H6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) - Rat Genome Database

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Gene: H6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) Rattus norvegicus
Analyze
Symbol: H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
RGD ID: 1306562
Description: Enables NADP binding activity; carbohydrate binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in NADP metabolic process; response to alcohol; and response to nutrient levels. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase); PARTICIPATES IN pentose phosphate pathway; INTERACTS WITH (S)-(-)-perillyl alcohol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GDH/6PGL endoplasmic bifunctional protein; H6pdh; hexose-6-phosphate dehydrogenase; LOC298655
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,717,456 - 165,753,158 (-)NCBIGRCr8
mRatBN7.25160,434,499 - 160,470,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,438,697 - 160,470,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,155,204 - 163,186,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,977,022 - 165,008,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,933,395 - 164,964,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05166,994,683 - 167,030,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,998,881 - 167,030,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,639,363 - 170,671,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,093,827 - 167,125,298 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,106,074 - 167,122,313 (-)NCBI
Celera5158,701,339 - 158,732,691 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-(-)-perillyl alcohol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
disulfiram  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
Evodiamine  (ISO)
fenthion  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
GSK-J4  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
leflunomide  (EXP)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
MeIQx  (ISO)
methapyrilene  (EXP,ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perillyl alcohol  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis. Alcina A, etal., Eur J Hum Genet. 2010 May;18(5):618-20. Epub 2009 Nov 25.
2. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper N, etal., Nat Genet. 2003 Aug;34(4):434-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat. Gomez-Sanchez EP, etal., Endocrinology. 2008 Feb;149(2):525-33. Epub 2007 Nov 26.
6. Characterization of the glucose 6-phosphate dehydrogenase activity in rat liver mitochondria. Grunwald M and Hill HZ, Biochem J. 1976 Dec 1;159(3):683-7.
7. Hexose-6-phosphate and 6-phosphogluconate dehydrogenases of rat liver microsomes. Involvement in NADPH and carbon dioxide generation in the luminal space of microsomal vesicles. Hino Y and Minakami S, J Biochem (Tokyo). 1982 Aug;92(2):547-57.
8. Effect of diabetes on enzymes involved in rat hepatic corticosterone production. Hyatt T, etal., J Diabetes. 2010 Dec;2(4):275-81. doi: 10.1111/j.1753-0407.2010.00087.x.
9. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
10. Increased 11beta-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in utero. Nammi S, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1101-9. Epub 2006 Nov 22.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12831846   PMID:16337333   PMID:16356929   PMID:17303657   PMID:18029473   PMID:18222920   PMID:18628520   PMID:21163329   PMID:21620971   PMID:23132696  


Genomics

Comparative Map Data
H6pd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,717,456 - 165,753,158 (-)NCBIGRCr8
mRatBN7.25160,434,499 - 160,470,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,438,697 - 160,470,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,155,204 - 163,186,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,977,022 - 165,008,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,933,395 - 164,964,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05166,994,683 - 167,030,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,998,881 - 167,030,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,639,363 - 170,671,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,093,827 - 167,125,298 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,106,074 - 167,122,313 (-)NCBI
Celera5158,701,339 - 158,732,691 (-)NCBICelera
Cytogenetic Map5q36NCBI
H6PD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,234,774 - 9,271,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,234,774 - 9,271,337 (+)EnsemblGRCh38hg38GRCh38
