Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Mxra8 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of MXRA8 mRNA | CTD | PMID:22206623 | Mxra8 | Rat | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of MXRA8 mRNA | CTD | PMID:17557909 | Mxra8 | Rat | 17beta-estradiol | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Estradiol results in increased expression of MXRA8 mRNA | CTD | PMID:19484750 | Mxra8 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MXRA8 mRNA | CTD | PMID:20106945 and PMID:21632981 | Mxra8 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MXRA8 mRNA | CTD | PMID:33387578 | Mxra8 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MXRA8 mRNA | CTD | PMID:34747641 | Mxra8 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of MXRA8 mRNA | CTD | PMID:22574217 | Mxra8 | Rat | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | Mxra8 | Rat | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of MXRA8 mRNA | CTD | PMID:28522335 | Mxra8 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | MXRA8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA8 mRNA | CTD | PMID:28628672 | Mxra8 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | bisphenol S results in increased expression of MXRA8 mRNA | CTD | PMID:30951980 | Mxra8 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of MXRA8 protein | CTD | PMID:34186270 | Mxra8 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Mxra8 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of MXRA8 exon | CTD | PMID:33297965 | Mxra8 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of MXRA8 mRNA | CTD | PMID:28973697 | Mxra8 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of MXRA8 mRNA | CTD | PMID:30047161 | Mxra8 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of MXRA8 mRNA | CTD | PMID:28959563 | Mxra8 | Rat | acrylamide | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of MXRA8 mRNA | CTD | PMID:32763439 | Mxra8 | Rat | acrylamide | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Acrylamide results in increased expression of MXRA8 mRNA | CTD | PMID:30807115 | Mxra8 | Rat | all-trans-retinoic acid | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of MXRA8 mRNA | CTD | PMID:23724009 | Mxra8 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of MXRA8 mRNA | CTD | PMID:35163327 | Mxra8 | Rat | antirheumatic drug | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of MXRA8 mRNA | CTD | PMID:24449571 | Mxra8 | Rat | aristolochic acid A | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of MXRA8 mRNA | CTD | PMID:33212167 | Mxra8 | Rat | arsenite(3-) | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | TRP53 protein affects the reaction [arsenite results in decreased expression of MXRA8 mRNA] | CTD | PMID:18929588 | Mxra8 | Rat | arsenite(3-) | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | arsenite results in decreased expression of MXRA8 mRNA | CTD | PMID:18929588 | Mxra8 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of MXRA8 mRNA | CTD | PMID:36841081 | Mxra8 | Rat | benzo[a]pyrene | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to MXRA8 promoter] | CTD | PMID:19654925 | Mxra8 | Rat | benzo[a]pyrene | affects methylation | ISO | MXRA8 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of MXRA8 promoter | CTD | PMID:27901495 | Mxra8 | Rat | benzo[a]pyrene | decreases methylation | ISO | MXRA8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of MXRA8 exon | CTD | PMID:27901495 | Mxra8 | Rat | benzo[a]pyrene | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of MXRA8 mRNA | CTD | PMID:22316170 | Mxra8 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of MXRA8 mRNA | CTD | PMID:25181051 | Mxra8 | Rat | bisphenol A | decreases methylation | ISO | MXRA8 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of MXRA8 gene | CTD | PMID:31601247 | Mxra8 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MXRA8 mRNA | CTD | PMID:34947998 | Mxra8 | Rat | bisphenol A | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | bisphenol A results in increased expression of MXRA8 mRNA | CTD | PMID:30951980 | Mxra8 | Rat | bisphenol F | multiple interactions | ISO | MXRA8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA8 mRNA | CTD | PMID:28628672 | Mxra8 | Rat | bisphenol F | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | bisphenol F results in increased expression of MXRA8 mRNA | CTD | PMID:30951980 | Mxra8 | Rat | cadmium dichloride | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Cadmium Chloride results in increased expression of MXRA8 mRNA | CTD | PMID:24982889 | Mxra8 | Rat | cadmium dichloride | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of MXRA8 mRNA | CTD | PMID:38568856 | Mxra8 | Rat | calcitriol | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of MXRA8 mRNA | CTD | PMID:26485663 | Mxra8 | Rat | carbon nanotube | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Mxra8 | Rat | choline | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MXRA8 gene | CTD | PMID:20938992 | Mxra8 | Rat | ciglitazone | decreases expression | EXP | | 6480464 | ciglitazone results in decreased expression of MXRA8 mRNA | CTD | PMID:22193206 | Mxra8 | Rat | clotrimazole | decreases expression | EXP | | 6480464 | Clotrimazole results in decreased expression of MXRA8 mRNA | CTD | PMID:30047161 | Mxra8 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of MXRA8 mRNA | CTD | PMID:26577399 | Mxra8 | Rat | cyclosporin A | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MXRA8 mRNA | CTD | PMID:25562108 | Mxra8 | Rat | dexamethasone | multiple interactions | ISO | MXRA8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA8 mRNA | CTD | PMID:28628672 | Mxra8 | Rat | dibutyl phthalate | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of MXRA8 mRNA | CTD | PMID:21266533 | Mxra8 | Rat | dimethyl sulfoxide | increases expression | EXP | | 6480464 | Dimethyl Sulfoxide results in increased expression of MXRA8 mRNA | CTD | PMID:22193206 | Mxra8 | Rat | dioxygen | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MXRA8 mRNA | CTD | PMID:30529165 | Mxra8 | Rat | diquat | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Diquat results in decreased expression of MXRA8 protein | CTD | PMID:36851058 | Mxra8 | Rat | disodium selenite | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of MXRA8 mRNA | CTD | PMID:18175754 | Mxra8 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of MXRA8 mRNA | CTD | PMID:25152437 | Mxra8 | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of MXRA8 mRNA | CTD | PMID:21551480 | Mxra8 | Rat | doxorubicin | decreases secretion | EXP | | 6480464 | Doxorubicin results in decreased secretion of MXRA8 protein | CTD | PMID:28885000 | Mxra8 | Rat | doxorubicin | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of MXRA8 mRNA | CTD | PMID:29803840 | Mxra8 | Rat | entinostat | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | entinostat results in increased expression of MXRA8 mRNA | CTD | PMID:27188386 | Mxra8 | Rat | fenthion | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Fenthion results in increased expression of MXRA8 mRNA | CTD | PMID:34813904 | Mxra8 | Rat | folic acid | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MXRA8 gene | CTD | PMID:20938992 | Mxra8 | Rat | folic acid | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of MXRA8 mRNA | CTD | PMID:27293554 | Mxra8 | Rat | formaldehyde | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of MXRA8 mRNA | CTD | PMID:27905399 | Mxra8 | Rat | FR900359 | increases phosphorylation | ISO | MXRA8 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of MXRA8 protein | CTD | PMID:37730182 | Mxra8 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of MXRA8 mRNA | CTD | PMID:27387713 | Mxra8 | Rat | indometacin | multiple interactions | ISO | MXRA8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MXRA8 mRNA | CTD | PMID:28628672 | Mxra8 | Rat | inulin | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of MXRA8 mRNA | CTD | PMID:36331819 | Mxra8 | Rat | L-methionine | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MXRA8 gene | CTD | PMID:20938992 | Mxra8 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of MXRA8 mRNA | CTD | PMID:30047161 | Mxra8 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of MXRA8 mRNA | CTD | PMID:25729387 | Mxra8 | Rat | ozone | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of MXRA8 mRNA | CTD | PMID:34911549 | Mxra8 | Rat | paracetamol | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of MXRA8 mRNA | CTD | PMID:22230336 | Mxra8 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MXRA8 mRNA | CTD | PMID:33387578 | Mxra8 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Mxra8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of MXRA8 mRNA | CTD | PMID:36331819 | Mxra8 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of MXRA8 mRNA | CTD | PMID:35163327 | Mxra8 | Rat | potassium dichromate | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of MXRA8 protein | CTD | PMID:23718831 | Mxra8 | Rat | resveratrol | multiple interactions | ISO | MXRA8 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of MXRA8 mRNA | CTD | PMID:23557933 | Mxra8 | Rat | rotenone | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Rotenone results in increased expression of MXRA8 mRNA | CTD | PMID:29955902 | Mxra8 | Rat | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide results in decreased expression of MXRA8 mRNA | CTD | PMID:22431001 | Mxra8 | Rat | silicon dioxide | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of MXRA8 mRNA | CTD | PMID:23221170 | Mxra8 | Rat | sodium arsenite | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of MXRA8 mRNA | CTD | PMID:37682722 | Mxra8 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of MXRA8 mRNA | CTD | PMID:19281266 | Mxra8 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of MXRA8 mRNA | CTD | PMID:30047161 | Mxra8 | Rat | sunitinib | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of MXRA8 mRNA | CTD | PMID:31533062 | Mxra8 | Rat | testosterone | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Testosterone results in increased expression of MXRA8 mRNA | CTD | PMID:33359661 | Mxra8 | Rat | tetrachloromethane | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of MXRA8 mRNA | CTD | PMID:27339419 | Mxra8 | Rat | thimerosal | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of MXRA8 mRNA | CTD | PMID:27188386 | Mxra8 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of MXRA8 mRNA | CTD | PMID:25729387 | Mxra8 | Rat | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of MXRA8 mRNA | CTD | PMID:25729387 | Mxra8 | Rat | tremolite asbestos | decreases expression | ISO | Mxra8 (Mus musculus) | 6480464 | tremolite results in decreased expression of MXRA8 mRNA | CTD | PMID:29279043 | Mxra8 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of MXRA8 mRNA | CTD | PMID:33387578 | Mxra8 | Rat | triptonide | increases expression | ISO | Mxra8 (Mus musculus) | 6480464 | triptonide results in increased expression of MXRA8 mRNA | CTD | PMID:33045310 | Mxra8 | Rat | valproic acid | increases methylation | ISO | MXRA8 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of MXRA8 gene | CTD | PMID:29154799 | Mxra8 | Rat | valproic acid | increases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of MXRA8 mRNA | CTD | PMID:23179753 more ... | Mxra8 | Rat | valproic acid | decreases expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of MXRA8 mRNA | CTD | PMID:29154799 | Mxra8 | Rat | valproic acid | affects expression | ISO | MXRA8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of MXRA8 mRNA | CTD | PMID:25979313 | Mxra8 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of MXRA8 mRNA | CTD | PMID:19015723 | Mxra8 | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of MXRA8 mRNA | CTD | PMID:23869203 | |