Errfi1 (ERBB receptor feedback inhibitor 1) - Rat Genome Database

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Gene: Errfi1 (ERBB receptor feedback inhibitor 1) Rattus norvegicus
Analyze
Symbol: Errfi1
Name: ERBB receptor feedback inhibitor 1
RGD ID: 1307599
Description: Enables SH3 domain binding activity; kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of macromolecule metabolic process; and negative regulation of signal transduction. Predicted to be located in cytosol and plasma membrane. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gene 33; gene 33 polypeptide; LOC313729; mig-6; mitogen-inducible gene 6 protein homolog; Ralt; receptor-associated late transducer; RGD1307599; similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide); Xxx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,323,981 - 161,337,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,323,998 - 161,337,282 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,041,130 - 164,054,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,857,948 - 165,871,237 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,819,770 - 165,833,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,951,564 - 167,966,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,952,728 - 167,966,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,529,354 - 171,542,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,012,683 - 168,025,963 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,022,870 - 168,036,149 (+)NCBI
Celera5159,577,700 - 159,590,979 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glyphosate  (ISO)
hydrogen cyanide  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
kenpaullone  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methylisothiazolinone  (ISO)
mocetinostat  (ISO)
naphthalene  (ISO)
naproxen  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sodium arsenite  (ISO)
sodium chromate  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sumatriptan  (EXP)
tacedinaline  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
bile acid biosynthetic process  (IEA,ISO)
cartilage development  (IEA,ISO)
cell migration  (IEA,ISO)
cellular hyperosmotic response  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
embryo implantation  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelium development  (ISO)
fat pad development  (IEA,ISO)
gene expression  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
limb joint morphogenesis  (IEA,ISO)
lipid metabolic process  (ISO)
liver development  (IEA,ISO)
lung alveolus development  (IEA,ISO,ISS)
lung epithelium development  (IEA,ISO,ISS)
lung vasculature development  (IEA,ISO,ISS)
negative regulation of cardiac muscle hypertrophy in response to stress  (IDA)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of epidermal growth factor receptor signaling pathway  (IBA,IEA,IMP,ISO)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of peptidyl-tyrosine phosphorylation  (IDA)
negative regulation of protein autophosphorylation  (IEA,ISO,ISS)
negative regulation of tumor necrosis factor production  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
progesterone receptor signaling pathway  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
regulation of keratinocyte differentiation  (IBA,IEA,ISO,ISS)
regulation of type B pancreatic cell proliferation  (IMP)
response to 1-oleoyl-sn-glycerol 3-phosphate  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to insulin  (IEA,ISO)
response to progesterone  (IEA,ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
skeletal system development  (ISO)
skin development  (ISO)
skin morphogenesis  (IEA,ISO,ISS)
tissue homeostasis  (IEA,ISO)
uterine epithelium development  (IEA,ISO)
uterus development  (ISO)

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
nucleus  (IEA)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity. Anastasi S, etal., Oncogene. 2007 Dec 13;26(57):7833-46. Epub 2007 Jun 18.
2. Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling. Cai J, etal., Hypertension. 2009 Mar;53(3):539-48. doi: 10.1161/HYPERTENSIONAHA.108.120816. Epub 2009 Feb 9.
3. Glucocorticoid-induced suppression of beta-cell proliferation is mediated by Mig6. Colvin ES, etal., Endocrinology. 2013 Mar;154(3):1039-46. doi: 10.1210/en.2012-1923. Epub 2013 Feb 5.
4. Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Fiorentino L, etal., Mol Cell Biol. 2000 Oct;20(20):7735-50.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Regulation of Gene33 expression by insulin requires MEK-ERK activation. Keeton AB, etal., Biochim Biophys Acta. 2004 Sep 17;1679(3):248-55.
7. Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress. Makkinje A, etal., J Biol Chem. 2000 Jun 9;275(23):17838-47.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. Xu D, etal., J Biol Chem. 2005 Jan 28;280(4):2924-33. Epub 2004 Nov 19.
Additional References at PubMed
PMID:2780291   PMID:2916834   PMID:3224831   PMID:12226756   PMID:12833145   PMID:15489334   PMID:15856022   PMID:16648858   PMID:18046415   PMID:18056042   PMID:19103603   PMID:19710174  
PMID:20421427   PMID:23432726   PMID:27358163   PMID:30597234  


Genomics

Comparative Map Data
Errfi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,323,981 - 161,337,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,323,998 - 161,337,282 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,041,130 - 164,054,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,857,948 - 165,871,237 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,819,770 - 165,833,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,951,564 - 167,966,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,952,728 - 167,966,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,529,354 - 171,542,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,012,683 - 168,025,963 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,022,870 - 168,036,149 (+)NCBI
Celera5159,577,700 - 159,590,979 (+)NCBICelera
Cytogenetic Map5q36NCBI
ERRFI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818,011,727 - 8,026,309 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18,004,404 - 8,026,309 (-)EnsemblGRCh38hg38GRCh38
GRCh3718,071,787 - 8,086,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,994,381 - 8,008,943 (-)NCBINCBI36Build 36hg18NCBI36
Celera17,178,838 - 7,193,452 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,219,226 - 7,233,836 (-)NCBIHuRef
CHM1_118,059,534 - 8,074,168 (-)NCBICHM1_1
T2T-CHM13v2.017,542,658 - 7,557,236 (-)NCBIT2T-CHM13v2.0
Errfi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,938,253 - 150,953,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,938,376 - 150,953,349 (+)EnsemblGRCm39 Ensembl
GRCm384150,853,796 - 150,868,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,853,919 - 150,868,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv374150,229,200 - 150,242,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,698,891 - 149,712,680 (+)NCBIMGSCv36mm8
Celera4153,132,313 - 153,145,977 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.5NCBI
Errfi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,941,143 - 4,955,693 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,941,143 - 4,955,693 (+)NCBIChiLan1.0ChiLan1.0
ERRFI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11218,844,232 - 218,858,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,771,619 - 6,786,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.118,019,048 - 8,033,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,011,848 - 8,033,674 (-)Ensemblpanpan1.1panPan2
ERRFI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,621,964 - 61,636,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,622,550 - 61,636,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,630,761 - 61,645,081 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0561,838,401 - 61,852,732 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,838,401 - 61,852,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,837,612 - 61,851,932 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,702,129 - 61,716,447 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,105,524 - 62,119,850 (-)NCBIUU_Cfam_GSD_1.0
Errfi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,972,493 - 31,977,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,456,294 - 2,462,467 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366232,457,709 - 2,462,956 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERRFI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,669,153 - 68,682,623 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,667,651 - 68,682,629 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,118,704 - 63,121,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERRFI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,738,971 - 123,753,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,738,973 - 123,755,809 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605427,772,809 - 27,787,441 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Errfi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,868,814 - 3,882,960 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,868,089 - 3,882,960 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Errfi1
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:119
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000071036
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 49 41 4 41 3 69 35 33 11
Low 23 8 15 8 8 5 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085315   ⟹   ENSRNOP00000072811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,323,998 - 161,337,282 (+)Ensembl
Rnor_6.0 Ensembl5167,952,728 - 167,966,009 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115083   ⟹   ENSRNOP00000082119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,332,364 - 161,337,274 (+)Ensembl
RefSeq Acc Id: NM_001014071   ⟹   NP_001014093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,324,005 - 161,337,289 (+)NCBI
Rnor_6.05167,952,728 - 167,966,011 (+)NCBI
Rnor_5.05171,529,354 - 171,542,775 (+)NCBI
RGSC_v3.45168,012,683 - 168,025,963 (+)RGD
Celera5159,577,700 - 159,590,979 (+)RGD
Sequence:
RefSeq Acc Id: XM_008764262   ⟹   XP_008762484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,323,981 - 161,337,289 (+)NCBI
Rnor_6.05167,952,720 - 167,966,002 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001014093 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762484 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB08828 (Get FASTA)   NCBI Sequence Viewer  
  AAH83845 (Get FASTA)   NCBI Sequence Viewer  
  EDL81192 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072811
  ENSRNOP00000072811.2
  ENSRNOP00000082119.1
GenBank Protein P05432 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001014093   ⟸   NM_001014071
- UniProtKB: P05432 (UniProtKB/Swiss-Prot),   A6IUE1 (UniProtKB/TrEMBL),   A0A8L2R6B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762484   ⟸   XM_008764262
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R6B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072811   ⟸   ENSRNOT00000085315
RefSeq Acc Id: ENSRNOP00000082119   ⟸   ENSRNOT00000115083
Protein Domains
Cdc42 binding   Mig-6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05432-F1-model_v2 AlphaFold P05432 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694283
Promoter ID:EPDNEW_R4808
Type:single initiation site
Name:Errfi1_1
Description:ERBB receptor feedback inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05167,952,724 - 167,952,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307599 AgrOrtholog
BioCyc Gene G2FUF-39056 BioCyc
Ensembl Genes ENSRNOG00000058186 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085315 ENTREZGENE
  ENSRNOT00000085315.2 UniProtKB/TrEMBL
  ENSRNOT00000115083.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121187 IMAGE-MGC_LOAD
InterPro Cdc42-bd-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Mig-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:313729 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95004 IMAGE-MGC_LOAD
NCBI Gene 313729 ENTREZGENE
PANTHER ERBB RECEPTOR FEEDBACK INHIBITOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GENE 33 POLYPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GTPase_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inhibitor_Mig-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Errfi1 PhenoGen
RatGTEx ENSRNOG00000058186 RatGTEx
UniProt A0A8I5ZT20_RAT UniProtKB/TrEMBL
  A0A8L2R6B1 ENTREZGENE, UniProtKB/TrEMBL
  A6IUE1 ENTREZGENE, UniProtKB/TrEMBL
  ERRFI_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Errfi1  ERBB receptor feedback inhibitor 1  RGD1307599  similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide)  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307599  similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide)  RGD1307599_predicted  similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307599_predicted  similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide) (predicted)  LOC313729_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC313729_predicted  similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL