Park7 (Parkinsonism associated deglycase) - Rat Genome Database

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Gene: Park7 (Parkinsonism associated deglycase) Rattus norvegicus
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Symbol: Park7
Name: Parkinsonism associated deglycase
RGD ID: 621808
Description: Predicted to have several functions, including DNA-binding transcription factor binding activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of NMDA glutamate receptor activity; and positive regulation of fertilization. Localizes to several cellular components, including endoplasmic reticulum; membrane raft; and sperm head. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1-bromopropane; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAP1; contraception-associated protein 1; DJ-1; Dj1; fertility protein SP22; maillard deglycase; Parkinson disease (autosomal recessive, early onset) 7; parkinson disease protein 7 homolog; parkinson protein 7; protein/nucleic acid deglycase DJ-1; SP22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC365828   LOC689000   RGD1560648  
Allele / Splice: Park7em1Sage  
Genetic Models: LE-Park7em1Sage-/- LE-Park7em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,353,718 - 161,376,993 (-)NCBI
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
astemizole  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butyric acid  (EXP,ISO)
cadmium dichloride  (ISO)
CCCP  (ISO)
chlorpyrifos  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenazaquin  (ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
glutathione  (ISO)
haloperidol  (ISO)
heparin  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
isoniazide  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
LY294002  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
meloxicam  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
nicotine  (ISO)
ouabain  (ISO)
oxidopamine  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
permethrin  (EXP)
phlorizin  (ISO)
potassium chromate  (ISO)
prostaglandin E2  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rotenone  (EXP,ISO)
rutin  (EXP)
sarin  (EXP,ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (EXP)
toluene  (EXP)
Tributyltin oxide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
aging  (IEP)
autophagy  (IEA)
cellular detoxification of aldehyde  (ISO,ISS)
cellular detoxification of methylglyoxal  (ISO,ISS)
cellular oxidant detoxification  (IEA)
cellular response to glyoxal  (IEA,ISO,ISS)
cellular response to hydrogen peroxide  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IEP)
cellular response to oxidative stress  (ISO,ISS)
cellular response to reactive oxygen species  (ISO)
detection of oxidative stress  (ISO)
detoxification of copper ion  (IEA,ISO,ISS)
detoxification of mercury ion  (IEA,ISO,ISS)
DNA repair  (IEA,ISO,ISS)
dopamine uptake involved in synaptic transmission  (ISO)
fertilization  (TAS)
glucose homeostasis  (ISO,ISS)
glutathione deglycation  (IEA,ISO)
glycolate biosynthetic process  (ISO,ISS)
glyoxal catabolic process  (IEA)
glyoxal metabolic process  (ISO)
guanine deglycation  (ISO,ISS)
guanine deglycation, glyoxal removal  (IBA,IEA,ISO,ISS)
guanine deglycation, methylglyoxal removal  (IEA,ISO,ISS)
histone modification  (IEA,ISO,ISS)
hydrogen peroxide metabolic process  (IEA,ISO,ISS)
inflammatory response  (IEA)
insulin secretion  (ISO,ISS)
lactate biosynthetic process  (ISO)
maternal process involved in female pregnancy  (IEP)
membrane depolarization  (ISO)
membrane hyperpolarization  (ISO)
methylglyoxal catabolic process to lactate  (IEA,ISO,ISS)
methylglyoxal metabolic process  (ISO,ISS)
mitochondrion organization  (ISO,ISS)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO,ISS)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (IEA,ISO,ISS)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of hydrogen peroxide-induced neuron death  (ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neuron death  (IMP,ISO)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of NMDA glutamate receptor activity  (IMP)
negative regulation of oxidative stress-induced cell death  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
negative regulation of protein acetylation  (IEA,ISO,ISS)
negative regulation of protein binding  (IEA,ISO,ISS)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein export from nucleus  (IEA,ISO,ISS)
negative regulation of protein K48-linked deubiquitination  (IEA,ISO,ISS)
negative regulation of protein kinase activity  (IEA,ISO,ISS)
negative regulation of protein phosphorylation  (ISO,ISS)
negative regulation of protein sumoylation  (IEA,ISO,ISS)
negative regulation of protein ubiquitination  (ISO,ISS)
negative regulation of reactive oxygen species biosynthetic process  (ISO,ISS)
negative regulation of TRAIL-activated apoptotic signaling pathway  (IEA,ISO,ISS)
negative regulation of ubiquitin-protein transferase activity  (IEA,ISO)
negative regulation of ubiquitin-specific protease activity  (IEA,ISO,ISS)
peptidyl-arginine deglycation  (IEA,ISO,ISS)
peptidyl-cysteine deglycation  (IEA,ISO)
peptidyl-lysine deglycation  (IEA,ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO,ISS)
positive regulation of androgen receptor activity  (IEA,ISO,ISS)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of dopamine biosynthetic process  (IEA,ISO,ISS)
positive regulation of fertilization  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of L-dopa biosynthetic process  (IEA,ISO,ISS)
positive regulation of L-dopa decarboxylase activity  (IEA,ISO,ISS)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (IEA,ISO,ISS)
positive regulation of NAD(P)H oxidase activity  (ISO,ISS)
positive regulation of oxidative phosphorylation uncoupler activity  (ISO,ISS)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of protein localization to nucleus  (IEA,ISO,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISO,ISS)
positive regulation of pyrroline-5-carboxylate reductase activity  (IEA,ISO,ISS)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of superoxide dismutase activity  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of transcription regulatory region DNA binding  (IEA,ISO)
positive regulation of tyrosine 3-monooxygenase activity  (IEA,ISO,ISS)
protein deglycation, glyoxal removal  (IBA,IEA,ISO)
protein deglycation, methylglyoxal removal  (IEA,ISO,ISS)
protein deglycosylation  (IEA,ISO,ISS)
protein stabilization  (IEA,ISO,ISS)
proteolysis  (IEA)
regulation of androgen receptor signaling pathway  (IEA,ISO,ISS)
regulation of histone acetylation  (IEA,ISO,ISS)
regulation of histone ubiquitination  (IEA,ISO,ISS)
regulation of inflammatory response  (ISO,ISS)
regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
regulation of neuron apoptotic process  (ISO,ISS)
regulation of TRAIL production  (ISO)
response to drug  (IEP)
response to hydrogen peroxide  (ISO)
response to oxidative stress  (IMP)
single fertilization  (IEA)
spermatogenesis  (IEP)
synaptic transmission, dopaminergic  (ISO)

Cellular Component
axon  (IDA)
cell body  (ISO)
chromatin  (IEA,ISO)
cytoplasm  (ISO,ISS)
cytosol  (IBA,IDA,IEA,ISO)
endoplasmic reticulum  (IDA,IEA,ISO)
extracellular exosome  (ISS)
membrane raft  (IDA,IEA)
mitochondrial intermembrane space  (ISO)
mitochondrial matrix  (ISO)
mitochondrion  (IDA,IEA,ISO,ISS)
neuron projection  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IEA)
PML body  (IEA,ISO,ISS)
presynapse  (IEA)
sperm head  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aleyasin H, etal., Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18748-53. doi: 10.1073/pnas.0709379104. Epub 2007 Nov 14.
2. Ariga H, etal., Oxid Med Cell Longev. 2013;2013:683920. doi: 10.1155/2013/683920. Epub 2013 May 16.
3. Bandopadhyay R, etal., Brain. 2004 Feb;127(Pt 2):420-30. Epub 2003 Dec 8.
4. Benoit AM, etal., Exp Biol Med (Maywood). 2005 Nov;230(10):721-30.
5. Benoit AM, etal., Exp Biol Med (Maywood). 2007 Jul;232(7):910-20.
6. Böhm MR, etal., Front Neuroanat. 2015 Mar 4;9:16. doi: 10.3389/fnana.2015.00016. eCollection 2015.
7. Chang N, etal., Aging Cell. 2010 Oct;9(5):837-50. doi: 10.1111/j.1474-9726.2010.00615.x.
8. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Inden M, etal., J Pharmacol Sci. 2011;117(3):189-203. Epub 2011 Oct 29.
11. Inden M, etal., Neurobiol Dis. 2006 Oct;24(1):144-58. Epub 2006 Jul 24.
12. Jin J, etal., Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18.
13. Kim KS, etal., Hum Mol Genet. 2013 Dec 1;22(23):4805-17. doi: 10.1093/hmg/ddt332. Epub 2013 Jul 11.
14. Klinefelter GR, etal., J Androl. 2002 Jan-Feb;23(1):48-63.
15. MGD data from the GO Consortium
16. Miller DW, etal., J Biol Chem. 2003 Sep 19;278(38):36588-95. Epub 2003 Jul 8.
17. Miyazaki S, etal., J Neurochem. 2008 Jun 1;105(6):2418-34. doi: 10.1111/j.1471-4159.2008.05327.x.
18. Moutaoufik MT, etal., iScience. 2019 Sep 27;19:1114-1132. doi: 10.1016/j.isci.2019.08.057. Epub 2019 Sep 4.
19. NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline
21. Pipeline to import KEGG annotations from KEGG into RGD
22. RGD automated data pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. RGD comprehensive gene curation
26. Sonia Angeline M, etal., Neuroscience. 2012 Sep 18;220:291-301. doi: 10.1016/j.neuroscience.2012.06.021. Epub 2012 Jun 16.
27. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.
28. Wagenfeld A, etal., Biochem Biophys Res Commun 1998 Oct 20;251(2):545-9.
29. Welch JE, etal., J Androl 1998 Jul-Aug;19(4):385-93.
30. Willis D, etal., J Neurosci. 2005 Jan 26;25(4):778-91.
31. Yanagida T, etal., J Pharmacol Sci. 2006 Oct;102(2):243-7. Epub 2006 Oct 12.
32. Yanagisawa D, etal., J Cereb Blood Flow Metab. 2008 Mar;28(3):563-78. doi: 10.1038/sj.jcbfm.9600553. Epub 2007 Sep 19.
33. Zhou W and Freed CR, J Biol Chem. 2005 Dec 30;280(52):43150-8. Epub 2005 Oct 14.
Additional References at PubMed
PMID:10022524   PMID:11477070   PMID:12446870   PMID:12477932   PMID:14652021   PMID:14749723   PMID:14752510   PMID:15502874   PMID:15721235   PMID:15784737   PMID:15790595   PMID:15799973  
PMID:15944198   PMID:15983381   PMID:16047164   PMID:16624565   PMID:16632486   PMID:16731528   PMID:17015834   PMID:17510388   PMID:17599367   PMID:17766438   PMID:18614015   PMID:18626009  
PMID:18711745   PMID:19056867   PMID:19199708   PMID:19229105   PMID:19276172   PMID:19703902   PMID:19822128   PMID:20186336   PMID:20304780   PMID:20458337   PMID:20969476   PMID:21068725  
PMID:21097510   PMID:21426932   PMID:21630459   PMID:21785459   PMID:22132160   PMID:22492997   PMID:22511790   PMID:22523093   PMID:22555455   PMID:22611253   PMID:22613231   PMID:22683601  
PMID:22878563   PMID:23376485   PMID:23533145   PMID:23743200   PMID:23792957   PMID:24144264   PMID:24303086   PMID:24567322   PMID:24899725   PMID:24947010   PMID:25037998   PMID:25416785  
PMID:25468996   PMID:25726699   PMID:25915512   PMID:26021615   PMID:26081287   PMID:26873851   PMID:26913805   PMID:26945066   PMID:26995087   PMID:27171370   PMID:27430285   PMID:27903648  
PMID:28035392   PMID:28245986   PMID:28596309   PMID:28941803   PMID:28993701   PMID:29069575   PMID:29109055   PMID:29287203   PMID:29431188   PMID:29476059   PMID:29649621   PMID:29791076  
PMID:30150385   PMID:30506316   PMID:30894531   PMID:31034784   PMID:31250274   PMID:31593688   PMID:31653696   PMID:31734455   PMID:31878239   PMID:32051471   PMID:32061171   PMID:32151250  
PMID:32157145  


