Draxin (dorsal inhibitory axon guidance protein) - Rat Genome Database

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Gene: Draxin (dorsal inhibitory axon guidance protein) Rattus norvegicus
Analyze
Symbol: Draxin
Name: dorsal inhibitory axon guidance protein
RGD ID: 1585098
Description: Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Predicted to be active in extracellular region. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein); INTERACTS WITH bisphenol A; Cuprizon; paracetamol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hypothetical protein LOC691317; LOC691317
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,813,308 - 163,846,609 (-)NCBIGRCr8
mRatBN7.25158,530,149 - 158,563,457 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,530,342 - 158,564,483 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05164,913,085 - 164,943,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,913,906 - 164,927,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,571,192 - 168,604,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,179,954 - 165,193,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5156,813,054 - 156,842,895 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19150847   PMID:19808066   PMID:19857465   PMID:20621059  


Genomics

Comparative Map Data
Draxin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,813,308 - 163,846,609 (-)NCBIGRCr8
mRatBN7.25158,530,149 - 158,563,457 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,530,342 - 158,564,483 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05164,913,085 - 164,943,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,913,906 - 164,927,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,571,192 - 168,604,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,179,954 - 165,193,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5156,813,054 - 156,842,895 (-)NCBICelera
Cytogenetic Map5q36NCBI
DRAXIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,686,635 - 11,725,857 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,691,710 - 11,725,857 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,751,767 - 11,785,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,674,368 - 11,702,923 (+)NCBINCBI36Build 36hg18NCBI36
Celera110,863,842 - 10,892,408 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,905,872 - 10,934,449 (+)NCBIHuRef
CHM1_1111,739,788 - 11,768,348 (+)NCBICHM1_1
T2T-CHM13v2.0111,230,691 - 11,269,932 (+)NCBIT2T-CHM13v2.0
Draxin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,182,894 - 148,215,582 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,182,894 - 148,215,155 (-)EnsemblGRCm39 Ensembl
GRCm384148,098,437 - 148,131,139 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,098,437 - 148,130,698 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,472,546 - 147,504,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,944,456 - 146,974,498 (-)NCBIMGSCv36mm8
Celera4150,340,046 - 150,392,279 (-)NCBICelera
Cytogenetic Map4E1- E2NCBI
cM Map478.67NCBI
Draxin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,161,913 - 2,174,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,161,927 - 2,185,230 (-)NCBIChiLan1.0ChiLan1.0
DRAXIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,496,154 - 216,533,049 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,142,280 - 215,179,165 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,453,708 - 10,488,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,670,651 - 11,700,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,670,651 - 11,700,012 (+)Ensemblpanpan1.1panPan2
DRAXIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,515,881 - 84,525,797 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,515,811 - 84,526,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,048,566 - 81,058,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,179,300 - 85,189,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,177,345 - 85,201,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,928,122 - 81,937,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,928,734 - 82,938,550 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,991,540 - 84,001,382 (-)NCBIUU_Cfam_GSD_1.0
Draxin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,735,958 - 34,748,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474561,822 - 571,622 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474561,822 - 571,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRAXIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,786,800 - 71,814,679 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,786,806 - 71,814,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,729,472 - 65,740,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRAXIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,073,073 - 120,099,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,073,430 - 120,085,279 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,934,170 - 23,968,426 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Draxin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,256,169 - 1,263,904 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,253,968 - 1,274,418 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Draxin
174 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:96
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000012080
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 53 7
Low 2 6 16 12 12 12 19 21 33 2
Below cutoff 1 9 23 11 7 11 3 5 2 9 1 9 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012080   ⟹   ENSRNOP00000012079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,530,342 - 158,564,483 (-)Ensembl
Rnor_6.0 Ensembl5164,913,906 - 164,927,869 (-)Ensembl
RefSeq Acc Id: XM_006239423   ⟹   XP_006239485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,813,308 - 163,846,609 (-)NCBI
mRatBN7.25158,534,342 - 158,563,457 (-)NCBI
Rnor_6.05164,913,085 - 164,943,012 (-)NCBI
Rnor_5.05168,571,192 - 168,604,145 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111355   ⟹   XP_038967283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,813,308 - 163,836,862 (-)NCBI
mRatBN7.25158,530,149 - 158,553,704 (-)NCBI
Protein Sequences
Protein RefSeqs XP_006239485 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967283 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012079
  ENSRNOP00000012079.4
Reference Protein Sequences
RefSeq Acc Id: XP_006239485   ⟸   XM_006239423
- Peptide Label: isoform X2
- UniProtKB: D3ZDG4 (UniProtKB/TrEMBL),   A6IU48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012079   ⟸   ENSRNOT00000012080
RefSeq Acc Id: XP_038967283   ⟸   XM_039111355
- Peptide Label: isoform X1
- UniProtKB: A6IU48 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDG4-F1-model_v2 AlphaFold D3ZDG4 1-342 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585098 AgrOrtholog
BioCyc Gene G2FUF-39177 BioCyc
Ensembl Genes ENSRNOG00000008911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012080.5 UniProtKB/TrEMBL
InterPro Draxin UniProtKB/TrEMBL
KEGG Report rno:691317 UniProtKB/TrEMBL
NCBI Gene 691317 ENTREZGENE
PANTHER DRAXIN UniProtKB/TrEMBL
  PTHR28610 UniProtKB/TrEMBL
Pfam Draxin UniProtKB/TrEMBL
PhenoGen Draxin PhenoGen
RatGTEx ENSRNOG00000008911 RatGTEx
UniProt A6IU48 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDG4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-02 Draxin  dorsal inhibitory axon guidance protein  LOC691317  hypothetical protein LOC691317  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691317  hypothetical protein LOC691317  LOC686619  hypothetical protein LOC686619  Data merged from RGD:1595029 1643240 APPROVED
2006-11-20 LOC686619  hypothetical protein LOC686619      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691317  hypothetical protein LOC691317      Symbol and Name status set to provisional 70820 PROVISIONAL