Mmel1 (membrane metallo-endopeptidase-like 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mmel1 (membrane metallo-endopeptidase-like 1) Rattus norvegicus
Analyze
Symbol: Mmel1
Name: membrane metallo-endopeptidase-like 1
RGD ID: 1309299
Description: Enables metalloendopeptidase activity and zinc ion binding activity. Predicted to be involved in protein processing. Located in extracellular space and membrane. Orthologous to human MMEL1 (membrane metalloendopeptidase like 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313755; mel transforming oncogene-like 1; Mell1; NEP2; NEP2(m); NEPII; neprilysin 2; neprilysin II; neprilysin-2; NL2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mmel1Tn(sb-T2/Bart3)2.255Mcwi  
Genetic Models: F344-Mmel1Tn(sb-T2/Bart3)2.255Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25165,431,278 - 165,461,716 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5165,431,343 - 165,461,716 (+)Ensembl
Rnor_6.05172,273,450 - 172,303,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,273,459 - 172,304,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,729,143 - 175,759,868 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,675,007 - 171,703,353 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15171,683,479 - 171,713,539 (+)NCBI
Celera5163,639,889 - 163,668,234 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. Rose C, etal., Biochem J. 2002 May 1;363(Pt 3):697-705.
7. A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2. Voisin S, etal., J Biol Chem. 2004 Oct 29;279(44):46172-81. Epub 2004 Aug 4.
Additional References at PubMed
PMID:10542292   PMID:10814502   PMID:12477932   PMID:12710972   PMID:15057822   PMID:16081046   PMID:18539150  


Genomics

Comparative Map Data
Mmel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25165,431,278 - 165,461,716 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5165,431,343 - 165,461,716 (+)Ensembl
Rnor_6.05172,273,450 - 172,303,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,273,459 - 172,304,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,729,143 - 175,759,868 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,675,007 - 171,703,353 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15171,683,479 - 171,713,539 (+)NCBI
Celera5163,639,889 - 163,668,234 (+)NCBICelera
Cytogenetic Map5q36NCBI
MMEL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,590,639 - 2,633,016 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12,590,639 - 2,633,016 (-)EnsemblGRCh38hg38GRCh38
GRCh3712,522,078 - 2,564,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,511,941 - 2,554,289 (-)NCBINCBI36hg18NCBI36
Celera121,530 - 63,919 (+)NCBI
Cytogenetic Map1p36.32NCBI
HuRef11,801,317 - 1,843,691 (-)NCBIHuRef
CHM1_112,509,160 - 2,551,374 (-)NCBICHM1_1
T2T-CHM13v2.012,032,284 - 2,074,662 (-)NCBI
Mmel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,954,042 - 154,979,987 (+)NCBIGRCm39mm39
GRCm39 Ensembl4154,954,042 - 154,979,985 (+)Ensembl
GRCm384154,869,585 - 154,895,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,869,585 - 154,895,528 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,243,694 - 154,269,639 (+)NCBIGRCm37mm9NCBIm37
MGSCv364153,713,436 - 153,739,330 (+)NCBImm8
Celera4157,143,798 - 157,167,036 (+)NCBICelera
Cytogenetic Map4E2NCBI
Mmel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,638,233 - 8,663,053 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,635,727 - 8,662,793 (+)NCBIChiLan1.0ChiLan1.0
MMEL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112,462,621 - 2,504,213 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,462,621 - 2,504,213 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011,323,914 - 1,362,178 (-)NCBIMhudiblu_PPA_v0panPan3
MMEL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,434,880 - 57,467,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,434,886 - 57,465,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,448,632 - 57,481,167 (-)NCBI
ROS_Cfam_1.0557,638,951 - 57,671,485 (-)NCBI
ROS_Cfam_1.0 Ensembl557,638,957 - 57,669,464 (-)Ensembl
UMICH_Zoey_3.1557,630,277 - 57,662,801 (-)NCBI
UNSW_CanFamBas_1.0557,522,566 - 57,555,107 (-)NCBI
UU_Cfam_GSD_1.0557,912,337 - 57,944,882 (-)NCBI
Mmel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,468,571 - 28,499,453 (-)NCBI
SpeTri2.0NW_004936737970,504 - 997,452 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMEL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,436,642 - 64,472,759 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,436,778 - 64,470,888 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,819,225 - 58,855,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225750
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,916,051 - 128,963,545 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20128,921,369 - 128,963,188 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605433,291,779 - 33,306,944 (+)NCBIVero_WHO_p1.0
Mmel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,453,177 - 7,485,439 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248187,451,213 - 7,481,988 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D5Got120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,455,774 - 165,455,905 (+)MAPPERmRatBN7.2
Rnor_6.05172,297,964 - 172,298,094NCBIRnor6.0
Rnor_5.05175,753,927 - 175,754,057UniSTSRnor5.0
RGSC_v3.45171,697,411 - 171,697,542RGDRGSC3.4
RGSC_v3.45171,697,412 - 171,697,542UniSTSRGSC3.4
RGSC_v3.15171,707,907 - 171,708,037RGD
Celera5163,662,293 - 163,662,423UniSTS
RH 3.4 Map51153.6UniSTS
RH 3.4 Map51153.6RGD
RH 2.0 Map51144.4RGD
Cytogenetic Map5q36UniSTS
AU047969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,431,956 - 165,432,116 (+)MAPPERmRatBN7.2
Rnor_6.05172,274,149 - 172,274,308NCBIRnor6.0
Rnor_5.05175,729,802 - 175,729,961UniSTSRnor5.0
RGSC_v3.45171,673,597 - 171,673,756UniSTSRGSC3.4
Celera5163,638,479 - 163,638,638UniSTS
Cytogenetic Map5q36UniSTS
RH138040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,461,470 - 165,461,682 (+)MAPPERmRatBN7.2
Rnor_6.05172,303,660 - 172,303,871NCBIRnor6.0
Rnor_5.05175,759,623 - 175,759,834UniSTSRnor5.0
RGSC_v3.45171,703,108 - 171,703,319UniSTSRGSC3.4
Celera5163,667,989 - 163,668,200UniSTS
RH 3.4 Map51153.9UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Genetic Models
This gene Mmel1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:672
Count of miRNA genes:152
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000017957, ENSRNOT00000064266, ENSRNOT00000064738
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 10 2 14 2 1 1 39 1 4 1 1
Below cutoff 3 15 30 22 5 22 7 9 21 10 25 9 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017957   ⟹   ENSRNOP00000017957
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,431,343 - 165,461,715 (+)Ensembl
Rnor_6.0 Ensembl5172,273,459 - 172,304,225 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000064266   ⟹   ENSRNOP00000062904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,433,367 - 165,461,716 (+)Ensembl
Rnor_6.0 Ensembl5172,275,734 - 172,303,596 (+)Ensembl
RefSeq Acc Id: NM_001107997   ⟹   NP_001101467
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,433,367 - 165,461,716 (+)NCBI
Rnor_6.05172,275,559 - 172,303,905 (+)NCBI
Rnor_5.05175,729,143 - 175,759,868 (+)NCBI
RGSC_v3.45171,675,007 - 171,703,353 (+)RGD
Celera5163,639,889 - 163,668,234 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239567   ⟹   XP_006239629
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,716 (+)NCBI
Rnor_6.05172,273,450 - 172,303,904 (+)NCBI
Rnor_5.05175,729,143 - 175,759,868 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239569   ⟹   XP_006239631
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,716 (+)NCBI
Rnor_6.05172,273,450 - 172,303,902 (+)NCBI
Rnor_5.05175,729,143 - 175,759,868 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239570   ⟹   XP_006239632
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,710 (+)NCBI
Rnor_6.05172,273,450 - 172,303,904 (+)NCBI
Rnor_5.05175,729,143 - 175,759,868 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764360   ⟹   XP_008762582
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,710 (+)NCBI
Rnor_6.05172,290,395 - 172,303,904 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110110   ⟹   XP_038966038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,716 (+)NCBI
RefSeq Acc Id: XM_039110111   ⟹   XP_038966039
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,710 (+)NCBI
RefSeq Acc Id: XM_039110112   ⟹   XP_038966040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,461,710 (+)NCBI
RefSeq Acc Id: XM_039110114   ⟹   XP_038966042
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,458,684 (+)NCBI
RefSeq Acc Id: XM_039110115   ⟹   XP_038966043
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,458,672 (+)NCBI
RefSeq Acc Id: XM_039110116   ⟹   XP_038966044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,457,041 (+)NCBI
RefSeq Acc Id: XM_039110117   ⟹   XP_038966045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,431,278 - 165,457,041 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101467   ⟸   NM_001107997
- Sequence:
RefSeq Acc Id: XP_006239629   ⟸   XM_006239567
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239631   ⟸   XM_006239569
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006239632   ⟸   XM_006239570
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008762582   ⟸   XM_008764360
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000062904   ⟸   ENSRNOT00000064266
RefSeq Acc Id: ENSRNOP00000017957   ⟸   ENSRNOT00000017957
RefSeq Acc Id: XP_038966038   ⟸   XM_039110110
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038966039   ⟸   XM_039110111
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038966040   ⟸   XM_039110112
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038966042   ⟸   XM_039110114
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038966043   ⟸   XM_039110115
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038966044   ⟸   XM_039110116
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038966045   ⟸   XM_039110117
- Peptide Label: isoform X9
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C1T0-F1-model_v2 AlphaFold P0C1T0 1-774 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694312
Promoter ID:EPDNEW_R4837
Type:initiation region
Name:Mmel1_1
Description:membrane metallo-endopeptidase-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05172,273,514 - 172,273,574EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309299 AgrOrtholog
BioCyc Gene G2FUF-38946 BioCyc
Ensembl Genes ENSRNOG00000012593 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017957 ENTREZGENE
  ENSRNOP00000017957.4 UniProtKB/TrEMBL
  ENSRNOP00000062904 ENTREZGENE
Ensembl Transcript ENSRNOT00000017957 ENTREZGENE
  ENSRNOT00000017957.7 UniProtKB/TrEMBL
  ENSRNOT00000064266 ENTREZGENE
Gene3D-CATH 1.10.1380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MMEL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 313755 ENTREZGENE
PANTHER PTHR11733 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11733:SF141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmel1 PhenoGen
PRINTS NEPRILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEPRILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt A0A0H2UHK7 ENTREZGENE, UniProtKB/TrEMBL
  MMEL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Mmel1  membrane metallo-endopeptidase-like 1  Mell1_predicted  mel transforming oncogene-like 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Mell1_predicted  mel transforming oncogene-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED