Gene: Tp73 (tumor protein p73) Rattus norvegicus
Analyze
Symbol:
Tp73
Name:
tumor protein p73
Description:
Exhibits sequence-specific DNA binding activity. Involved in several processes, including activation of MAPK activity; positive regulation of apoptotic process; and regulation of neurogenesis. Localizes to the chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in breast cancer; lung cancer; nephroblastoma; and renal cell carcinoma. Orthologous to human TP73 (tumor protein p73); PARTICIPATES IN Ras mediated signaling pathway; altered p53 signaling pathway; measles pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2-acetamidofluorene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
P73; transformation related protein 73; Trp73
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TP73 (tumor protein p73) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Trp73 (transformation related protein 73) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tp73 (tumor protein p73) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TP73 (tumor protein p73) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TP73 (tumor protein p73) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tp73 (tumor protein p73) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TP73 (tumor protein p73) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TP63 (tumor protein p63) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
TP73 (tumor protein p73)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Trp73 (transformation related protein 73)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
tp73 (tumor protein p73)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 171,355,876 - 171,415,354 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 171,355,876 - 171,415,354 (-) Ensembl Rnor_5.0 5 174,843,033 - 174,868,415 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 5 174,889,051 - 174,901,875 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 170,848,979 - 171,078,739 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 170,861,458 - 170,885,614 (-) NCBI Celera 5 162,833,132 - 162,892,871 (-) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Neurodevelopmental Disorders ISO RGD:1316062 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
adult T-cell leukemia ISO RGD:1316062 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26437031 alveolar rhabdomyosarcoma ISO RGD:1316062 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21245298 Breast Neoplasms ISO RGD:1316062 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28212736 Inflammation ISO RGD:1316062 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28212736 Lung Neoplasms ISO RGD:1316062 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28212736 Nervous System Malformations ISO RGD:1316063 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24190996 Neurologic Manifestations ISO RGD:1316063 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24190996 Imported Annotations - MGI
otitis media ISS RGD:1316063 13592920 OMIM:166760 MouseDO
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one increases degradation ISO RGD:1316062 6480464 cyclopiazonic acid results in increased degradation of TP73 protein modified form CTD PMID:21516125 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o, p'-DDT results in increased expression of TP73 mRNA CTD PMID:22937105 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression EXP 6480464 o, p'-DDT analog results in decreased expression of TP73 mRNA CTD PMID:22937105 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of TP73 mRNA CTD PMID:30723492 17beta-estradiol multiple interactions ISO RGD:1316062 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of TP73 mRNA CTD PMID:30165855 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one multiple interactions ISO RGD:1316062 6480464 2 more ... CTD PMID:21647879 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1316063 6480464 Tetrachlorodibenzodioxin results in decreased expression of TRP73 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1316063 6480464 Tetrachlorodibenzodioxin affects the expression of TRP73 mRNA CTD PMID:21570461 2-acetamidofluorene decreases expression EXP 6480464 2-Acetylaminofluorene results in decreased expression of TP73 mRNA CTD PMID:22213190 4-hydroxynon-2-enal increases expression ISO RGD:1316062 6480464 4-hydroxy-2-nonenal results in increased expression of TP73 protein CTD PMID:15607904 5-aza-2'-deoxycytidine decreases methylation ISO RGD:1316062 6480464 Decitabine results in decreased methylation of TP73 promoter CTD PMID:19194470 5-azacytidine multiple interactions ISO RGD:1316062 6480464 TP73 protein promotes the reaction [Azacitidine results in increased expression of HMGA2 mRNA] more ... CTD PMID:21245298 5-fluorouracil affects response to substance ISO RGD:1316062 6480464 TP73 protein affects the susceptibility to Fluorouracil CTD PMID:18714155 5-fluorouracil multiple interactions ISO RGD:1316062 6480464 TP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA] CTD PMID:21127500 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of TP73 mRNA CTD PMID:25825206 adenosine 5'-monophosphate affects abundance ISO RGD:1316063 6480464 TP73 protein affects the abundance of Adenosine Monophosphate CTD PMID:25554796 aflatoxin B1 multiple interactions ISO RGD:1316062 6480464 [Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA CTD PMID:28965971 all-trans-retinoic acid increases expression ISO RGD:1316062 6480464 Tretinoin results in increased expression of TRP73 protein CTD PMID:24190996 all-trans-retinoic acid multiple interactions ISO RGD:1316062 6480464 TP73 protein affects the reaction [Tretinoin promotes the reaction [bafilomycin A results in increased expression of MAP1LC3B protein modified form]] more ... CTD PMID:28978663 apigenin increases expression ISO RGD:1316062 6480464 Apigenin results in increased expression of TP73 protein CTD PMID:19397994 aprepitant multiple interactions ISO RGD:1316062 6480464 [Arsenic Trioxide co-treated with Aprepitant] results in increased expression of TP73 mRNA CTD PMID:30145367 arsane affects methylation ISO RGD:1316062 6480464 Arsenic affects the methylation of TP73 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1316062 6480464 Arsenic affects the methylation of TP73 gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:1316062 6480464 Arsenic Trioxide results in increased expression of TP73 mRNA CTD PMID:19763917 , PMID:20458559 arsenous acid multiple interactions ISO RGD:1316062 6480464 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3 more ... CTD PMID:15031205 more ... asbestos affects localization ISO RGD:1316062 6480464 Asbestos affects the localization of TP73 protein CTD PMID:25466987 benzo[a]pyrene increases expression ISO RGD:1316062 6480464 Benzo(a)pyrene results in increased expression of TP73 mRNA CTD PMID:20862736 benzo[a]pyrene multiple interactions ISO RGD:1316063 6480464 [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of TRP73 mRNA CTD PMID:25820237 benzo[a]pyrene increases expression ISO RGD:1316063 6480464 Benzo(a)pyrene results in increased expression of TRP73 mRNA CTD PMID:23735875 , PMID:27195522 benzo[a]pyrene affects activity ISO RGD:1316062 6480464 Benzo(a)pyrene affects the activity of TP73 protein CTD PMID:20624995 benzophenanthridine decreases expression ISO RGD:1316062 6480464 Benzophenanthridines analog results in decreased expression of TP73 mRNA CTD PMID:23117580 bexarotene increases expression ISO RGD:1316062 6480464 bexarotene results in increased expression of TP73 protein CTD PMID:19067706 biphenyl-4-amine decreases expression ISO RGD:1316062 6480464 4-biphenylamine results in decreased expression of TP73 mRNA CTD PMID:24857880 bisphenol A decreases expression ISO RGD:1316063 6480464 bisphenol A results in decreased expression of TRP73 CTD PMID:25205691 bisphenol A affects methylation ISO RGD:1316063 6480464 bisphenol A affects the methylation of TRP73 promoter CTD PMID:27334623 bisphenol A decreases methylation ISO RGD:1316063 6480464 bisphenol A results in decreased methylation of TRP73 promoter CTD PMID:27312807 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TP73 