Tp73 (tumor protein p73) - Rat Genome Database

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Gene: Tp73 (tumor protein p73) Rattus norvegicus
Analyze
Symbol: Tp73
Name: tumor protein p73
RGD ID: 1307083
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of neuron differentiation; positive regulation of MAPK cascade; and positive regulation of oligodendrocyte differentiation. Located in chromatin. Human ortholog(s) of this gene implicated in several diseases, including Epstein-Barr virus infectious disease; cervical cancer; colorectal cancer; kidney cancer (multiple); and lung cancer (multiple). Orthologous to human TP73 (tumor protein p73); PARTICIPATES IN Ras mediated signaling pathway; altered p53 signaling pathway; measles pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: P73; transformation related protein 73; Trp73
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85169,903,801 - 169,988,075 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5169,903,801 - 169,963,552 (-)EnsemblGRCr8
mRatBN7.25164,621,377 - 164,703,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,621,377 - 164,681,128 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5167,325,484 - 167,385,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,146,894 - 169,206,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,109,342 - 169,169,082 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,355,876 - 171,415,354 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,355,876 - 171,415,354 (-)Ensemblrn6Rnor6.0
Rnor_5.05174,843,033 - 174,868,415 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.05174,889,051 - 174,901,875 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45170,848,979 - 171,078,739 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5162,833,132 - 162,892,871 (-)NCBICelera
RGSC_v3.15170,861,458 - 170,885,614 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adenoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
alveolar rhabdomyosarcoma  (ISO)
breast cancer  (ISO)
breast ductal carcinoma  (ISO)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
CILIARY DYSKINESIA, PRIMARY, 47, AND LISSENCEPHALY  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Ehlers-Danlos syndrome spondylodysplastic type 2  (ISO)
Endometrial Neoplasms  (ISO)
Epstein-Barr virus infectious disease  (ISO)
genetic disease  (ISO)
Goldberg-Shprintzen syndrome  (ISO)
hepatocellular carcinoma  (ISO)
immunodeficiency 16  (ISO)
immunodeficiency 38  (ISO)
Inflammation  (ISO)
Joubert syndrome 25  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
nephroblastoma  (ISO)
Nervous System Malformations  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
Neurologic Manifestations  (ISO)
otitis media  (ISS)
Ovarian Neoplasms  (ISO)
Peroxisome Biogenesis Disorder, Complementation Group 7  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
prostatic hypertrophy  (ISO)
renal cell carcinoma  (ISO)
respiratory failure  (ISO)
Shprintzen-Goldberg Craniosynostosis  (ISO)
skin melanoma  (ISO)
stomach cancer  (ISO)
transitional cell carcinoma  (ISO)
triple-receptor negative breast cancer  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vulvar Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
adenosine 5'-monophosphate  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
apigenin  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzophenanthridine  (ISO)
bexarotene  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
Bufotalin  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calpeptin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
doxorubicin  (ISO)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
etoposide  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
IMP  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
manganese(II) chloride  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nickel dichloride  (ISO)
Nutlin-3  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
pentanal  (ISO)
permethrin  (EXP)
phosphoramide mustard  (EXP)
pyrethrins  (ISO)
quercetin  (ISO)
quinoline yellow  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selinexor  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
VX nerve agent  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cerebrospinal fluid secretion  (IEA,ISO)
digestive tract morphogenesis  (IEA,ISO)
DNA damage response  (IEA,ISO)
forebrain development  (IEA,ISO)
hippocampus development  (IEA,ISO)
inflammatory response  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IBA,IEA,ISO)
kidney development  (IEP)
negative regulation of cardiac muscle cell proliferation  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of neuron differentiation  (IMP)
neuron development  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell size  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
positive regulation of lung ciliated cell differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of oligodendrocyte differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
post-embryonic development  (IEA,ISO)
protein tetramerization  (IEA)
regulation of apoptotic process  (IBA)
regulation of cell cycle  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of mitotic cell cycle  (IEA,ISO)
regulation of neuron apoptotic process  (IEA,ISO)
release of cytochrome c from mitochondria  (IEA)
response to xenobiotic stimulus  (IEP)

Cellular Component
cell junction  (IEA,ISO)
centrosome  (IEA,ISO)
chromatin  (IBA,IDA)
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA)
Golgi apparatus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers. Ahomadegbe JC, etal., Oncogene. 2000 Nov 9;19(47):5413-8.
2. Deregulation of p73 isoform equilibrium in benign prostate hyperplasia and prostate cancer. Arvanitis DA, etal., Oncol Rep. 2004 Nov;12(5):1131-7.
3. Roles for p53 and p73 during oligodendrocyte development. Billon N, etal., Development. 2004 Mar;131(6):1211-20. Epub 2004 Feb 11.
4. E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia. Brooks LA, etal., Br J Cancer. 2002 Jan 21;86(2):263-8.
5. Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors. Castillo J, etal., Gastroenterology. 2009 Nov;137(5):1805-15.e1-4. doi: 10.1053/j.gastro.2009.07.065. Epub 2009 Aug 5.
6. P73 gene expression in ovarian cancer tissues and cell lines. Chen CL, etal., Clin Cancer Res. 2000 Oct;6(10):3910-5.
7. Elevated and biallelic expression of p73 is associated withprogression of human bladder cancer. Chi SG, etal., Cancer Res. 1999 Jun 15;59(12):2791-3.
8. Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis. Choi YW, etal., Int J Gynecol Cancer. 2007 May-Jun;17(3):687-96.
9. p73 participates in male germ cells apoptosis induced by etoposide. Codelia VA, etal., Mol Hum Reprod. 2010 Oct;16(10):734-42. doi: 10.1093/molehr/gaq045. Epub 2010 Jun 2.
10. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Comprehensive genomic profiles of small cell lung cancer. George J, etal., Nature. 2015 Aug 6;524(7563):47-53. doi: 10.1038/nature14664. Epub 2015 Jul 13.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score. Guan M and Chen Y, J Clin Pathol. 2005 Nov;58(11):1175-9.
15. p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y. Hackzell A, etal., J Biol Chem 2002 Oct 18;277(42):39769-76.
16. Allelic expression of the putative tumor suppressor gene p73 in human fetal tissues and tumor specimens. Hu JF, etal., Biochim Biophys Acta. 2000 Apr 25;1491(1-3):49-56.
17. Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma. Jin Y, etal., J Transl Med. 2019 Aug 20;17(1):273. doi: 10.1186/s12967-019-2025-x.
18. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Kaghad M, etal., Cell. 1997 Aug 22;90(4):809-19.
19. The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers. Leong CO, etal., J Clin Invest. 2007 May;117(5):1370-80. Epub 2007 Apr 19.
20. Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival. Li H, etal., Carcinogenesis. 2007 Feb;28(2):372-7. Epub 2006 Aug 31.
21. [Expressions and significances of PTEN mRNA and p73 mRNA in the benign and malignant lesions of stomach]. Liu B and Lu FG, Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Aug;30(4):481-2, 486.
22. Association between p73 gene G4C14-to-A4T14 polymorphism and risk of lung cancer: A meta-analysis. Liu J, etal., J Pak Med Assoc. 2020 Feb;70(2):313-319. doi: 10.5455/JPMA.5150.
23. Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma. Liu SS, etal., Clin Cancer Res. 2006 Jul 1;12(13):3922-7.
24. Loss of imprinting and allele switching of p73 in renal cell carcinoma. Mai M, etal., Oncogene. 1998 Oct 1;17(13):1739-41.
25. TP73 G4C14-A4T14 polymorphism and cancer susceptibility: evidence from 36 case-control studies. Meng J, etal., Biosci Rep. 2018 Dec 14;38(6). pii: BSR20181452. doi: 10.1042/BSR20181452. Print 2018 Dec 21.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. Molnár B, etal., BMC Cancer. 2018 Jun 27;18(1):695. doi: 10.1186/s12885-018-4609-x.
28. p53 mutations in cancer. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
29. Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects. Niwa Y, etal., Cancer Lett. 2005 Mar 10;219(2):183-90.
30. Expression of p73 and c-Abl proteins in human ovarian carcinomas. Niyazi M, etal., J Nippon Med Sch. 2003 Jun;70(3):234-42.
31. p73 is over-expressed in vulval cancer principally as the Delta 2 isoform. O'Nions J, etal., Br J Cancer. 2001 Nov 16;85(10):1551-6.
32. Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas. Okada T, etal., Cancer Sci. 2013 Oct;104(10):1309-14. doi: 10.1111/cas.12228. Epub 2013 Aug 9.
33. Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal carcinomas. Peña C, etal., Genes Chromosomes Cancer. 2004 Mar;39(3):257-62. doi: 10.1002/gcc.10322.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. Saifudeen Z, etal., J Biol Chem. 2005 Jun 17;280(24):23094-102. Epub 2005 Apr 1.
39. Alteration of the MDM2-p73-P14ARF pathway related to tumour progression during urinary bladder carcinogenesis. Schlott T, etal., Int J Mol Med. 2004 Nov;14(5):825-36.
40. p73 mutations are not detected in sporadic and hereditary breast cancer. Schwartz DI, etal., Breast Cancer Res Treat. 1999 Nov;58(1):25-9.
41. Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. Simile MM, etal., Oncotarget. 2016 Aug 2;7(31):49194-49216. doi: 10.18632/oncotarget.10246.
42. Quantitative TP73 transcript analysis in hepatocellular carcinomas. Stiewe T, etal., Clin Cancer Res. 2004 Jan 15;10(2):626-33. doi: 10.1158/1078-0432.ccr-0153-03.
43. TNF-alpha-mediated apoptosis in vascular smooth muscle cells requires p73. Tang V, etal., Am J Physiol Cell Physiol. 2005 Jul;289(1):C199-206. Epub 2005 Feb 16.
44. Detection of p73 antibodies in patients with various types of cancer: immunological characterization. Tominaga O, etal., Br J Cancer. 2001 Jan 5;84(1):57-63.
45. The prognostic value of p73 overexpression in colorectal carcinoma: a clinicopathologic, immunohistochemical, and statistical study of 204 patients. Toumi AA, etal., Appl Immunohistochem Mol Morphol. 2010 Mar;18(2):128-36. doi: 10.1097/PAI.0b013e3181bcb2da.
46. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Tudzarova-Trajkovska S and Wesierska-Gadek J, J Cell Biochem. 2003 Nov 1;90(4):837-55.
47. Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
48. The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC. Wang C, etal., Sci Rep. 2016 Jun 1;6:26526. doi: 10.1038/srep26526.
49. Piper betle leaf extracts induced human hepatocellular carcinoma Hep3B cell death via MAPKs regulating the p73 pathway in vitro and in vivo. Wu PF, etal., Food Funct. 2014 Dec;5(12):3320-8. doi: 10.1039/c4fo00810c.
50. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. Yang HJ, etal., BMC Cancer. 2006 Aug 23;6:212.
51. Common genetic variants in cell cycle pathway are associated with survival in stage III-IV non-small-cell lung cancer. Yin J, etal., Carcinogenesis. 2011 Dec;32(12):1867-71. doi: 10.1093/carcin/bgr217. Epub 2011 Sep 28.
52. Relationship between TP73 polymorphism (G4C14-A4T14) and cancer risk: a meta-analysis based on literatures. Yu XJ, etal., Gene. 2011 Sep 15;484(1-2):42-6. doi: 10.1016/j.gene.2011.05.022. Epub 2011 Jun 13.
53. DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA. Zhang J and Chen X, Mol Cell Biol. 2007 May;27(10):3868-80. Epub 2007 Mar 12.
54. Genetic variants in p53 signaling pathway genes predict chemotherapy efficacy in colorectal cancer. Zhang K, etal., Cancer Med. 2019 Jul;8(7):3428-3436. doi: 10.1002/cam4.2215. Epub 2019 May 15.
Additional References at PubMed
PMID:10373484   PMID:10716451   PMID:10894779   PMID:11748232   PMID:12427836   PMID:12730672   PMID:14555234   PMID:15483136   PMID:15525772   PMID:15678106   PMID:15983387   PMID:16044147  
PMID:16343436   PMID:16363065   PMID:16645632   PMID:18174154   PMID:18362891   PMID:18421303   PMID:18634800   PMID:19194497   PMID:19490146   PMID:19815500   PMID:20883783   PMID:22340593  
PMID:22474346   PMID:23086675   PMID:23354845   PMID:24652652   PMID:25417702   PMID:29482641   PMID:30476470  


Genomics

Comparative Map Data
Tp73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85169,903,801 - 169,988,075 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5169,903,801 - 169,963,552 (-)EnsemblGRCr8
mRatBN7.25164,621,377 - 164,703,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,621,377 - 164,681,128 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5167,325,484 - 167,385,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,146,894 - 169,206,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,109,342 - 169,169,082 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,355,876 - 171,415,354 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,355,876 - 171,415,354 (-)Ensemblrn6Rnor6.0
Rnor_5.05174,843,033 - 174,868,415 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.05174,889,051 - 174,901,875 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45170,848,979 - 171,078,739 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5162,833,132 - 162,892,871 (-)NCBICelera
RGSC_v3.15170,861,458 - 170,885,614 (-)NCBI
Cytogenetic Map5q36NCBI
TP73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,652,516 - 3,736,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,652,516 - 3,736,201 (+)Ensemblhg38GRCh38
GRCh3713,569,080 - 3,652,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,558,989 - 3,639,716 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3413,592,285 - 3,673,013NCBI
Celera12,823,557 - 2,904,508 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef12,864,839 - 2,947,956 (+)NCBIHuRef
CHM1_113,555,405 - 3,639,797 (+)NCBICHM1_1
T2T-CHM13v2.013,162,389 - 3,247,802 (+)NCBIT2T-CHM13v2.0
Trp73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,140,706 - 154,224,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,140,706 - 154,224,665 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384154,056,249 - 154,139,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,056,249 - 154,140,208 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl4154,056,253 - 154,140,208 (-)Ensemblmm10GRCm38
MGSCv374153,430,358 - 153,514,317 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364152,902,644 - 152,984,008 (-)NCBIMGSCv36mm8
Celera4156,338,953 - 156,424,405 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.79NCBI
Tp73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554867,914,440 - 7,952,982 (-)Ensembl
ChiLan1.0NW_0049554867,914,608 - 7,961,992 (-)NCBIChiLan1.0ChiLan1.0
TP73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,577,312 - 224,657,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,216,998 - 223,301,768 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012,323,399 - 2,405,295 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113,476,064 - 3,529,206 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13,476,064 - 3,529,206 (+)EnsemblpanPan2panpan1.1
TP73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1558,194,385 - 58,241,159 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl558,187,826 - 58,240,839 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha558,188,725 - 58,251,651 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0558,379,191 - 58,448,746 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl558,442,630 - 58,448,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1558,393,659 - 58,456,555 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0558,262,432 - 58,325,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,652,679 - 58,715,711 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tp73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505829,244,172 - 29,294,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936737172,467 - 211,464 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936737171,894 - 211,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl665,182,456 - 65,228,990 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1665,169,770 - 65,228,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,826,402 - 59,869,412 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TP73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120127,958,002 - 128,035,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20127,958,809 - 128,013,691 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605432,183,910 - 32,243,642 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248186,775,599 - 6,809,289 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248186,775,588 - 6,817,187 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tp73
