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Gene: Park7 (Parkinsonism associated deglycase) Rattus norvegicus
Symbol: Park7
Name: Parkinsonism associated deglycase
Description: Predicted to have several functions, including DNA-binding transcription factor binding activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including cellular response to lipopolysaccharide; maternal process involved in female pregnancy; and negative regulation of NMDA glutamate receptor activity. Localizes to several cellular components, including endoplasmic reticulum; membrane raft; and sperm head. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1-bromopropane; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAP1; contraception-associated protein 1; DJ-1; Dj1; fertility protein SP22; maillard deglycase; Parkinson disease (autosomal recessive, early onset) 7; parkinson disease protein 7 homolog; parkinson protein 7; protein/nucleic acid deglycase DJ-1; SP22
Homo sapiens (human) : PARK7 (Parkinsonism associated deglycase)  HGNC  Alliance
Mus musculus (house mouse) : Park7 (Parkinson disease (autosomal recessive, early onset) 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Park7 (Parkinsonism associated deglycase)
Pan paniscus (bonobo/pygmy chimpanzee) : PARK7 (Parkinsonism associated deglycase)
Canis lupus familiaris (dog) : PARK7 (Parkinsonism associated deglycase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Park7 (Parkinsonism associated deglycase)
Sus scrofa (pig) : PARK7 (Parkinsonism associated deglycase)
Chlorocebus sabaeus (African green monkey) : PARK7 (Parkinsonism associated deglycase)
Heterocephalus glaber (naked mole-rat) : Park7 (Parkinsonism associated deglycase)
more info ...
Related Pseudogenes: LOC365828   LOC689000   RGD1560648  
Allele / Splice: Park7em1Sage  
Genetic Models: LE-Park7em1Sage-/- LE-Park7em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Park7
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621808
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.