Genomics

Comparative Map Data
Park7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,353,718 - 161,376,993 (-)NCBI
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
PARK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl17,954,291 - 7,985,505 (+)EnsemblGRCh38hg38GRCh38
GRCh3817,961,711 - 7,985,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3718,021,771 - 8,045,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,944,380 - 7,967,926 (+)NCBINCBI36hg18NCBI36
Build 3417,956,058 - 7,979,602NCBI
Celera17,128,771 - 7,152,398 (+)NCBI
Cytogenetic Map1p36.23NCBI
HuRef17,169,316 - 7,193,163 (+)NCBIHuRef
CHM1_118,009,469 - 8,033,097 (+)NCBICHM1_1
Park7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBImm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
Park7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
PARK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0panPan3
PARK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,576,219 - 61,592,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,576,069 - 61,592,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,584,413 - 61,601,125 (+)NCBI
ROS_Cfam_1.0561,791,984 - 61,808,701 (+)NCBI
UMICH_Zoey_3.1561,791,244 - 61,807,961 (+)NCBI
UNSW_CanFamBas_1.0561,656,017 - 61,672,730 (+)NCBI
UU_Cfam_GSD_1.0562,059,399 - 62,076,120 (+)NCBI
Park7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,937,508 - 31,951,577 (+)NCBI
SpeTri2.0NW_0049366232,422,780 - 2,436,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,629,214 - 68,645,520 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,629,327 - 68,645,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,023,779 - 63,033,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARK7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,776,084 - 123,808,031 (-)NCBI
ChlSab1.1 Ensembl20123,776,297 - 123,798,434 (-)Ensembl
Park7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248183,900,917 - 3,915,457 (-)NCBI

Position Markers
RH142283  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map21059.6UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5157319671171194163Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5157319671173707219Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5161084664173707219Rat


Genetic Models
This gene Park7 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ007291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM055257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM061417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM069664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN087054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN087057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN087058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024711   ⟹   ENSRNOP00000024711
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5167,988,385 - 168,004,724 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087402   ⟹   ENSRNOP00000072068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5167,988,385 - 167,999,853 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091206   ⟹   ENSRNOP00000074942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5167,982,439 - 168,000,083 (-)Ensembl
RefSeq Acc Id: NM_001277249   ⟹   NP_001264178
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,353,718 - 161,372,352 (-)NCBI
Rnor_6.05167,982,438 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,607,648 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277250   ⟹   NP_001264179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,352 (-)NCBI
Rnor_6.05167,988,385 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277251   ⟹   NP_001264180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,352 (-)NCBI
Rnor_6.05167,988,385 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277252   ⟹   NP_001264181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,352 (-)NCBI
Rnor_6.05167,988,385 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277253   ⟹   NP_001264182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,376,993 (-)NCBI
Rnor_6.05167,988,385 - 168,004,724 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,630,713 (-)NCBI
Sequence:
RefSeq Acc Id: NM_057143   ⟹   NP_476484
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,122 (-)NCBI
Rnor_6.05167,988,385 - 167,999,853 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
RGSC_v3.45168,050,149 - 168,061,616 (-)RGD
Celera5159,614,374 - 159,625,842 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476484   ⟸   NM_057143
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264178   ⟸   NM_001277249
- Peptide Label: isoform 1
- UniProtKB: Q5BKC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264182   ⟸   NM_001277253
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264181   ⟸   NM_001277252
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264179   ⟸   NM_001277250
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264180   ⟸   NM_001277251
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024711   ⟸   ENSRNOT00000024711
RefSeq Acc Id: ENSRNOP00000072068   ⟸   ENSRNOT00000087402
RefSeq Acc Id: ENSRNOP00000074942   ⟸   ENSRNOT00000091206
Protein Domains
DJ-1_PfpI

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694284
Promoter ID:EPDNEW_R4809
Type:initiation region
Name:Park7_1
Description:Parkinsonism associated deglycase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4810  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05168,000,070 - 168,000,130EPDNEW
RGD ID:13694285
Promoter ID:EPDNEW_R4810
Type:initiation region
Name:Park7_2
Description:Parkinsonism associated deglycase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4809  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05168,004,692 - 168,004,752EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621808 AgrOrtholog
Ensembl Genes ENSRNOG00000018289 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024711 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072068 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074942 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024711 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000087402 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000091206 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7376914 IMAGE-MGC_LOAD
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DJ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DJ-1/PfpI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117287 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108615 IMAGE-MGC_LOAD
NCBI Gene 117287 ENTREZGENE
Pfam DJ-1_PfpI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Park7 PhenoGen
Superfamily-SCOP SSF52317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs not_thiJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O88767 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5BKC3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Park7  parkinson protein 7  Park7  Parkinson disease (autosomal recessive, early onset) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Park7  Parkinson disease (autosomal recessive, early onset) 7    fertility protein SP22  Name updated 1299863 APPROVED
2004-09-10 Park7  fertility protein SP22  SP22    Symbol and Name updated 1299863 APPROVED
2002-08-07 SP22  fertility protein SP22      Symbol and Name status set to provisional 70820 PROVISIONAL