340 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:850
Count of miRNA genes:303
Interacting mature miRNAs:382
Transcripts:ENSRNOT00000055398
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 2 10 134 41 51 21 59 21 6 193 81 8 125 79 77 30 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000055398   ⟹   ENSRNOP00000052265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5169,903,801 - 169,963,552 (-)Ensembl
mRatBN7.2 Ensembl5164,621,377 - 164,681,128 (-)Ensembl
Rnor_6.0 Ensembl5171,355,876 - 171,415,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112069   ⟹   ENSRNOP00000089968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5169,905,811 - 169,944,807 (-)Ensembl
mRatBN7.2 Ensembl5164,624,388 - 164,662,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112725   ⟹   ENSRNOP00000077235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5169,903,801 - 169,944,801 (-)Ensembl
mRatBN7.2 Ensembl5164,621,377 - 164,662,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116647   ⟹   ENSRNOP00000095004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5169,903,801 - 169,944,801 (-)Ensembl
mRatBN7.2 Ensembl5164,621,377 - 164,662,397 (-)Ensembl
RefSeq Acc Id: NM_001108696   ⟹   NP_001102166
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,903,801 - 169,963,552 (-)NCBI
mRatBN7.25164,621,377 - 164,681,128 (-)NCBI
Rnor_6.05171,355,876 - 171,415,354 (-)NCBI
Rnor_5.05174,843,033 - 174,868,415 (-)NCBI
Rnor_5.05174,889,051 - 174,901,875 (-)NCBI
RGSC_v3.45170,848,979 - 171,078,739 (-)RGD
Celera5162,833,132 - 162,892,871 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110454   ⟹   XP_038966382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,903,806 - 169,988,075 (-)NCBI
mRatBN7.25164,621,382 - 164,703,958 (-)NCBI
RefSeq Acc Id: XM_039110455   ⟹   XP_038966383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,903,806 - 169,944,822 (-)NCBI
mRatBN7.25164,621,382 - 164,662,401 (-)NCBI
RefSeq Acc Id: NP_001102166   ⟸   NM_001108696
- UniProtKB: D4AA88 (UniProtKB/TrEMBL),   A6IUK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052265   ⟸   ENSRNOT00000055398
RefSeq Acc Id: XP_038966382   ⟸   XM_039110454
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966383   ⟸   XM_039110455
- Peptide Label: isoform X2
- UniProtKB: A0A8I6APF4 (UniProtKB/TrEMBL),   A0A8I5ZJF2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089968   ⟸   ENSRNOT00000112069
Ensembl Acc Id: ENSRNOP00000095004   ⟸   ENSRNOT00000116647
Ensembl Acc Id: ENSRNOP00000077235   ⟸   ENSRNOT00000112725
Protein Domains
p53 DNA-binding   p53 tetramerisation   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA88-F1-model_v2 AlphaFold D4AA88 1-684 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307083 AgrOrtholog
BioCyc Gene G2FUF-38964 BioCyc
Ensembl Genes ENSRNOG00000024707 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055398 ENTREZGENE
  ENSRNOT00000055398.3 UniProtKB/TrEMBL
  ENSRNOT00000112069.1 UniProtKB/TrEMBL
  ENSRNOT00000112725.1 UniProtKB/TrEMBL
  ENSRNOT00000116647 ENTREZGENE
  ENSRNOT00000116647.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.720 UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd UniProtKB/TrEMBL
  p53_DNA-bd UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/TrEMBL
  p53_tetrameristn UniProtKB/TrEMBL
  p53_tumour_Ag UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
  Tumour-p73_SAM UniProtKB/TrEMBL
KEGG Report rno:362675 UniProtKB/TrEMBL
NCBI Gene 362675 ENTREZGENE
PANTHER PTHR11447:SF21 UniProtKB/TrEMBL
  Trp53 UniProtKB/TrEMBL
Pfam P53 UniProtKB/TrEMBL
  P53_tetramer UniProtKB/TrEMBL
PhenoGen Tp73 PhenoGen
PRINTS P53SUPPRESSR UniProtKB/TrEMBL
PROSITE P53 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024707 RatGTEx
SMART SAM UniProtKB/TrEMBL
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
  p53_tetrameristn UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A8I5ZJF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADJ7_RAT UniProtKB/TrEMBL
  A0A8I6APF4 ENTREZGENE, UniProtKB/TrEMBL
  A6IUK8 ENTREZGENE, UniProtKB/TrEMBL
  D4AA88 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tp73  tumor protein p73  Trp73  transformation related protein 73  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-08 Trp73  transformation related protein 73  Trp73_predicted  transformation related protein 73 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Trp73_predicted  transformation related protein 73 (predicted)      Symbol and Name status set to approved 70820 APPROVED