(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one increases degradation ISO RGD:1316062 6480464 cyclopiazonic acid results in increased degradation of TP73 protein modified form CTD PMID:21516125 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o, p'-DDT results in increased expression of TP73 mRNA CTD PMID:22937105 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression EXP 6480464 o, p'-DDT analog results in decreased expression of TP73 mRNA CTD PMID:22937105 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of TP73 mRNA CTD PMID:30723492 17beta-estradiol multiple interactions ISO RGD:1316062 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of TP73 mRNA CTD PMID:30165855 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one multiple interactions ISO RGD:1316062 6480464 2 more ... CTD PMID:21647879 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1316063 6480464 Tetrachlorodibenzodioxin results in decreased expression of TRP73 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1316063 6480464 Tetrachlorodibenzodioxin affects the expression of TRP73 mRNA CTD PMID:21570461 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2-acetamidofluorene decreases expression EXP 6480464 2-Acetylaminofluorene results in decreased expression of TP73 mRNA CTD PMID:22213190 4-hydroxynon-2-enal increases expression ISO RGD:1316062 6480464 4-hydroxy-2-nonenal results in increased expression of TP73 protein CTD PMID:15607904 5-aza-2'-deoxycytidine decreases methylation ISO RGD:1316062 6480464 Decitabine results in decreased methylation of TP73 promoter CTD PMID:19194470 5-azacytidine multiple interactions ISO RGD:1316062 6480464 TP73 protein promotes the reaction [Azacitidine results in increased expression of HMGA2 mRNA] more ... CTD PMID:21245298 5-fluorouracil affects response to substance ISO RGD:1316062 6480464 TP73 protein affects the susceptibility to Fluorouracil CTD PMID:18714155 5-fluorouracil multiple interactions ISO RGD:1316062 6480464 TP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA] CTD PMID:21127500 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of TP73 mRNA CTD PMID:25825206 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of TP73 mRNA CTD PMID:31881176 adenosine 5'-monophosphate affects abundance ISO RGD:1316063 6480464 TP73 protein affects the abundance of Adenosine Monophosphate CTD PMID:25554796 aflatoxin B1 multiple interactions ISO RGD:1316062 6480464 [Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA CTD PMID:28965971 all-trans-retinoic acid increases expression ISO RGD:1316062 6480464 Tretinoin results in increased expression of TRP73 protein CTD PMID:24190996 all-trans-retinoic acid multiple interactions ISO RGD:1316062 6480464 TP73 protein affects the reaction [Tretinoin promotes the reaction [bafilomycin A results in increased expression of MAP1LC3B protein modified form]] more ... CTD PMID:28978663 apigenin increases expression ISO RGD:1316062 6480464 Apigenin results in increased expression of TP73 protein CTD PMID:19397994 aprepitant multiple interactions ISO RGD:1316062 6480464 [Arsenic Trioxide co-treated with Aprepitant] results in increased expression of TP73 mRNA CTD PMID:30145367 arsane affects methylation ISO RGD:1316062 6480464 Arsenic affects the methylation of TP73 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1316062 6480464 Arsenic affects the methylation of TP73 gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:1316062 6480464 Arsenic Trioxide results in increased expression of TP73 mRNA CTD PMID:19763917 , PMID:20458559 arsenous acid multiple interactions ISO RGD:1316062 6480464 2-2-chloro-4-iodophenylamino-N-cyclopropylmethoxy-3 more ... CTD PMID:15031205 more ... asbestos affects localization ISO RGD:1316062 6480464 Asbestos affects the localization of TP73 protein CTD PMID:25466987 benzo[a]pyrene increases expression ISO RGD:1316062 6480464 Benzoapyrene results in increased expression of TP73 mRNA CTD PMID:20862736 , PMID:32234424 benzo[a]pyrene decreases methylation ISO RGD:1316063 6480464 Benzoapyrene results in decreased methylation of TRP73 promoter CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:1316062 6480464 Benzoapyrene affects the methylation of TP73 5' UTR, Benzoapyrene affects the methylation of TP73 promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO RGD:1316062 6480464 Benzoapyrene results in decreased methylation of TP73 exon CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:1316063 6480464 [chromium hexavalent ion co-treated with Benzoapyrene] affects the expression of TRP73 mRNA CTD PMID:25820237 benzo[a]pyrene increases expression ISO RGD:1316063 6480464 Benzoapyrene results in increased expression of TRP73 mRNA CTD PMID:23735875 , PMID:27195522 