mRNA CTD PMID:25181051 Brevetoxin B increases expression ISO RGD:1316062 6480464 brevetoxin 2 results in increased expression of TP73 mRNA CTD PMID:20498034 cadmium dichloride decreases activity ISO RGD:1316062 6480464 Cadmium Chloride results in decreased activity of TP73 protein CTD PMID:25446071 cadmium dichloride multiple interactions ISO RGD:1316062 6480464 [Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene], Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 calcitriol multiple interactions ISO RGD:1316062 6480464 [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol CTD PMID:17716971 calcium atom multiple interactions ISO RGD:1316062 6480464 [Calcium co-treated with CAPN1 protein] results in increased degradation of TP73 protein modified form CTD PMID:21516125 calcium(0) multiple interactions ISO RGD:1316062 6480464 [Calcium co-treated with CAPN1 protein] results in increased degradation of TP73 protein modified form CTD PMID:21516125 Calpeptin multiple interactions ISO RGD:1316062 6480464 calpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form] CTD PMID:21516125 carbon nanotube decreases expression ISO RGD:1316063 6480464 Nanotubes, Carbon analog results in decreased expression of TRP73 mRNA, Nanotubes, Carbon results in decreased expression of TRP73 mRNA CTD PMID:25554681 chromium(6+) multiple interactions ISO RGD:1316063 6480464 [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of TRP73 mRNA CTD PMID:25820237 chrysin increases expression ISO RGD:1316062 6480464 chrysin results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 cisplatin multiple interactions ISO RGD:1316062 6480464 [[[Cisplatin co-treated with 2 more ... CTD PMID:14678968 more ... cisplatin increases expression ISO RGD:1316062 6480464 Cisplatin results in increased expression of TP73 protein CTD PMID:17076661 more ... cisplatin increases activity ISO RGD:1316062 6480464 Cisplatin results in increased activity of TP73 protein CTD PMID:14678968 cisplatin decreases expression ISO RGD:1316062 6480464 Cisplatin results in decreased expression of TP73 mRNA, Cisplatin results in decreased expression of TP73 protein modified form CTD PMID:21516125 , PMID:21737676 cisplatin affects localization ISO RGD:1316062 6480464 Cisplatin affects the localization of TP73 protein modified form CTD PMID:21516125 cisplatin increases expression ISO RGD:1316063 6480464 Cisplatin results in increased expression of TRP73 CTD PMID:22002055 cisplatin decreases response to substance ISO RGD:1316063 6480464 TRP73 alternative form results in decreased susceptibility to Cisplatin CTD PMID:22002055 cisplatin decreases expression ISO RGD:1316063 6480464 Cisplatin results in decreased expression of TRP73 alternative form CTD PMID:22002055 cisplatin increases response to substance ISO RGD:1316062 6480464 TP73 protein modified form results in increased susceptibility to Cisplatin, TP73 results in increased susceptibility to Cisplatin CTD PMID:20100536 , PMID:21516125 cobalt dichloride decreases activity ISO RGD:1316062 6480464 cobaltous chloride results in decreased activity of TP73 protein CTD PMID:25446071 cobalt dichloride multiple interactions ISO RGD:1316062 6480464 [cobaltous chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene] CTD PMID:25446071 copper atom decreases expression ISO RGD:1316062 6480464 Copper results in decreased expression of TP73 mRNA CTD PMID:16391388 copper(0) decreases expression ISO RGD:1316062 6480464 Copper results in decreased expression of TP73 mRNA CTD PMID:16391388 copper(II) chloride affects expression ISO RGD:1316063 6480464 cupric chloride affects the expression of TRP73 protein CTD PMID:23313662 copper(II) chloride increases expression ISO RGD:1316063 6480464 cupric chloride results in increased expression of TRP73 protein CTD PMID:24170445 cyclosporin A decreases methylation ISO RGD:1316062 6480464 Cyclosporine results in decreased methylation of TP73 promoter CTD PMID:27989131 diarsenic trioxide multiple interactions ISO RGD:1316062 6480464 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3 more ... CTD PMID:15031205 more ... diarsenic trioxide increases expression ISO RGD:1316062 6480464 Arsenic Trioxide results in increased expression of TP73 mRNA CTD PMID:19763917 , PMID:20458559 diazinon increases methylation ISO RGD:1316062 6480464 Diazinon results in increased methylation of TP73 gene CTD PMID:22964155 doxorubicin multiple interactions ISO RGD:1316062 6480464 [[[Doxorubicin co-treated with 2 more ... CTD PMID:21214929 , PMID:25124555 doxorubicin increases expression ISO RGD:1316062 6480464 Doxorubicin results in increased expression of TP73 mRNA, Doxorubicin results in increased expression of TP73 protein CTD PMID:17716971 more ... ethylenediaminetetraacetic acid multiple interactions ISO RGD:1316062 6480464 Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 etoposide multiple interactions ISO RGD:1316062 6480464 [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol more ... CTD PMID:17716971 , PMID:21801448 etoposide increases expression ISO RGD:1316062 6480464 Etoposide results in increased expression of TP73 mRNA, Etoposide results in increased expression of TP73 protein CTD PMID:17716971 , PMID:21801448 furan decreases expression EXP 6480464 furan results in decreased expression of TP73 mRNA CTD PMID:25539665 Fusarenone X increases expression ISO RGD:1316063 6480464 fusarenon-X results in increased expression of TRP73 mRNA CTD PMID:24983900 hydrogen peroxide affects response to substance ISO RGD:1316063 6480464 TRP73 protein affects the susceptibility to Hydrogen Peroxide CTD PMID:27119504 hydroxyurea increases expression ISO RGD:1316063 6480464 Hydroxyurea results in increased expression of TRP73 mRNA CTD PMID:29228353 hydroxyurea multiple interactions ISO RGD:1316063 6480464 TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA] CTD PMID:29228353 IMP affects abundance ISO RGD:1316063 6480464 TP73 protein affects the abundance of Inosine Monophosphate CTD PMID:25554796 kaempferol increases expression ISO RGD:1316062 6480464 kaempferol results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of TP73 mRNA CTD PMID:25808816 luteolin increases expression ISO RGD:1316062 6480464 Luteolin results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 manganese(II) chloride decreases response to substance EXP 6480464 TP73 protein modified form results in decreased susceptibility to manganese chloride CTD PMID:27107493 manganese(II) chloride decreases expression ISO RGD:1316063 6480464 manganese chloride results in decreased expression of TRP73 protein modified form CTD PMID:27107493 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of TP73 mRNA, manganese chloride results in decreased expression of TP73 protein modified form CTD PMID:27107493 methyl methanesulfonate increases expression ISO RGD:1316062 6480464 Methyl Methanesulfonate results in increased expression of TP73 mRNA CTD PMID:23649840 mitomycin C increases expression ISO RGD:1316062 6480464 Mitomycin results in increased expression of TRP73 protein CTD PMID:17530733 mitomycin C multiple interactions ISO RGD:1316062 6480464 TRP53 protein affects the reaction [Mitomycin results in increased expression of TRP73 protein] CTD PMID:17530733 myricetin increases expression ISO RGD:1316062 6480464 myricetin results in increased expression of TP73 protein CTD PMID:19397994 myristicin decreases expression ISO RGD:1316062 6480464 myristicin results in decreased expression of TP73 mRNA CTD PMID:24792648 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO RGD:1316062 6480464 N more ... CTD PMID:18778698 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO RGD:1316062 6480464 TP53 mutant form inhibits the reaction [N more ... CTD PMID:18778698 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1316062 6480464 U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of TP73 mRNA] CTD PMID:12710931 N-nitrosodiethylamine multiple interactions ISO RGD:1316063 6480464 AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP73 mRNA] CTD PMID:19996281 N-nitrosodiethylamine decreases expression ISO RGD:1316063 6480464 Diethylnitrosamine results in decreased expression of TRP73 mRNA CTD PMID:19996281 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of TP73 protein CTD PMID:14587038 nickel dichloride increases phosphorylation ISO RGD:1316062 6480464 nickel chloride results in increased phosphorylation of TP73 protein CTD PMID:21466819 nickel dichloride multiple interactions ISO RGD:1316062 6480464 [nickel chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene] CTD PMID:25446071 nickel dichloride decreases activity ISO RGD:1316062 6480464 nickel chloride results in decreased activity of TP73 protein CTD PMID:25446071 Nutlin-3 multiple interactions ISO RGD:1316062 6480464 nutlin 3 inhibits the reaction [TP73 binds to MDM2] CTD PMID:20422343 p-menthan-3-ol decreases expression ISO RGD:1316062 6480464 Menthol results in decreased expression of TP73 mRNA CTD PMID:26760959 pentanal increases expression ISO RGD:1316062 6480464 pentanal results in increased expression of TP73 mRNA CTD PMID:26079696 phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of TP73 mRNA, phosphoramide mustard results in increased expression of TP73 protein CTD PMID:26708502 quercetin increases expression ISO RGD:1316062 6480464 Quercetin results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 raloxifene decreases expression ISO RGD:1316062 6480464 Raloxifene Hydrochloride results in decreased expression of TP73 mRNA CTD PMID:19429434 resveratrol increases expression ISO RGD:1316062 6480464 Resveratrol results in increased expression of TP73 mRNA, Resveratrol results in increased expression of TP73 protein CTD PMID:18347188 sirolimus multiple interactions ISO RGD:1316062 6480464 [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein more ... CTD PMID:20686837 , PMID:21245298 sirolimus increases expression ISO RGD:1316062 6480464 Sirolimus results in increased expression of TP73 protein CTD PMID:21245298 sodium arsenite increases expression ISO RGD:1316062 6480464 sodium arsenite results in increased expression of TP73 mRNA CTD PMID:28595984 sodium arsenite affects expression ISO RGD:1316062 6480464 sodium arsenite affects the expression of TP73 mRNA CTD PMID:29319823 sodium arsenite affects response to substance ISO RGD:1316063 6480464 TRP73 protein affects the susceptibility to sodium arsenite CTD PMID:20477944 sodium arsenite multiple interactions ISO RGD:1316063 6480464 TRP73 protein affects the reaction [sodium arsenite results in increased activity of BBC3 protein] more ... CTD PMID:20477944 sodium arsenite increases expression ISO RGD:1316063 6480464 sodium arsenite results in increased expression of TRP73 protein modified form CTD PMID:20477944 sodium arsenite increases activity ISO RGD:1316063 6480464 sodium arsenite results in increased activity of TRP73 protein modified form CTD PMID:20477944 sodium arsenite affects methylation ISO RGD:1316062 6480464 sodium arsenite affects the methylation of TP73 gene CTD PMID:28589171 tert-butyl hydroperoxide decreases expression ISO RGD:1316062 6480464 tert-Butylhydroperoxide results in decreased expression of TP73 mRNA CTD PMID:27509014 tert-butyl hydroperoxide increases methylation ISO RGD:1316062 6480464 tert-Butylhydroperoxide results in increased methylation of TP73 gene CTD PMID:27509014 titanium dioxide affects expression ISO RGD:1316063 6480464 titanium dioxide affects the expression of TRP73 mRNA CTD PMID:23557971 trimellitic anhydride increases expression ISO RGD:1316063 6480464 trimellitic anhydride results in increased expression of TRP73 mRNA CTD PMID:19042947 urethane decreases expression ISO RGD:1316062 6480464 Urethane results in decreased expression of TP73 mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:1316062 6480464 Valproic Acid results in increased methylation of TP73 gene CTD PMID:28853863 more ... wortmannin multiple interactions ISO RGD:1316062 6480464 wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein], wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein] CTD PMID:21214929 zearalenone multiple interactions ISO RGD:1316062 6480464 [Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA CTD PMID:28965971 zinc atom multiple interactions ISO RGD:1316062 6480464 Zinc binds to and affects the folding of and affects the activity of TP73 protein CTD PMID:17170001 zinc atom decreases expression ISO RGD:1316062 6480464 Zinc deficiency results in decreased expression of TP73 mRNA CTD PMID:18356318 zinc(0) multiple interactions ISO RGD:1316062 6480464 Zinc binds to and affects the folding of and affects the activity of TP73 protein CTD PMID:17170001 zinc(0) decreases expression ISO RGD:1316062 6480464 Zinc deficiency results in decreased expression of TP73 mRNA CTD PMID:18356318
Biological Process activation of MAPK activity IMP 2291838 RGD cell cycle arrest ISO RGD:1316063 1624291 (MGI:MGI:3612718, PMID:16044147) RGD MGI:MGI:3612718 , PMID:16044147 cell cycle arrest IEA InterPro:IPR032646 1600115 GO_REF:0000002 InterPro GO_REF:0000002 cellular response to DNA damage stimulus ISO RGD:1316062 1624291 (PMID:18174154) RGD PMID:18174154 cellular response to DNA damage stimulus ISO RGD:1316063 1624291 (MGI:MGI:3612718, PMID:16044147) RGD MGI:MGI:3612718 , PMID:16044147 cerebrospinal fluid secretion ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:1354064 , PMID:10716451) RGD MGI:MGI:1354064 , PMID:10716451 digestive tract morphogenesis ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:1354064 , PMID:10716451) RGD MGI:MGI:1354064 , PMID:10716451 forebrain development ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:3530985 , PMID:15525772) RGD MGI:MGI:3530985 , PMID:15525772 hippocampus development ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:1354064 , PMID:10716451) RGD MGI:MGI:1354064 , PMID:10716451 inflammatory response ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:1354064 , PMID:10716451) RGD MGI:MGI:1354064 , PMID:10716451 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO RGD:1316062 1624291 (PMID:18174154), (PMID:19490146) RGD PMID:18174154 , PMID:19490146 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 kidney development IEP 1599582 RGD negative regulation of cardiac muscle cell proliferation ISO RGD:1316062 1624291 (PMID:18634800) RGD PMID:18634800 negative regulation of cardiac muscle cell proliferation IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell population proliferation ISO RGD:1316062 1624291 (PMID:12730672) RGD PMID:12730672 negative regulation of JUN kinase activity ISO RGD:1316063 1624291 (MGI:MGI:3574697, PMID:15483136) RGD MGI:MGI:3574697 , PMID:15483136 negative regulation of neuron apoptotic process ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:1860990 more ... RGD MGI:MGI:1860990 more ... negative regulation of neuron differentiation IMP 2291838 RGD neuron development ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:3626124 , PMID:12427836) RGD MGI:MGI:3626124 , PMID:12427836 positive regulation of apoptotic process IMP 2291842 RGD positive regulation of apoptotic signaling pathway ISO RGD:1316063 1624291 UniProtKB:Q9QXE4-2 (MGI:MGI:3612718 , PMID:16044147) RGD MGI:MGI:3612718 , PMID:16044147 positive regulation of cell cycle arrest ISO RGD:1316062 1624291 (PMID:18421303) RGD PMID:18421303 positive regulation of cell cycle arrest IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell size ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:3574697 more ... RGD MGI:MGI:3574697 more ... positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO RGD:1316063 1624291 MGI:MGI:2442925 more ... RGD MGI:MGI:3584078 , PMID:15983387 positive regulation of oligodendrocyte differentiation IMP 2291843 RGD positive regulation of transcription by RNA polymerase II ISO RGD:1316062 1624291 (PMID:16343436), (PMID:18174154), (PMID:18421303), (PMID:19490146), (PMID:24652652) RGD PMID:16343436 more ... positive regulation of transcription by RNA polymerase II IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated ISO RGD:1316063 1624291 (MGI:MGI:3612718, PMID:16044147) RGD MGI:MGI:3612718 , PMID:16044147 positive regulation of transcription, DNA-templated ISO RGD:1316062 1624291 (PMID:15678106), (PMID:16343436), (PMID:25417702) RGD PMID:15678106 more ... post-embryonic