas_1.0282,962,035 - 82,968,196 (-)NCBI
UU_Cfam_GSD_1.0284,024,909 - 84,031,072 (-)NCBI
Fbxo6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,707,679 - 34,713,814 (+)NCBI
SpeTri2.0NW_004936474531,873 - 538,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,743,261 - 71,774,223 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,755,335 - 71,774,264 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,674,308 - 65,693,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,116,125 - 120,127,025 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,116,169 - 120,126,920 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605423,984,628 - 23,995,338 (-)NCBIVero_WHO_p1.0
Fbxo6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,286,819 - 1,292,565 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BE114020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,578,242 - 158,578,401 (+)MAPPERmRatBN7.2
Rnor_6.05164,957,800 - 164,957,958NCBIRnor6.0
Rnor_5.05168,615,838 - 168,615,996UniSTSRnor5.0
RGSC_v3.45165,224,373 - 165,224,531UniSTSRGSC3.4
Celera5156,857,526 - 156,857,684UniSTS
RH 3.4 Map51108.2UniSTS
Cytogenetic Map5q36UniSTS
RH133258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,576,936 - 158,577,117 (+)MAPPERmRatBN7.2
Rnor_6.05164,956,494 - 164,956,674NCBIRnor6.0
Rnor_5.05168,614,532 - 168,614,712UniSTSRnor5.0
RGSC_v3.45165,223,067 - 165,223,247UniSTSRGSC3.4
Celera5156,856,220 - 156,856,400UniSTS
RH 3.4 Map51104.4UniSTS
Cytogenetic Map5q36UniSTS
AA848404  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map51108.2UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:44
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000012301
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 51 35 19 35 8 11 74 35 41 11 8
Low 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012301   ⟹   ENSRNOP00000012301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,576,764 - 158,581,616 (-)Ensembl
Rnor_6.0 Ensembl5164,956,280 - 164,959,851 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096248   ⟹   ENSRNOP00000082391
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,576,759 - 158,582,525 (-)Ensembl
RefSeq Acc Id: NM_138917   ⟹   NP_620272
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,576,879 - 158,580,290 (-)NCBI
Rnor_6.05164,956,436 - 164,959,847 (-)NCBI
Rnor_5.05168,614,323 - 168,620,072 (-)NCBI
RGSC_v3.45165,223,009 - 165,226,420 (-)RGD
Celera5156,856,162 - 156,859,573 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239372   ⟹   XP_006239434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,576,729 - 158,582,330 (-)NCBI
Rnor_6.05164,956,285 - 164,961,886 (-)NCBI
Rnor_5.05168,614,323 - 168,620,072 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239373   ⟹   XP_006239435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,576,729 - 158,582,330 (-)NCBI
Rnor_6.05164,956,285 - 164,961,886 (-)NCBI
Rnor_5.05168,614,323 - 168,620,072 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239374   ⟹   XP_006239436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,576,729 - 158,582,520 (-)NCBI
Rnor_6.05164,956,285 - 164,962,075 (-)NCBI
Rnor_5.05168,614,323 - 168,620,072 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239375   ⟹   XP_006239437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,576,729 - 158,582,506 (-)NCBI
Rnor_6.05164,956,285 - 164,962,075 (-)NCBI
Rnor_5.05168,614,323 - 168,620,072 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_620272   ⟸   NM_138917
- UniProtKB: Q923V4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239436   ⟸   XM_006239374
- Peptide Label: isoform X1
- UniProtKB: Q923V4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239437   ⟸   XM_006239375
- Peptide Label: isoform X1
- UniProtKB: Q923V4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239435   ⟸   XM_006239373
- Peptide Label: isoform X1
- UniProtKB: Q923V4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239434   ⟸   XM_006239372
- Peptide Label: isoform X1
- UniProtKB: Q923V4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012301   ⟸   ENSRNOT00000012301
RefSeq Acc Id: ENSRNOP00000082391   ⟸   ENSRNOT00000096248
Protein Domains
F-box   FBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923V4-F1-model_v2 AlphaFold Q923V4 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 165223129 165223130 G T snv HCR/1Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620418 AgrOrtholog
BioCyc Gene G2FUF-39174 BioCyc
Ensembl Genes ENSRNOG00000009217 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000012301 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000082391 ENTREZGENE
Ensembl Transcript ENSRNOT00000012301 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000096248 ENTREZGENE
IMAGE_CLONE IMAGE:6921385 IMAGE-MGC_LOAD
InterPro F-box-assoc_dom UniProtKB/Swiss-Prot
  F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  F-box_only UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:192351 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72682 IMAGE-MGC_LOAD
NCBI Gene 192351 ENTREZGENE
PANTHER PTHR12125 UniProtKB/Swiss-Prot
Pfam F-box-like UniProtKB/Swiss-Prot
  FBA UniProtKB/Swiss-Prot
PhenoGen Fbxo6 PhenoGen
PROSITE FBA UniProtKB/Swiss-Prot
  FBOX UniProtKB/Swiss-Prot
SMART FBA UniProtKB/Swiss-Prot
  FBOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot
  SSF81383 UniProtKB/Swiss-Prot
UniProt FBX6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6P512 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Fbxo6  F-box protein 6  Fbxo6b  F-box only protein 6b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Fbxo6b  F-box only protein 6b    F-box only protein 6 b  Name updated 1299863 APPROVED
2002-08-07 Fbxo6b  F-box only protein 6 b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs okadaic acid inhibits the expression in hepatoma cells 632656
gene_expression mRNA expressed in foetal liver which decreases after birth and re-accumalates in adult liver 632656
gene_product member of the third subfamily of mammalian F-box proteins 632656
gene_protein 180 amino-acid protein with six exons and five introns and a conserved C-terminal domain 632656