Tas1r3 (taste 1 receptor member 3) - Rat Genome Database

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Gene: Tas1r3 (taste 1 receptor member 3) Rattus norvegicus
Analyze
Symbol: Tas1r3
Name: taste 1 receptor member 3
RGD ID: 620539
Description: Enables taste receptor activity. Involved in sensory perception of sweet taste and sensory perception of umami taste. Predicted to be located in membrane. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Orthologous to human TAS1R3 (taste 1 receptor member 3); INTERACTS WITH ammonium chloride; bisphenol A; diclofenac.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: sweet taste receptor T1R3; T1r3; taste receptor type 1 member 3; taste receptor, type 1, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25166,469,589 - 166,472,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,469,589 - 166,472,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,174,257 - 169,177,410 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05170,995,678 - 170,998,831 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,958,209 - 170,961,362 (-)NCBIRnor_WKY
Rnor_6.05173,307,325 - 173,312,950 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,308,870 - 173,312,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,784,486 - 176,787,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,718,551 - 172,721,704 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,729,045 - 172,732,199 (-)NCBI
Celera5164,670,308 - 164,673,461 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Human receptors for sweet and umami taste. Li X, etal., Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4692-6.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Mammalian sweet taste receptors. Nelson G, etal., Cell 2001 Aug 10;106(3):381-90.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12892531   PMID:15299024   PMID:16720576   PMID:20156422   PMID:20943918   PMID:24898279   PMID:26096555   PMID:28474538   PMID:28782537   PMID:31655082  


Genomics

Comparative Map Data
Tas1r3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25166,469,589 - 166,472,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,469,589 - 166,472,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,174,257 - 169,177,410 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05170,995,678 - 170,998,831 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,958,209 - 170,961,362 (-)NCBIRnor_WKY
Rnor_6.05173,307,325 - 173,312,950 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,308,870 - 173,312,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,784,486 - 176,787,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,718,551 - 172,721,704 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,729,045 - 172,732,199 (-)NCBI
Celera5164,670,308 - 164,673,461 (-)NCBICelera
Cytogenetic Map5q36NCBI
TAS1R3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,331,280 - 1,335,314 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11,331,280 - 1,335,314 (+)EnsemblGRCh38hg38GRCh38
GRCh3711,266,660 - 1,270,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,256,589 - 1,259,707 (+)NCBINCBI36Build 36hg18NCBI36
Celera11,311,298 - 1,314,416 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1537,931 - 541,049 (+)NCBIHuRef
CHM1_111,253,754 - 1,256,872 (+)NCBICHM1_1
T2T-CHM13v2.01762,865 - 766,899 (+)NCBIT2T-CHM13v2.0
Tas1r3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,943,725 - 155,947,810 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,943,725 - 155,947,819 (-)EnsemblGRCm39 Ensembl
GRCm384155,859,268 - 155,863,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,859,268 - 155,863,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,233,377 - 155,237,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,703,068 - 154,707,153 (-)NCBIMGSCv36mm8
Celera4158,130,220 - 158,134,291 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.65NCBI
Tas1r3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,470,626 - 9,473,780 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,469,954 - 9,475,421 (-)NCBIChiLan1.0ChiLan1.0
TAS1R3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111,287,841 - 1,292,094 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,287,841 - 1,292,094 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0188,514 - 92,505 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TAS1R3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,503,720 - 56,506,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,503,720 - 56,506,898 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,580,045 - 56,583,207 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,705,942 - 56,709,102 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,705,942 - 56,709,117 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,696,682 - 56,699,843 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,588,966 - 56,592,124 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,979,204 - 56,982,368 (+)NCBIUU_Cfam_GSD_1.0
Tas1r3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,649,632 - 27,654,945 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,811,815 - 1,814,982 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367371,811,123 - 1,814,982 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAS1R3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,607,990 - 63,617,809 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,613,536 - 63,617,831 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,111,612 - 58,115,907 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q22-q23NCBI
LOC103225805
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,119,451 - 130,122,920 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,119,804 - 130,122,903 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605434,682,289 - 34,686,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tas1r3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,279,161 - 8,282,304 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248188,279,161 - 8,282,304 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tas1r3
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:31
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000026671
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 8 24 8 16 8 8 8 8 9 8 9 8
Below cutoff 3 5 5 5 3 5 3 19 6 11 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026671   ⟹   ENSRNOP00000026671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,469,589 - 166,472,742 (-)Ensembl
Rnor_6.0 Ensembl5173,308,870 - 173,312,023 (-)Ensembl
RefSeq Acc Id: NM_130818   ⟹   NP_570831
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25166,469,589 - 166,472,742 (-)NCBI
Rnor_6.05173,308,870 - 173,312,023 (-)NCBI
Rnor_5.05176,784,486 - 176,787,639 (-)NCBI
RGSC_v3.45172,718,551 - 172,721,704 (-)RGD
Celera5164,670,308 - 164,673,461 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_570831 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK51601 (Get FASTA)   NCBI Sequence Viewer  
  AAM10636 (Get FASTA)   NCBI Sequence Viewer  
  EDL81337 (Get FASTA)   NCBI Sequence Viewer  
  Q923K1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_570831   ⟸   NM_130818
- Peptide Label: precursor
- UniProtKB: Q923K1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026671   ⟸   ENSRNOT00000026671

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923K1-F1-model_v2 AlphaFold Q923K1 1-858 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620539 AgrOrtholog
BioCyc Gene G2FUF-38892 BioCyc
Ensembl Genes ENSRNOG00000019589 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000026671 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026671 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  GPCR_3 UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot
  GPCR_3_C UniProtKB/Swiss-Prot
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/Swiss-Prot
  GPCR_3_CS UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:170634 UniProtKB/Swiss-Prot
NCBI Gene 170634 ENTREZGENE
PANTHER PTHR24061 UniProtKB/Swiss-Prot
Pfam 7tm_3 UniProtKB/Swiss-Prot
  ANF_receptor UniProtKB/Swiss-Prot
  NCD3G UniProtKB/Swiss-Prot
PhenoGen Tas1r3 PhenoGen
PRINTS CASENSINGR UniProtKB/Swiss-Prot
  GPCRMGR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
UniProt Q923K1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Tas1r3  taste 1 receptor member 3  Tas1r3  taste receptor, type 1, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tas1r3  taste receptor, type 1, member 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tas1r3  taste receptor, type 1, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function heterodimeric sweet taste receptor 634155