benzo[a]pyrene affects activity ISO RGD:1316062 6480464 Benzoapyrene affects the activity of TP73 protein CTD PMID:20624995 benzophenanthridine decreases expression ISO RGD:1316062 6480464 Benzophenanthridines analog results in decreased expression of TP73 mRNA CTD PMID:23117580 bexarotene increases expression ISO RGD:1316062 6480464 bexarotene results in increased expression of TP73 protein CTD PMID:19067706 biphenyl-4-amine decreases expression ISO RGD:1316062 6480464 4-biphenylamine results in decreased expression of TP73 mRNA CTD PMID:24857880 bisphenol A decreases expression ISO RGD:1316063 6480464 bisphenol A results in decreased expression of TRP73 CTD PMID:25205691 bisphenol A affects methylation ISO RGD:1316063 6480464 bisphenol A affects the methylation of TRP73 promoter CTD PMID:27334623 bisphenol A decreases methylation ISO RGD:1316063 6480464 bisphenol A results in decreased methylation of TRP73 promoter CTD PMID:27312807 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TP73 mRNA CTD PMID:25181051 Brevetoxin B increases expression ISO RGD:1316062 6480464 brevetoxin 2 results in increased expression of TP73 mRNA CTD PMID:20498034 cadmium dichloride decreases activity ISO RGD:1316062 6480464 Cadmium Chloride results in decreased activity of TP73 protein CTD PMID:25446071 cadmium dichloride multiple interactions ISO RGD:1316062 6480464 [Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene], Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 calcitriol multiple interactions ISO RGD:1316062 6480464 [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol CTD PMID:17716971 calcium atom multiple interactions ISO RGD:1316062 6480464 [Calcium co-treated with CAPN1 protein] results in increased degradation of TP73 protein modified form CTD PMID:21516125 calcium(0) multiple interactions ISO RGD:1316062 6480464 [Calcium co-treated with CAPN1 protein] results in increased degradation of TP73 protein modified form CTD PMID:21516125 Calpeptin multiple interactions ISO RGD:1316062 6480464 calpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form] CTD PMID:21516125 carbon nanotube decreases expression ISO RGD:1316063 6480464 Nanotubes more ... CTD PMID:25554681 chromium(6+) multiple interactions ISO RGD:1316063 6480464 [chromium hexavalent ion co-treated with Benzoapyrene] affects the expression of TRP73 mRNA CTD PMID:25820237 chrysin increases expression ISO RGD:1316062 6480464 chrysin results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 cisplatin multiple interactions ISO RGD:1316062 6480464 [[[Cisplatin co-treated with 2 more ... CTD PMID:14678968 more ... cisplatin increases expression ISO RGD:1316062 6480464 Cisplatin results in increased expression of TP73 protein CTD PMID:17076661 more ... cisplatin increases activity ISO RGD:1316062 6480464 Cisplatin results in increased activity of TP73 protein CTD PMID:14678968 cisplatin decreases expression ISO RGD:1316062 6480464 Cisplatin results in decreased expression of TP73 mRNA, Cisplatin results in decreased expression of TP73 protein modified form CTD PMID:21516125 , PMID:21737676 cisplatin affects localization ISO RGD:1316062 6480464 Cisplatin affects the localization of TP73 protein modified form CTD PMID:21516125 cisplatin increases expression ISO RGD:1316063 6480464 Cisplatin results in increased expression of TRP73 CTD PMID:22002055 cisplatin decreases response to substance ISO RGD:1316063 6480464 TRP73 alternative form results in decreased susceptibility to Cisplatin CTD PMID:22002055 cisplatin decreases expression ISO RGD:1316063 6480464 Cisplatin results in decreased expression of TRP73 alternative form CTD PMID:22002055 cisplatin increases response to substance ISO RGD:1316062 6480464 TP73 protein modified form results in increased susceptibility to Cisplatin, TP73 results in increased susceptibility to Cisplatin CTD PMID:20100536 , PMID:21516125 cobalt dichloride decreases activity ISO RGD:1316062 6480464 cobaltous chloride results in decreased activity of TP73 protein CTD PMID:25446071 cobalt dichloride multiple interactions ISO RGD:1316062 6480464 [cobaltous chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene] CTD PMID:25446071 copper atom decreases expression ISO RGD:1316062 6480464 Copper results in decreased expression of TP73 mRNA CTD PMID:16391388 copper(0) decreases expression ISO RGD:1316062 6480464 Copper results in decreased expression of TP73 mRNA CTD PMID:16391388 copper(II) chloride affects expression ISO RGD:1316063 6480464 cupric chloride affects the expression of TRP73 protein CTD PMID:23313662 copper(II) chloride increases expression ISO RGD:1316063 6480464 cupric chloride results in increased expression of TRP73 protein CTD PMID:24170445 cyclosporin A decreases methylation ISO RGD:1316062 6480464 Cyclosporine results in decreased methylation of TP73 promoter CTD PMID:27989131 diarsenic trioxide multiple interactions ISO RGD:1316062 6480464 2-2-chloro-4-iodophenylamino-N-cyclopropylmethoxy-3 more ... CTD PMID:15031205 more ... diarsenic trioxide increases expression ISO RGD:1316062 6480464 Arsenic Trioxide results in increased expression of TP73 mRNA CTD PMID:19763917 , PMID:20458559 diazinon increases methylation ISO RGD:1316062 6480464 Diazinon results in increased methylation of TP73 gene CTD PMID:22964155 doxorubicin multiple interactions ISO RGD:1316062 6480464 [[[Doxorubicin co-treated with 2 more ... CTD PMID:21214929 , PMID:25124555 doxorubicin increases expression ISO RGD:1316062 6480464 Doxorubicin results in increased expression of TP73 mRNA, Doxorubicin results in increased expression of TP73 protein CTD PMID:17716971 more ... ethylenediaminetetraacetic acid multiple interactions ISO RGD:1316062 6480464 Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 etoposide multiple interactions ISO RGD:1316062 6480464 [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol more ... CTD PMID:17716971 , PMID:21801448 etoposide increases expression ISO RGD:1316062 6480464 Etoposide results in increased expression of TP73 mRNA, Etoposide results in increased expression of TP73 protein CTD PMID:17716971 , PMID:21801448 folic acid decreases expression ISO RGD:1316063 6480464 Folic Acid results in decreased expression of TRP73 mRNA CTD PMID:25629700 furan decreases expression EXP 6480464 furan results in decreased expression of TP73 mRNA CTD PMID:25539665 Fusarenone X increases expression ISO RGD:1316063 6480464 fusarenon-X results in increased expression of TRP73 mRNA CTD PMID:24983900 genistein increases expression ISO RGD:1316063 6480464 Genistein results in increased expression of TRP73 mRNA CTD PMID:32186404 hydrogen peroxide affects response to substance ISO RGD:1316063 6480464 TRP73 protein affects the susceptibility to Hydrogen Peroxide CTD PMID:27119504 hydroxyurea increases expression ISO RGD:1316063 6480464 Hydroxyurea results in increased expression of TRP73 mRNA CTD PMID:29228353 hydroxyurea multiple interactions ISO RGD:1316063 6480464 TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA] CTD PMID:29228353 IMP affects abundance ISO RGD:1316063 6480464 TP73 protein affects the abundance of Inosine Monophosphate CTD PMID:25554796 kaempferol increases expression ISO RGD:1316062 6480464 kaempferol results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of TP73 mRNA CTD PMID:25808816 Lasiocarpine increases expression ISO RGD:1316062 6480464 lasiocarpine results in increased expression of TP73 mRNA CTD PMID:32234424 luteolin increases expression ISO RGD:1316062 6480464 Luteolin results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 manganese(II) chloride decreases response to substance EXP 6480464 TP73 protein modified form results in decreased susceptibility to manganese chloride CTD PMID:27107493 manganese(II) chloride decreases expression ISO RGD:1316063 6480464 manganese chloride results in decreased expression of TRP73 protein modified form CTD PMID:27107493 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of TP73 mRNA, manganese chloride results in decreased expression of TP73 protein modified form CTD PMID:27107493 methyl methanesulfonate increases expression ISO RGD:1316062 6480464 Methyl Methanesulfonate results in increased expression of TP73 mRNA CTD PMID:23649840 mitomycin C increases expression ISO RGD:1316062 6480464 Mitomycin results in increased expression of TRP73 protein CTD PMID:17530733 mitomycin C multiple interactions ISO RGD:1316062 6480464 TRP53 protein affects the reaction [Mitomycin results in increased expression of TRP73 protein] CTD PMID:17530733 myricetin increases expression ISO RGD:1316062 6480464 myricetin results in increased expression of TP73 protein CTD PMID:19397994 myristicin decreases expression ISO RGD:1316062 6480464 myristicin results in decreased expression of TP73 mRNA CTD PMID:24792648 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO RGD:1316062 6480464 N more ... CTD PMID:18778698 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO RGD:1316062 6480464 TP53 mutant form inhibits the reaction [N more ... CTD PMID:18778698 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1316062 6480464 U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of TP73 mRNA] CTD PMID:12710931 N-nitrosodiethylamine multiple interactions ISO RGD:1316063 6480464 AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP73 mRNA] CTD PMID:19996281 N-nitrosodiethylamine decreases expression ISO RGD:1316063 6480464 Diethylnitrosamine results in decreased expression of TRP73 mRNA CTD PMID:19996281 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of TP73 protein CTD PMID:14587038 nickel dichloride increases phosphorylation ISO RGD:1316062 6480464 nickel chloride results in increased phosphorylation of TP73 protein CTD PMID:21466819 nickel dichloride multiple interactions ISO RGD:1316062 6480464 [nickel chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene] CTD PMID:25446071 nickel dichloride decreases activity ISO RGD:1316062 6480464 nickel chloride results in decreased activity of TP73 protein CTD PMID:25446071 Nutlin-3 multiple interactions ISO RGD:1316062 6480464 nutlin 3 inhibits the reaction [TP73 binds to MDM2] CTD PMID:20422343 p-menthan-3-ol decreases expression ISO RGD:1316062 6480464 Menthol results in decreased expression of TP73 mRNA CTD PMID:26760959 pentanal increases expression ISO RGD:1316062 6480464 pentanal results in increased expression of TP73 mRNA CTD PMID:26079696 phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of TP73 mRNA, phosphoramide mustard results in increased expression of TP73 protein CTD PMID:26708502 quercetin increases expression ISO RGD:1316062 6480464 Quercetin results in increased expression of TP73 protein CTD PMID:18331776 , PMID:19397994 raloxifene decreases expression ISO RGD:1316062 6480464 Raloxifene Hydrochloride results in decreased expression of TP73 mRNA CTD PMID:19429434 resveratrol increases expression ISO RGD:1316062 6480464 Resveratrol results in increased expression of TP73 mRNA, Resveratrol results in increased expression of TP73 protein CTD PMID:18347188 sirolimus multiple interactions ISO RGD:1316062 6480464 [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein more ... CTD PMID:20686837 , PMID:21245298 sirolimus increases expression ISO RGD:1316062 6480464 Sirolimus results in increased expression of TP73 protein CTD PMID:21245298 sodium arsenite increases expression ISO RGD:1316062 6480464 sodium arsenite results in increased expression of TP73 mRNA CTD PMID:28595984 sodium arsenite affects expression ISO RGD:1316062 6480464 sodium arsenite affects the expression of TP73 mRNA CTD PMID:29319823 sodium arsenite affects response to substance ISO RGD:1316063 6480464 TRP73 protein affects the susceptibility to sodium arsenite CTD PMID:20477944 sodium arsenite multiple interactions ISO RGD:1316063 6480464 TRP73 protein affects the reaction [sodium arsenite results in increased activity of BBC3 protein] more ... CTD PMID:20477944 sodium arsenite increases expression ISO RGD:1316063 6480464 sodium arsenite results in increased expression of TRP73 protein modified form CTD PMID:20477944 sodium arsenite increases activity ISO RGD:1316063 6480464 sodium arsenite results in increased activity of TRP73 protein modified form CTD PMID:20477944 sodium arsenite affects methylation ISO RGD:1316062 6480464 sodium arsenite affects the methylation of TP73 gene CTD PMID:28589171 sulforaphane increases expression ISO RGD:1316062 6480464 sulforafan results in increased expression of TP73 protein CTD PMID:27878984 tert-butyl hydroperoxide decreases expression ISO RGD:1316062 6480464 tert-Butylhydroperoxide results in decreased expression of TP73 mRNA CTD PMID:27509014 tert-butyl hydroperoxide increases methylation ISO RGD:1316062 6480464 tert-Butylhydroperoxide results in increased methylation of TP73 gene CTD PMID:27509014 titanium dioxide affects expression ISO RGD:1316063 6480464 titanium dioxide affects the expression of TRP73 mRNA CTD PMID:23557971 trimellitic anhydride increases expression ISO RGD:1316063 6480464 trimellitic anhydride results in increased expression of TRP73 mRNA CTD PMID:19042947 urethane decreases expression ISO RGD:1316062 6480464 Urethane results in decreased expression of TP73 mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:1316062 6480464 Valproic Acid results in increased methylation of TP73 gene CTD PMID:28853863 more ... wortmannin multiple interactions ISO RGD:1316062 6480464 wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein], wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein] CTD PMID:21214929 zearalenone multiple interactions ISO RGD:1316062 6480464 [Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA CTD PMID:28965971 zinc atom multiple interactions ISO RGD:1316062 6480464 Zinc binds to and affects the folding of and affects the activity of TP73 protein CTD PMID:17170001 zinc atom decreases expression ISO RGD:1316062 6480464 Zinc deficiency results in decreased expression of TP73 mRNA CTD PMID:18356318 zinc(0) multiple interactions ISO RGD:1316062 6480464 Zinc binds to and affects the folding of and affects the activity of TP73 protein CTD PMID:17170001 zinc(0) decreases expression ISO RGD:1316062 6480464 Zinc deficiency results in decreased expression of TP73 mRNA CTD PMID:18356318