development ISO RGD:1316063 1624291 MGI:MGI:1859911 (MGI:MGI:1354064 more ... RGD MGI:MGI:1354064 more ... protein tetramerization IEA InterPro:IPR010991 , InterPro:IPR036674 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of gene expression ISO RGD:1316062 1624291 (PMID:18634800) RGD PMID:18634800 regulation of mitotic cell cycle ISO RGD:1316062 1624291 (PMID:18634800) RGD PMID:18634800 regulation of mitotic cell cycle IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of neuron apoptotic process ISO RGD:1316063 1624291 MGI:MGI:98834 (MGI:MGI:3574697 , PMID:15483136) RGD MGI:MGI:3574697 , PMID:15483136 release of cytochrome c from mitochondria ISO RGD:1316063 1624291 (MGI:MGI:3574697, PMID:15483136) RGD MGI:MGI:3574697 , PMID:15483136 response to drug IEP 8693585 RGD response to organonitrogen compound IEP 2291845 RGD Cellular Component cell junction ISO RGD:1316062 1624291 RGD GO_REF:0000052 cell junction IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell junction IEA UniProtKB:A0A024R4C3 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin IDA 1599582 RGD cytoplasm IDA 8693585 RGD Golgi apparatus ISO RGD:1316062 1624291 RGD GO_REF:0000052 Golgi apparatus IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 Golgi apparatus IEA UniProtKB:A0A024R4C3 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 intracellular membrane-bounded organelle ISO RGD:1316062 1624291 RGD GO_REF:0000052 nucleoplasm ISO RGD:1316062 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A024R4C3 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 1599582 RGD nucleus ISO RGD:1316062 1624291 (PMID:12730672), (PMID:19490146) RGD PMID:12730672 , PMID:19490146 nucleus ISO RGD:1316063 1624291 (MGI:MGI:2679148 more ... RGD MGI:MGI:2679148 more ... Molecular Function DNA binding ISO RGD:1316063 1624291 (MGI:MGI:3612630, PMID:16363065) RGD MGI:MGI:3612630 , PMID:16363065 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1316062 1624291 (PMID:16343436) RGD PMID:16343436 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity ISO RGD:1316063 1624291 (MGI:MGI:3612718, PMID:16044147) RGD MGI:MGI:3612718 , PMID:16044147 DNA-binding transcription factor activity ISO RGD:1316062 1624291 (PMID:15678106), (PMID:25417702) RGD PMID:15678106 , PMID:25417702 DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1316062 1624291 (PMID:24652652) RGD PMID:24652652 identical protein binding ISO RGD:1316062 1624291 UniProtKB:O15350 (PMID:19815500), (PMID:22340593), (PMID:22474346) RGD PMID:19815500 more ... identical protein binding IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 MDM2/MDM4 family protein binding ISO RGD:1316062 1624291 UniProtKB:Q00987 (PMID:25417702) RGD PMID:25417702 MDM2/MDM4 family protein binding IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000038 UniProt GO_REF:0000038 p53 binding ISO RGD:1316062 1624291 UniProtKB:P04637 (PMID:25417702) RGD PMID:25417702 p53 binding IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 p53 binding ISO RGD:1316063 1624291 UniProtKB:P02340 (MGI:MGI:1860990 , PMID:10894779) RGD MGI:MGI:1860990 , PMID:10894779 protein binding ISO RGD:1316063 1624291 UniProtKB:P46938 more ... RGD MGI:MGI:3574697 more ... protein binding ISO RGD:1316062 1624291 UniProtKB:O14965 more ... RGD PMID:10469568 more ... protein kinase binding ISO RGD:1316062 1624291 UniProtKB:P53350 , UniProtKB:Q9H4B4 (PMID:18174154), (PMID:19490146) RGD PMID:18174154 , PMID:19490146 protein kinase binding IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1316062 1624291 (PMID:16343436) RGD PMID:16343436 RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 sequence-specific DNA binding IDA 1599582 RGD transcription factor binding ISO RGD:1316062 1624291 UniProtKB:P09429 , UniProtKB:P17208 (PMID:11748232), (PMID:18421303) RGD PMID:11748232 , PMID:18421303 transcription factor binding IEA UniProtKB:O15350 , ensembl:ENSP000003675451600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription regulatory region DNA binding ISO RGD:1316062 1624291 (PMID:16343436) RGD PMID:16343436
Gene-Chemical Interaction Annotations
