Tprg1l (tumor protein p63 regulated 1-like) - Rat Genome Database

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Gene: Tprg1l (tumor protein p63 regulated 1-like) Rattus norvegicus
Analyze
Symbol: Tprg1l
Name: tumor protein p63 regulated 1-like
RGD ID: 1590079
Description: Predicted to enable calmodulin binding activity and identical protein binding activity. Involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in calyx of Held and glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human TPRG1L (tumor protein p63 regulated 1 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC687090; LOC687090; Mossy fiber terminal-associated vertebrate-specific presynaptic protein; mossy-fiber terminal-associated vertebrate-specific presynaptic protein; mover; Tumor protein p63-regulated gene 1-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,004,577 - 170,007,784 (-)NCBIGRCr8
mRatBN7.25164,722,151 - 164,725,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,710,285 - 164,725,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,426,253 - 167,429,460 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,247,671 - 169,250,878 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,210,188 - 169,213,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,456,299 - 171,459,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,456,302 - 171,459,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05174,938,793 - 174,941,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5162,933,950 - 162,937,177 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. Kremer T, etal., FEBS Lett. 2007 Oct 2;581(24):4727-33. Epub 2007 Sep 6.
3. Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. Körber C, etal., Neuron. 2015 Aug 5;87(3):521-33. doi: 10.1016/j.neuron.2015.07.001. Epub 2015 Jul 23.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11591653   PMID:12477932   PMID:15489334   PMID:19199708  


Genomics

Comparative Map Data
Tprg1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,004,577 - 170,007,784 (-)NCBIGRCr8
mRatBN7.25164,722,151 - 164,725,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,710,285 - 164,725,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,426,253 - 167,429,460 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,247,671 - 169,250,878 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,210,188 - 169,213,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,456,299 - 171,459,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,456,302 - 171,459,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05174,938,793 - 174,941,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5162,933,950 - 162,937,177 (-)NCBICelera
Cytogenetic Map5q36NCBI
TPRG1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,625,015 - 3,630,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,625,015 - 3,630,127 (+)EnsemblGRCh38hg38GRCh38
GRCh3713,541,579 - 3,546,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,531,416 - 3,536,555 (+)NCBINCBI36Build 36hg18NCBI36
Celera12,796,682 - 2,801,797 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef12,837,972 - 2,843,088 (+)NCBIHuRef
CHM1_113,528,259 - 3,533,375 (+)NCBICHM1_1
T2T-CHM13v2.013,135,110 - 3,140,200 (+)NCBIT2T-CHM13v2.0
Tprg1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,241,942 - 154,246,763 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,241,942 - 154,245,123 (-)EnsemblGRCm39 Ensembl
GRCm384154,157,485 - 154,162,306 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,157,485 - 154,160,666 (-)EnsemblGRCm38mm10GRCm38
MGSCv374153,531,594 - 153,534,793 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,001,285 - 153,004,484 (-)NCBIMGSCv36mm8
Celera4156,441,404 - 156,444,603 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.88NCBI
Tprg1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,007,842 - 8,013,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,007,678 - 8,013,996 (-)NCBIChiLan1.0ChiLan1.0
TPRG1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,678,694 - 224,683,810 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,323,817 - 223,328,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012,296,601 - 2,301,687 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113,420,294 - 3,425,007 (+)NCBIpanpan1.1PanPan1.1panPan2
TPRG1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1558,155,178 - 58,159,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl558,157,096 - 58,159,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha558,166,902 - 58,170,424 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0558,357,363 - 58,360,885 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl558,357,400 - 58,360,877 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1558,371,849 - 58,375,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0558,240,675 - 58,244,129 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,630,852 - 58,634,383 (+)NCBIUU_Cfam_GSD_1.0
Tprg1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505829,207,191 - 29,212,194 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936737253,752 - 258,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPRG1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl665,150,903 - 65,154,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1665,150,897 - 65,154,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,884,843 - 59,888,257 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPRG1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,057,629 - 128,062,545 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20128,059,137 - 128,062,455 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605432,334,644 - 32,339,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tprg1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248186,850,486 - 6,858,136 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248186,850,479 - 6,857,979 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tprg1l
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:225
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000075423
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
RH133418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25164,722,250 - 164,722,457 (+)MAPPERmRatBN7.2
Rnor_6.05171,456,399 - 171,456,605NCBIRnor6.0
Rnor_5.05174,938,893 - 174,939,099UniSTSRnor5.0
Celera5162,934,050 - 162,934,256UniSTS
RH 3.4 Map51144.3UniSTS
Tprgl  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25164,723,144 - 164,723,906 (+)MAPPERmRatBN7.2
Rnor_6.05171,457,293 - 171,458,054NCBIRnor6.0
Rnor_5.05174,939,787 - 174,940,548UniSTSRnor5.0
Celera5162,934,944 - 162,935,705UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000075423   ⟹   ENSRNOP00000064778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,722,151 - 164,725,425 (-)Ensembl
Rnor_6.0 Ensembl5171,456,302 - 171,459,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080686   ⟹   ENSRNOP00000072129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,722,154 - 164,725,425 (-)Ensembl
Rnor_6.0 Ensembl5171,456,302 - 171,459,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106906   ⟹   ENSRNOP00000087991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,722,151 - 164,725,190 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108794   ⟹   ENSRNOP00000093607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,710,285 - 164,725,425 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118355   ⟹   ENSRNOP00000080324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,724,427 - 164,725,358 (-)Ensembl
RefSeq Acc Id: NM_001110318   ⟹   NP_001103788
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,004,577 - 170,007,784 (-)NCBI
mRatBN7.25164,722,151 - 164,725,358 (-)NCBI
Rnor_6.05171,456,299 - 171,459,488 (-)NCBI
Rnor_5.05174,938,793 - 174,941,982 (-)NCBI
Celera5162,933,950 - 162,937,177 (-)RGD
Sequence:
RefSeq Acc Id: NM_001271085   ⟹   NP_001258014
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,004,577 - 170,007,784 (-)NCBI
mRatBN7.25164,722,151 - 164,725,358 (-)NCBI
Rnor_6.05171,456,299 - 171,459,488 (-)NCBI
Rnor_5.05174,938,793 - 174,941,982 (-)NCBI
Celera5162,933,950 - 162,937,177 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001103788   ⟸   NM_001110318
- Peptide Label: isoform 1
- UniProtKB: A8WCF8 (UniProtKB/Swiss-Prot),   A0A8L2QW99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258014   ⟸   NM_001271085
- Peptide Label: isoform 2
- UniProtKB: A0A8I5ZPI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072129   ⟸   ENSRNOT00000080686
RefSeq Acc Id: ENSRNOP00000064778   ⟸   ENSRNOT00000075423
RefSeq Acc Id: ENSRNOP00000080324   ⟸   ENSRNOT00000118355
RefSeq Acc Id: ENSRNOP00000087991   ⟸   ENSRNOT00000106906
RefSeq Acc Id: ENSRNOP00000093607   ⟸   ENSRNOT00000108794
Protein Domains
hSac2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A8WCF8-F1-model_v2 AlphaFold A8WCF8 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694310
Promoter ID:EPDNEW_R4835
Type:initiation region
Name:Tprg1l_1
Description:tumor protein p63 regulated 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05171,459,355 - 171,459,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590079 AgrOrtholog
BioCyc Gene G2FUF-38962 BioCyc
Ensembl Genes ENSRNOG00000046227 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075423.3 UniProtKB/TrEMBL
  ENSRNOT00000080686.2 UniProtKB/TrEMBL
  ENSRNOT00000106906.1 UniProtKB/TrEMBL
  ENSRNOT00000108794.1 UniProtKB/TrEMBL
  ENSRNOT00000118355.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324838 IMAGE-MGC_LOAD
InterPro hSac2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inositol_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPRG1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:687090 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188227 IMAGE-MGC_LOAD
NCBI Gene 687090 ENTREZGENE
PANTHER PTHR31108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam hSac2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tprg1l PhenoGen
PROSITE HSAC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046227 RatGTEx
UniProt A0A0G2K272_RAT UniProtKB/TrEMBL
  A0A8I5ZPI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A704_RAT UniProtKB/TrEMBL
  A0A8I6GKR0_RAT UniProtKB/TrEMBL
  A0A8L2QW99 ENTREZGENE, UniProtKB/TrEMBL
  A8WCF8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-16 Tprg1l  tumor protein p63 regulated 1-like  LOC687090  hypothetical protein LOC687090  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687090  hypothetical protein LOC687090      Symbol and Name status set to provisional 70820 PROVISIONAL