Cptp (ceramide-1-phosphate transfer protein) - Rat Genome Database

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Gene: Cptp (ceramide-1-phosphate transfer protein) Rattus norvegicus
Analyze
Symbol: Cptp
Name: ceramide-1-phosphate transfer protein
RGD ID: 1359656
Description: Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in several processes, including lipid transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Predicted to be located in Golgi apparatus; bounding membrane of organelle; and plasma membrane. Predicted to be active in cytosol. Orthologous to human CPTP (ceramide-1-phosphate transfer protein); INTERACTS WITH bisphenol A; gentamycin; paracetamol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gltpd1; glycolipid transfer protein domain containing 1; glycolipid transfer protein domain-containing protein 1; MGC94339; similar to BC002216 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Cptp-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25166,474,947 - 166,479,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,474,966 - 166,479,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,179,617 - 169,183,722 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05171,001,038 - 171,005,143 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,963,569 - 170,967,674 (-)NCBIRnor_WKY
Rnor_6.05173,314,219 - 173,318,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,314,228 - 173,318,313 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,789,844 - 176,794,000 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,723,909 - 172,727,994 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,734,403 - 172,738,489 (-)NCBI
Celera5164,675,665 - 164,679,750 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:23863933   PMID:29164996  


Genomics

Comparative Map Data
Cptp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25166,474,947 - 166,479,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,474,966 - 166,479,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,179,617 - 169,183,722 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05171,001,038 - 171,005,143 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,963,569 - 170,967,674 (-)NCBIRnor_WKY
Rnor_6.05173,314,219 - 173,318,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,314,228 - 173,318,313 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,789,844 - 176,794,000 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,723,909 - 172,727,994 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,734,403 - 172,738,489 (-)NCBI
Celera5164,675,665 - 164,679,750 (-)NCBICelera
Cytogenetic Map5q36NCBI
CPTP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,324,802 - 1,328,896 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11,324,756 - 1,328,896 (+)EnsemblGRCh38hg38GRCh38
GRCh3711,260,182 - 1,264,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,250,006 - 1,254,139 (+)NCBINCBI36Build 36hg18NCBI36
Celera11,316,866 - 1,320,999 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1531,348 - 535,481 (+)NCBIHuRef
CHM1_111,247,171 - 1,251,304 (+)NCBICHM1_1
T2T-CHM13v2.01756,387 - 760,481 (+)NCBIT2T-CHM13v2.0
Cptp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,949,180 - 155,953,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,949,180 - 155,953,897 (-)EnsemblGRCm39 Ensembl
GRCm384155,864,723 - 155,869,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,864,723 - 155,869,440 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,238,832 - 155,243,549 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,708,523 - 154,713,240 (-)NCBIMGSCv36mm8
Celera4158,135,645 - 158,140,363 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.66NCBI
Cptp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,475,520 - 9,478,925 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,475,520 - 9,478,925 (-)NCBIChiLan1.0ChiLan1.0
CPTP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111,281,504 - 1,285,620 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,281,979 - 1,285,620 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0181,942 - 86,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CPTP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,498,163 - 56,501,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,498,207 - 56,500,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,574,487 - 56,578,246 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,700,384 - 56,704,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,700,409 - 56,705,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,691,124 - 56,694,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,583,408 - 56,587,167 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,973,645 - 56,977,405 (+)NCBIUU_Cfam_GSD_1.0
Cptp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,645,591 - 27,649,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,816,475 - 1,820,320 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367371,816,461 - 1,820,353 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPTP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1663,607,991 - 63,612,325 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,106,067 - 58,110,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPTP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,124,705 - 130,128,745 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,125,790 - 130,126,711 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605434,688,042 - 34,692,100 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cptp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,283,926 - 8,287,274 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248188,283,925 - 8,287,410 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cptp
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:488
Count of miRNA genes:253
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000039117
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH129679  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,475,009 - 166,475,206 (+)MAPPERmRatBN7.2
Rnor_6.05173,314,291 - 173,314,487NCBIRnor6.0
Rnor_5.05176,789,907 - 176,790,103UniSTSRnor5.0
RGSC_v3.45172,723,972 - 172,724,168UniSTSRGSC3.4
Celera5164,675,728 - 164,675,924UniSTS
RH 3.4 Map51175.0UniSTS
Cytogenetic Map5q36UniSTS
BF386962  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,475,504 - 166,475,694 (+)MAPPERmRatBN7.2
Rnor_6.05173,314,786 - 173,314,975NCBIRnor6.0
Rnor_5.05176,790,402 - 176,790,591UniSTSRnor5.0
RGSC_v3.45172,724,467 - 172,724,656UniSTSRGSC3.4
Celera5164,676,223 - 164,676,412UniSTS
RH 3.4 Map51175.0UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 1 1 1 60 20 11 9
Low 43 55 40 18 40 8 11 14 15 30 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039117   ⟹   ENSRNOP00000034006
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,474,966 - 166,479,017 (-)Ensembl
Rnor_6.0 Ensembl5173,314,228 - 173,318,313 (-)Ensembl
RefSeq Acc Id: NM_001007703   ⟹   NP_001007704
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25166,474,947 - 166,479,032 (-)NCBI
Rnor_6.05173,314,228 - 173,318,313 (-)NCBI
Rnor_5.05176,789,844 - 176,794,000 (-)NCBI
RGSC_v3.45172,723,909 - 172,727,994 (-)RGD
Celera5164,675,665 - 164,679,750 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239576   ⟹   XP_006239638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25166,474,948 - 166,479,103 (-)NCBI
Rnor_6.05173,314,219 - 173,318,384 (-)NCBI
Rnor_5.05176,789,844 - 176,794,000 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110121   ⟹   XP_038966049
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25166,474,948 - 166,479,037 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001007704 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239638 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83599 (Get FASTA)   NCBI Sequence Viewer  
  EDL81338 (Get FASTA)   NCBI Sequence Viewer  
  Q5XIS2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001007704   ⟸   NM_001007703
- UniProtKB: Q5XIS2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239638   ⟸   XM_006239576
- Peptide Label: isoform X1
- UniProtKB: Q5XIS2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034006   ⟸   ENSRNOT00000039117
RefSeq Acc Id: XP_038966049   ⟸   XM_039110121
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIS2-F1-model_v2 AlphaFold Q5XIS2 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694334
Promoter ID:EPDNEW_R4859
Type:initiation region
Name:Cptp_1
Description:ceramide-1-phosphate transfer protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,318,277 - 173,318,337EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359656 AgrOrtholog
BioCyc Gene G2FUF-38891 BioCyc
Ensembl Genes ENSRNOG00000022455 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000034006 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039117 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.3520.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133008 IMAGE-MGC_LOAD
InterPro GLTP_sf UniProtKB/Swiss-Prot
  Glycolipid_transfer_prot_dom UniProtKB/Swiss-Prot
KEGG Report rno:313771 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94339 IMAGE-MGC_LOAD
NCBI Gene 313771 ENTREZGENE
Pfam GLTP UniProtKB/Swiss-Prot
PhenoGen Cptp PhenoGen
Superfamily-SCOP SSF110004 UniProtKB/Swiss-Prot
UniProt CPTP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Cptp  ceramide-1-phosphate transfer protein  Gltpd1  glycolipid transfer protein domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Gltpd1  glycolipid transfer protein domain containing 1  MGC94339  similar to BC002216 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 MGC94339  similar to BC002216 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference