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Gene: Gnb1 (G protein subunit beta 1) Rattus norvegicus
Symbol: Gnb1
Name: G protein subunit beta 1
RGD ID: 2718
Description: Exhibits alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to hypoxia; and positive regulation of cytosolic calcium ion concentration. Localizes to several cellular components, including heterotrimeric G-protein complex; photoreceptor inner segment; and photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and autosomal dominant non-syndromic intellectual disability 42. Orthologous to human GNB1 (G protein subunit beta 1); PARTICIPATES IN G protein mediated signaling pathway via Galpha12/Galpha13 family; adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
Also known as: guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein, beta 1; Guanine nucleotide-binding protein beta 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; transducin beta chain 1
Homo sapiens (human) : GNB1 (G protein subunit beta 1)  HGNC  Alliance
Mus musculus (house mouse) : Gnb1 (guanine nucleotide binding protein (G protein), beta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnb1 (G protein subunit beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNB1 (G protein subunit beta 1)
Canis lupus familiaris (dog) : GNB1 (G protein subunit beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnb1 (G protein subunit beta 1)
Sus scrofa (pig) : GNB1 (G protein subunit beta 1)
Chlorocebus sabaeus (African green monkey) : GNB1 (G protein subunit beta 1)
Heterocephalus glaber (naked mole-rat) : Gnb1 (G protein subunit beta 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05172,914,025 - 172,981,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,934,990 - 172,979,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,388,373 - 176,456,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,341,135 - 172,386,772 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15172,366,363 - 172,398,680 (+)NCBI
Celera5164,297,726 - 164,342,470 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gnb1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2718
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.