GRCh3719,294,833 - 9,331,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,217,450 - 9,253,983 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419,229,099 - 9,260,797NCBI
Celera18,404,605 - 8,441,131 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,445,791 - 8,481,724 (+)NCBIHuRef
CHM1_119,285,083 - 9,321,616 (+)NCBICHM1_1
T2T-CHM13v2.018,769,418 - 8,805,954 (+)NCBIT2T-CHM13v2.0
H6pd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,063,931 - 150,093,480 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,063,932 - 150,093,480 (-)EnsemblGRCm39 Ensembl
GRCm384149,979,474 - 150,009,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,979,475 - 150,009,023 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,353,590 - 149,383,132 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,823,281 - 148,852,823 (-)NCBIMGSCv36mm8
Celera4152,253,494 - 152,283,077 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.65NCBI
H6pd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,115,077 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,088,354 - 4,115,077 (-)NCBIChiLan1.0ChiLan1.0
H6PD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21218,956,890 - 218,992,571 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,601,960 - 217,637,627 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017,996,315 - 8,031,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119,232,668 - 9,263,094 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,232,666 - 9,256,631 (+)Ensemblpanpan1.1panPan2
H6PD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,548,136 - 62,577,346 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,548,221 - 62,608,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,565,183 - 62,594,414 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,774,365 - 62,803,560 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,774,303 - 62,803,557 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,772,315 - 62,801,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,636,227 - 62,665,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0563,040,668 - 63,069,873 (+)NCBIUU_Cfam_GSD_1.0
H6pd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,871,094 - 32,893,170 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,351,716 - 3,375,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,359,624 - 3,376,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
H6PD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,666,601 - 69,700,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,666,348 - 69,700,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
H6PD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,502,084 - 122,531,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,503,687 - 122,526,074 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605426,514,853 - 26,546,615 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
H6pd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,025,252 - 3,051,260 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,025,323 - 3,052,486 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in H6pd
185 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:315
Count of miRNA genes:180
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000023543
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
AI785303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,439,088 - 160,439,188 (+)MAPPERmRatBN7.2
Rnor_6.05166,999,273 - 166,999,372NCBIRnor6.0
Rnor_5.05170,640,681 - 170,640,780UniSTSRnor5.0
RGSC_v3.45167,094,219 - 167,094,318UniSTSRGSC3.4
Celera5158,701,731 - 158,701,830UniSTS
Cytogenetic Map5q36UniSTS
RH140648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,439,207 - 160,439,426 (+)MAPPERmRatBN7.2
Rnor_6.05166,999,392 - 166,999,610NCBIRnor6.0
Rnor_5.05170,640,800 - 170,641,018UniSTSRnor5.0
RGSC_v3.45167,094,338 - 167,094,556UniSTSRGSC3.4
Celera5158,701,850 - 158,702,068UniSTS
RH 3.4 Map51120.6UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:546813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,440,463 - 160,441,275 (+)MAPPERmRatBN7.2
Rnor_6.05167,000,648 - 167,001,459NCBIRnor6.0
Rnor_5.05170,642,056 - 170,642,867UniSTSRnor5.0
Celera5158,703,106 - 158,703,917UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023543   ⟹   ENSRNOP00000023543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,438,697 - 160,470,171 (-)Ensembl
Rnor_6.0 Ensembl5166,998,881 - 167,030,441 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109227   ⟹   ENSRNOP00000079574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,438,697 - 160,457,028 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113819   ⟹   ENSRNOP00000097852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,438,697 - 160,456,723 (-)Ensembl
RefSeq Acc Id: NM_001106698   ⟹   NP_001100168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,721,654 - 165,753,125 (-)NCBI
mRatBN7.25160,438,697 - 160,470,171 (-)NCBI
Rnor_6.05166,998,881 - 167,030,441 (-)NCBI
Rnor_5.05170,639,363 - 170,671,849 (-)NCBI
RGSC_v3.45167,093,827 - 167,125,298 (-)RGD
Celera5158,701,339 - 158,732,691 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239459   ⟹   XP_006239521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,717,456 - 165,747,885 (-)NCBI
mRatBN7.25160,434,499 - 160,464,942 (-)NCBI
Rnor_6.05166,994,683 - 167,025,264 (-)NCBI
Rnor_5.05170,639,363 - 170,671,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239460   ⟹   XP_006239522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,717,456 - 165,747,886 (-)NCBI
mRatBN7.25160,434,499 - 160,464,943 (-)NCBI
Rnor_6.05166,994,683 - 167,025,264 (-)NCBI
Rnor_5.05170,639,363 - 170,671,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109705   ⟹   XP_038965633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,717,456 - 165,753,158 (-)NCBI
mRatBN7.25160,434,499 - 160,470,203 (-)NCBI
RefSeq Acc Id: XM_039109706   ⟹   XP_038965634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,717,456 - 165,745,176 (-)NCBI
mRatBN7.25160,434,499 - 160,462,217 (-)NCBI
RefSeq Acc Id: NP_001100168   ⟸   NM_001106698
- Peptide Label: precursor
- UniProtKB: D4A7D7 (UniProtKB/TrEMBL),   A6IUC4 (UniProtKB/TrEMBL),   A0A8I5ZNT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239522   ⟸   XM_006239460
- Peptide Label: isoform X1
- UniProtKB: A6IUC5 (UniProtKB/TrEMBL),   A0A8I5ZNT3 (UniProtKB/TrEMBL),   A0A8I6ANS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239521   ⟸   XM_006239459
- Peptide Label: isoform X1
- UniProtKB: A6IUC5 (UniProtKB/TrEMBL),   A0A8I5ZNT3 (UniProtKB/TrEMBL),   A0A8I6ANS1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023543   ⟸   ENSRNOT00000023543
RefSeq Acc Id: XP_038965633   ⟸   XM_039109705
- Peptide Label: isoform X1
- UniProtKB: A6IUC5 (UniProtKB/TrEMBL),   A0A8I5ZNT3 (UniProtKB/TrEMBL),   A0A8I6ANS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965634   ⟸   XM_039109706
- Peptide Label: isoform X1
- UniProtKB: A6IUC5 (UniProtKB/TrEMBL),   A0A8I5ZNT3 (UniProtKB/TrEMBL),   A0A8I6ANS1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097852   ⟸   ENSRNOT00000113819
Ensembl Acc Id: ENSRNOP00000079574   ⟸   ENSRNOT00000109227
Protein Domains
Glucosamine/galactosamine-6-phosphate isomerase   Glucose-6-phosphate dehydrogenase C-terminal   Glucose-6-phosphate dehydrogenase NAD-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7D7-F1-model_v2 AlphaFold D4A7D7 1-797 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694278
Promoter ID:EPDNEW_R4803
Type:initiation region
Name:H6pd_1
Description:hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05167,030,409 - 167,030,469EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306562 AgrOrtholog
BioCyc Gene G2FUF-39091 BioCyc
Ensembl Genes ENSRNOG00000017523 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023543 ENTREZGENE
  ENSRNOT00000023543.6 UniProtKB/TrEMBL
  ENSRNOT00000109227.1 UniProtKB/TrEMBL
  ENSRNOT00000113819.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1360 UniProtKB/TrEMBL
  Dihydrodipicolinate Reductase, domain 2 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro 6-phosphogluconolactonase_DevB UniProtKB/TrEMBL
  G6P_DH UniProtKB/TrEMBL
  G6P_DH_AS UniProtKB/TrEMBL
  G6P_DH_C UniProtKB/TrEMBL
  G6P_DH_NAD-bd UniProtKB/TrEMBL
  Glc/Gal-6P_isomerase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
KEGG Report rno:298655 UniProtKB/TrEMBL
NCBI Gene 298655 ENTREZGENE
PANTHER G6PDH UniProtKB/TrEMBL
  GDH/6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN UniProtKB/TrEMBL
Pfam G6PD_C UniProtKB/TrEMBL
  G6PD_N UniProtKB/TrEMBL
  Glucosamine_iso UniProtKB/TrEMBL
PhenoGen H6pd PhenoGen
PRINTS G6PDHDRGNASE UniProtKB/TrEMBL
PROSITE G6P_DEHYDROGENASE UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017523 RatGTEx
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/TrEMBL
  SSF100950 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8I5ZNT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANS1 ENTREZGENE, UniProtKB/TrEMBL
  A6IUC4 ENTREZGENE, UniProtKB/TrEMBL
  A6IUC5 ENTREZGENE, UniProtKB/TrEMBL
  D4A7D7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 H6pd  hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)   H6pd_predicted  hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 H6pd_predicted  hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (predicted)      Symbol and Name status set to approved 70820 APPROVED